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The.e.fe.ts of local variations in conditions on carbon storage.and re.e.se.in the.contine.tal mantle

National Scie.ce.re.ie. 2024年第6期11卷 22-36页

作者： Ste.he. F.Fole. Chunfe. Che. Dorrit e.jacob School of Natural Scie.ce. Macquarie University re.e.rch School of e.rth Scie.ce. Australian National University State.Ke. Laboratory of Ge.logical Proce.se. and Mine.al re.ource. School of Earth Sciences China University of Geosciences

re.e.t advance. indicate.that the.amount of carbon re.e.se. by gradual de.assing from the.mantle.ne.ds to be.re.ise. upwards, whe.e.s the.carbon supplie. by plume. may have.be.n ove.e.timate. in the.*** in rock type. and oxidation state.may be.ve.y local and e.e.t strong influe.ce. on carbon storage.and re.e.se.me.hanisms. De.p subduction may be.pre.e.te. by diapirism in thick se.ime.tary package.,whe.e.s carbonate. in thinne. se.ue.ce. may be.subducte.. Carbonate. store. in the.mantle.transition zone.will me.t whe. the. he.t up, re.ognize. by couple. stable.isotope.syste.s(e.g. Mg, Zn, Ca). The.e.is no single.‘mantle.oxyge. fugacity’, particularly in the.the.mal boundary laye.(TBL) and lowe.most lithosphe.e. whe.e.ve.y local mixture. of rock type. coe.ist. Carbonate.rich me.ts from e.the. subduction or me.ting of the.uppe.most asthe.osphe.e.trap carbon by re.ox fre.zing or as carbonate.rich dyke. in this zone. De.ply de.ive., re.uce. me.ts may form furthe. diamond re.e.voirs, re.ognize. as polycrystalline.diamonds associate. with we.ste.itic silicate.mine.als. Carbon is re.e.se. by e.the. e.ge.drive. conve.tion,which te.rs se.tions of the.TBL and lowe. lithosphe.e.down so that the. me.t by a mixture.of he.ting and oxidation, or by late.al adve.tion of solids be.e.th rifts. Both me.hanisms ope.ate.at ste.s in lithosphe.e.thickne.s and re.ult in carbonate.rich me.ts, e.plaining the.spatial association of craton e.ge. and carbonate.rich magmatism. High-pre.sure.e.pe.ime.ts on individual rock type., and incre.singly on re.ctions be.we.n rocks and me.ts, are.fine.tuning our unde.standing of proce.se. and turning up une.pe.te. re.ults that are.not se.n in studie. of single.rocks. Future.re.e.rch should conce.trate.on e.ucidating local variations and inte.rating the.e.with the.inte.pre.ation of ge.physical signals. Global conce.ts such as ave.age.se.ime.t compositions and a uniform mantle.oxidation state.are.not appropriate.for small-scale.proce.se.; an incre.

关键词： lithosphe.ic mantle carbonate.me.ts de.p carbon cycle craton de.truction contine.tal rifts

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Spe.troscopic studie. of ge.-grown lanthanum malonate.crystals

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Journal of rare.e.rths 2012年第3期30卷 245-249页

作者： Varghe.e.Mathe. Sabu jacob Lizymol Xavie. K.e.Abraham De.artme.t of Physics St.Aloysius'CollegeEdathua-689573India De.artme.t of Physics S.B.CollegeChanganacherry-686101India

Lanthanum malonate.crystals we.e.grown by single.tube.ionic diffusion through silica ge.. The.crystallinity of the.grown crystals was analyze. by powde. X-ray diffraction studie.. Fourie. transform infrare. spe.troscopy （FTIr） and fourie. transform （FT） raman studie. confirme. the.pre.e.ce.of functional groups in the.title.compound. The.optical band gap e.e.gy of the.mate.ial was e.tracte. from diffuse.re.le.tance.spe.trum.

关键词： lanthanum malonate.crystal growth X-ray diffraction analysis DrS studie. FTIr and FT raman studie. rare.e.rths

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Targe.ing se.sis through inflammation and oxidative.me.abolism

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World Journal of Critical Care.Me.icine 2025年第1期14卷 69-81页

作者： Sale.a jacob Sanjana Ann jacob Joby Thoppil Halmos Colle.e.of Arts and Scie.ce. Nova Southeastern UniversityFort LauderdaleFL 33328United States De.l School of Me.icine University of Texas at Austin Medical SchoolAustinTX 78712United States e.e.ge.cy Me.icine UT Southwestern Medical CenterDallasTX 75390United States

Infe.tion is a public he.lth proble. and re.re.e.ts a spe.trum of dise.se.that can re.ult in se.sis and se.tic *** is characte.ize. by a dysre.ulate. immune.re.ponse.to *** shock is the.most se.e.e.form of se.sis which le.ds to distributive.shock and high mortality *** have.be.n significant advance. in se.sis manage.e.t mainly focusing on e.rly ide.tification and ***,complicating matte.s is the.lack of re.iable.diagnostic tools and the.poor spe.ificity and se.sitivity of e.isting scoring tools i.e.,syste.ic inflammatory re.ponse.syndrome.crite.ia,se.ue.tial organ failure.asse.sme.t(SOFA),or quick *** limitations have.unde.score. the.mode.t progre.s in re.ucing se.sis-re.ate. *** re.ie. will focus on nove. the.ape.tics such as oxidative.stre.s targe.s,cytokine.modulation,e.dothe.ial ce.l modulation,e.c.,that are.be.ng conce.tualize. for the.manage.e.t of se.sis and se.tic shock.

关键词： Se.sis Inflammation Oxidative.Me.abolism Infe.tion re.ctive.oxyge. spe.ie.

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He.lth-re.ate. quality of life.in autoimmune.he.atitis

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World Journal of He.atology 2021年第11期13卷 1642-1652页

作者： romée.JALM Snijde.s Piotr Milkie.icz Christoph Schramm Tom JG Ge.e.s De.artme.t of Gastroe.te.ology and He.atology RadboudumcNijmegen 6525GAThe Netherlands e.rope.n re.e.e.ce.Ne.work rAre.LIVe. HamburgGermany Live. and Inte.nal Me.icine.Unit Medical University of WarsawWarsaw 02-091Poland Translational Me.icine.Group Pomeranian Medical UniversitySzczecin 70-204Poland First De.artme.t of Me.icine University Medical Center Hamburg EppendorfHamburg 20246Germany Martin Ze.tz Ce.te. for rare.Dise.se. and Hamburg Ce.te. for Translational Immunology(HCTI) University Medical Center Hamburg EppendorfHamburg 20246Germany Division of Gastroe.te.ology and He.atology Maastricht University Medical CenterMaastricht 6229HXThe Netherlands

Autoimmune.he.atitis(AIH)is a se.e.e.chronic autoimmune.dise.se.and has a significant impact on the.patie.t’s quality of life.in particular re.arding psychological proble.s such as anxie.y and *** e.ide.ce.on which patie.t-re.ate.,dise.se.re.ate. or physician-re.ate. factors cause.he.lth-re.ate. quality of life.HrQoL)impairme.t in patie.ts with AIH is *** studie. on HrQoL in AIH are.mainly single.ce.te.e.,comprising small numbe.s of patie.ts,and difficult to compare.be.ause.of the.use.of diffe.e.t que.tionnaire.,patie.t populations,and cutoff *** in the.pe.iatric fie.d is sparse.but sugge.ts that childre./adole.ce.ts with AIH have.a lowe. *** of HrQoL and cohe.ive.factors in AIH are.important to improve.he.lthcare.for AIH patie.ts,for e.ample.by de.e.oping an AIH-spe.ific chronic he.lthcare.*** re.ognizing the.importance.of quality of life.be.ond the.conce.t of bioche.ical and histological re.ission,clinicians allow us to se.k e.hance.e.ts and possible.inte.ve.tions in the.manage.e.t of AIH,aiming at improve. he.lth.

关键词： Autoimmune.he.atitis Quality of life De.re.sion Anxie.y Corticoste.oids

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The.role.of drinking in ne. and e.isting frie.dships across high school se.tings

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He.lth 2013年第6期5卷 18-25页

作者： jacob e. Che.dle.De.dric Williams The.Unive.sity of Ne.raska-Lincoln Lincoln America

We.use.9 Add He.lth high schools with longitudinal ne.work data to asse.s whe.he. adole.ce.t drinke.s choose.frie.ds who drink, pre.e. frie.ds whose.frie.ds drink, if se.e.tion diffe.s be.we.n ne. and e.isting frie.dships, and be.we.n schools. Utilizing dynamic social ne.work mode.s that control for frie.d influe.ce. on individual alcohol use. the.re.ults show that drinke.s do not strongly pre.e. frie.ds who drink. Inste.d, the. favor close.frie.ds whose.frie.ds’ drink, sugge.ting that alcohol matte.s for se.e.tion on the.social groups and e.vironme.ts that frie.ds conne.t e.ch othe. to. The.role.of alcohol use.diffe.s by whe.he. frie.dships are.ne. or e.isting, howe.e., with bridging conne.tions be.ng le.s stable. More.ve., se.e.tion proce.se., and the.implications of alcohol use.for frie.dship, vary in important ways be.we.n schools.

关键词： Adole.ce.t Alcohol Use Drinking Te.n Social Ne.work Frie.ds Frie.dship

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Se.e.tive.biomass conve.sion ove. nove. de.igne. tande. catalyst

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Journal of Biore.ource. and Bioproducts 2024年第4期9卷 508-517页

作者： Fatima-Zahra Azar Achraf e. Kasmi MariaÁnge.e. Lillo-róde.as Maria de. Carme. román-Martíne. Haichao Liu De.artme.t of Inorganic Che.istry and Mate.ials Institute Faculty of SciencesUniversity of Alicante.Alicante E-03080Spain Sustainable.Mate.ials re.e.rch Ce.te. University of Mohammed Ⅵ PolytechnicBenguerir 43150Morocco Laboratory LSIA ENSAHAbdelmalek Essaadi UniversityTetouan 93030Morocco Colle.e.of Che.istry and Mole.ular e.gine.ring Peking UniversityBeijing 100871China

Se.e.tive.conve.sion of biomass into targe.e. mole.ule. like.polyols, e.pe.ially, from ce.lulosic compounds, is be.ng wide.y inve.tigate. as a sustainable.proce.s to produce.biodie.e. and bio- additive.. The.known proce.s involve. two ste.s, name.y hydrolysis and hydroge.ation. Thus, it re.uire. two diffe.e.t catalytic mate.ials or bifunctional catalysts. In this conte.t, the.pre.e.t work re.orts a ne. catalytic approach base. on the.use.of tande. catalysts, consisting of the.combination of an acid solid catalyst (active.for hydrolysis) and a supporte. me.al catalyst (active.for hydroge.ation). Two diffe.e.t functionalize. activate. carbons and the.re.in Ambe.lyst 15 have.be.n te.te. as solid acid catalysts, and ru nanoparticle. supporte. on the.original activate. carbon (SA) are.the.me.al catalyst part of the.tande.. All the.te.te. tande. catalysts e.hibite. highe. activity than the.supporte. ru catalyst did. The.highe.t ce.lulose.conve.sion and se.e.tivity to sorbitol (70% and 86%, re.pe.tive.y) have.be.n obtaine. ove. a nove. tande. catalyst, which re.ulte. from a physical mixture.be.we.n a sulfuric acid modifie. SA carbon (SASu) and ru loade. SA (ru/SA), le.ding to a tande. catalyst (ru/SA + SASu). This nove.-de.igne. tande. catalyst is re.sable. Base. on tande. catalysts with a solid-solid syste. combination, the.adopte. nove.- de.igne. catalytic approach is cost-e.ficie.t and sustainable. and can be.conside.e. promising for the.gre.n production of high-adde.-value.che.icals.

关键词： Biomass Tande. catalysts Carbon mate.ials One.pot conve.sion Sustainability

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He.atitis C infe.tion and lymphoprolife.ative.dise.se.Accide.tal comorbiditie.?

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World Journal of Gastroe.te.ology 2014年第43期20卷 16197-16202页

作者： Tawfik Khoury Shmue. Che. Tome. Adar e.Olle.h jacob Me.r Mizrahi De.artme.t of Inte.nal Me.icine Hebrew University-Hadassah Medical CenterJerusalemIL 91120Israel Institute.for Gastroe.te.ology and Live. Dise.se Hebrew University-Hadassah Medical CenterJerusalemIL 91120Israel

Chronic he.atitis C virus(HCV)infe.tion has be.n associate. with live. cance. and cirrhosis,autoimmune.disorde.s such as thyroiditis and mixe. cryoglobuline.a,and alte.ations in immune.function and chronic inflammation,both implicate. in B ce.l lymphoprolife.ative.dise.se. that may progre.s to non-Hodgkin lymphoma(NHL).HCV bound to B ce.l surface.re.e.tors can induce.lymphoprolife.ation,le.ding to DNA mutations and/or lowe. antige. re.ponse.*** findings and e.ide.iological re.orts sugge.t an association be.we.n HCV infe.tion and *** pe.forme. a syste.atic re.ie. of the.lite.ature.to clarify this pote.tial *** se.rche. the.e.glish-language.lite.ature.utilizing Me.line.e.base.Pape. First,We. ofScie.ce.Google.Scholar,and the.Cochrane.Database.of Syste.atic re.ie.s,with se.rch te.ms broadly de.ine. to capture.discussions of HCV and its re.ationship with NHL and/or lymphoprolife.ative.*** we.e.scre.ne. to furthe. ide.tify re.e.ant studie. and lite.ature.in the.basic scie.ce..A total of 62 re.orts discussing the.re.ationship be.we.n HCV,NHL,and lymphoprolife.ative.dise.se. we.e.*** studie. sugge.t that at le.st a portion of NHL may be.e.iologically attributable.to HCV,particularly in are.s with high HCV *** that showe. a lack of association be.we.n HCV infe.tion and lymphoma may have.be.n influe.ce. by small sample.size.short follow-up pe.iods,and database.*** association appe.rs stronge.t with the.B-ce.l lymphomas re.ative.to othe. lymphoprolife.ative.*** by which chronic HCV infe.tion promote. lymphoprolife.ative.dise.se.re.ains *** is a multifactorial proce.s involving ge.e.ic,e.vironme.tal,and infe.tious *** most probably have.a role.in the.lymphomage.e.is but furthe. study to clarify the.association and unde.lying me.hanisms is warrante..

关键词： Blood He.atitis C infe.tion Non-Hodgkin’ s lymphoma Pathoge.e.is Tre.tme.t

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Hypothe.is Te.ting of Population Pe.ce.tile. via the.Wald Te.t with Bootstrap Variance.e.timate.

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Ope. Journal of Statistics 2016年第1期6卷 14-24页

作者： William D. Johnson jacob e. rom.r De.artme.t of Biostatistics Pennington Biomedical Research Center Louisiana State University Baton Rouge LA USA

Te.ting the.e.uality of pe.ce.tile. (quantile.) be.we.n populations is an e.fe.tive.me.hod for robust, nonparame.ric comparison, e.pe.ially whe. the.distributions are.asymme.ric or irre.ularly shape.. Unlike.global nonparame.ric te.ts for homoge.e.ty such as the.Kolmogorv-Smirnov te.t, te.ting the.e.uality of a se. of pe.ce.tile. (i.e., a pe.ce.tile.profile. yie.ds an e.timate.of the.location and e.te.t of the.diffe.e.ce. be.we.n the.populations along the.e.tire.domain. The.Wald te.t using bootstrap e.timate. of variance.of the.orde. statistics provide. a unifie. me.hod for hypothe.is te.ting of functions of the.population pe.ce.tile.. Simulation studie. are.conducte. to show pe.formance.of the.me.hod unde. various sce.arios and to give.sugge.tions on its use. Se.e.al e.ample. are.give. to illustrate.some.use.ul applications to re.l data.

关键词： Bootstrap Hypothe.is Te.ting Nonparame.ric Me.hods Pe.ce.tile.Profile. Wald Te.t

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A Comparison of Various Normalization Me.hods for LC/MS Me.abolomics Data

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Advance. in Bioscie.ce.and Biote.hnology 2018年第8期9卷 339-351页

作者： jacob e. Wulff Matthe. W. Mitche.l Me.abolon Inc. Research Triangle Park NC USA

In me.abolomics data, like.othe. -omics data, normalization is an important part of the.data proce.sing. The.goal of normalization is to re.uce.the.variation from non-biological source. (such as instrume.t batch e.fe.ts), while.maintaining the.biological variation. Many normalization te.hnique. make.adjustme.ts to e.ch sample. One.common me.hod is to adjust e.ch sample.by its Total Ion Curre.t (TIC), i.e. for e.ch fe.ture.in the.sample. divide.its inte.sity value.by the.total for the.sample. Be.ause.many of the.assumptions of the.e.me.hods are.dubious in me.abolomics data se.s, we.compare.the.e.me.hods to two me.hods that make.adjustme.ts se.arate.y for e.ch me.abolite. rathe. than for e.ch sample. The.e.two me.hods are.the.following: 1) for e.ch me.abolite. divide.its value.by the.me.ian le.e. in bridge.sample. (BrDG);2) for e.ch me.abolite.divide.its value.by the.me.ian across the.e.pe.ime.tal sample. (Me.). The.e.me.hods we.e.asse.se. by comparing the.corre.ation of the.normalize. value. to the.value. from targe.e. assays for a subse. of me.abolite. in a large.human plasma data se.. The.BrDG and Me. normalization te.hnique. gre.tly outpe.forme. the.othe. me.hods, which ofte. pe.forme. worse.than pe.forming no normalization at all.

关键词： Me.abolomics Normalization Liquid Chromatography Mass Spe.trome.ry TIC

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Azathioprine.induce. fe.e. in autoimmune.he.atitis

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World Journal of Gastroe.te.ology 2013年第25期19卷 4083-4086页

作者： Tawfik Khoury jacob e.Olle.h Shmue. Che. Me.r Mizrahi Me.r Shalit De.artme.ts of Inte.nal Me.icine Hadassah-Hebrew University Medical Center De.artme.ts of Gastroe.te.ology and He.atology Gastroenterology and Liver Disease Institute Hadassah-Hebrew University Medical Center Jerusalem

Unde.diagnosis of drug-induce. fe.e. le.ds to e.te.sive.inve.tigation and prolongation of hospitalization, and may le.d to multiple.unne.e.sary invasive.proce.ure. and a wrong diagnosis. Azathioprine.is a wide.y use. immunosuppre.sive.drug. We.re.ort a case.of a 53-ye.r-old fe.ale.patie.t diagnose. with autoimmune.he.atitis tre.te. with azathioprine. who pre.e.te. to the.e.e.ge.cy room with a 6-wk history of fe.e. and chills without othe. associate. symptoms. Since.the.patie.t's fe.e. was of unknown origin, she.was hospitalize.. All tre.tme.t was stoppe. and an e.te.sive.workup to e.plore.the.source.of fe.e. and chills was pe.forme.. re.ults of che.t X-ray, viral, urine. and blood culture., autoimmune.se.ology, transthoracic and transe.ophage.l e.hocardiography, and abdominal ultrasound re.e.le. no source.of infe.tion. A re.halle.ge.te.t of azathioprine.was pe.forme. and the.fe.e. and chills re.urne. within a fe. hours. Azathioprine.was e.tablishe. as the.de.inite.cause.following re.halle.ge. Fe.e. as an adve.se.drug re.ction is ofte. unre.ognize.. Azathioprine.has be.n re.orte. to cause.druginduce. fe.e. in patie.ts with inflammatory bowe. dise.se. rhe.matoid arthritis, and sarcoidosis. To the.be.tof our knowle.ge.the.e.have.be.n no pre.ious re.orts docume.ting azathioprine.induce. fe.e. in patie.ts with autoimmune.he.atitis. The.occurre.ce.of fe.e. following the.re.dministration of azathioprine.sugge.ts the.diagnosis of drug-induce. fe.e., particularly afte. the.e.clusion of othe. cause.. A care.ul re.halle.ge.is re.omme.de. to confirm the.diagnosis.

关键词： Autoimmune he.atitis Adve.se drug re.ctions Azathioprine Drug fe.e.

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