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中华耳鼻咽喉头颈外科杂志 2018年第11期53卷 870-874页

作者：罗蓉张驰孔维佳蒋家琪华中科技大学同济医学院附属协和医院耳鼻咽喉科武汉430022 首都医科大学附属北京友谊医院耳鼻咽喉头颈外科 100050 复旦大学附属眼耳鼻喉科医院耳鼻喉科上海200031

19世纪70年代,Isshiki系统地发展了甲状软骨成形术。2001年欧洲喉科学会在Isshiki甲状软骨成形术分类的基础上规范了喉框架手术(laryngeal framework surgery,LFS)的命名和分类,使其更加系统规范,并在临床应用和基础理论研究领域不断发... 详细信息

19世纪70年代,Isshiki系统地发展了甲状软骨成形术。2001年欧洲喉科学会在Isshiki甲状软骨成形术分类的基础上规范了喉框架手术(laryngeal framework surgery,LFS)的命名和分类,使其更加系统规范,并在临床应用和基础理论研究领域不断发展。近年来影像、计算机等基础学科突飞猛进的发展推动着喉框架手术不断进步,本文主要阐述喉框架手术近5年的新进展。

关键词：嗓音外科喉框架手术甲状软骨成形术

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声带时空振动行为的高速摄影成像及分析

声带时空振动行为的高速摄影成像及分析

Revolutionizing plasmonic platform via magnetic field-assisted confined ultrafast laser deposition of high-density,uniform,and ultrafine nanoparticle arrays

中国声学学会第九届青年学术会议

作者：张宇 Christopher R.Krausert 梁玉芳张赛 jack j.jiang 厦门大学水声通信与海洋信息技术教育部重点实验室美国威斯康辛大学麦迪逊分校医学院上海复旦大学五官科医院

＜正＞1引言声带振动对于语音产生有极其重要的作用。常用的传声器测量耦合了声道滤波和声辐射,因而不能直接记录声带振动。作为近年来先进的成像技术,高速摄像仪的成像速度可高达4000帧/秒,能够直接观察声带振动,记录语音发声系统的物... 详细信息

＜正＞1引言声带振动对于语音产生有极其重要的作用。常用的传声器测量耦合了声道滤波和声辐射,因而不能直接记录声带振动。作为近年来先进的成像技术,高速摄像仪的成像速度可高达4000帧/秒,能够直接观察声带振动,记录语音发声系统的物理结构和形态特征,是一种非常有发展前景的研究工

关键词：声带振动振动信号高速摄影成像技术 Lagrange内插法 Canny边缘检测

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International journal of Extreme Manufacturing 2024年第3期6卷 428-438页

作者： jin Xu Lingfeng Wang Peilin Yang Haoqing jiang Huai Zheng Licong An Xingtao Liu Gary j Cheng School of Industrial Engineering Purdue UniversityWest LafayetteIN 47906United States of America Institute of Technological Sciences Wuhan UniversityWuhanHubei 430072People’s Republic of China

The remarkable capabilities of 2D plasmonic surfaces in controlling optical waves havegarnered significant ***,the challenge of large-scale manufacturing of uniform,well-aligned,and tunable plasmonic surfaces has hindered their *** address this,we present a groundbreaking tunable plasmonic platform design achieved throughmagnetic field(MF)assisted ultrafast laser direct deposition in *** precise control of metal nanoparticles(NPs),with cobalt(Co)serving as the model material,employing an MF,and fine-tuning ultrafast laser parameters,we have effectively converted coarse and non-uniform NPs into densely packed,uniform,and ultrafine NPs(~3 nm).This revolutionary advancement results in the creation of customizable plasmonic‘hot spots,’which play a pivotal role insurface-enhanced Raman spectroscopy(SERS)*** profound impact of this designable plasmonic platform lies in its close association with plasmonic resonance and *** the plasmonic nanostructures resonate with incident light,they generate intense local electromagnetic fields,thus vastly increasing the Raman scattering *** enhancement leads to an outstanding 2–18 fold boost in SERS performance and unparalleled sensing sensitivity down to 10^(-10)***,the plasmonic platform also demonstratesrobustness,retaining its sensing capability even after undergoing 50 cycles of rinsing andre-loading of ***,this work adheres to green manufacturing standards,making it an efficient and environmentally friendly method for customizing plasmonic‘hot spots’inSERS *** study not only achieves the formation of high-density,uniform,and ultrafine NP arrays on a tunable plasmonic platform but also showcases the profound relation betweenplasmonic resonance and energy *** outstanding results observed in SERS sensors further emphasize the immense potential of this technology for energy-relatedapplications,including photocatalysis,ph

关键词： magnetic field manipulation laser deposition metasurface SERS

Adeno-associated virus as a delivery vector for gene therapy of human diseases

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1808-1840页

作者： jiang-Hui Wang Dominic j.Gessler Wei Zhan Thomas L.Gallagher Guangping Gao Horae Gene Therapy Center University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Microbiology and Physiological Systems University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVIC3002Australia Department of Neurological Surgery University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Neurosurgery University of MinnesotaMinneapolisMN55455USA Department of Medicine University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Li Weibo Institute for Rare Diseases Research University of Massachusetts Chan Medical SchoolWorcesterMA01605USA

Adeno-associated virus(AAV)has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different *** AAV(rAAV)has been engineered for enhanced specificity and developed as a tool for treating various ***,as rAAV is being more widely used as a therapy,the increased demand has created challenges for the existing manufacturing *** rAAV-based gene therapy products have received regulatory approval,but there continue to be concerns about safely using high-dose viral therapies in humans,including immune responses and adverse effects such as genotoxicity,hepatotoxicity,thrombotic microangiopathy,and *** this review,we explore AAV biology with an emphasis on current vector engineering strategies and manufacturing *** discuss how rAAVs are being employed in ongoing clinical trials for ocular,neurological,metabolic,hematological,neuromuscular,and cardiovascular diseases as well as *** outline immune responses triggered by rAAV,address associated side effects,and discuss strategies to mitigate these *** hope that discussing recent advancements and current challenges in the field will be a helpful guide for researchers and clinicians navigating the ever-evolving landscape of rAAV-based gene therapy.

关键词： diseases specificity approval

A Reverse Path Planning Approach for Enhanced Performance of Multi-Degree-of-Freedom Industrial Manipulators

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1357-1379页

作者： Zhiwei Lin Hui Wang Tianding Chen Yingtao jiang jianmei jiang Yingpin Chen Key Laboratory of Light Field Manipulation and System Integration Applications in Fujian Province School of Physics and Information EngineeringMinnan Normal UniversityZhangzhou363000China Department of Electrical and Computer Engineering University of NevadaLas Vegas89154USA College of Material Engineering Fujian Agriculture and Forestry UniversityFuzhou350000China

In the domain of autonomous industrial manipulators,precise positioning and appropriate posture selection in path planning are pivotal for tasks involving obstacle avoidance,such as handling,heat sealing,and *** Multi-Degree-of-Freedom(MDOF)manipulators offer kinematic redundancy,aiding in the derivation of optimal inverse kinematic solutions to meet position and posture requisites,their path planning entails intricate multiobjective optimization,encompassing path,posture,and joint motion *** satisfactory results in practical scenarios remains *** response,this study introduces a novel Reverse Path Planning(RPP)methodology tailored for industrial *** approach commences by conceptualizing the manipulator’s end-effector as an agent within a reinforcement learning(RL)framework,wherein the state space,action set,and reward function are precisely defined to expedite the search for an initial collision-free *** enhance convergence speed,the Q-learning algorithm in RL is augmented with ***,we formulate the cylindrical bounding box of the manipulator based on its Denavit-Hartenberg(DH)parameters and propose a swift collision detection ***,the motion performance of the end-effector is refined through a bidirectional search,and joint weighting coefficients are introduced to mitigate motion in high-power *** efficacy of the proposed RPP methodology is rigorously examined through extensive simulations conducted on a six-degree-of-freedom(6-DOF)manipulator encountering two distinct obstacle configurations and target *** results substantiate that the RPP method adeptly orchestrates the computation of the shortest collision-free path while adhering to specific posture constraints at the target ***,itminimizes both posture angle deviations and joint motion,showcasing its prowess in enhancing the operational performance of MDOF industrial manipulators.

关键词： Reverse path planning Dyna-Q bidirectional search posture angle joint motion

A Planning Method for Operational Test of UAV Swarm Based on Mission Reliability

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1889-1918页

作者： jingyu Wang Ping jiang jianjun Qi College of Systems Engineering National University of Defense TechnologyChangsha410073China Beijing Special Engineering Design Institution Beijing100028China

The unmanned aerial vehicle(UAV)swarm plays an increasingly important role in the modern battlefield,and the UAV swarm operational test is a vital means to validate the combat effectiveness of the UAV *** to the high cost and long duration of operational tests,it is essential to plan the test in *** solve the problem of planning UAV swarm operational test,this study considers the multi-stage feature of a UAV swarm mission,composed of launch,flight and combat stages,and proposes a method to find test plans that can maximize mission ***,a multi-stage mission reliability model for a UAV swarm is proposed to ensure successful implementation of the mission.A multi-objective integer optimization method that considers both mission reliability and cost is then formulated to obtain the optimal test *** study first constructs a mission reliability model for the UAV swarm in the combat ***,the launch stage and flight stage are integrated to develop a complete PMS(Phased Mission Systems)reliability ***,the Binary Decision Diagrams(BDD)and Multi Objective Quantum Particle Swarm Optimization(MOQPSO)methods are proposed to solve the *** optimal plans considering both reliability and cost are *** proposed model supports the planning of UAV swarm operational tests and represents a meaningful exploration of UAV swarm test planning.

关键词： UAV swarm PMS MOQPSO BDD mission reliability operational test planning

Recent advancements in thermal conductivity of magnesium alloys

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journal of Magnesium and Alloys 2024年第5期12卷 1687-1708页

作者： Hao Lv jun Tan Qian Yuan Fanglei Wang Yunxuan Zhou Quan Dong Aitao Tang jürgen Eckert Bin jiang Fusheng Pan National Engineering Research Center for Magnesium Alloys College of Materials Science and EngineeringChongqing UniversityChongqing 400044China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044China Department of Materials Science Chair of Materials PhysicsMontanuniversität LeobenJahnstraße 12Leoben A-8700Austria Erich Schmid Institute of Materials Science Austrian Academy of SciencesJahnstraße 12Leoben A-8700Austria

As highly integrated circuits continue to advance,accompanied by a growing demand for energy efficiency and weight reduction,materials are confronted with mounting challenges pertaining to thermal conductivity and lightweight *** virtue of numerous intrinsic mechanisms,as a result,the thermal conductivity and mechanical properties of the Mg alloys are often inversely related,which becomes a bottleneck limiting the application of Mg *** on several effective modification methods to improve the thermal conductivity of Mg alloys,this paper describes the law of how they affect the mechanical properties,and clearly indicates that peak aging treatment is one of the best ways to simultaneously enhance an alloy's thermal conductivity and mechanical *** the most frequently used Mg alloy,cast alloys exhibit substantial potential for achieving high thermal ***,recent reports indicate that hot deformation can significantly improve the mechanical properties while maintaining,and potentially slightly enhancing,the alloy's thermal *** presents a meaningful way to develop Mg alloys for applications in the field of small-volume heat dissipation components that require high *** comprehensive review begins by outlining standard testing and prediction methods,followed by the theoretical models used to predict thermal conductivity,and then explores the primary influencing factors affecting thermal *** review summarizes the current development status of Mg alloys,focusing on the quest for alloys that offer both high thermal conductivity and high *** concludes by providing insights into forthcoming prospects and challenges within this field.

关键词： Mg alloy Thermal conductivity Mechanical properties Solute atom Second phase

Experimental and numerical simulation study on forced ventilation and dust removal of coal mine heading surface

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International journal of Coal Science & Technology 2024年第1期11卷 204-220页

作者： Haotian Zheng Bingyou jiang Haoyu Wang Yuannan Zheng Key Laboratory of Industrial Dust Prevention and Control&Occupational Health and Safety Ministry of EducationAnhui University of Science and TechnologyHuainan232001China joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan232001China School of Safety Science and Engineering Anhui University of Science and TechnologyHuainan232001China

In order to study the problems of unreasonable airflow distribution and serious dust pollution in a heading surface,an experimental platform for forced ventilation and dust removal was built based on the similar *** the similar experiment and numerical simulation,the distribution of airflow field in the roadway and the spatial and temporal evolution of dust pollution under the conditions of forced ventilation were *** airflow field in the roadway can be divided into three zones:jet zone,vortex zone and reflux *** dust concentration gradually decreases from the head to the rear of the *** the forced ventilation conditions,there is a unilateral accumulation of dust,with higher dust concentrations away from the *** position of the equipment has an interception effect on the *** maximum error between the test value and the simulation result is 12.9%,which verifies the accuracy of the experimental *** research results can provide theoretical guidance for the application of dust removal technology in coal mine.

关键词： Heading surface Forced ventilation Airflow field Dust pollution

The human-derived novel gut commensal Luoshenia tenuis regulates body weight and food intake in mice

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Food Science and Human Wellness 2024年第2期13卷 830-841页

作者： Yu jiang Mengxuan Du Lisheng Xie Minzhi jiang Yaokun Zhang Mingxia Bi Chang Liu Hongwei Liu Shuangjiang Liu State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China College of Life Science Hebei UniversityBaoding 071000China State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Many studies have revealed that gut microbes modulate host *** this study,we characterized the therapeutic effects of a novel gut commensal Luoshenia tenuis against host metabolic ***,by in silico analysis,we demonstrated that the *** was prevalent in the gut microbiomes of healthy humans but were depleted specifically in obesity *** in vitro cultivation revealed that *** produced short chain fatty acids that were verified to modulate host metabolism and some other volatile metabolites to benefit hosts by anti-inflammation and ***,gavage of the *** significantly decreased the body weight gain and food intake of high-fat diet-feeding C57BL/6j mice,which was in parallel with the changed expression level of genes related to satiety and feeding *** then performed the gavage trial using diet induced obese mice,and it revealed that the administration of *** alleviated significantly the abnormal glucose and lipid metabolisms and reduced the inflammatory *** summary,this study revealed a previously-unknown human gut commensal microbe that benefited host metabolism,and set the stage for the development of novel next-generation probiotic applicable for treatment of obesity and related metabolic disorders.

关键词： Luoshenia tenuis Gut microbe Feeding behavior Obesity Next-generation probiotic