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Tailored eradication vs empirical bismuth-containing quadruple therapy for first-line Helicobacter pylori eradication: A comparative,open trial

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World Journal of Gastroenterology 2019年第46期25卷 6743-6751页

作者： Youn I Choi Jun Won Chung Dong Kyun Park Kyoung Oh Kim Kwang An Kwon Yoon jae Kim ja young seo Department of Gastroenterology Gil Medical CenterGachon UniversityIncheon 21565South Korea Department of Laboratory Medicine Gil Medical CenterGachon UniversityIncheon 21565South Korea

BACKGROUND Few studies have compared the efficacy and safety profile of a tailored eradication(TR)strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy(EBQT)for first-line eradication of Helicobacter pylori(***)in Korean *** To compare the efficacy and safety of a TR strategy and those of EBQT regimen as first-line eradication therapy for *** This is an open-label,comparative study in which we prospectively enrolled patients over 18 years of age with *** infection and retrospectively reviewed their ***-positive patients diagnosed by rapid urease test,Giemsa staining,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR)were enrolled from May 2016 to September 2018 at Gil Medical *** with *** infection received either a TR regimen or the EBQT *** the tailored therapy group that underwent DPO-PCR testing,patients with A2142G and/or A2143G point mutations were treated with a bismuth-containing quadruple *** eradication rate,patient-reported side effect rate,and *** eradication success rate were evaluated and compared between the *** A total of 150 patients were assigned to the TR(n=50)or EBQT group(n=100).The first-line eradication rate of *** did not differ between the groups(96.0%vs 95.7%,P=0.9).The rate of eradication-related side effects for TR was 12.0%,which differed significantly from that of EBQT(43.0%)for first-line treatment(P<0.001).CONCLUSION DPO-PCR-based TR for *** eradication may be equally efficacious,with less treatment-related complications,compared to EBQT in Korea,where clarithromycin resistance is high.

关键词： Helicobacter pylori Eradication Tailored Empirical Quadruple

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Tailored eradication strategy vs concomitant therapy for Helicobacter pylori eradication treatment in Korean patients

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World Journal of Gastroenterology 2021年第31期27卷 5247-5258页

作者： Youn I Choi Jun-Won Chung Kyoung Oh Kim Kwang An Kwon Yoon jae Kim Jung Ho Kim ja young seo Dong Kyun Park Division of Internal Medicine Department of GastroenterologyGachon University College of MedicineGil Medical CenterInchoen 21565South Korea Department of Laboratory Medicine Gil Medical CenterGachon UniversityInchoen 21565South Korea Health IT Research Center Gachon University Gil HospitalIncheon 21565South Korea

BACKGROUND Antibiotic resistance to Helicobacter pylori(***)infection,which ultimately results in eradication failure,has been an emerging issue in the clinical ***,to overcome this problem,an antibiotic sensitivity-based tailored therapy(TT)for *** infection has received *** To investigate the efficacy and safety profiles of TT for *** infection treatment compared to a non-bismuth quadruple therapy,concomitant therapy(CT)*** We included patients(>18 years)with an *** infection and without a history of Helicobacter eradication who visited the Gil Medical Center between March 2016 and October *** being randomly assigned to either the TT or CT treatment group in 1 to 1 manner,patient compliance,eradication success rate(ESR),and patient-reported side effects profiles were assessed and compared between the two *** infection was diagnosed using a rapid urease test,Giemsa stain,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR).Tailored eradication strategy based through the presence of a 23S ribosomal RNA point *** the TT group,a DPO-PCR test,which detected A2142G and/or A2143G point mutations,and a clarithromycin resistance test were *** in the clarithromycin-resistant group were treated with a bismuth-containing quadruple combination therapy,while those with sensitive results were treated with the standard triple *** Of the 217 patients with a treatment naive *** infection,110 patients[mean age:58.66±13.03,men,n=55(50%)]were treated with TT,and 107 patients[mean age:56.67±10.88,men,n=52(48.60%)]were treated with *** compliance(TT vs CT,100%vs 98.13%,P=0.30),and follow-up loss rates(8.18%vs 9.35%,P=0.95)were not significantly different between the *** ESR after treatment was also not statistically different between the groups(TT vs CT,82.73%vs 82.24%,P=0.95).However,the treatment-related and patient-reported side effects were signifi

关键词： Helicobacter pylori Eradication Tailored therapy Conco-mitant therapy regimen

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Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer

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World Journal of Clinical Cases 2021年第24期9卷 6999-7008页

作者： Jong Beom Kim young Il Kim Yong Sik Yoon Jihun Kim seo young Park Jong Lyul Lee Chan Wook Kim In ja Park seok-Byung Lim Chang Sik Yu Jin Cheon Kim Division of Colon and Rectal Surgery University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND The microsatellite instability(MSI)test and immunohistochemistry(IHC)are widely used to screen DNA mismatch repair(MMR)deficiency in sporadic colorectal cancer(CRC).For IHC,a two-antibody panel of MLH1 and MSH2 or four-antibody panel of MLH1,MSH2,PMS2,and MSH6 are *** general,MSI is known as a more accurate screening test than *** To compare two-and four-antibody panels of IHC in terms of accuracy and cost benefit on the basis of MSI testing for detecting MMR *** We retrospectively analyzed patients with CRC who underwent curative surgery between 2015 and 2017 at a tertiary referral *** IHC with four antibodies and MSI tests were routinely *** sensitivity and specificity of a fourand two types of two-antibody panels(PMS2/MSH6 and MLH1/MSH2)were compared on the basis of MSI testing for detecting MMR *** High-frequency MSI was found in 5.5%(n=193)of the patients(n=3486).The sensitivities of the four-and two types of two-antibody panels were 97.4%,92.2%,and 87.6%,*** specificities of the three types of panels did not differ significantly(99.6%for the four-antibody and PMS2/MSH6 panels,99.7%for the MLH1/MSH2 panel).Based on Cohen's kappa statistic(κ),four-and twoantibody panels were in almost perfect agreement with the MSI test(κ>0.9).The costs of the MSI test and the four-and two-antibody panels of IHC were approximately$200,$160,and$80,*** Considering the cost of the four-antibody panel IHC compared to that of the twoantibody panel IHC,a two-antibody panel of PMS2/MSH6 might be the best choice in terms of balancing cost-effectiveness and accuracy.

关键词： Adenocarcinoma DNA mismatch repair Immunochemistry Monoclonal antibody Microsatellite instability Cost-effectiveness

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Comparison of litterfall production in three forest types in Jeju Island, South Korea

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Journal of Forestry Research 2020年第3期31卷 945-952页

作者： Ji young An Si Ho Han Woo Bin Youn Sang Ick Lee Afroja Rahman Huong Thi Thuy Dao Jeong Min seo Aung Aung Hyung-Soon Choi Hwa ja Hyun Byung Bae Park Department of Natural Resources Kyoto UniversityKyoto 606-8502Japan Department of Environment and Forest Resources Chungnam National UniversityDaejeon 34134Republic of Korea Forest Environment Conservation Division Korea Forest ServiceDaejeon 35208Republic of Korea Forest Conservation Department National Institute of Forest ScienceSeoul 02455Republic of Korea Warm Temperate and Subtropical Forest Research Center National Institute of Forest ScienceSeogwipo 63582Republic of Korea

Litterfall, which is influenced by physical and biological factors, is a major pathway for carbon and nutrient cycling in forest ecosystems. The purpose of this study was to investigate monthly litterfall production in three forests in Jeju Island differentiated by forest composition and precipitation: Cheongsu(Quercus glauca as the dominant species;low precipitation), seonheulb(Q. glauca as the dominant species;high precipitation), and seonheulm(Q. glauca and Pinus thunbergii as the dominant species;high precipitation). Litterfall was collected monthly from April to December 2015 and divided into leaf litter, twig, bark, seeds, and unidentified *** patterns of litterfall production varied across stands according to their species composition. However,the amount of leaf litterfall and total litterfall were comparable among stands, ranging from 362 to 375 g m-2 for leaf litter and 524 g m-2 to 580 g m-2 for total *** leaf litter in May was the highest in all stands, while needle litter was the highest in December in *** twig litterfall in July may be attributable to high rainfall with strong winds and storms during the rainy season. Although forest type and climate factor had no influence on litterfall amounts in this study, the pattern of litterfall production was species dependent, suggesting diverse effects on carbon and nutrient cycling in these forests.

关键词： Coniferous forest Evergreen broadleaved forest Gotjawal Leaf litter Precipitation Temperature

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Additional Sensitivity Penalty of Burst Mode Receivers in Ethernet PON due to Extinction Ratio

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光学学报 2003年第S1期23卷 647-648页

作者： Sub Han ja-Won seo Tae-Whan Yoo Man-seop Lee Information and Communications University (ICU) 58-4 Hwaam-Dong Yuseong-Gu Daejeon 305-732 KOREAInformation and Communications University (ICU) 58-4 Hwaam-Dong Yuseong-Gu Daejeon 305-732 KOREAElectronics and Telecommunications Research Institute (ETRI)Information and Communications University (ICU) 58-4 Hwaam-Dong Yuseong-Gu Daejeon 305-732 KOREA

An additional sensitivity penalty of burst mode receivers due to the extinction ratio is analyzed considering the specific transmitter control in Ethernet PON. For an extinction ratio of 6dB, a penalty of 8dB occurs a... 详细信息

关键词： PON of Additional Sensitivity Penalty of Burst Mode Receivers in Ethernet PON due to Extinction Ratio in

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In vitro,in vivo and in silico anti-hyperglycemic inhibition by sinigrin

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Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 352-358页

作者： Qamar Abbas Mubashir Hassan Hussain Raza Song ja Kim Ki-Wha Chung Gwang-Hoon Kim Sung-Yum seo Department of Biological Sciences College of Natural SciencesKongju National University56 Gongjudehak-Ro 56GongjuChungnam 32588Republic of Korea

Objective:To evaluate the anti-hyperglycemic potential of sinigrin using in *** silico and in riro streptozotocin(STZ) induced hyperglycemic zebrafish ***:The in vitro enzyme inhibition assay was carried out to determine the IC_(50) value against α-glucosidase and α-*** silico molecular docking was performed against both enzymes with PyRx tool and simulations were performed using GROMACS *** was induced in zebrafishes using three intraperitoneal injections on alternating days for one week at 350mg/kg of *** fishes were treated intraperitoncally with 50.100 and 150 mg of sinigrin/kg of body weight for 24 h and glucose levels were ***:The sinigrin showed very strong inhibition against α-glucosidase and α-amylase with 0.248 and0.00124 μM while reference drug acarbose showed IC_(50) value of 73.0700 and 0.0017 μM against α-glucosidase and α-amylase,*** analysis revealed that sinigrin has the mixed type mode of inhibition against α-*** docking results revealed its strong binding affinity with α-glucosidase(-10.00 Kcal/mol) and α-amylase(-8.10 Kcal/mol).Simulations graphs confirmed its stability against both *** hyperglycemic zebrafishes most significant(P<0.001) reduction of glucose was occurred at150 mg/*** significant reduction of glucose was observed at 100 mg/kg and no any significant reduction of glucose was measured at 50 mg/***:It can be evident from the present results that sinigrin has potent anti-hyperglycemic activity and it may prove to be effective treatment for the hyperglycemia.

关键词： Anti-hyperglycemia MD simulations Sinigrin Zebrafish α-amylase α-glucosidase

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Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4

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World Journal of Gastroenterology 2005年第30期11卷 4674-4678页

作者： Youn-Jung Kim Hae-Jeong Park seo-Hyun Yoon Mi-ja Kim Kang-Hyun Leem Joo-Ho Chung Hye-Kyung Kim Department of Dental Hygiene Department of Pharmacology Department of Obesity Management College of Oriental Medicine Department of Food and Biotechnology

AIM: Oligomeric proanthocyanidins (OPC), natural polyphenolic compounds found in plants, are known to have antioxidant and anti-cancer effects. We investigated whether the anti-cancer effects of the OPC are induced by apoptosis on human colorectal cancer cell line, ***: Colorectal cancer cell line, SNU-C4 was cultured in RPMI 1640 medium supplemented with 10% fetal bovine serum. The cytotoxic effect of OPC was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenylt-etrazolium bromide (MTT) assay. To find out the apoptotic cell death, 4, 6-diamidino-2-phenylindole (DAPI) staining,terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcriptionpolymerase chain reaction (RT-PCR), and caspase-3 enzyme assay were ***: In this study, cytotoxic effect of OPC on SNUC4 cells appeared in a dose-dependent manner. OPC treatment (100 μg/mL) revealed typical morphological apoptotic features. Additionally OPC treatment (100 μg/mL)increased level of BAX and CASPASE-3, and decreased level of BCL-2 mRNA expression. Caspase-3 enzyme activity was also significantly increased by treatment of OPC (100 μg/mL) compared with ***: These data indicate that OPC caused cell death by apoptosis through caspase pathways on human colorectal cancer cell line, SNU-C4.

关键词： Oligomeric pranthocyanidins Apoptosis Anticancer effects Colorectal cancer

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王不留行与硬叶女娄菜止痛、消炎效能的比较研究

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河南中医学院学报 2006年第2期21卷 31-32页

作者：徐富一金正子申舜植韩国大邱韩医大学校韩国东义大学校

目的:比较验证中国临床所用王不留行与韩国临床所用王不留行即硬叶女娄菜的止痛和消炎功效。方法:取韩国出产的硬叶女娄菜和中国河南出产的王不留行分别煎汤、减压浓缩,灌胃两组Sprague Dawley系大鼠和I.C.R小鼠30min后,用0.7%醋酸腹腔... 详细信息

目的:比较验证中国临床所用王不留行与韩国临床所用王不留行即硬叶女娄菜的止痛和消炎功效。方法:取韩国出产的硬叶女娄菜和中国河南出产的王不留行分别煎汤、减压浓缩,灌胃两组Sprague Dawley系大鼠和I.C.R小鼠30min后,用0.7%醋酸腹腔注射及5%醋酸足跖皮下注射,并与生理盐水作对照,测量和观察止痛和消炎效果。结果:王不留行组与硬叶女娄菜组在止痛和消炎功效上较生理盐水组显示显著差异。结论:王不留行与硬叶女娄菜止痛和消炎效能优秀。

关键词：王不留行硬叶女娄菜止痛消炎药效学

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罗格列酮对前驱糖尿病或非糖尿病代谢综合症血浆脂联素水平和动脉僵硬度的影响

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中国动脉硬化杂志 2006年第6期14卷 510-510页

作者： Kim SG Ryu OH Kim HY Lee KW seo ja Kim NH 徐丽梅

目的:噻唑烷二酮类对糖尿病患者动脉粥样硬化替代标记物如脂联素和动脉僵硬度有较好的作用。这些有益的作用是否会在非糖尿病患者(如前驱糖尿病或非糖尿病代谢综合症)出现还不明确。目前的研究是评价非糖尿病患者胰岛素致敏剂罗格列酮... 详细信息

目的:噻唑烷二酮类对糖尿病患者动脉粥样硬化替代标记物如脂联素和动脉僵硬度有较好的作用。这些有益的作用是否会在非糖尿病患者(如前驱糖尿病或非糖尿病代谢综合症)出现还不明确。目前的研究是评价非糖尿病患者胰岛素致敏剂罗格列酮对循环脂肪细胞因子水平和肱踝脉搏波传递速度的作用。方法: 99例前驱糖尿病或非糖尿病患者随机分配到罗格列酮组和对照组(分别为50和49例)。罗格列酮组每日4峭罗格列酮,持续12周。所有患者均口服葡萄糖75g,检测口服葡萄糖耐量试验前后肱踝脉搏波传递速度、脂联素、抵抗素和高敏C反应蛋白水平。结果:相对于对照组来说,试验后罗格列酮组循环脂联素水平显著增加(P<0.001)。试验前后两组血浆抵抗素水平没有变化。试验后罗格列酮组肱踝脉搏波传递速度(P<0.001)和高敏C反应蛋白(P=0.003)显著降低。多元线性回归分析表明血浆脂联素和肱踝脉搏波传递速度变化受罗格列酮处理的显著影响。结论:这些数据提示,罗格列酮在前驱糖尿病或非糖尿病代谢综合症患者具有抗动脉粥样硬化作用。[第一段]

关键词：细胞因子水平血浆脂联素代谢综合症罗格列酮非糖尿病动脉僵硬度抗动脉粥样硬化作用口服葡萄糖耐量高敏C反应蛋白糖尿病患者

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