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Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： Jun-Kyul Song Min Sung Kim Seungwon Yoo ja Hoon koo Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

Lactic Acid Fermentation from Coffee Ground Waste Hydrolysate by Lactobacillus rhamnosus

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Journal of Renewable Materials 2019年第4期7卷 365-372页

作者： ja-Ryong koo Hye Min Park Se Kyung Kim Hyun Shik Yun Department of Biological Engineering Inha UniversityIncheon 22212Korea Institute of Industrial Biotechnology Inha University Research and Business FoundationIncheon 22212Korea

Lactic acid is an important organic acid that is widely used in the food,pharmaceutical,and cosmetic *** acid was produced from coffee ground waste which contains fermentable sugars and is increasingly generated from our daily dietary *** 114 strains of Lactobacillus species,Lactobacillus rhamnosus ATCC 10863 was selected for the production of lactic acid from coffee ground *** alkali pretreatment and saccharification,cellulose and hemicellulose in coffee ground waste were converted into fermentable *** experiments were conducted at various alkali solution,concentrations,and *** pretreatment with 35 g/L of KOH at 121oC for 60 min,the highest concentration of fermentable sugars was *** optimum concentration of Viscozyme L was 2%when saccharification was proceeded at 55oC for 7 *** productivity of lactic acid fermentation was the highest(0.59 g/L/h)at 100 g of coffee ground waste(1x concentration),whereas the lactic acid concentration was the highest at 600 g of coffee ground waste(6x concentration).As the concentration of coffee ground increased,the lactic acid concentration was also increased,however,the amount was not proportional to the coffee ground waste *** this study,it was found that coffee ground waste could be used as a culture medium for Lactobacillus rhamnosus ATCC 10863 through pretreatment and saccharification for the production of lactic acid.

关键词： Coffee ground waste Lactobacillus rhamnosus lactic acid fermentable sugars saccharification alkali pretreatment

Natural Variation in OsPRR37 Regulates Heading Date and Contributes to Rice Cultivation at a Wide Range of Latitudes

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Molecular Plant 2013年第6期6卷 1877-1888页

作者： Bon-Hyuk koo Soo-Cheul Yoo Joon-Woo Park choon-Tak Kwon Byoung-Doo Lee Gynheung An Zhanying Zhang linjie Li Zichao Li Nam-Chon Paek Department of Plant Science Plant Genomics and Breeding Institute and Research Institute for Agriculture and Life Sciences Seoul National UniversitySeoul 151-921 Korea Department of Plant Systems Biotech and Crop Biotech Institute Kyung Hee University Yongin 446-701 Korea Key Lab of Crop Heterosis and Utilization of Ministry of Education and Beijing Key Lab of Crop Genetic Improvement China Agriculture UniversityBeijing 100193 China Institute of Green Bio Science and Technology Seoul National University Pyeongchang 232-916 Korea

Heading date and photoperiod sensitivity are fundamental traits that determine rice adaptation to a wide range of geographic environments. By quantitative trait locus （QTL） mapping and candidate gene analysis using whole- genome re-sequencing, we found that Oryza sativa Pseudo-Response Regulator37 （OsPRR37; hereafter PRR37） is respon- sible for the Early heading7-2 （EH7-2）/Heading date2 （Hd2） QTL which was identified from a cross of late-heading rice ＇Milyang23 （M23）＇ and early-heading rice ＇H143＇. H143 contains a missense mutation of an invariantly conserved amino acid in the CCT （CONSTANS, CO-like, and TOC1） domain of PRR37 protein. In the world rice collection, different types of nonfunctional PRR37 alleles were found in many European and Asian rice cultivars. Notably, the japonica varieties harboring nonfunctional alleles of both Ghd7/Hd4 and PRR37/Hd2 flower extremely early under natural long-day condi- tions, and are adapted to the northernmost regions of rice cultivation, up to 53~ N latitude. Genetic analysis revealed that the effects of PRR37 and Ghd7 alleles on heading date are additive, and PRR37 down-regulates Hd3a expression to suppress flowering under long-day conditions. Our results demonstrate that natural variations in PRR37/Hd2 and GhdT/ Hd4 have contributed to the expansion of rice cultivation to temperate and cooler regions.

关键词： rice heading date quantitative trait locus natural variation Ghd7 OsPRR37.

Workplace Wellness,Mental Health Literacy,and Usage Intention of E-Mental Health amongst Digital Workers during the COVID-19

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International Journal of Mental Health Promotion 2023年第1期25卷 99-126页

作者： choon-Hong Tan Ah-Choo koo Hawa Rahmat Wei-Fern Siew Alexius Weng-Onn Cheang Elyna Amir Sharji Faculty of Creative Multimedia Multimedia UniversityCyberjaya63000Malaysia Faculty of Applied Communication Multimedia UniversityCyberjaya63000Malaysia International Medical University(IMU) Bukit Jalil57000Malaysia

The prevalence of mental health problems in both Malaysian and global workplaces has signiﬁcantly increased due to the presence of the coronavirus disease(COVID-19)pandemic,globalization,technology advancement in Industry 4.0,and other contributing *** pervasiveness of the issue poses a huge challenge to improving the occupational safety and health(OSH)of workers in various industries,especially in the digital *** emergence of the innovative industry is evident mainly due to the rapid development of Industry 4.0 and the rele-vant demands of multiple businesses in the digital ***,limited studies and academic dis-cussions were conducted on the OSH topic of digital ***,the current study serves toﬁll the existing gap and provide academic contributions by scrutinising the perceptions of digital workers regarding their work-place well-being,mental health literacy,and the impression of employing e-mental *** objectives of this study are:1)To examine the mental health literacy and workplace wellness of digital workers,2)to explore the e-mental health usage intention and actual e-mental health utilization,and 3)to identify digital workers’feedback on e-mental *** the current context,e-mental health focuses on three dimensions,namely,1)“health in our hand(HIOH)”,2)“interacting for health(IFH)”,and 3)“data enabling health(DEH)”.The present study employed an online cross-sectional survey and received 326 digital workers’completed ***,such as“mental health literacy(MHL)”,“workplace wellness(WW)”,and e-mental health intention and usage were explicated by analysing the data through descriptive *** study results indicated a moderate to a high level of the MHL and the *** than half of the workers possessed a high intention level to employ e-mental health,with the HIOH dimension being the most prevalent ***,the actual e-mental health usage was very low,owing to the online r

关键词： E-mental health intention digital workers digital industry workplace wellness mental health literacy

Second-line bismuth-containing quadruple therapy for Helicobacter pylori eradication and impact of diabetes

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World Journal of Gastroenterology 2017年第6期23卷 1059-1066页

作者： Sung Eun Kim Moo In Park Seun ja Park Won Moon jae Hyun Kim Kyoungwon Jung Hae koo Kim Young Dal Lee Department of Internal Medicine Kosin University College of MedicineBusan 49267South Korea

To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication *** study included 636 patients who failed first-line triple therapy and received 7 d of bismuth-containing quadruple therapy between january 2005 and December 2015. We retrospectively demonstrated H. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 wk after the completion of bismuth-based quadruple therapy: proton pump inhibitor, metronidazole, bismuth, and *** overall eradication rates by intention-to-treat analysis and per-protocol analysis were 73.9% (95%CI: 70.1%-77.4%) and 94.5% (95%CI: 92.4%-96.5%), respectively. Annual eradication rates from 2005 to 2015 were 100.0%, 92.9%, 100.0%, 100.0%, 100.0%, 97.4%, 100.0%, 93.8%, 84.4%, 98.9%, and 92.5%, respectively, by per-protocol analysis. A multivariate analysis showed that diabetes mellitus (OR = 3.99, 95%CI: 1.56-10.20, P = 0.004) was associated with H. pylori eradication therapy *** second-line bismuth-containing quadruple therapy for H. pylori infection is still effective in Korea, and diabetes mellitus is suggested to be a risk factor for eradication failure.

关键词： Helicobacter pylori Disease eradication Treatment failure Bismuth Diabetes mellitus

Two-year delay in ulcerative colitis diagnosis is associated with anti-tumor necrosis factor alpha use

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World Journal of Gastroenterology 2019年第8期25卷 989-1001页

作者： Ho Suk Kang ja-Seol koo Kang Moon Lee Dae-Bum Kim Ji Min Lee Yoon jae Kim Hyuk Yoon Hyun Joo jang Department of Internal Medicine Hallym Sacred Heart HospitalHallym University College of MedicineAnyang 14068South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalDepartment of Internal MedicineKorea University College of MedicineAnsan 15355South Korea Department of Internal Medicine The Catholic University of KoreaSt.Vincent’s HospitalSuwon 16247South Korea Department of Gastroenterology Gachon Graduate School of Medicine Gil Medical CenterIncheon 21565South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam 13620South Korea Division of Gastroenterology Department of Internal MedicineDongtan Sacred Heart HospitalHallym University College of MedicineHwaseong 18450South Korea

BACKGROUND Ulcerative colitis(UC)is an uncommon inflammatory bowel disease(IBD).However,its incidence has recently increased in South ***,UC diagnoses are frequently delayed,and the relationship between diagnostic delay and UC prognosis has not been extensively studied in South Korean *** To identify meaningful diagnostic delay affecting UC prognosis and to evaluate risk factors associated with diagnostic delay in South Korean *** Medical records of 718 patients with UC who visited the outpatient clinic of six university hospitals in South Korea were reviewed;167 cases were excluded because the first symptom date was *** evaluated the relationship between the prognosis and a diagnostic delay of 3,6,12,18,and 24 mo by comparing the prognostic factors[anti-tumor necrosis factor(TNF)-αuse,admission history due to acute flare-ups,frequent admission due to flare-ups,surgery associated with UC,and the clinical remission state at the latest followup]at each diagnostic *** The mean diagnostic interval was 223.3±483.2 d(median,69 d;75th percentile,195 d).Among the prognostic factors,anti-TNFαuse was significantly increased after a diagnostic delay of 24 *** risk factors predictive of a 24-mo diagnostic delay were age24 mo was associated with increased anti-TNFα***<60 years at diagnosis,smoking history,and misdiagnosis of hemorrhoids were risk factors for delayed diagnosis.

关键词： Ulcerative colitis Diagnostic delay Anti-tumor necrosis factor alpha Smoking

Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage Ⅲ and Ⅳcolorectal cancer

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World Journal of Gastroenterology 2017年第3期23卷 505-515页

作者： jae Hyun Kim Jun Yeop Lee Hae koo Kim Jin Wook Lee Sung Gyu Jung Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun ja Park Division of Gastroenterology Department of Internal MedicineKosin University College of MedicineBusan 602-702South Korea

AIM To evaluate the prognostic value of the neutrophil-tolymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with colorectal cancer(CRC).METHODS Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression *** The median follow-up duration was 46 mo(interquartile range, 22-73). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR (≥ 3.0) and high PLR(≥ 160) were independent risk factors predicting poor long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. However, high NLR and high PLR were not prognostic factors in patients with stage Ⅰ and Ⅱ *** In this study, we identified that high NLR (≥ 3.0) and high PLR (≥ 160) are useful prognostic factors to predict long-term outcomes in patients with stage Ⅲ and Ⅳ CRC.

关键词： Colorectal cancer Neutrophil Lymphocyte Platelet Prognosis

Recent advances in soft electronic materials for intrinsically stretchable optoelectronic systems

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Opto-Electronic Advances 2022年第8期5卷 21-49页

作者： ja Hoon koo Huiwon Yun Woongchan Lee Sung-Hyuk Sunwoo Hyung Joon Shim Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea.

In recent years,significant progress has been achieved in the design and fabrication of stretchable optoelectronic *** general,stretchability has been achieved through geometrical modifications of device components,such as with serpentine interconnects or buckled ***,the local stiffness of individual pixels and the limited pixel density of the array have impeded further advancements in stretchable ***,intrinsically stretch-able optoelectronics have been proposed as an alternative ***,we review the recent advances in soft elec-tronic materials for application in intrinsically stretchable optoelectronic ***,we introduce various intrinsically stretchable electronic materials,comprised of electronic fillers,elastomers,and surfactants,and exemplify different in-trinsically stretchable conducting and semiconducting *** also describe the processing methods used to fabricate the electrodes,interconnections,charge transport layers,and optically active layers used in intrinsically stretch-able optoelectronic ***,we review representative examples of intrinsically stretchable optoelectronic devices,including light-emitting capacitors,light-emitting diodes,photodetectors,and ***,we briefly discuss intrinsically stretchable integrated optoelectronic systems.

关键词： stretchable optoelectronics light-emitting capacitors light-emitting diodes photodetectors photovoltaics intrinsically stretchable devices

Study on Embryo-Fetal Development to Artesunate in Rats

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中国实验动物学报 2005年第S1期13卷 48-页

作者： Moon-koo Chung Jong-choon Kim Korea Institute of Toxicology KRICT Daejeon 305-600 KoreaCollege of Veterinary Medicine Chonnam National University Gwangju 500-575Korea