检索结果-南通市图书馆

维普期刊数据库

More forks on the road to replication stress recovery

在线全文

学校读者我要写书评

暂无评论

分子细胞生物学报:英文版 2011年第1期3卷 4-12页

作者： Chris Allen Amanda K.Ashley Robert Hromas jac.a.nickoloff Department of Environmental and Radiological Health Sciences Colorado State UniversityFt CollinsCO 80523USA University of New Mexico Cancer Center and Department of Internal Medicine University of New Mexico School of MedicineAlbuquerqueNM 87131USA

High-fidelity replication of DNA,and its accurate segregation to daughter cells,is critical for maintaining genome stability and suppressing *** replication forks are stalled by many DNA lesions,activating checkpoint proteins that stabilize stalled *** forks may eventually collapse,producing a broken DNA *** restart is typically mediated by proteins initially identified by their roles in homologous recombination repair of DNA double-strand breaks(DSBs).In recent years,several proteins involved in DSB repair by non-homologous end joining(NHEJ)have been implicated in the replication stress response,including DNA-PKcs,Ku,DNA Ligase IV-XRCC4,Artemis,XLF and *** is currently unclear whether NHEJ proteins are involved in the replication stress response through indirect(signaling)roles,and/or direct roles involving DNA end *** complexity in the replication stress response centers around RPA,which undergoes significant post-translational modification after stress,and RAD52,a conserved HR protein whose role in DSB repair may have shifted to another protein in higher eukaryotes,such as BRCA2,but retained its role in fork *** cancer therapeutic strategies create DNA replication ***,it is imperative to gain a better under-standing of replication stress response proteins and pathways to improve cancer therapy.

关键词： DNA repair genome instability cancer therapy

Exploiting DNA repair pathways for tumor sensitization,mitigation of resistance,and normal tissue protection in radiotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2021年第2期4卷 244-263页

作者： jac.a.nickoloff Lynn Taylor Neelam Sharma Takamitsu A.Kato Department of Environmental and Radiological Health Sciences Colorado State UniversityFt.CollinsCO 80523USA.

More than half of cancer patients are treated with radiotherapy,which kills tumor cells by directly and indirectly inducing DNA damage,including cytotoxic DNA double-strand breaks(DSBs).Tumor cells respond to these threats by activating a complex signaling network termed the DNA damage response(DDR).The DDR arrests the cell cycle,upregulates DNA repair,and triggers apoptosis when damage is *** DDR signaling and DNA repair pathways are fertile terrain for therapeutic *** review highlights strategies to improve therapeutic gain by targeting DDR and DNA repair pathways to radiosensitize tumor cells,overcome intrinsic and acquired tumor radioresistance,and protect normal *** biological and environmental factors determine tumor and normal cell responses to ionizing radiation and genotoxic *** include cell type and cell cycle phase distribution;tissue/tumor microenvironment and oxygen levels;DNA damage load and quality;DNA repair capacity;and susceptibility to apoptosis or other active or passive cell death *** provide an overview of radiobiological parameters associated with X-ray,proton,and carbon ion radiotherapy;DNA repair and DNA damage signaling pathways;and other factors that regulate tumor and normal cell responses to *** then focus on recent studies exploiting DSB repair pathways to enhance radiotherapy therapeutic gain.

关键词： DNA repair DNA double-strand break repair non-homologous end-joining homologous recombination radiosensitization radioprotection cancer therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

jac外贸谈判手记

Accuracy of Helicobacter pylori serology in two peptic ulcer populations and in healthy controls

作者： jac

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第32期14卷 5039-5045页

作者： Rolv-Ole Lindsetmo Roar Johnsen Tor jac Eide Tore Gutteberg Hanne Haukland Husum Arthur Revhaug Department of Gastrointestinal Surgery University Hospital of North Norway and Institute of Clinical Medicine Troms University Institute of Public Health and General Practice Norwegian University of Science and Technology Department of Pathology National Hospital Department of Microbiology University Hospital of North Norway

AIM： To estimate the test characteristics of Heli- cobacter pylori （H pylori） serology and of C14-urea breath test （C14-UBT） in two different peptic ulcer populations and in community controls. Second, the aim was to explore the association between the level of Hpylori IgG antibodies and severity of inflammation as to active peptic ulceration in the same populations. METHODS： Vagotomized （n = 83）, medically treated peptic ulcer patients （n = 73） and one reference group of community controls （n = 88） were gastroscoped. H pylori status was determined by histology, bacterial growth, C14-UBT and serology. Based on the updated Sydney System, cumulative scores from biopsies from the prepyloruos, incisura angularis, corpus and fundus were calculated. RESULTS： The prevalence of Hpylori infection varied from 70% to 79%. The C14-UBT had high accuracy compared to the serology test. The sensitivity of the serology test was good, but the specificity was low （41%-71%）. The association between H pylori IgG antibodies and scores of gastric mucosal inflammation and current or previous peptic ulcer were weak. CONCLUSION： The accuracy of CI4-UBT to diagnose Hpylori infection was good, and the clinical utility of a negative H pylori serology test was substantial, while the gain in clinical information of a positive test was meagre. Positive H pylori titres could not distinguish between subjects with or those without active peptic ulceration.

关键词： C14-urea breath test Gastric inflammation Helicobacter pylori serology Peptic ulcers Test characteristics

Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第2期17卷 219-225页

作者： Patricia Kuiper Lukas jac Hawinkels Eveline SM de Jonge-Muller Izk Biemond Cornelis BHW Lamers Hein W Verspaget Department of Gastroenterology and Hepatology Leiden University Medical Centre Department of Molecular Cell Biology and Centre for Biomedical Genetics Leiden University Medical Centre

AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 *** addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial ***31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs.

关键词： Neuroendocrine tumor Carcinoid tumor Angiogenesis factors Endoglin Vascular endothelial growth factor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

移动式安全座椅的乘员保护性能的研究

汽车工程 2011年第7期33卷 603-607页

作者：肖志 jac．Wismans 蒋小晴杨济匡湖南大学汽车车身先进设计制造国家重点实验室长沙410082 Safeteq汽车安全咨询公司荷兰宋5691

传统的座椅在汽车前碰撞中是不允许产生明显变形的,本文中提出了3种移动式的汽车安全座椅,它们可在汽车前碰撞时发生相应的变形,具有防止乘员下潜,消除安全带与乘员之间的初始间隙和降低胸部加速度的作用;建立了使用3种移动式座椅和传... 详细信息

传统的座椅在汽车前碰撞中是不允许产生明显变形的,本文中提出了3种移动式的汽车安全座椅,它们可在汽车前碰撞时发生相应的变形,具有防止乘员下潜,消除安全带与乘员之间的初始间隙和降低胸部加速度的作用;建立了使用3种移动式座椅和传统座椅的汽车前碰撞乘员动力学响应和损伤分析的仿真模型,并进行4种座椅的对比仿真。结果表明,与传统座椅和其它两种移动座椅相比,第一种移动式安全座椅对乘员头部、颈部和胸部具有较好的防护性能。

关键词：汽车前碰撞移动式安全座椅乘员保护

维普期刊数据库

心脏磁共振评估肾素-血管紧张素-醛固酮系统的心血管相互作用：动脉粥样硬化的多种族研究

在线全文

学校读者我要写书评

暂无评论

中华高血压杂志(中英文) 2024年第6期32卷 600-600页

作者： Varadarajan V Marques MD Venkatesh BA Allison M Ostovaneh MR Yoneyama K Donekal S Shah RV Murthy VL Wu CO Tracy RP Ouyang P Rochitte EC Bluemke DA Lima jac 袁源练桂丽

小型研究已描述了肾素-血管紧张素-醛固酮系统在心血管系统中的作用。该研究旨在探讨醛固酮和血浆肾素活性（plasma renin activity,PRA）与心血管结构和功能的关系。方法：研究者评估在2003-2005年进行醛固酮和PRA检测，并在2010年接...

小型研究已描述了肾素-血管紧张素-醛固酮系统在心血管系统中的作用。该研究旨在探讨醛固酮和血浆肾素活性（plasma renin activity,PRA）与心血管结构和功能的关系。方法：研究者评估在2003-2005年进行醛固酮和PRA检测，并在2010年接受心脏磁共振检查的动脉粥样硬化多种族研究参与者的随机样本。排除服用血管紧张素转换酶抑制药或血管紧张素受体阻滞药的参与者。结果：醛固酮组615例，平均年龄（61.6±8.9）岁；肾素组580例，平均年龄（61.5±8.8）岁，两组女性占比均约50%。

关键词：

Effects of integrated nitrogen fertilization and irrigation systems, rootstocks, and cultivars on productivity, water and nitrogen consumption, and mineral nutrition of pear

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Agricultural Sciences 2012年第2期3卷 257-267页

作者： Xinhua Yin Xiao-Lan Huang jac le Roux Department of Plant Sciences The University of Tennessee Jackson USA IRRINET Dalles USA

Water and nitrogen (N) management are key factors for sustainable pear production in many areas. Effects of integrated N fertilization and irrigation systems, rootstocks, and cultivars on pear (Pyrus communis) mineral nutrition, irrigation water and N consumption, and fruit productivity were investigated on a fine sandy loam soil at Hood River, Oregon from 2005 through 2007. Nitrogen application reduced to 80% of the current broadcast application rate and fertigated in five equal split applications could supply bearing pear trees with adequate N nutrition without reducing soil N reserves. Shifting from the broadcast of dry N fertilizer on soil surface and micro sprinkler irrigation system (BSS) to the split N fertigation and drip irrigation system (FDS) did not affect tree growth, fruit yield, or fruit size of pear. However, FDS produced more Bartlett fruit in color categories of 390 - 417 and 417 - 496 nm than BSS. Irrigation water consumption was reduced by 42.0% to 78.3%, but water use efficiency was enhanced by 51.0% to 264.2% with FDS relative to BSS. Split N fertigation and drip irrigation system may be used as an alternate N fertilization and irrigation system on bearing pear orchards to reduce irrigation water and N consumption in Hood River and other similar areas.

关键词： N Fertigation Drip Irrigation Irrigation Water Consumption Fruit Yield Fruit Weight Pear

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

形态分析：分析科学的新动向

光谱学与光谱分析 1995年第5期15卷 121-123页

作者： Bro.,jac 刘克玲德国多特蒙德大学化学系

形态分析：分析科学的新动向ＪＡＣＢｒｏｅｋａｅｒｔ德国多特蒙德大学化学系，Ｄ４４２２１多特蒙德，德国在生态毒理学、药物剂量学和生物剂量学的研究中，首先感兴趣的不是无机元素的含量，而是含无机元素的化合物。这就要求我们能... 详细信息

形态分析：分析科学的新动向ＪＡＣＢｒｏｅｋａｅｒｔ德国多特蒙德大学化学系，Ｄ４４２２１多特蒙德，德国在生态毒理学、药物剂量学和生物剂量学的研究中，首先感兴趣的不是无机元素的含量，而是含无机元素的化合物。这就要求我们能准确可靠地分析测定含无机元素的不同...

关键词：形态分析无机元素分析科学生态毒理学

维普期刊数据库