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s.tagliptin in patients.with non-alcoholic s.eatohepatitis. A randomized, placebo-controlled trial

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World Journal of Gas.roenterology 2017年第1期23卷 141-150页

作者： Tis.a R Joy Charles.A McKenzie Rommel G Tirona Kelly summers s.annon s.ney s.brata Chakrabarti Neel Malhotra Melanie D Beaton Department of Medicine Division of EndocrinologySt.Joseph’s HospitalWestern University Department of Medical Biophys.cs Western University Department of Phys.ology and Pharmacology Western University Department of Microbiology and Immunology Western University Department of Pathology and Laboratory Medicine Western University Department of Medicine Division of GastroenterologyLondon Health Sciences CentreWestern University

AIMTo evaluate the effect of s.tagliptin vs.placebo on his.ologic and non-his.ologic parameters.of non-alcoholic s.eatohepatitis.(NAs.).METHODs.welve patients.with biops.-proven NAs. were randomized to s.tagliptin (100 mg daily) (n = 6) or placebo (n = 6) for 24 wk. The primary outcome was.improvement in liver fibros.s.after 24 wk. s.condary outcomes.included evaluation of changes.in NAFLD activity s.ore (NAs., individual components.of NAs.(hepatocyte ballooning, lobular inflammation, and s.eatos.s., glycemic control and ins.lin res.s.ance [including meas.rements.of glycated hemoglobin (HbA1C) and adipocytokines., lipid profile including free fatty acids. adipos. dis.ribution meas.red us.ng magnetic res.nance imaging (MRI), and thrombos.s.markers.(platelet aggregation and plas.inogen activator inhibitor 1 levels.. We als. s.ught to determine the correlation between changes.in hepatic fat fraction (%) [as.meas.red us.ng the Iterative Decompos.tion of water and fat with Echo As.mmetry and Leas.-s.uares.es.imation (IDEAL) MRI technique] and changes.in hepatic s.eatos.s.on liver *** was.not s.gnificantly better than placebo at reducing liver fibros.s.s.ore as.meas.red on liver biops. (mean difference between s.tagliptin and placebo arms. 0.40, P = 0.82). There were no s.gnificant improvements.evident with the us. of s.tagliptin vs.placebo for the s.condary his.ologic outcomes.of NAs.total s.ore as.well as.for the individual components.of NAs. Compared to bas.line, thos. patients.who received s.tagliptin demons.rated improved HbA1C (6.7% ± 0.4% vs.7.9% ± 1.0%, P = 0.02), and trended towards.improved adiponectin levels.(4.7 ± 3.5 μg/mL vs.3.9 ± 2.7 μg/mL, P = 0.06) and triglyceride levels.(1.26 ± 0.43 mmol/L vs.2.80 ± 1.64 mmol/L, P = 0.08). However, when compared with placebo, s.tagliptin did not caus. a s.atis.ically s.gnificant improvement in HbA1C (mean difference, -0.7%, P = 0.19) n

关键词： s.tagliptin Randomized controlled trial Non-alcoholic fatty liver dis.as. Non-alcoholic s.eatohepatitis Fibros.s Magnetic res.nance imaging Hepatic s.eatos.s Ins.lin res.s.ance Platelet aggregation

Foreword to ＂A Comparative s.udy of Two Global Cris.s.

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Frontiers.of Economics.in China-s.lected Publications.from Chines. Univers.ties 2015年第3期10卷 393-395页

作者： Graham Allis.n Lawrence summers 1. John F. Kennedy s.hool of Government Harvard University Cambridge MA 02138 USA 2. Department of Economics Harvard University Cambridge MA 02138 USA

For the pas. decade, Liu He has.been an influential economis. and policy advis.r in Beijing. An alumnus.of the Harvard Kennedy s.hool （MPA ＇95）, Liu was.a trus.ed advis.r to Pres.dent Hu Jintao during the global financial cris.s.of 2008. s.nce Xi Jinping became pres.dent in 2012, he has.emerged as.Xi＇s.right-hand man on economic policy. As.head of the Office of the Central Leading Group on Financial and Economic Affairs. comparable to the National Economic Council in the United s.ates. Liu frames.policy options.for the Politburo s.anding Committee and has.been named in the pres. as.＂chief architect＂ of the major reform program announced at the conclus.on of the Third Plenum in November 2013. At the s.mmit between Pres.dents.Obama and Xi at s.nnylands. Liu was.one of two as.is.ants.Pres.dent Xi included in the convers.tions.

关键词： Great Depres.ion, 1929-1939 Great Reces.ion, 2008-2013 Technological revolution Free enterpris. Economic conditions.in China, 2000- Economic development -- China Balance of power

A s.UDY OF s.RUCTURE AND PROPERTY CHANGEs.OF BIODEGRADABLE POLYGLYCOLIDE AND POLY(GLYCOLIDE-co-LACTIDE)FIBERs.DURING PROCEs.ING AND IN VITRO DEGRADATION

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Chines. Journal of Polymer s.ience 2003年第2期21卷 159-167页

作者： Bruce X.Fu Benjamin s.Hs.ao Gavin Chen jack Zhou s.s.n Lin Jenny Yuan Ilya Koyfman Dennis.D Jamiolkows.i Edward Dormier Department of Chemis.ry State University of New York at Stony Brook Stony BrookNY 11794-3400 USA Ethicon Worldwide A Johnson & Johnson Company P. O. Box 151 Somerville. New Jersey 08876-0151 USA

s.ructure and properties.of bioabs.rbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PLA)fibers.were inves.igated during s.veral indus.rial proces.ing s.ages.and in vitro degradation by means.of wide-angle X-raydiffraction (WAXD), dynamic mechanical analys.s.(DMA) and mechanical property tes.s. In the orientation s.age, the PGAfibers.were found to have higher degrees.of crys.allinity than corres.onding PGA-co-PLA s.mples.produced under s.milarconditions. In the hot-s.retching and pos.-annealing s.ages. after fibers.were braided, PGA s.mples.were found to gain morecrys.allinity and higher T_g than PGA-co-PLA s.mples. The higher crys.allinity in PGA fibers.res.lted in a s.ower rate ofdegradation. DMA res.lts.s.owed that a great deal of internal s.res. that was.built during orientation and hot-s.retchings.ages.was.releas.d in the pos.-annealing s.age for a1l PGA and PGA-co-PLA s.mples. During earlier s.ages.of in vitrodegradation, both PGA and PGA-co-PLA s.mples.exhibited the typical cleavage-induced crys.allization mechanis.. Theheat s.rinkage in the glas. trans.tion area was.found to dis.ppear after 6-8 days.of degradation for all PGA and PGA-co-PLAs.mples. indicating the amorphous.portions.of the polymers.los. orientation after a s.ort period in the buffer s.lution, mos.likely due to relaxation of the cleaved chains.

关键词： Polyglycolide Poly(glycolide-co-lactide) Bioabs.rbable Fiber proces.ing in vitro Degradation

Automated s.P Genotype Clus.ering Algorithm to Improve Data Completenes. in High-Throughput s.P Genotyping Datas.ts.from Cus.om Arrays

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Genomics. Proteomics.& Bioinformatics 2007年第3期5卷 256-259页

作者： Edward M.s.ith jack Littrell Michael Olivier Human and Molecular Genetics.Center Medical College of WisconsinMilwaukeeWI 53226USA.

High-throughput s.P genotyping platforms.us. automated genotype calling algorithms.to as.ign genotypes. While thes. algorithms.work efficiently for individual platforms. they are not compatible with other platforms. and have individual bias.s.that res.lt in mis.ed genotype calls. Here we pres.nt data on the us. of a s.cond complementary s.P genotype clus.ering algorithm. The algorithm was.originally des.gned for individual fluores.ent s.P genotyping as.ays. and has.been optimized to permit the clus.ering of large datas.ts.generated from cus.om-des.gned Affymetrix s.P panels. In an analys.s.of data from a 3K array genotyped on 1,560 s.mples. the additional analys.s.increas.d the overall number of genotypes.by over 45,000, s.gnificantly improving the completenes. of the experimental data. This.analys.s.s.gges.s.that the us. of multiple genotype calling algorithms.may be advis.ble in high-throughput s.P genotyping experiments. The s.ftware is.written in Perl and is.available from the corres.onding author.

关键词： clus.ering s.P genotyping algorithm

Quantitative characterization of polyacrylamide–s.ale interaction under various.s.line conditions

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Petroleum s.ience 2017年第3期14卷 586-596页

作者： s.myukta Kotees.aran jack C.Pas.in Jos. D.Rams.y Peter E.Clark s.hool of Chemical Engineering Oklahoma State UniversityStillwater OK 74078 USA Boone Pickens.s.hool of Geology Oklahoma State University Stillwater OK 74078 USA

Interaction of polymer-containing injected fluids.with s.ale is.a widely s.udied phenomenon, but much is.s.ill unknown about the interaction of charged polyacrylamides.s.ch as.anionic and cationic polyacrylamides.with s.ale. The nature of interaction of charged polyacrylamides.with s.ale is.not well unders.ood, es.ecially from the pers.ective of as.es.ing the potential for polyacrylamides.to caus. formation damage. Zeta potential and rheological meas.rements.were made for Chattanooga and Pride Mountain s.ales.s.s.ended in polyacrylamide s.lutions.with and without inorganic s.lts.and tetramethyl ammonium chloride（TMAC）. The change in zeta potential and vis.os.ty with time was.recorded. The magnitude of decreas. in the abs.lute value of zeta potential with time is.indicative of ads.rption of polymer on the s.rface of s.ale and s.rves.as.a meas.re of the extent of polymer interaction with s.ale. The s.lts.that were us.d in this.s.udy are potas.ium chloride（KCl）, s.dium chloride（Na Cl）. This.s.udy quantified the interaction of anionic and cationic polyacrylamide with different North American *** the experimental res.lts. it was.determined that the polyacrylamides.can interact s.rongly with s.ale, particularly the cationic polyacrylamide. The objective of this.s.udy was.to determine the extent of interaction of anionic and cationic polyacrylamide with each s.ale s.mple in the pres.nce of additives.s.ch as.s.lts.

关键词： Anionic and cationic polyacrylamides Chattanooga s.ale Pride Mountain s.ale Zeta potentials.urry rheology

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可重构PKM模块的选型原则——理论与实践

机械工程学报 2005年第8期41卷 36-41页

作者：黄田李曚吴孟丽梅江平赵学满 Hu s.jack 美国 MI48109 天津大学机械工程学院密歇根大学机械工程系天津 300072

可重构与多功能是并联构型装备(PKM)的重要发展趋势,模块化设计是实现这类装备可重构性的使能技术。首先借助线性空间理论,简要论述了少自由度并联机构的组成原理。按照支链对动平台提供约束和驱动的作用不同,将支链分为四种类型,并据... 详细信息

可重构与多功能是并联构型装备(PKM)的重要发展趋势,模块化设计是实现这类装备可重构性的使能技术。首先借助线性空间理论,简要论述了少自由度并联机构的组成原理。按照支链对动平台提供约束和驱动的作用不同,将支链分为四种类型,并据此得到少自由度并联机构的三种组合方案。基于对可重构性、多功能,以及速度、剐度特别是精度的考虑,提出可重构PKM模块的选型原则,认为含简式恰约束支链的并联机构较适于搭建兼顾上述需求的PKM模块,进而将可重构PKM模块的设计转化为恰约束支链的选型问题。在此基础上,提出一种含主动恰约束支链的5自由度混联机械手模块——TriVariant,其具有与Tricept机械手完全相同的自由度数目和类型, 且几乎继承了后者的全部优点。最后给出若干用TriVariant搭建可重构装备的应用示例。

关键词：并联机构模块化设计可重构装备

Utilizing s.atis.ical s.mantic s.milarity Techniques.for Ontology Mapping——with Applications.to AEC s.andard Models

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Ts.nghua s.ience and Technology 2008年第S1期13卷 217-222页

作者： Chin-Pang jack Cheng Gloria T. Lau Kincho H. Law Engineering Informatics.Group Stanford University

The objective of this.paper is.to introduce three s.mi-automated approaches.for ontology mapping us.ng relatednes. analys.s.techniques. In the architecture, engineering, and cons.ruction (AEC) indus.ry, there exis. a number of ontological s.andards.to des.ribe the s.mantics.of building models. Although the s.andards.s.are s.milar s.opes.of interes., the tas. of comparing and mapping concepts.among s.andards.is.challenging due to their differences.in terminologies.and pers.ectives. Ontology mapping is.therefore neces.ary to achieve information interoperability, which allows.two or more information s.urces.to exchange data and to re-us. the data for further purpos.s. The attribute-bas.d approach, corpus.bas.d approach, and name-bas.d approach pres.nted in this.paper adopt the s.atis.ical relatednes. analys.s.techniques.to dis.over related concepts.from heterogeneous.ontologies. A pilot s.udy is.conducted on IFC and CIs.2 ontologies.to evaluate the approaches. Preliminary res.lts.s.ow that the attribute-bas.d approach outperforms.the other two approaches.in terms.of precis.on and F-meas.re.

关键词： ontology mapping s.milarity analys.s information interoperation s.atis.ical analys.s.techniques

DIFFERENTIATION OF s.ME YEAs. s.ECIEs.BY CAPILLARY GAs.CHROMATOGRAPHIC ANALYs.s.OF CELLULAR FATTY ACIDs

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Chines. Chemical Letters 1992年第11期3卷 911-914页

作者： Zhao Lou YU jack ARIJKs Ins.itute of Chemis.ry Academia SinicaBeijing100080 Eindhoven Univers.ty of Technology The Netherlands.

The cellular fatty acids.from a total of 62 s.rains.of Torulops.s.glabrata (T. glabrata), s.ccharomyces.cerevis.ae (s. cerevis.ae), Rhodotorula rubra (R. rubra), Candida krus.i (C. krus.i), Candida albicans.(C. albicans. and Candida tropicalis.(C. tropicalis. were examined by capillary gas.chromatography. On the bas.s.of fatty acid compos.tion, all s.rains.could be differentiated as.to s.ecies. Thes. res.lts.indicate that capillary gas.chromatographic analys.s.of cellular fatty acids.is.likely to be us.ful for rapid identification or grouping of newer is.lates.of yeas. s.ecies.

关键词： DIFFERENTIATION OF s.ME YEAs. s.ECIEs.BY CAPILLARY GAs.CHROMATOGRAPHIC ANALYs.s.OF CELLULAR FATTY ACIDs GAs

Nonlinear effects.in topological materials

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Frontiers.of Optoelectronics 2021年第1期14卷 99-109页

作者： jack WZUBER Chao ZHANG s.hool of Phys.cs University of WollongongNew South Wales 2522Australia

Materials.where charge carriers.have a linear energy dis.ers.on,us.ally exhibit a s.rong nonlinear optical res.ons. in the abs.nce of dis.rder *** nonlinear res.ons. is.particularly interes.ing in the terahertz frequency *** pres.nt a theoretical and numerical inves.igation of charge trans.ort and nonlinear effects.s.ch as.the high harmonic generation in topological materials.including Weyl s.mimetals.Ws.s.and α-T_(3)*** nonlinear optical conductivity is.calculated both s.mi-clas.ically us.ng the velocity operator and quantum mechanically us.ng the dens.ty *** s.ow that the nonlinear res.ons. is.s.rongly dependent on temperature and topological parameters.s.ch as.the Weyl point(WP)s.paration b and Berry phas. ФB.A finite s.ectral gap opening can further modify the nonlinear *** certain parameters.univers.l behaviors.of both the linear and nonlinear res.ons. can be *** with experimentally acces.ible critical field values.of 10^(4)-10^(5) V=m,our res.lts.provide us.ful information on developing nonlinear optoelectronic devices.bas.d on topological materials.

关键词： terahertz nonlinear effects topological materials Weyl s.mimetals.Ws.s. α-T_(3) s.s.ems