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Mixture models detect large effect QTL better than GBLUP and result in more accurate and persistent predictions

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journal of Animal Science and Biotechnology 2016年第4期7卷 468-473页

作者： Anna Wolc jesus Arango Petek Settar janet E.Fulton Neil P.O'Sullivan jack C.M.Dekkers Rohan Fernando Dorian j.Garrick Department of Animal Science Iowa State University Hy-Line International Dallas Center

Background： Accurate evaluation of SNP effects is important for genome wide association studies and for genomic prediction. The genetic architecture of quantitative traits differs widely, with some traits exhibiting few if any quantitative trait loci （QTL） with large effects, while other traits have one or several easily detectable QTL with large effects. Methods： Body weight in broilers and egg weight in layers are two examples of traits that have QTL of large effect A commonly used method for genome wide association studies is to fit a mixture model such as BayesB that assumes some known proportion of SNP effects are zero. In contrast, the most commonly used method for genomic prediction is known as GBLUP, which involves fitting an animal model to phenotypic data with the variance-covariance or genomic relationship matrix among the animals being determined by genome wide SNP genotypes. Genotypes at each SNP are typically weighted equally in determining the genomic relationship matrix for GBLUP. We used the equivalent marker effects model formulation of GBLUP for this study. We compare these two classes of models using egg weight data collected over 8 generations from 2,324 animals genotyped with a 42 K SNP ***： Using data from the first 7 generations, both BayesB and GBLUP found the largest QTL in a similar well-recognized QTL region, but this QTL was estimated to account for 24 % of genetic variation with BayesB and less than 1% with GBLUP. When predicting phenotypes in generation 8 BayesB accounted for 36 % of the phenotypic variation and GBLUP for 25 %. When using only data from any one generation, the same QTL was identified with BayesB in all but one generation but never with GBLUP. Predictions of phenotypes in generations 2 to 7 based on only 295 animals from generation 1 accounted for 10 % phenotypic variation with BayesB but only 6 % with GBLUP. Predicting phenotype using only the marker effects in the 1 Mb region that accounted for the largest e

关键词： Bayesian methods Bias QTL

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红外热成像在猪生物监测中的应用

国外畜牧学（猪与禽） 2022年第5期42卷 23-26页

作者：孟霞(译) 张涛(校) jack Behan Nigel j Cook Allan L Schaefer 不详 Alpha Phenomics公司

畜禽疾病尤其是人畜共患病会威胁人类和动物的健康,也会影响社会和经济发展,导致食品短缺。在密集型生产系统中,动物的疾病无法得到有效的监控,而技术可以为密切监测和生物监视提供解决方案,走向商业性应用市场的红外热成像正成为动物... 详细信息

畜禽疾病尤其是人畜共患病会威胁人类和动物的健康,也会影响社会和经济发展,导致食品短缺。在密集型生产系统中,动物的疾病无法得到有效的监控,而技术可以为密切监测和生物监视提供解决方案,走向商业性应用市场的红外热成像正成为动物疾病的有效监控监测设备,在确保人类健康和食品安全方面发挥着积极的作用。

关键词：红外热成像半双重射频识别标签红外热像仪动物疾病

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Vocal Fold Hydration:Implications for Physiology and Treatment

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Vocal Fold Hydration:Implications for Physiology and Treatme...

Personal finance / 8th ed.

2014年首次中国中西医结合耳鼻咽喉科中青年学术会议

作者： jack j.jiang University of Wisconsin-Madison

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Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1

2007年

作者： jack R. Kapoor Les R. Dlabay Robert j. Hughes.

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Acta Pharmaceutica Sinica B 2019年第5期9卷 997-1007页

作者： Alexander j.Trevarton Yan Zhou Dehua Yang Gordon W.Rewcastle jack U.Flanagan Antony Braithwaite Peter R.Shepherd Cristin G.Print Ming-Wei Wang Annette Lasham Department of Molecular Medicine and Pathology University of AucklandAucklandNew Zealand The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences(CAS)Shanghai201203China Auckland Cancer Society Research Centre AucklandNew Zealand Maurice Wilkins Centre for Molecular Biodiscovery University of AucklandAucklandNew Zealand Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedinNew Zealand Maurice Wilkins Centre for Molecular Biodiscovery University of OtagoDunedinNew Zealand School of Pharmacy Fudan UniversityShanghai201203China

We have previously shown that high expression of the nucleic acid binding factor YB-1 is strongly associated with poor prognosis in a variety of cancer types. The 3-dimensional protein structure of YB-1 has yet to be determined and its role in transcriptional regulation remains elusive. Drug targeting of transcription factors is often thought to be difficult and there are very few published high-throughput screening approaches. YB-1 predominantly binds to single-stranded nucleic acids, adding further difficulty to drug discovery. Therefore, we have developed two novel screening assays to detect compounds that interfere with the transcriptional activation properties of YB-1, both of which may be generalizable to screen for inhibitors of other nucleic acid binding molecules. The first approach is a cell-based luciferase reporter gene assay that measures the level of activation of a fragment of the E2 F1 promoter by YB-1. The second approach is a novel application of the Alpha Screen system, to detect interference of YB-1 interaction with a single-stranded DNA binding site. These complementary assays examine YB-1 binding to two discrete nucleic acid sequences using two different luminescent signal outputs and were employed sequentially to screen 7360 small molecule compounds leading to the identification of three putative YB-1 inhibitors.

关键词： Cancer YB-1 Luciferase Alpha Screen Transcription factor Single-stranded DNA

2021亚太心脏病学会P2Y12受体拮抗剂应用于亚太特殊人群的共识

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中华心血管病杂志 2023年第1期51卷 19-31页

作者： jack Wei Chieh Tan Derek P Chew Kin Lam Tsui Doreen Tan Dmitry Duplyakov Ayman Hammoudeh 张波李毅徐凯 Paul j Ong DoniFirman Habib Gamra Wael Almahmeed jamshed Dalal Lihua Tan Gabriel Steg Quang N Nguyen junya Ako jassim Al Suwaidi Mark chan Mohamed Sobhy Abdulla Shehab Wacin Buddhari 王祖禄 Alan Yean Yip Fong Bilgehan Karadag Byeong-Keuk Kim Usman Baber Chee Tang Chin 韩雅玲新加坡国立心脏中心新加坡盛港综合医院澳大利亚弗林德斯大学医学与公共卫生学院香港特别行政区东区尤德夫人那打素医院新加坡国立大学理学院药学系俄罗斯萨马拉地区心脏病医院约旦安曼Istishari医院心脏病科大连医科大学第一附属医院心内科大连116000 北部战区总医院心内科沈阳110840 新加坡伊丽莎白诺维娜医院新加坡陈笃生医院印度尼西亚Harapan Kita国家心血管中心、印度尼西亚大学医学院心脏病学和血管医学系突尼斯Fattouma Bourguiba大学医院/莫纳斯提尔大学心脏病科阿拉伯联合酋长国阿布扎比克利夫兰诊所印度孟买Kokilaben Dhirubhai Ambani医院心脏中心香港特别行政区广华医院法国巴黎比夏医院心脏病科越南河内医科大学心脏病科日本神奈川县相模原市北里大学医学院心血管内科卡塔尔多哈哈马德医疗公司成人心脏病科新加坡国立大学心脏中心埃及亚历山大大学医学院阿拉伯联合酋长国阿联酋大学医学与健康科学学院泰国曼谷朱拉隆功国王纪念医院马来西亚砂拉越哥打三马拉汉心脏中心土耳其伊斯坦布尔大学-Cerrahpasa医学院韩国首尔延世大学医学院Severance心血管医院心脏病科美国俄克拉荷马大学健康科学中心

高龄、糖尿病(DM)和慢性肾脏疾病(CKD)不仅会增加慢性冠状动脉综合征(CCS)患者缺血事件的风险,还会增加其接受抗血小板治疗期间的出血风险。此类特殊人群可能需要调整治疗方案,尤其是亚洲的特殊人群,往往表现出与西方人群不同的临床特... 详细信息

高龄、糖尿病(DM)和慢性肾脏疾病(CKD)不仅会增加慢性冠状动脉综合征(CCS)患者缺血事件的风险,还会增加其接受抗血小板治疗期间的出血风险。此类特殊人群可能需要调整治疗方案,尤其是亚洲的特殊人群,往往表现出与西方人群不同的临床特征。关于亚洲人群CCS高风险的分类和急性冠状动脉综合征(ACS)后使用新一代强效P2Y12受体抑制剂(如替格瑞洛和普拉格雷)的国际指南已相继发表。本共识总结了在特殊人群中使用强效P2Y12受体抑制剂的相关证据,提出了在冠状动脉疾病(CAD)特殊人群中应用标准疗程双联抗血小板治疗(DAPT)、短期DAPT和单一抗血小板治疗的推荐意见。本共识的特殊人群包括从ACS过渡至CCS,老年,或患有CKD、DM、多血管CAD和治疗期间发生出血并发症等特征的患者。

关键词：血小板聚集抑制剂亚洲心肌缺血共识双联抗血小板治疗

The role of emerging organic contaminants in the development of antimicrobial resistance

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Emerging Contaminants 2021年第1期7卷 160-171页

作者： Izzie Alderton Barry R.Palmer jack A.Heinemann Isabelle Pattis Louise Weaver Maria j.Gutierrez-Gines jacqui Horswell Louis A.Tremblay Institute of Environmental Science&Research(ESR) New Zealand School of Health Sciences Massey UniversityWellingtonNew Zealand School of Biological Sciences University of CanterburyChristchurchNew Zealand Cawthron Institute NelsonNew Zealand School of Biological Sciences University of AucklandAucklandNew Zealand

Antimicrobial resistance(AMR)threatens human and ecological health *** major changes occur across the human,animal and environmental sectors,the problem will continue to *** important component of AMR that deserves greater attention is the influence of emerging organic contaminants(EOCs)e ubiquitous compounds found,amongst others,in pharmaceuticals,personal care products,food,industrial and agricultural products,plastics and building *** are widely used and can accumulate in the environment from varied sources,predominantly via waste *** can interact with microbial communities potentially leading to the emergence and spread of *** and pharmaceuticals have been demonstrated to promote AMR *** resistance is a multi-faceted problem that requires input from all sectors,with robust strategies and policies needed to make headway with solving the issues of this important threat.

关键词： Resistance transfer Mechanisms of resistance Antimicrobial pollutants Antibiotics Personal care products Pharmaceuticals

Video Demystified A Handbook for the Digital Engineer 4th ed 4th

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