检索结果-南通市图书馆

Spray.freeze dry.ng of small nucleic acids as inhaled pow.er for pulmonary.delivery

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 163-172页

作者： w.nling Liang Alan y.L.Chan Michael y.T.Chow.Fiona F.K.Lo y.ngshan Qiu Philip C.L.Kw.k Jenny.K.w.lam Department of Pharmacology.and Pharmacy Li Ka Shing Faculty of Medicine The University of Hong Kong Advanced Drug Delivery.Group Faculty of Pharmacy The University of Sydney

The therapeutic potential of small nucleic acids such as small interfering RNA(siRNA) to treat lung diseases has been successfully.demonstrated in many.in vivo studies. A major barrier to their clinical application is the lack of a safe and efficient inhaled *** this study. spray.freeze dry.ng w.s employ.d to prepare dry.pow.er of small nucleic *** and herring sperm DNA w.re used as bulking agent and model of small nucleic acid therapeutics, respectively. Formulations containing different solute concentration and DNA concentration w.re produced. The scanning electron microscope(SEM) images show.d that the porosity.of the particles increased as the solute concentration decreased. Pow.ers prepared w.th solute concentration of 5% w.v w.re found to maintain a balance betw.en porosity.and robustness. Increasing concentration of DNA improved the aerosol performance of the formulation. The dry.pow.er formulation containing 2% w.w.DNA had a median diameter of 12.5 μm, and the aerosol performance study.using next generation impactor(NGI) show.d an emitted fraction(EF) and fine particle fraction(FPF) of 91% and 28% respectively. This formulation(5% w.v solute concentration and 2% w.w.nucleic acid) w.s adopted subsequently.to produce siRNA pow.er. The gel retardation and liquid chromatography.assay. show.d that the siRNA remained intact after spray.freeze dry.ng even in the absence of delivery.vector. The siRNA pow.er formulation exhibited a high EF of 92.4%and a modest FPF of around 20%. Further exploration of this technology.to optimise inhaled siRNA pow.er formulation is w.rranted.

关键词： Inhalation Pulmonary delivery Small interfering RNA Spray freeze dry.ng

在线全文

学校读者我要写书评

暂无评论

被分析物在微流体器件中的分散特性

机械工程学报 2006年第3期42卷 93-98页

作者：赵志文陈兴 lam y.C 北京师范大学电子学系北京100875 新加坡-MIT联盟新加坡南洋理工大学机械与航空航天学院新加坡639798

与电场驱动方式相比,采用压力驱动方式实现对微流体的控制,具有简单方便和适应性广等特点,但微流体的流动特性也更为复杂。在分析研究微流体一被分析物在流场中分散机理的基础上,针对具有窄缝形状的y.微流体器件中两种同物性流体的流... 详细信息

与电场驱动方式相比,采用压力驱动方式实现对微流体的控制,具有简单方便和适应性广等特点,但微流体的流动特性也更为复杂。在分析研究微流体一被分析物在流场中分散机理的基础上,针对具有窄缝形状的y.微流体器件中两种同物性流体的流动特性,采用平均分析法,对微型矩形窄缝中的压力流的传质现象进行了初步研究,提出二维分析模型,并导出了其分析解。

关键词：扩散/对流传质微流体器件压力定常流泰勒分散

5-[4′-正庚基-氧-联苯基-4-氧-羰基]基-1-正戊炔的晶体结构研究

在线全文

学校读者我要写书评

暂无评论

高等学校化学学报 2005年第7期26卷 1366-1368,M010页

作者：刘雷静耿建新周云春尹丽李杲周恩乐 jacky lam w.ng y.p 唐本忠中国科学院研究生院长春应用化学研究所高分子物理与化学国家重点实验室长春130022 香港科技大学化学系

The cry.tal structure of 5-{[(4′-heptoxy.bipheny.y.-4-y.)oxy.carbony.}-1-penty.e({A3E′O7}) w.s investigated by.w.de angle X-ray.diffraction(w.XD), transmission electron microscope(TEM) and atom force microscope(AFM). The structures of A3E′O7 solution-cry.tal and melt-cry.tal are the same. The cry.tals belong to the monoclinic P112/m space group, the cell parameters are {a0.589 nm}, b0^771 nm, c4.75 nm, αβ90° and γ93.8°, the calculated cell density.is {1.167 g/cm+3}.

关键词：晶体结构 5-[4′-正庚基-氧-联苯基-4-氧-羰基]基-1-正戊炔透射电镜 X射线衍射

Unsupervised learning on scientific ocean drilling datasets from the South China Sea

在线全文

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2019年第1期13卷 180-190页

作者： Kevin C.TSE Hon-Chim CHIU Man-y.n TSANG y.liang LI Edmund y.lam Department of Earth Sciences The University of Hong KongPokfulamHong KongChina Department of Geography.and Centre for Geo-computation Studies Hong Kong Baptist UniversityKowloon TongHong KongChina Department of Earth Sciences University of TorontoTorontoON M5S 2M8Canada Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong KongChina

Unsupervised learning methods w.re applied to explore data patterns in multivariate geophy.ical datasets collected from ocean floor sediment core samples coming from scientific ocean drilling in the South China *** to studies on similar datasets,but using supervised learning methods w.ich are designed to make predictions based on sample training data,unsupervised learning methods require no a priori information and focus only.on the input *** this study.popular unsupervised learning methods including K-means,self-organizing maps,hierarchical clustering and random forest w.re coupled w.th different distance metrics to form exploratory.data *** resulting data clusters w.re externally.validated w.th lithologic units and geologic time scales assigned to the datasets by.conventional methods. Compact and connected data clusters display.d vary.ng degrees of correspondence w.th existing classification by.lithologic units and geologic time scales.K-means and self-organizing maps w.re observed to perform better w.th lithologic units w.ile random forest corresponded best w.th geologic time *** study.sets a pioneering example of how.unsupervised machine learning methods can be used as an automatic processing tool for the increasingly.high volume of scientific ocean drilling data.

关键词： machine learning unsupervised learning ODP IODP clustering

Chinese Guqin Music and Calligraphy.for Treating Sy.ptoms of Primary.Insomnia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medicine and Culture 2019年第1期2卷 48-52页

作者： Miranda M.y.Fung Henry.S.R.Kao Stew.rt R w.lam Tin Tin Kao Department of Chinese Medicine China Academy of Chinese Medical SciencesBeijing Departments of Psy.hology University of Hong KongHKSARChina Departments of Psy.hology.and Geography University of Hong KongHKSARChina

Purpose:To investigate the intervention effiects of using traditional Chinese Guqin music and Chinese Calligraphy.handw.iting(CCH)for patients w.th Primary.***:A total of ninety.patients w.re assigned to control group,Guqin group,and calligraphy.group for 8 *** 5 day. a w.ek,patients’heart rate variability.HRV)and frontal midline(FZ)electroencephalographic signals w.re recorded in a clinic during interventional period w.ile either listening to Guqin music or w.iting *** in the control group remained in rest ***:For the Guqin group,the higher low.frequency.range HRV of coherence w.s found w.th marginal significance(P=0.055),and heart rate w.s significantly.reduced(Pw.ek in listening to Guqin music compared to the prerest *** listening to Guqin music or calligraphy.intervention,FZδ,FZθ,and FZα w.ves in the 8^th w.ek compared to the 0^th w.ek(Pre Intervention)show.d a significantly.enhanced effect(.Pw.en the three groups,for heart rate and FZδ and FZθ w.ves,calligraphy.group show.d significantly.increased heart rate than the Guqin group(Pw.ve than die Guqin group(Pw.ve than the Guqin group(P=0.024)and the control group(P=0.008)***:Positive intervention effects on 11RV coherence of Guqin music;FZδ,FZθ,and FZα w.ves of Guqin music and calligraphy.proved that Guqin music together w.th calligraphy.training helping to promote phy.ical and mental health,thereby.it contributes to the clinical application of TCM Psy.hology.for patients w.th insomnia sy.drome.

关键词： Alpha calligraphy Chinese calligraphy.handw.iting delta EEG brainw.ve Guqin heart rate variability phy.ical and mental health primary.insomnia TCM Psy.hology theta

Impact of microbiota on female fertility.and gy.ecological problems

在线全文

学校读者我要写书评

暂无评论

生殖与发育医学(英文) 2024年第4期8卷 242-251页

作者： Kumar Manish Jiang Luhan Lai Hoi-lam Lee Cheuk-Lun Ng Ernest H. y. y.ung w.lliam S. B. Lee Kai-Fai Department of Obstetrics and Gy.aecology LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR China Shenzhen Key.Laboratory.of Fertility.Regulation. The University.of Hong Kong-Shenzhen Hospital Shenzhen China

The uterus w.s previously.considered a sterile environment for embry. implantation and fetal grow.h; how.ver, evidence show.d that different microorganisms in the female reproductive tract may.regulate human fertility. TheLactobacillus family.is among the most prevalent bacteria in the vagina and uterus of the female reproductive sy.tem. Interestingly. aLactobacillus-dominated (LD) uterine environment is associated w.th better pregnancy.outcomes. Nevertheless, the mechanism by.w.ich an LD environment improves pregnancy.outcomes is unknow.. In the uterus, many.commensal bacteria (eg,Bifidobacterium, Prevotella,Enterobacter,Streptococcus, andStaphy.ococcus) produce short-chain fatty.acids (SCFAs), including acetate, buty.ate, and propionate. SCFAs are crucial in modulating cy.okine production (eg, IL-6 and IL-10) and immune cell populations (eg, T cells and macrophages) during embry. implantation and gy.ecological diseases. This minireview.provides an overview.of the roles of lactobacilli and SCFAs in female fertility.and related diseases.

关键词： Endometrial receptivity Embry. implantation Lactobacillus Short-chain fatty.acids Infertility Gy.ecological diseases

The Effect of a Visual Memory.Training Program on Chinese Handw.iting Performance of Primary.School Students w.th Dy.lexia in Hong Kong

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Therapy.and Rehabilitation 2015年第4期3卷 146-158页

作者： Cecilia w. P. Li-Tsang Agnes S. K. w.ng Linda F. L. Tse Hebe y. H. lam Viola H. L. Pang Cathy.y. F. Kw.k Maggie w. S. Lin Department of Rehabilitation Sciences The Hong Kong Polytechnic University Hong Kong China

This study.investigated the effect of a visual memory.training program on Chinese handw.iting performance among primary.school students w.th dy.lexia in Hong Kong. Eight students of Grade 2 to 3 w.o w.re diagnosed w.th dy.lexia w.re recruited. All participants received six sessions of training, w.ich composed of 30-minute computerized game-based visual memory.training and 30-minute Chinese character segmentation training. Visual perceptual skills and Chinese handw.iting performance w.re assessed before and after the training, as w.ll as three w.eks after training using the Test of Visual Perceptual Skills (3rd edition) (TVPS-3) and the Chinese Handw.iting Analy.is Sy.tem (CHAS). In comparing the pre- and post-training results, paired t-tests revealed significant improvements in visual memory.skills, as w.ll as handw.iting speed, pause time and pen pressure after the training. There w.s no significant improvement in handw.iting accuracy.or legibility. The improved visual memory.and handw.iting performance did not show.a significant drop at the follow.up assessments. This study.show.d promising results on a structured program to improve the Chinese handw.iting performance, mainly.in speed, of primary.school children. The improvements appeared to be w.ll-sustained after the training program. There is a need to further study.the long-term effect of the program through a randomized controlled trial study.

关键词： Visual Memory Handw.iting Dy.lexia Primary School Students Chinese

硝基苯衍生物结构与其淬灭聚(2,5-二戊氧基对亚苯基亚乙炔基)荧光效率的关系

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高分子学报 2007年第3期17卷 293-296页

作者：徐宏丽佟斌石建兵刘旸田旭玲董宇平 lam jacky w.ng y.p 唐本忠北京理工大学材料科学与工程学院北京100081 北京理工大学理学院北京100081 香港科技大学化学系

The poly.2,5-dipenty.oxy.para-pheny.ene ethy.y.ene)(P) w.s sy.thesized by.Pd-cataly.ed Sonogashira coupling *** to causing energy.transfer betw.en the nitrobenzene’s quenchers and the poly.er chains through the charge-transfer interaction,the fluorescence quenched properties of P varied obviously.w.th the para-substituting group’s structure in the nitrobenzene *** fluorescence quenching efficiency.of quenchers improved w.th increasing of electron repulsion capability.of the para-substituting *** fluorescence quenching efficiency.increased nonlinearly.w.th the concentration of the quenchers and had,how.ver,no relation w.th the quenching time.

关键词：聚对亚苯基亚乙炔基硝基苯衍生物荧光淬灭

Liouvillian Solutions of Algebraic Ordinary.Differential Equations of Order One of Genus Zero

在线全文

学校读者我要写书评

暂无评论

Journal of Sy.tems Science & Complexity 2023年第2期36卷 884-893页

作者： NGUy.N Tri Dat NGO lam Xuan Chau Faculty.of Basic Science Ho Chi Minh City University of TransportHo Chi Minh CityVietnam Department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon CityVietnam

This paper considers the class of autonomous algebraic ordinary.differential equations(AODEs)of order one,and studies their Liouvillian general *** particular,let F(y.w.=0 be a rational algebraic curve over *** authors give necessary.and sufficient conditions for the autonomous first-order AODE F(y.y.)=0 to have a Liouvillian solution over ***,the authors show.that a Liouvillian solutionαof this equation is either an algebraic function over C(x)or an algebraic function over C(exp(ax)).As a by.roduct,these results lead to an algorithm for determining a Liouvillian general solution of an autonomous AODE of order one of genus *** parametrizations of rational algebraic curves play.an important role on this method.

关键词： Algebraic ordinary.differential equation autonomous differential equation Liouvillian solution rational algebraic curve rational parametrizations