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Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that Drives Metabolic Disease

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Engineering 2023年第1期20卷 9-18页

作者： Tamana Yousof Jae Hyun Byun jack Chen Richard C.Austin Department of Medicine Division of NephrologyMcMaster UniversityThe Research Institute of St.Joe’s Hamilton and the Hamilton Centre for Kidney ResearchHamiltonOntarioL8N 4A6Canada

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is a multifaceted intracellular protein belonging to the evolutionarily conserved pleckstrin homology-related domain family. Its murine homologue, T-cell death-associated 51 (TDAG51) gene, was initially discovered for its role in activation-induced apoptosis in T-cell hybridomas. In recent years, PHLDA1 has received increased attention due to its association with obesity, fatty liver disease, diabetes, atherosclerosis, and cancer. Accumulating evidence also supports its role in endoplasmic reticulum stress signaling pathways as a crucial mediator of apoptosis, autophagy, and cell proliferation. In this review, the current knowledge of PHLDA1 gene and protein regulation, localization, and function is summarized. This review highlights the pro- and anti-apoptotic roles of PHLDA1 that contribute to vast array of metabolic diseases.

关键词： er-stress Metabolism Apoptosis Cell survival PHLDA1

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高速铁路轨道板沉降与水平偏位机械复位技术

铁道标准设计 2017年第7期61卷 46-50页

作者：李显于莉萍王海苟金成吴二军上海同罡建筑工程有限公司上海201101 河海大学南京210098

高速铁路的安全运行对轨道的线性要求十分严格,但随着我国高速铁路的大量建设,轨道板沉降现象时有发生。结合郑徐高铁某段路基沉降与水平偏移工程,简单分析位移偏差原因,提出并设计针对高铁无砟轨道板沉降和水平偏位的机械式双向偏位复... 详细信息

高速铁路的安全运行对轨道的线性要求十分严格,但随着我国高速铁路的大量建设,轨道板沉降现象时有发生。结合郑徐高铁某段路基沉降与水平偏移工程,简单分析位移偏差原因,提出并设计针对高铁无砟轨道板沉降和水平偏位的机械式双向偏位复位体系,体系包括由底座、提升分配梁、提升吊杆、顶升千斤顶组成的竖向提升体系和水平反力支座、水平复位千斤顶组成的水平复位体系两部分。介绍工程中的复位控制单元划分方案和同步位移控制方案,单元划分方案中采用单元重叠、二次加载方法解决了单元相交部位受力影响的难题;位移同步控制采用PLC自动位移同步控制系统。给出该体系实施过程中吊杆提升力、吊杆锚固部位底板冲切承载力、横梁支承部位轨道板局部受压的计算方法,方案在郑徐高铁工程中成功实施,为铁路轨道板偏移复位提供新的技术思路。

关键词：高速铁路轨道板沉降水平偏位顶升机械复位

Fungal diversity notes 1151-1276:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2020年第1期100卷 5-277页

作者： Kevin DHyde Yang Dong Rungtiwa Phookamsak Rajesh Jeewon DJayarama Bhat EBGareth Jones Ning‑Guo Liu Pranami DAbeywickrama Ausana Mapook Deping Wei Rekhani HPerera Ishara SManawasinghe Dhandevi Pem Digvijayini Bundhun Anuruddha Karunarathna Anusha HEkanayaka Dan‑Feng Bao Junfu Li Milan CSamarakoon Napalai Chaiwan Chuan‑Gen Lin Kunthida Phutthacharoen Sheng‑Nan Zhang Indunil CSenanayake Ishani DGoonasekara Kasun MThambugala Chayanard Phukhamsakda Danushka STennakoon Hong‑Bo Jiang Jing Yang Ming Zeng Naruemon Huanraluek Jian‑Kui(jack)Liu Subodini NWijesinghe Qing Tian Saowaluck Tibpromma Rashika SBrahmanage Saranyaphat Boonmee Shi‑Ke Huang Vinodhini Thiyagaraja Yong‑Zhong Lu Ruvishika SJayawardena Wei Dong er‑Fu Yang Sanjay KSingh Shiv Mohan Singh Shiwali Rana Sneha SLad Garima Anand Bandarupalli Devadatha MNiranjan VVenkateswara Sarma Kare Liimatainen 馻‑ Tuula Niskanen Andy Overall Renato Lúcio Mendes Alvarenga Tatiana Baptista Gibertoni Walter PPfliegler EnikőHorváth Alexandra Imre Amanda Lucia Alves Ana Carla da Silva Santos Patricia Vieira Tiago Timur SBulgakov Dhanushaka NWanasinghe Ali HBahkali Mingkwan Doilom Abdallah MElgorban Sajeewa SNMaharachchikumbura Kunhiraman CRajeshkumar Danny Haelewaters Peter EMortimer Qi Zhao Saisamorn Lumyong Jianchu Xu Jun Sheng Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina State Key Laboratory for Conservation and Utilization of Bio‑Resources in Yunnan Yunnan Agricultural UniversityKunming 650201China Yunnan Research Institute for Local Plateau Agriculture and Industry Kunming 650201China Key Laboratory for Agro‑biodiversity and Pest Control of Ministry of Education Yunnan Agricultural UniversityKunming 650201China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanChina Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanChina Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius No.128/1‑J Azad Co‑Op Housing SocietyCurcaGoa Velha 403108India Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Kingdom of Saudi Arabia School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Faculty of Agriculture National Resources and EnvironmentNaresuan UniversityPhitsanulok 65000Thailand Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Department of Soil Ecology UFZ-Helmholtz Centre for Environmental ResearchHalleGermany Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060China Department of Plant M

Fungal diversity notes is one of the important journal series of fungal taxonomy that provide detailed descriptions and illustrations of new fungal taxa,as well as providing new information of fungal taxa *** article is the 11th contribution to the fungal diversity notes series,in which 126 taxa distributed in two phyla,six classes,24 orders and 55 families are described and *** in this study were mainly collected from Italy by erio Camporesi and also collected from China,India and Thailand,as well as in some other European,North American and South American *** described in the present study include two new families,12 new genera,82 new species,five new combinations and 25 new records on new hosts and new geographical distributions as well as sexual-asexual *** two new families are eriomycetaceae(Dothideomycetes,family incertae sedis)and Fasciatisporaceae(Xylariales,Sordariomycetes).The twelve new genera comprise Bhagirathimyces(Phaeosphaeriaceae),Camporesiomyces(Tubeufiaceae),eriocamporesia(Cryphonectriaceae),eriomyces(eriomycetaceae),Neomonodictys(Pleurotheciaceae),Paraloratospora(Phaeosphaeriaceae),Paramonodictys(Parabambusicolaceae),Pseudoconlarium(Diaporthomycetidae,genus incertae sedis),Pseudomurilentithecium(Lentitheciaceae),Setoapiospora(Muyocopronaceae),Srinivasanomyces(Vibrisseaceae)and Xenoanthostomella(Xylariales,genera incertae sedis).The 82 new species comprise Acremonium chiangraiense,Adustochaete nivea,Angustimassarina camporesii,Bhagirathimyces himalayensis,Brunneoclavispora camporesii,Camarosporidiella camporesii,Camporesiomyces mali,Camposporium appendiculatum,Camposporium multiseptatum,Camposporium septatum,Canalisporium aquaticium,Clonostachys eriocamporesiana,Clonostachys eriocamporesii,Colletotrichum hederiicola,Coniochaeta vineae,Conioscypha verrucosa,Cortinarius ainsworthii,Cortinarius aurae,Cortinarius britannicus,Cortinarius heatherae,Cortinarius scoticus,Cortinarius subsaniosus,Cytospora fusispor

关键词： 96 new taxa Agaricomycetes Ascomycota Basidiomycota Dothideomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Saccharomycetes Taxonomy

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摩擦翻转式路桥防超载装置及参数分析

公路 2021年第12期66卷 252-257页

作者：徐博文吴二军蒋勇胡雨晴张栋培河海大学土木与交通学院南京市210098

针对路桥因车辆超载事故频发与寿命大幅缩短问题,提出了道路"保险丝"概念,设计研发了车辆超载自动判别限行装置,并介绍了其运行方法。装置由台座、可翻转滑块、控速限位弹簧、复位单元和超载报警单元组成,利用翻转滑块和台座之间的界面... 详细信息

针对路桥因车辆超载事故频发与寿命大幅缩短问题,提出了道路"保险丝"概念,设计研发了车辆超载自动判别限行装置,并介绍了其运行方法。装置由台座、可翻转滑块、控速限位弹簧、复位单元和超载报警单元组成,利用翻转滑块和台座之间的界面摩擦力与车重产生力矩的力的平衡原理,自动识别超载并转动形成路障,限制超载车通行。建立了装置的受力简图,并基于有车超载界限工况下的力的平衡条件,建立了翻转滑块尺寸、自动、界面摩擦系数、超载限值、控速限位弹簧弹性系数、复位千斤顶额定荷载值等参数的相互关系方程;推导出左右摩擦副界面所需支承力之比和限载值计算表达式。最后假定已知参数,给出一个设计案例。装置的使用可以有效防止超载车辆通行,确保路桥结构安全,延长使用寿命。

关键词：超载治理自动限载装置界面摩擦翻转平衡条件限载值

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运架梁施工对既有桥梁结构影响分析

湖南工程学院学报（自然科学版） 2020年第3期30卷 89-94页

作者：郑军星郝先慧李二伟徐旭升中铁七局集团勘测设计研究院郑州450000

研究预制梁运输与架设过程中对相邻跨既有简支梁结构的影响,为类似工程项目提供参考经验.本文依托郑济客专工程,总结分析了运架梁施工过程中的四种荷载工况.采用Midas Civil软件建立梁桥单元模型,研究运架梁施工对既有简支梁桥纵向、横... 详细信息

研究预制梁运输与架设过程中对相邻跨既有简支梁结构的影响,为类似工程项目提供参考经验.本文依托郑济客专工程,总结分析了运架梁施工过程中的四种荷载工况.采用Midas Civil软件建立梁桥单元模型,研究运架梁施工对既有简支梁桥纵向、横向结构承载力的影响.分析表明,除了需在架桥机中支腿作用处的梁端永久支座横桥向附近各增设1台200 t千斤顶外,桥梁其他结构都满足设计要求.

关键词：运架梁预制简支梁承载力

Fungal diversity notes 1277-1386:taxonomic and phylogenetic contributions to fungal taxa

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Fungal Diversity 2020年第5期104卷 1-266页

作者： Hai-Sheng Yuan Xu Lu Yu-Cheng Dai Kevin D.Hyde Yu-He Kan Ivana Kušan Shuang-Hui He Ning-Guo Liu V.Venkateswara Sarma Chang-Lin Zhao Bao-Kai Cui Nousheen Yousaf Guangyu Sun Shu-Yan Liu Fang Wu Chuan-Gen Lin Monika C.Dayarathne Tatiana Baptista Gibertoni Lucas B.Conceição Roberto Garibay-Orijel Margarita Villegas-Ríos Rodolfo Salas-Lizana Tie-Zheng Wei Jun-Zhi Qiu Ze-Fen Yu Rungtiwa Phookamsak Ming Zeng Soumitra Paloi Dan-Feng Bao Pranami DAbeywickrama De-Ping Wei Jing Yang Ishara S.Manawasinghe Dulanjalee Harishchandra Rashika S.Brahmanage Nimali Ide Silva Danushka S.Tennakoon Anuruddha Karunarathna Yusufjon Gafforov Dhandevi Pem Sheng-Nan Zhang AndréL.C.Mde Azevedo Santiago Jadson Diogo Pereira Bezerra Bálint Dima Krishnendu Acharya Julieta Alvarez-Manjarrez Ali H.Bahkali Vinod K.Bhatt Tor erik Brandrud Timur S.Bulgakov E.Camporesi Ting Cao Yu-Xi Chen Yuan-Yuan Chen Bandarupalli Devadatha Abdallah M.Elgorban Long-Fei Fan Xing Du Liu Gao Camila Melo Gonçalves Luis F.P.Gusmão Naruemon Huanraluek Margita Jadan Ruvishika S.Jayawardena Abdul Nasir Khalid Ewald Langer Diogo X.Lima Nelson Correia de Lima-Júnior Carla Rejane Sousa de Lira Jian-Kui(jack)Liu Shun Liu Saisamorn Lumyong Zong-Long Luo Neven Matočec M.Niranjan JoséRibamar costa Oliveira-Filho Viktor Papp Eduardo Pérez-Pazos Alan J.L.Phillips Peng-Lei Qiu Yihua Ren Rafael F.Castañeda Ruiz Kamal C.Semwal Karl Soop Carlos A.Fde Souza Cristina Maria Souza-Motta Li-Hua Sun Meng-Le Xie Yi-Jian Yao Qi Zhao Li-Wei Zhou CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110164People’s Republic of China University of the Chinese Academy of Sciences Beijing 100049People’s Republic of China School of Ecology and Nature Conservation Beijing Advanced Innovation Center for Tree Breeding By Molecular DesignBeijing Forestry UniversityBeijing 100083People’s Republic of China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Centre of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanChina Ruđer BoškovićInstitute Bijenička cesta 5410000 ZagrebCroatia Faculty of Agriculture Natural Resources and EnvironmentNaresuan UniversityPhitsanulok 65000Thailand Department of Biotechnology School of Life SciencesPondicherry UniversityR.V.NagarKalapetPondicherry 605014India College of Biodiversity Conservation Southwest Forestry UniversityKunming 650224People’s Republic of China Department of Botany Govt.College UniversityKatchery RoadLahorePakistan State Key Laboratory of Crop Stress Biology in Arid Areas and College of Plant Protection Northwest A&F UniversityYanglingShaanxiPeople’s Republic of China Laboratory of Plant Pathology College of Plant ProtectionJilin Agricultural UniversityChangchun 130118Jilin ProvincePeople’s Republic of China Centro de Biociências Departamento de MicologiaUniversidade Federal de PernambucoCidade UniversitáriaAvenida da Engenharia s/nRecifePernambuco 50740-600Brazil Departamento de Ciências Biológicas Universidade Estadual de Feira de SantanaAv.Transnordestina s/nNovo HorizonteFeira de SantanaBA 44036-900Brazil L

This is the twelfth contribution to the Fungal Diversity Notes series on fungal taxonomy,based on materials collected from many countries which were examined and described using the methods of morphology,anatomy,and strain culture,combined with DNA sequence analyses.110 taxa are described and illustrated,including five new genera,92 new species,eight new combinations and other taxonomic contributions(one new sequenced species,one new host and three new records)which are accommodated in 40 families and 1 incertae sedis in *** new genera are Amyloceraceomyces,Catenuliconidia,Hansenopezia,Ionopezia and *** new species are Amyloceraceomyces angustisporus,Amylocorticium ellipsosporum,Arthrinium sorghi,Catenuliconidia uniseptata,Clavulina sphaeropedunculata,Colletotrichum parthenocissicola,Coniothyrium triseptatum,Cortinarius indorusseus,***,***,***,***,Diaporthe pimpinel-lae,Dictyosporella guizhouensis,Diplodia torilicola,Fuscoporia marquesiana,***,Hansenopezia decora,Helicoarcta-tus thailandicus,Hirsutella hongheensis,Humidicutis brunneovinacea,Lentaria gossypina,***,Lycoperdon lahorense,***,Magnopulchromyces scorpiophorus,Moelleriella gracilispora,Neodevriesia manglicola,Neodidymelliopsis salvia,***,Neoroussoella magnoliae,Neottiella gigaspora,Ophiosphaerella chiangraiensis,Phaeotremella yunnanensis,Podosphaera yulii,Rigidoporus juniperinus,Rhodofomitopsis pseudofeei,Russula benghalensis,Scleroramularia vermispora,Scytinopogon minisporus,Sporormurispora paulsenii,Thaxteriellopsis obliqus,Tomentella asiae-orientalis,***,***,***,***,***,***,***,***,***-nocystidiata,***,***,***,***,***,***,***,***,***,***,***,***,***,***,***,

关键词： 110 taxa Agaricomycetes Ascomycota Basidiomycota Mucoromycota New combinations New genera New species Phylogeny Taxonomy