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Effect of Mushroom Extract Hericium erinaceus on Spatial Memory and Morphology of Neurons in the CA1 and CA3 Regions of the Hippocampus in Ovariectomized Rats

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Open Journal of Veterinary Medicine 2024年第7期14卷 163-179页

作者： Lucia Garcia-Delgado Mariana Monserrath Verdía-Venegas jacinto bañuelos-pineda Esther Albarrán-Rodríguez Guillermo Nolasco-Rodriguez José Ricardo Cuellar-Pérez Sergio Fausto-Guerra Manuel Rosales-Cortés Master in Behavioral Sciences Institute of Neurosciences University of Guadalajara Zapopan Mexico Department of Veterinary Medicine Division of Veterinary Sciences CUCBA University of Guadalajara Zapopan Mexico Botany and Zoology Laboratory CUCBA University of Guadalajara Zapopan Mexico

Various studies indicate that low levels of estradiol negatively impact cognitive abilities. Extracts from the fungus Hericium erinaceus (HE) contain bioactive components that promote the proper functioning of the nervous system and potential effects on protection against neurodegenerative diseases, including dementia and motor dysfunctions. The objective was to evaluate the effects of the administration of the HE mushroom extract on visuospatial memory and morphology of neurons in the CA1 and CA3 regions of the hippocampus in ovariectomized rats. 40 young Wistar rats weighing 90 ± 10 g BW were used, which were distributed into four groups of 10 animals;Control Group, non-ovariectomized and untreated rats;Group E2, ovariectomized rats treated with estradiol (2 μg/kg/body weight);Group HE, ovariectomized rats treated with the extract of the fungus Hericium erinaceus (0.5 mg/kg body weight) and Group Ovx/ST, ovariectomized rats, without treatment. The animals were tested in the barnes and Open Field maze, then they were sacrificed, and their brains were obtained to perform a histological analysis of neuronal morphology in the CA1 and CA3 areas of the hippocampus. The most outstanding results showed that the Ovx/ST group recorded the longest time to arrive at the escape box and stay in the barnes maze. A correlation was observed between neuronal damage and function;in the groups that did not present satisfactory performance in the maze tests, morphological alterations were identified such as the presence of some neuronal somata with degeneration characteristics such as pyknosis, nuclear basophilia and shrinkage of the cells. Its soma, as well as a decrease in the nuclear area of CA1 and CA3 neurons. It is concluded that the fungus Hericium erinaceus exerted a neuroprotective effect on the neuronal bodies of the hippocampus, associated with better performance in the visuospatial recognition memory test.

关键词： Ovariectomized Rats Ovarian Hypofunction Estradiol Hericium erinaceus barnes Circular Labyrinth Open Field Labyrinth

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Effect of Mushroom Extract Hericium erinaceus on Spatial Memory and Morphology of Neurons in the CA1 and CA3 Regions of the Hippocampus in Ovariectomized Rats

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Open Journal of Veterinary Medicine（兽医学） 2024年第7期 163页

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Diabetes, Allopathic and Alternative Methods (Kombucha) for Its Treatment

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Journal of Diabetes Mellitus 2022年第4期12卷 187-203页

作者： Guillermo Nolasco-Rodríguez Laura Esmeralda Ordaz-Castro Esther Albarrán-Rodríguez Lucia García-Delgado jacinto bañuelos-pineda Manuel Rosales-Cortés Department of Veterinary Medicine University Science Center Biological and Agricultural Zapopan Mexico

Introduction: Diabetes is a disease characterized by an increase in blood glucose due to disorders in insulin production, this disease is widely distributed throughout the world. Objective: to review and systematize the general information on diabetes, as well as the traditional treatments and the findings on kombucha as an alternative method. Method: the information retrieval technique or literature review was used on the topics of diabetes, allopathic methods, kombucha, preparation procedures, chemical and microbiological components and pharmacological effects of the drink. Results: Various sources of information were found that explain the definition of diabetes and its classification. it commonly presents in four ways depending on the signs, the common ones being type 1, associated with destruction of the β cells of the pancreas and mainly affects minors, and type 2, which is related to genetic and environmental problems and It affects people over 18 years of age, and less frequently gestational diabetes and MODY type. Traditional drugs such as sulfonylureas, glinides and biguanides, thiazolidinediones and α-glucosidase inhibitors are used to control this disease, or alternative therapies are used such as kombucha, a fermented beverage that has its origins in China and is spread worldwide by its beneficial effects in chronic degenerative diseases such as diabetes, due to its chemical and microbiological content. Conclusion: The information establishes important data on kombucha as one of the complementary alternatives for the treatment of diabetes.

关键词： Diabetes Mellitus Alternative Medicine Kombucha Traditional Medicine Pathophysiology of Diabetes

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Effect of Kombucha and Its Non-Polar Components on Morphological Aspects of the Pancreas of Diabetic Rats with Streptozotocin

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Open Journal of Veterinary Medicine 2022年第12期12卷 201-217页

作者： Guillermo Nolasco-Rodríguez Rubén González-Valadez Lucia García-Delgado Esther Albarrán-Rodríguez José Ricardo Cuellar-Pérez jacinto bañuelos-pineda Manuel Rosales-Cortés University Center Biological and Agricultural Sciences University of Guadalajara Zapopan México Department of Veterinary Medicine University Center of Biological and Agricultural Sciences University of Guadalajara Zapopan México

Objective: to evaluate the protective effect of kombucha and its components not polar, in pancreas of diabetic rats treated with streptozotocin. Material and methods: ninety-six male Wistar rats of 120 to 170 g of PC were used;four groups of 24 animals were formed: control (GC), control treatment (GCTx), kombucha treatment (GTxK) and treatment with non-polar components of kombucha (GTxCNP). Diabetes was induced in the last three groups with an intraperitoneal injection of streptozotocin at a dose of 65 mg/kg BW. At the same time, treatment was started in the different groups;GC and GCTx groups were administered, orally, 1 ml of sterile saline solution;to the GTxK group 324 mg/kg of kombucha;and to GTxCNP 0.006 mg/kg of the non-polar components. For the histopathological study, pancreas samples were obtained on days 1, 7, 14 and 21 and fixed in formalin. They were processed with the histological technique, 5-micron-thick sections were made and stained with the hematoxylin-eosin technique. Finally, the number of islets of Langerhans per field observed with the 10x objective was quantified. The results were subjected to a one-way analysis of variance and Tukey’s test (p Results: Significant changes in the number of islets were observed in histological sections of the pancreas. The groups treated with streptozotocin showed a significant decrease in the number of islets 7 days after starting treatment;Likewise, their number was lower in the GCTx group compared to the GTxK and GTxCNP groups (p ≤ 0.05). At 14 and 21 days, the lowest number of islets was maintained, although only in the GCTx and GTxK groups (p ≤ 0.05). Streptozotocin is a drug that can be used in rats to induce an experimental model of diabetes with an effect that can last up to 21 days. Conclusions: This fermented beverage and its non-polar components can be a complementary treatment alternative for diabetes mellitus, since it prevents further damage to the β cells of the pancreas and the Islets of Langerh

关键词： Diabetes Kombucha Rats Streptozotocin Non-Polar Components of Kombucha

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Diabetes, Allopathic and Alternative Methods (Kombucha) for Its Treatment

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Journal of Diabetes Mellitus（糖尿病） 2022年第4期

作者： guillermo nolasco-rodríguez* laura esmeralda ordaz-castro esther albarrán-rodríguez lucia garcía-delgado jacinto bañuelos-pineda manuel rosales-cortés

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Mapping of the Brazilian Groups Studying Nanocellulose

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Journal of Renewable Materials 2019年第5期7卷 429-440页

作者： Asaph Armando jacinto Márcia Aparecida da Silva Spinacé Center of Natural and Human Sciences Federal University of ABCSanto AndréSPBrazil

The nanocellulose is a material that has gained much attention in the recent ***,the relevance of Brazil in this field was evaluated concerning the scientific publications in Web of ***,the Brazilian groups were mapped using a bibliometric procedure on these ***,more factors were analyzed from them *** were the sources to extract the nanocellulose in Brazil,the methods to do it,the characterizations to determine its dimensions and the funding agencies of these *** results identified 69 Brazilian ***,the bacterial cellulose was the most common *** the acid hydrolysis was the most used *** its turn,the size characterization was mostly by scanning electron *** last,the most important agencies were the CNPq,the CAPES and the *** these points,it was possible to suggest the opportunities to develop the nanocellulose research in Brazil.

关键词： Nanocellulose bibliometry scientometrics scientific publication web of science

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Phase-field modeling of fracture for quasi-brittle materials

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Underground Space 2019年第1期4卷 10-21页

作者： jacinto Ulloa Patricio Rodríguez Cristóbal Samaniego Esteban Samaniego Department of Civil Engineering Katholieke Universiteit LeuvenB-3001 LeuvenBelgium Departamento de Recursos Hídricos y Ciencias Ambientales Universidad de CuencaCuenca 010151Ecuador Universidad de Cuenca Cuenca 010151Ecuador Institut für Kontinuumsmechanik Leibniz Universität HannoverHannover 30167Germany Inria Bordeaux-Sud-Ouest Research Center 200 Avenue de la Vieille TourTalence 33405France Facultad de Ingeniería Universidad de CuencaEcuador

This paper addresses the modeling of fracture in quasi-brittle materials using a phase-field approach to the description of crack *** the computational mechanics community,several studies have treated the issue of modeling fracture using phase *** of these studies have used an approach that implies the lack of a damage *** herein explore an alternative model that includes a damage threshold and study how it compares with the most popular *** formulation is systematically explained within a rigorous variational ***,we present the corresponding three-dimensional finite element discretization that leads to a straightforward numerical *** simulations in two dimensions and three dimensions are then *** results show that while an elastic stage and a damage threshold are ensured by the present model,good agreement with the results reported in the literature can be obtained,where such features are generally absent.

关键词： Quasi-brittle materials Fracture Variational formulation Phase fields Gradient damage

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Biocultural Diversity of Sarangani Province, Philippines: An Ethno-Ecological Analysis

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Rice science 2015年第3期22卷 138-146页

作者： Florence Lasalita ZAPICO Catherine Hazel AGUILAR Angelie ABISTANO Josephine Carino TURNER Lolymar jacinto REYES Science Department College of Natural Sciences and Mathematics Mindanao State University-Fatima Graduate School Crop Science Cluster University of the Philippines Los Baos College Galing Foundation Incorporated Dole Philippines Agrarian Reform Beneficiaries Cooperative Inc.Homes Sociology Department College of Social Sciences and Humanities Mindanao State University-Fatima

This paper discussed effects of lowland-associated influences on upland ecology, food security and biocultural diversity in the Sarangani farming communities of the Philippines. In the uplands of Sarangani Province, the conservation of traditional rice varieties, the centrality of rice in tribal life, and the continued observance of planting rituals attest to its cultural significance and convey a common desire for cultural preservation and community solidarity. Economic and socio-political pressures had transformed tribal communities, although vestiges of traditional farming systems are still being practiced in remote sitios（villages）. Changing land use patterns had also resulted in shrinking farm sizes and consequently in food insecurity in the Sarangani uplands. Extractive industries（i.e. logging, mining and charcoal making） and swidden farming were observed to cause widespread environmental degradation, while modern agriculture had undermined the capacity of indigenous peoples to survive because of their complete dependence on lands and resources. With the reality that cultural and biological diversities are inextricably linked, trans-disciplinary strategies coupling indigenous knowledge systems with scientific knowledge should, therefore, be instituted to save the Sarangani upland ecosystem, the indigenous peoples and their tribal resources.

关键词： indigenous knowledge system rice swidden farming traditional agriculture

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Extract of Codiaeum luzonicum Merr. overcomes multidrug resistance in human colon cancer cells by modulating P-glycoprotein

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Asian Pacific Journal of Tropical Biomedicine 2022年第9期12卷 400-410页

作者： Regina Joyce E.Ferrer Marc Justin C.Ong Sonia D.jacinto Institute of Biology University of the Philippines DilimanQuezon CityMetro ManilaPhilippines

Objective:To investigate anti-multidrug resistance(MDR)activity and safety of the bioactive fraction(CL11)from Codiaeum luzonicum crude leaf ***:Cytotoxic activity of CL11 against MDR and nonresistant colon cancer cells was assessed using MTT *** of cell death was investigated by annexin V-propidium iodide staining,TUNEL,and JC-1 *** examine mechanism of action,the effect on the expression and function of the MDR-implicated protein P-glycoprotein was tested using Western blotting and calcein assay,***:CL11 had an EC50 of 0.18,1.03 and 38.52µg/mL against HCT-15,HCT-15/Dox and HCT116,*** was mediated by inhibition of P-glycoprotein function and *** mode of cell death involved mitochondrial membrane depolarization and was mostly non-apoptotic at EC50 concentrations against HCT-15 and HCT-15/***:Fraction CL11 of Codiaeum luzonicum induces nonapoptotic cell death in MDR cancer cells by overcoming MDR through inhibition of P-glycoprotein expression and function.

关键词： Natural product Leaf extract Codiaeum luzonicum MDR cancer P-gp inhibitor Colorectal cancer

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Plant extracts as natural photosensitizers in photodynamic therapy:in vitro activity against human mammary adenocarcinoma MCF-7 cells

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Asian Pacific Journal of Tropical Biomedicine 2017年第4期7卷 358-366页

作者： Rigo baluyot Villacorta Kristine Faith Javier Roque Giovanni Alarkon Tapang Sonia Donaldo jacinto Institute of Biology University of the Philippines National Institute of Physics University of the Philippines

Objective: To examine three plant extracts [Lumnitzera racemosa(Combretaceae)(***), Albizia procera(Fabaceae)(***) and Cananga odorata(Annonaceae)] for their potential as source of photosensitizers in photodynamic ***: Human mammary adenocarcinoma(MCF-7) cells were treated with the plant extracts, which were irradiated with 5.53 m W and 0.553 mW broadband *** viability was assessed using MTT assay and induction of apoptosis was determined using terminal deoxynucleotidyl transferase-dUTP nick end labeling ***: The crude ethanolic extracts, independently, were nontoxic against cancer and non-cancer cells but when irradiated with 5.53 mW broadband light, *** and *** extracts were cytotoxic against MCF-7 with IC_(50) of 11.63 mg/mL and10.73 mg/mL, *** 0.553 mW broadband light, the IC_(50) values were higher at 17.14 mg/mL and 19.59 mg/mL, *** *** and *** extracts were found to be more cytotoxic against MCF-7 than the non-cancer cell line, human dermal ***, the cytotoxicity of the extracts was mediated by ***: Two of the plant extracts used, *** and *** were toxic and induced apoptosis to mammary cell adenocarcinoma, MCF-7 when *** extracts were also more toxic to human cancer than non-cancer cell lines.

关键词： Photodynamic therapy MCF-7 Photosensitizer Lumnitzera racemosa Albizia procera Cananga odorata

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