检索结果-南通市图书馆

A mitochondria-targeted AIE photosensitizer for enhancing specificity and efficacy of ferroptosis inducer

Science China Chemistry 2022年第5期65卷 870-876页

作者： Shan wang Chao Chen Jianmin wu Jianyu Zhang jacky.w.y.lam Hongyang wang Lei Chen Ben Zhong Tang Fudan University Shanghai Cancer Center Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyState Key Laboratory of Molecular NanoscienceDivision of Life Scienceand Department of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China Institute of Metabolism and Integrative Biology Fudan UniversityShanghai 200433China The International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China National Center for Liver Cancer Shanghai 200441China Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China AIE Institute Guangzhou Development DistrictGuangzhou 510530China

Ferroptosis is a form of regulated cell death characterized by iron-dependent accumulation of lipid peroxidation and lethal reactive oxygen species(ROS).To date,misregulated ferroptosis has been implicated in several types of cancers,and ferroptosis inducers can be used to promote ferroptosis in tumor cells and play an anti-tumor ***,the specificity and efficacy of ferroptosis inducers remain ***,a new mitochondria-targeted photosensitizer(PS)with aggregation-induced emission(AIE)characteristic named TCSVP was designed,which efficiently generates ROS in mitochondria after light *** administration significantly sensitizes tumor cells to ferroptosis inducer(RSL3)-mediated cell death by specifically and light-dependently triggering a moderate ROS generation in vitro and in ***,the expression levels of ferroptosis related proteins Acyl-CoA synthetase long-chain family member 4(FACL4/ACSL4)and cyclooxygenase-2(COX2)were increased in TCSVP/RSL3-treated cells after light exposure,coupled with decreased Glutathione peroxidase 4(GPX4)activity and excessive malondialdehyde(MDA)*** study declared that light-induced moderate ROS generation within mitochondria in cancer cells by AIE-PS can be used to enhance the specificity and efficacy of ferroptosis inducers,bringing a new synergistic strategy for tumor intervention.

关键词： controlling ROS generation high-performance AIE-PS lipid peroxidation ferroptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Monotropic smectic A to double layer smectic C transition of biphenyl containing liquid crystal acetylene

引用

Chinese Chemical Letters 2011年第11期22卷 1355-1358页

作者： Zhen Qiang yu CaiZhenZhu Zhe Zhang Jian Hong Liu jacky w.y. lam Ben Zhong Tang Shenzhen Key Laboratory of Functional Polymers and School of Chemistry and Chemical Engineering Shenzhen University Shenzhen 518060 China Department of Chemistry The Hong Kong University of Science and Technology Clear Water BayKowloonChina

5-[（4＇-Heptoxy-4-biphenylyl）carbonyloxy]-1-pentyne（A-3,7） was synthesized and the phase structures and transitions were investigated by differential scanning calorimetry（DSC）,wide angle X-ray diffraction（wAXD）,polarized light microscopy（PLM） and the molecular packing in the crystal and liquid crystalline phases were simulated by molecular dynamic *** results showed that the sample formed thermodynamically metastable SmA and SmC_2 phases before crystallized during cooling and the crystal phase directly transformed into isotropic phase during heating.

关键词： Liquid crystal Phase structure Phase transition Smectic phase X-ray diffraction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SyNTHESIS AND PHOTOLUMINESCENCE OF AN ANTHRACENE-CONTAINING HyPERBRANCHED POLy(ARyLENEETHyNyLENE)

引用

Chinese Journal of Polymer Science 2005年第6期23卷 665-669页

作者： yong-qiang Dong Zhen Li jacky w. y. lam yu-ping Dong Xin-de Feng Ben-zhong Tang Department of Polymer Science and Engineering College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Department of Chemistry Center for Display Research The Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China

A hyperbranched poly（aryleneethynylene） containing anthracene chromophore was synthesized by palladiumcatalyzed cross-coupling reaction of 2,4,6-triiodophenyl 9-anthracenylcarboxylate with 9,9-bis[4-（2-propynyloxy）phenyl]- 9H-fluorene. The structure and properties of the polymer are characterized and evaluated by NMR, IR, UV, PL and TGA analyses. The polymer is soluble in common organic solvents, possesses high thermal stability （Td 〉 330℃）, and emits a strong blue light of 465 nm in both solution and solid states.

关键词： Hyperbranched polymer Cross-coupling Blue light emission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SyNTHESIS,HELICITy,AND BIOLOGICAL PROPERTIES OF MONOSACCHARIDE-CONTAININGPOLy(PHENyLACETyLENE)S

引用

Chinese Journal of Polymer Science 2007年第2期25卷 119-122页

作者： jacky w. y. lam Kevin K. L. Cheuk Bing-shi Li yong Xie Ben-zhong Tang Department of Chemistry The Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China Department of Biology The Hong Kong University of Science ＆ Technology Clear Water Bay Kowloon Hong Kong China Department of Polymer Science ＆ Engineering Zhejiang University Hangzhou 310027 China

Poly（phenylacetylene）s beating monosaccharide pendant groups are synthesized in high yields by [Rh（nbd）Cl]2 catalyst. The polymers have high molecular weights and give satisfactory spectroscopic data corresponding to their molecular structures. They are thermally quite stable （≥ 300℃） and show strong circular dichroism signals in the visible spectral region owing to the helicity of the polyene backbone. The monosaccharide-containing polyacetylenes are cytophilic and can stimulate the growth of living cells.

关键词： Biocompatibility Biomimetic Helicity Monosaccharides Polyacetylenes Sugars.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A general powder dusting method for latent fingerprint development based on AIEgens

引用

Science China Chemistry 2018年第8期61卷 966-970页

作者： Zijie Qiu Bin Hao Xinggui Gu Zhaoyu wang Ni Xie jacky.w.y.lam Hongxia Hao Ben Zhong Tang Key Laboratory of Evidence Science (China University of Political Science and Law) Ministry of Education Beijing 100088 China Collaborative Innovation Center of Judicial Civilization China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Molecular Neuroscienee Institute for Advanced Study Institute of Molecular Functional Materials Division of Biomedical Engineering the Hong Kong University of Science and Technology Clear Water Bay Kowloon China NSFC Center for Luminescence from Molecular Aggregates SCUT-HKUST Joint Research Institute State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China

Powder dusting method is the most practically useful approach for latent fingerprint development in the crime scene. Herein, a general powder dusting method has been explored for latent fingerprint development based on aggregation-induced emission luminogens(AIEgens). A series of tetraphenylethene(TPE) derivatives with multiple diphenylamine(DPA), namely, TPE-DPA,TPE-2 DPA and TPE-4 DPA, were selected as candidates to dope with magnetic powders and applied for latent fingerprint development. After screening, the magnetic powder 3 doped with TPE-4 DPA proves to be the best, in terms of fluorescent intensity, resolution and adhesiveness. Afterwards, the magnetic powder 3 was applied for visualization of latent fingerprint on various smooth and porous substrates, including glass, stainless steel, leaf, ceram, plastic bag, lime wall, wood and paper *** details, such as island, core, termination and bifurcation, can be clearly observed for the fluorescent fingerprint images.

关键词： latent fingerprint development powder dusting aggregation-induced emission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New carbazole-substituted siloles for the fabrication of efficient non-doped OLEDs

引用

Chinese Chemical Letters 2019年第3期30卷 592-596页

作者： yi Xiong Jiajie Zeng Bin Chen jacky.w.y.lam Zujin Zhao Shuming Chen Ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Center for Aggregation-Induced Emission South China University of Technology Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science & Technology Department of Electrical and Electronic Engineering South University of Science and Technology of China

Luminogenic molecules with aggregation-induced emission(AIE) property are free of aggregationcaused quenching and thus have great potential in the fabrication of efficient non-doped OLEDs. Herein, a series of new carbazole-substituted siloles have been synthesized and characterized. Their crystal and electronic structures, thermal stabilities, electrochemical behaviors, and photophysical properties are thoroughly investigated. These silole derivatives exhibit prominent AIE characteristics with high emission efficiencies in solid films. They can function as light-emitting layers in non-doped OLEDs,affording eminent electroluminescence efficiencies of 17.59 cd/A, 12.55 Im/w and 5.63%, amongst the most efficient non-doped OLEDs based on fluorescent emitters, indicating their promising applications in OLEDs.

关键词： Aggregation-induced emission Silole Photoluminescence Electroluminescence Organic light-emitting diode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-situ generation of poly(quinolizine)s via catalyst-free polyannulations of activated diyne and pyridines

引用

Science China Chemistry 2022年第4期65卷 789-795页

作者： Benzhao He Jiachang Huang Jing Zhang Xinyue Liu Dong wang Herman H.y.Sung yajun Liu Anjun Qin jacky.w.y.lam Ben Zhong Tang Center for Advanced Materials Research Science and Technology Experimental PlatformAdvanced Institute of Natural SciencesBeijing Normal University at ZhuhaiZhuhai 519085China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstructionand Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science&TechnologyKowloonHong KongChina Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesCenter for Aggregation-Induced EmissionSouth China University of TechnologyGuangzhou 510640China HKUST-Shenzhen Research Institute Shenzhen 518057China Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China

The development of new polymerization routes to afford N-heterocyclic polymers is of vital importance and highly desired for various practical applications. Herein, a facile and efficient polyannulation reaction of dual-activated alkyne and pyridines was developed to construct novel N-heterocyclic poly(quinolizine)s. This polymerization can proceed smoothly under catalystfree conditions with 100% atom utilization to furnish poly(quinolizine)s with high molecular weights(up to 34,100) and welldefined structures in acceptable yields. The resulting polymers show good solubility, high thermal stability and strong red emission. Moreover, the prepared poly(quinolizine)s exhibit low cytotoxicity and can selectively label lysosomes in live *** the remarkable advantages of readily available raw materials, mild polymerization conditions, atom economy, and excellent product performance, this new and efficient polymerization tool will open up enormous opportunities for preparing functional N-heterocyclic polymers.

关键词： polyannulation activated alkyne N-heterocyclic polymers poly(quinolizine)s bioimaging

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Red-emitting salicylaldehyde Schiff base with AIE behaviour and large Stokes shift

引用

Chinese Chemical Letters 2018年第10期29卷 1493-1496页

作者： Junyi Gong Peifa wei yuanan Su ying Li Xing Feng jacky.w.y.lam Dongzhou Zhang Xiangzhi Song Ben Zhong Tang College of Chemistry and Chemical Engineering Central South University Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionDivision of Life Science and Division of Biomedical EngineeringThe Hong Kong University of Science and Technology Partnership for Extreme Crystallography Hawaii Institute of Geophysiscs and PlanetologyUniversity of Hawaii at Manoa

Three salicylaldehyde Schiff base（SSB）, iso-PBP, PBP and EPB, were facilely synthesized and exhibited aggregation-induced emission. The introduction of C= N-N = C moiety in these SSB dyes largely extend the conjugation system and push their emission to yellow to red spectral region. These SSB dyes were negligibly fluorescent in dilute THF solution. In THF/water mixtures with high water fractions, they displayed strong yellow to red fluorescence（up to 617nm） and large Stokes shifts（up to 152 nm）. Single crystal analysis on EBP showed the longer emission of in aggregated state was attributed to the molecular packing effect as compared with that in dilute solution. The bio-imaging application indicated EBP could specifically accumulate in lipid droplets in living cells.

关键词： Aggregation-induced emission Salicylaldehyde Schiff base Red-emitting ESIPT Aldehyde-amine condensation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Crystalline Behavior and Structure of a Liquid Crystal Com- pound, 5-{[4＇-（（（Pentyl）oxy）-4-biphenylyl）carbonyl]oxy}- 1 -pentyne

引用

Chinese Journal of Chemistry 2011年第4期29卷 631-638页

作者：刘雷静李杲周恩乐 lam,jacky wing yip 唐本忠 State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun Jilin 130012 China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Graduate School of Chinese Academy of Sciences Changchun Jilin 130022 China Department of Chemistry Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong China

Single crystals of two liquid crystal compounds, 5-{[4＇-（（（pentyl）oxy）-4-biphenylyl）carbonyl]oxy}-1-pentyne （A3EO5） and 5-{[（4＇-nonyloxy-4-biphenylyl）carbonyl]oxy}-1-pentyne （A3EO9）, have been prepared by solution growth technique. The morphologies and structures of A3EO5 and A3EO9 crystals were investigated by wide angle X-ray diffraction （wXRD）, atom force microscope （AFM） and transmission electron microscope （TEM）. In contrast to the same series of compounds which have a longer alkyl tail, 5-{[（4＇-heptoxy-4-biphenylyl）carbonyl]oxy}-1-pentyne （A3EO7）, 5-{[（4＇-heptoxy-4-biphenylyl）oxy]carbonyl}-1-pentyne （A3E＇O7） and A3EO9, A3EO5 shows strikingly different crystalline behavior. The former three compounds have only one crystal form, whereas A3EO5 exhibits polymorphism. Specifically, A3EO5 crystals grown from toluene solution show two crys- tal forms. The first one is crystal I which adopts a monoclinic P112/m space group with unit cell parameters of a= 5.79A, b=8.34A, c=43.92/k, y=96°, and the other one is crystal II which adopts a monoclinic P112 space group with unit cell parameters of a=5.55A, b=7.38A, c=31.75 ]k, y=94°. when using dioxane as the solvent to grow A3EO5 crystal, we can selectively obtain crystal Ⅰ. A3EO5 melt-grown crystals also have two crystal forms which derive from crystal I and crystal Ⅱ, respectively. The different crystalline behavior of the compounds should correlate with their different electron dipole moment resulting from the different length of alkyl tail.

关键词： crystal growth crystal morphology crystal structure electron diffraction single crystal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of an AIE-active fluorogen and its application in cell imaging

引用

Science China Chemistry 2009年第1期52卷 15-19页

作者： lam jacky wing yip FAISAL Mahtab NG Ka Ming LUO Kathy Qian Department of Chemistry The Hong Kong University of Science & Technology (HKUST) Clear Water Bay Department of Chemical and Biomolecular Engineering HKUST Clear Water Bay Bioengineering Graduate Program HKUST Clear Water Bay

A fluorogen named 1-decyl-1-methyl-2,5-bis{4-[(N,N-diethylamino)methyl]phenyl}-3,4-diphenylsilole (3) was synthesized. It emitted weakly as isolated molecule but strongly as supramolecular aggregate, showing a characteristic behavior of aggregation-induced emission (AIE). The molecules of 3 formed highly emissive nanoparticles in aqueous media, which quickly and selectively marked cytoplasm of HeLa cells and posed no toxicity to the living cells. The fluorogen is thus a promising candidate mate-rial for cell imaging as a sensitive, selective and cytocompatible biosensor.

关键词： aggregation-induced emission biosensor cell imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：