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peperomia pellucida(L.) Kunth and eye diseases: A review on phytochemistry, pharmacology and toxicology

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Journal of Integrative Medicine 2022年第4期20卷 292-304页

作者： Keat lam Ho phaik Har yong Chee woon wang Umah Rani Kuppusamy Chek Tung ngo Festo Massawe Zhi Xiang ng School of Biosciences Faculty of Science and EngineeringUniversity of Nottingham Malaysia43500 SelangorMalaysia School of Bioscience Faculty of MedicineBioscience and NursingMAHSA University42610 SelangorMalaysia Department of Biochemistry Faculty of MedicineBioscience and NursingMAHSA University42610 SelangorMalaysia Department of Biomedical Science Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Optimax Sunway Eye Specialist Centre Bandar Sunway46150 SelangorMalaysia

peperomia pellucida(L.) Kunth is a medicinal plant used to manage inflammatory illnesses such as conjunctivitis, and gastrointestinal and respiratory tract disorders in tropical and subtropical ***, little is known about its pharmacological mechanism of action against eye diseases. This review aims to critically discuss the phytochemistry, pharmacology and toxicology of p. pellucida as well as its roles in the treatment of cataract, glaucoma and diabetic retinopathy. Recent developments in the uses of p. pellucida for healthcare and nutraceutical products by the pharmaceutical industry are also covered in this review. For this review, a literature search was performed with pubMed, ScienceDirect, SciFinder Scholar and Scopus databases, using relevant keywords. Among the various phytochemicals identified from p. pellucida, β-cary.phyllene, carotol, dillapiole, ellagic acid, pellucidin A, phytol and vitexin exhibit strong pharmacological activities within the mitogen-activated protein kinase and nuclear factor-κB signalling pathways in inflammatory eye diseases. The antihypertensive, anti-inflammatory, antioxidant,antihyperglycemic and anti-angiogenic activities displayed by.p. pellucida extracts in many in vitro,in vivo and clinical studies suggest its potential role in the management of inflammatory eye diseases.p. pellucida extract was non-toxic against normal cell lines but displayed mild toxicity in animal *** growing public interest in p. pellucida has inspired the nutraceutical and pharmaceutical industries to process the plant into health products. Although the potential pharmacological mechanisms against eye diseases have been summarized, further studies of the interactions among constituent phytochemicals from p. pellucida within various signalling pathways shall support the use of the plant as an alternative therapeutic source.

关键词： peperomia pellucida phytochemistry pharmacology Toxicology Cataract Diabetic retinopathy Glaucoma

A versatile AIE fluorogen with selective reactivity to primary amines for monitoring amination,protein labeling,and mitochondrial staining

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Aggregate 2023年第1期4卷 250-259页

作者： Xinyuan He Huilin Xie Lianrui Hu pengchao Liu Changhuo Xu wei He wutong Du Siwei Zhang Hao Xing Xinyue Liu Hojeong park Tsz Shing Cheung Min-Hui Li Ryan T.K.Kwok jacky w.y.lam Jian Lu Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionState Key Laboratory of Molecular NeuroscienceDivision of Life Science and Department of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyKowloonHong KongChina Department of Mechanical Engineering City University of Hong KongGreater Bay Joint DivisionShenyang National Laboratory for Materials ScienceKowloonHong KongChina Chimie parisTech pSL University.paris CNRSInstitut de Recherche de Chimie ParisParisFrance Department of Chemistry Guangdong-Hongkong-Macou Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science and TechnologyKowloonHong KongChina Center for Aggregation-Induced Emission SCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhouChina School of Science and Engineering Shenzhen Key Laboratory of Functional Aggregate MaterialsThe Chinese University of Hong KongShenzhen CityGuangdongChina

Specific bioconjugation for native primary amines is highly valuable for both chemistry and biomedical *** all the efforts,scientists lack a proper strategy to achieve high selectivity for primary amines,not to mention the requirement of fast response in real ***,we report a chromone-based aggregation-induced emission(AIE)fluorogen called CMVMN as a self-reporting bioconjugation reagent for selective primary amine identification,and its applications for monitoring bioprocesses of amination and protein *** is AIE-active and capable of solid-state ***,its electrospun films are manufactured for visualization of amine diffusion and leakage *** also shows good biocompatibility and potential mitochondria-staining ability,which provides new insight for organelle-staining probe *** with its facile synthesis and good reversibility,CMVMN would not only show wide potential applications in biology,but also offer new possibilities for molecular engineering.

关键词： aggregation-induced emission(AIE) bioconjugation mitochondria-staining primary amines protein labeling

“On water”Effect for Green Click Reaction:Spontaneous polymerization of Activated Alkyne with“Inert”Aromatic Amine in Aqueous Media

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CCS Chemistry 2023年第2期5卷 385-396页

作者： Xinyue Liu Chen Zhang Lianrui Hu Jinghan wang Kai Li Hai-Tao Feng jacky wylam Benzhao He Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionGuangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 HKUST-Shenzhen Research Institute Shenzhen 518057 Department of Biomedical Engineering SUSTech Academy for Advanced Interdisciplinary StudiesSouthern University of Science and TechnologyShenzhen 518055 AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013 Center for Advanced Materials Research Beijing Normal University at ZhuhaiZhuhai 519085 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen 518172

Organic reactions in water have attracted great attention due to their advantages such as unique reaction performance and environmental *** reactions as well as polymerizations in aqueous media have been extensively investigated,and so far,there has been a massive amount of reporting about polymerizations in ***,reports about click polymerization in water have been ***,click polymerization of activated alkyne and aromatic amine in aqueous media is ***“on water”effect facilitates polymerization in aqueous media better than in organic solvents,and its mechanism is deciphered through experimental data and theoretical *** participates in the reaction and reduces the energy barrier to some ***,polymerization makes it possible for aromatic amine with low reactivity to be *** using this strategy.polymers with high molecular weights can be obtained in high yields(up to 95.4%).They show good thermal stability and high *** can be *** polymers with tetraphenylethylene moieties show aggregation-induced emission and can be used as materials for generating photopatterns and visualizing agents for specific staining of lysosome in living cells.

关键词： “on water”effect click polymerization aromatic amine photodegradation specific lysosome-staining

聚｛11-[(4′-正庚氧基-4-联苯基)羰基]氧-1-十一炔｝的相结构与相转变

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高分子学报 2010年第6期20卷 759-764页

作者：余振强刘嘉浩朱才镇陈尔强 lam jacky.w.ng y.p 唐本忠北京大学化学与分子工程学院高分子科学与工程系高分子化学与物理教育部重点实验室北京100871 深圳大学化学与化工学院深圳市功能高分子重点实验室深圳518060 香港科技大学化学系

采用示差扫描量热法(DSC)、一维(1D)、二维(2D)广角X-射线衍射(wAXD)和偏光显微镜(pLM)等研究手段对聚{11-[(4′-正庚氧基-4-联苯基)羰基]氧-1-十一炔}(pA-9,7)的本体相转变和相结构进行研究,并采用分子动力学方法对相结构进行模拟.结... 详细信息

采用示差扫描量热法(DSC)、一维(1D)、二维(2D)广角X-射线衍射(wAXD)和偏光显微镜(pLM)等研究手段对聚{11-[(4′-正庚氧基-4-联苯基)羰基]氧-1-十一炔}(pA-9,7)的本体相转变和相结构进行研究,并采用分子动力学方法对相结构进行模拟.结果表明,样品的相转变为近晶B相(SmB)近晶A相(SmA)各向同性态(Iso).在近晶B相中,侧链在层状结构中排列成具有六次对称性的准长程有序结构。

关键词：聚炔液晶相结构相转变X-射线衍射

Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary.plexus in patients with diabetes

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Eye and Vision 2020年第1期7卷 64-74页

作者： Fang yao Tang Erica O.Chan Zihan Sun Raymond wong Jerry Lok Simon Szeto Jason C.Chan Alexander lam Clement C.Tham Danny S.ng Carol y.Cheung Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionKowloonChina Hong Kong Eye Hospital Hong Kong Special Administrative RegionKowloonChina CUHK Eye Centre Hong Kong Eye Hospital147K Argyle StreetKlnKowloonHong KongChina

Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary.plexus(DCp)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCp images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCp morphology from the artifact-free DCp images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 *** the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;pwith older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCp metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic *** effects of ocular and systemic factors should be considered for meaningful interpretations of DCp changes in DM patients.

关键词： Optical coherence tomography angiography Diabetic retinopathy Deep capillary.plexus Visual acuity

A Simple Approach to Achieve Organic Radicals with Unusual Solid-State Emission and persistent Stability

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CCS Chemistry 2022年第6期4卷 1912-1920页

作者： Xueqian Zhao Junyi Gong parvej Alam Chao Ma yanpei wang Jing Guo Zebin Zeng Zikai He Herman H.y.Sung Ian D.williams Kam Sing wong Sijie Chen jacky w.y.lam Zheng Zhao Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced Study and Guangdong-Hong Kong-Macro Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsHong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 Department of physics Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan Province 410082 School of Science Harbin Institute of TechnologyShenzhenHIT Campus of University TownShenzhenGuangdong Province 518055 Ming wai Lau Centre for Reparative Medicine Karolinska InstitutetHong Kong 999077 School of Science and Engineering Chinese University of Hong KongShenzhenGuangdong Province 518172 HKUST-Shenzhen Research Institute South Area Hi-Tech ParkNanshanShenzhenGuangdong Province 518057 Center for Aggregation-Induced Emission SCUTHKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhouGuangdong Province 510640 AIE Institute Guangzhou Development DistrictHuangpuGuangzhouGuangdong Province 510530

Sable organic radicals are promising materials for information storage,molecular magnetism,electronic devices,and biological *** organic radicals have been prepared,but most are non-or weakly emissive and degrade easily upon *** remains challenging to produce stable and efficient luminescent radicals because of the absence of general guidelines for their ***,we present a photoactivation approach to generate a stable luminescent radical from tris(4-chlorophenyl)phosph ine(TCpp)with red emission in the crystal *** mechanistic study suggests that the molecular symmetry breaking in the crystal causes changes of molecular conformation,redox properties,andmolecular packing that facilitates radical generation and *** design strategy demonstrates a straightforward approach to develop stable organic luminescent radicals that will open new doors to photoinduced luminescent radical materials.

关键词： luminescent radicals symmetry breaking tris(4-chlorophenyl)phosphine anticounterfeiting photoinduced electron transfer

Impact of microbiota on female fertility and gynecological problems

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生殖与发育医学(英文) 2024年第4期8卷 242-251页

作者： Kumar Manish Jiang Luhan Lai Hoi-lam Lee Cheuk-Lun ng Ernest H. y. yeung william S. B. Lee Kai-Fai Department of Obstetrics and Gynaecology LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR China Shenzhen Key Laboratory of Fertility Regulation. The University of Hong Kong-Shenzhen Hospital Shenzhen China

The uterus was previously considered a sterile environment for embryo implantation and fetal growth; however, evidence showed that different microorganisms in the female reproductive tract may regulate human fertility. TheLactobacillus family is among the most prevalent bacteria in the vagina and uterus of the female reproductive system. Interestingly, aLactobacillus-dominated (LD) uterine environment is associated with better pregnancy outcomes. Nevertheless, the mechanism by which an LD environment improves pregnancy outcomes is unknown. In the uterus, many commensal bacteria (eg,Bifidobacterium, prevotella,Enterobacter,Streptococcus, andStaphylococcus) produce short-chain fatty acids (SCFAs), including acetate, butyrate, and propionate. SCFAs are crucial in modulating cytokine production (eg, IL-6 and IL-10) and immune cell populations (eg, T cells and macrophages) during embryo implantation and gynecological diseases. This minireview provides an overview of the roles of lactobacilli and SCFAs in female fertility and related diseases.

关键词： Endometrial receptivity Embryo implantation Lactobacillus Short-chain fatty acids Infertility Gynecological diseases

Development and Implementation of an Advanced planning & Scheduling (ApS) System for Semiconductor Backend Assembly

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厦门大学学报（自然科学版） 2002年第S1期41卷 189-190页

作者： T J Chua T X Cai F y wang william Liu X F yin w J yan J p Zhu Joanne lam Gintic Institute of Manufacturing Technology Gintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing Technology SingaporeSingaporeSingaporeSingaporeSingaporeSingaporeSingaporeSingapore

In this paper, the design, customization and implem en tation of an integrated Advanced planning and Scheduling (ApS) system for a Semi conductor Backend Assembly environment is described. The company is one of the w orldwide market leaders in semiconductor packaging technology. The project was d riven by the company’s quest to achieve a competitive edge as a manufacturing po werhouse by.providing the shortest possible cycle time with a high degree of fle xibility through the application of Computer Integrated Manufacturing (CIM) tech nology. Gintic was responsible for the planning & Scheduling functions through o ur ApS tool kit, which is called Gintic Scheduling System (GSS). Our ApS system is to be integrated with the other two key software systems, namely, the Enterpr ise Resource planning (ERp) and Manufacturing Execution System (MES), with the C IM framework. The project was divided into four major execution phases. phase One activities w ere focused on the gathering and analysis of the end users requirements in order to establish the ’As-Is’ situation and the wish list & the expectation of the ’To-Be’ system. planning and Scheduling prototypes were built using GSS to iden tify the functionality gap between the existing GSS system and the ’To-Be’ mode l, in order to determine the customization effort needed. The project team perfo rmed detailed system analysis, design and development of the ’To-Be’ system dur ing phase Two of the project. There are a total of four planning and scheduling modules, including Capacity.planning (Cp), Daily Lot Release (DLR), Daily.produc tion Scheduling (DpS) and Dynamic Operation Scheduling (DOS). The detailed desig n specifications of each of the features and functionality were confirmed and ac cepted by the end users before the commencement of the development effort. The c ompleted and tested modules were delivered in stages for testing and acceptance by the end user during the phase Three of the project. pilot product line was

关键词： integrated planning scheduling semiconductor b ackend assembly

packing and film thickness theories for the mix design of high-performance concrete

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Journal of Zhejiang University-Science A(Applied physics & Engineering) 2016年第10期17卷 759-781页

作者： pui-lam ng Albert Kwok-Hung KwAN Leo Gu LI Department of Civil Engineering The University of Hong Kong Pokfulam Hong Kong China Faculty of Civil Engmeering Vilnius Gediminas Technical University Vilnius Lithuania Schoo of Cicil and Transportation Engmeering Guangdong University of Technology Guangzhou 510006 China

A high-performance concrete （HpC） is required to have superior performance in various aspects such as workability,strength, durability, dimensional stability, segregation stability, and passing ability. The mix design of HpC is rather complicatedbecause the number of ingredients in HpC is usually more than those in conventional concrete and some of the required propertiesare conflicting with each other in the sense that improvement in one property would at the same time cause impairment of anotherproperty. However, there is still lack of understanding regarding how the various mix parameters should be optimised forachieving best overall performance. Most practitioners are still conducting mix design primarily through trial concrete mixing,which is laborious, ineffective, and often unable to timely respond to fluctuations in the properties of raw materials. To addressthese issues, the authors have been developing the packing and film thickness theories of concrete materials, in order to revamp themix design philosophy of HpC in terms of the water film thickness （wFT）, paste film thickness （pFT）, and mortar film thickness（MFT） in the concrete. Based on the findings from an extensive experimental programme, suitable ranges ofwFT, pFT, and MFThave been recommended.

关键词： Concrete mix design, Concrete science, Film thickness, High-performance concrete, packing density, Sustainability