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Renal impairment in multiple myelomas

The Chinese-German Journal of Clinical Oncology 2011年第7期10卷 418-422页

作者： Cheng Yang Tianbiao Lan yi Cheng Department of nephrology Wuhan General Hospital of Guangzhou Command Wuhan 430070 China Tongji Cancer Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective: The aim of the study was to investigate the clinic manifestation, diagnosis and treatment on multiple myeloma (MM) with the onset of renal impairment. Methods: The 27 cases of multiple myeloma with the onset of renal impair-ment were collected in Department of nephrology, Wuhan General Hospital of Guangzhou Command, China, from January 2007 to January 2011. All cases were divided into the groups with renal dysfunction (n = 16) and normal renal function (n = 11). The clinic manifestations, treatments and prognosis of all patients were analyzed. Results: Of all the patients in normal renal function group, 5 suffered nephrotic syndrome, 4 had abnormal results of routine urinalysis (hematuria or proteinuria) which were not caused by nephrotic syndrome, and 1 suffered urinary tract infection. Five pathological specimens of renal biopsy revealed that light chain protein, immunoglobulin and complement C3 were deposited mainly in the glomerular base-ment membrane and mesangia, tubular basement membrane and arteriolar walls. Two pathological specimens were proved to be renal amyloidosis. Patients with renal dysfunction had poorer prognosis, severer anemia, higher values of serum lactate dehydrogenase (LDH) and β2-microglobulin (β2-MG), worse responses to chemotherapy. Of 16 patients with renal dysfunc-tion, 14 (87.5%) were stage III, which were significantly higher than that in the group of normal renal function [63.6% (7/11)]. Of 16 cases with renal dysfunction, 9 were treated with blood purification, and 5 of 9 cases were treated with plasma exchange. Conclusion: Multiple myeloma with the onset of renal impairment was easily misdiagnosed. Hemodialysis concomitant with chemotherapy could contribute to recovery of renal function.

关键词： multiple myeloma (MM) renal impairment diagnosis treatment

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龙岗河流域水生态系统监测与评估

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中国农村水利水电 2014年第6期 54-56页

作者：王文瑾黄奕龙陈凯深圳市龙岗区水污染治理办公室广东深圳518000 深圳市水务规划设计院广东深圳508008

为了解河流生态修复状况,并明确未来河流整治的内容和方向,以深圳市的龙岗河为例,对河流整治前后的水生态系统状况进行监测和评估,研究结果表明:①龙岗河流域治理以后,河流生态流量有了较大程度的改善,即使是在枯水期也基本满足河流最... 详细信息

为了解河流生态修复状况,并明确未来河流整治的内容和方向,以深圳市的龙岗河为例,对河流整治前后的水生态系统状况进行监测和评估,研究结果表明:①龙岗河流域治理以后,河流生态流量有了较大程度的改善,即使是在枯水期也基本满足河流最小生态需水的要求,而平水期的生态流量达到较好的水平;②龙岗河流域治理以后,河流主要水质指标(CODMn、BOD5、nH3-n、TP)均有明显的好转,但各指标的绝对值仍然较高,特别是nH3-n仍是劣Ⅴ类水平;③龙岗河流域治理以后,浮游动物多样性指数略有上升,浮游植物和底栖动物多样性都略有下降,这与河流修复时间较短,水生态系统尚不稳定有关外,还与河流生态补水水质不高有关。

关键词：水生态系统生态需水监测与评估龙岗河

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Effects of positive acceleration(+Gz stress) on liver enzymes,energy metabolism,and liver histology in rats

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World Journal of Gastroenterology 2019年第3期25卷 346-355页

作者： Bin shi Xian-Qiang Wang Wei-Dong Duan Guo-Dong Tan Han-jing Gao ying-Wei Pan Qing-Jun Guo Hong-yi Zhang Department of Hepatobiliary Surgery Air Force Medical Center PLA Department of Pediatrics Chinese PLA General Hospital and PLA Medical School Department of Hepatobiliary Surgery Chinese PLA General Hospital and PLA Medical School Outpatient Department Air Command Headquarters Department of Ultrasound Chinese PLA General Hospital and PLA Medical School Department of Endocrinology Changhai Hospital Second Military Medical University

BACKGROUnD Exposure to high sustained +Gz(head-to-foot inertial load) is known to have harmful effects on pilots' body in flight. Although clinical data have shown that liver dysfunction occurs in pilots, the precise cause has not been well *** To investigate rat liver function changes in response to repeated +Gz *** ninety male Wistar rats were randomly divided into a blank control group(BC group, n = 30), a +6 Gz/5 min stress group(6 GS group, n = 30), and a +10 Gz/5 min stress group(10 GS group, n = 30). The 6 GS and 10 GS groups were exposed to +6 Gz and +10 Gz, respectively, in an animal centrifuge. The onset rate of +Gz was 0.5 G/s. The sustained time at peak +Gz was 5 min for each exposure(for 5 exposures, and 5-min intervals between exposures for a total exposure and non-exposure time of 50 min). We assessed liver injury bymeasuring the portal venous flow volume, serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST), liver tissue malondialdehyde(MDA), na+-K+-ATPase, and changes in liver histology. These parameters were recorded at 0 h, 6 h, and 24 h after repeated +Gz *** After repeated +Gz exposures in the 6 GS and the 10 GS groups, the velocity and flow signal in the portal vein(PV) were significantly decreased as compared to the BC group at 0 h after exposure. Meanwhile, we found that the PV diameter did not change significantly. However, rats in the 6 GS group had a much higher portal venous flow volume than the 10 GS group at 0 h after exposure. The 6 GS group had significantly lower ALT, AST, and MDA values than the 10 GS group 0 h and 6 h post exposure. The na^+-K^+-ATPase activity in the 6 GS group was significantly higher than that in the 10 GS group 0 h and 6 h post *** injury, determined pathologically, was significantly lower in the 6 GS group than in the 10 GS *** Repeated +Gz exposures transiently cause hepatocyte injury and affect liver metabolism and morphologica

关键词： Positive acceleration +Gz Liver function Animal models Liver metabolism Ischemia-reperfusion injury

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Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells

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World Journal of Stem Cells 2022年第10期14卷 756-776页

作者： Ping Li Yang Wang Pei Li Yuan-Lin Liu Wei-Jiang Liu Xiao-Yu Chen Tian-Tian Tang Ke-Min Qi yi Zhang Laboratory of nutrition and Development Key Laboratory of Major Diseases in Children's Ministry of EducationBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Experimental Hematology and Biochemistry Beijing Institute of Radiation MedicineBeijing 100085China Department of Pediatrics General Hospital of Tianjin Medical UniversityTianjin Medical UniversityTianjin 300070China

BACKGROUnD The effects of inappropriate dietary calcium intake in early life on later obesity have not been fully *** To raise the mechanism of maternal calcium intake on the multi-differentiation potential of mesenchymal stem cells among their male *** Four-week-old female C57BL/6n mice were fed by deficient,low,normal and excessive calcium reproductive diets throughout pregnancy and *** MSCs(BMSCs)were obtained from 7-day-old male offspring to measure the adipogenic differentiation potential by the Wnt/β-catenin signaling *** other weaning male pups were fed a high-fat diet for 16 wk,along with normalfat diet as the *** the serum was collected for the measurement of biochemical ***,the adipose tissues were excised to analyze the adipocyte sizes and inflammatory *** the target gene expressions on the adipogenic differentiation and Wnt/β-catenin signaling pathway in the adipose tissues and BMSCs were determined by real-time reverse transcription polymerase chain *** Compared with the control group,maternal deficient,low and excessive calcium intake during pregnancy and lactation aggravated dietary-induced obesity,with larger adipocytes,more serious inflammatory infiltration and higher serum metabolism indicators by interfering with higher expressions of adipogenic differentiation(PPARγ,C/EBPα,Fabp4,LPL,Adiponectin,Resistin and/or Leptin)among their male offspring(Pnd there were significantly different expression of similar specific genes in the BMSCs to successfully polarize adipogenic differentiation and suppress osteogenic differentiation in vivo and in vitro,respectively(Pnwhile,it was accompanied by more significant disorders on the expressions of Wnt/β-catenin signaling pathway both in BMSCs and adulthood adipose tissues among the offspring from maternal inappropriate dietary calcium intake *** Early-life abnormal dietary calcium intak

关键词： Calcium Obesity Bone mesenchymal stem cells Wnt/β-catenin signaling pathway Adipogenic differentiation Male offspring

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Dl- 3 -n-Butylphthalide, a multi -target drug for the treatment of acute ischemic stroke

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中国药理通讯 2005年第4期22卷 54-55页

作者： Zhang li - ying Feng yi - pu Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050

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基于数位信息的信息隐藏方法

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电子与信息学报 2005年第8期27卷 1304-1309页

作者：程义民钱振兴王以孝田源中国科学技术大学电子科学与技术系合肥230026

描述了一种基于数字位置信息的信息隐藏方法,给出了一个单位增广矩阵,并在此基础上给出了具体算法。该方法若用单个数位信息,在n=2m-1时,嵌入效率可达到m,有较高的数据嵌入效率;若用多个数位组合信息,可在保持嵌入效率不变的条件下,数... 详细信息

描述了一种基于数字位置信息的信息隐藏方法,给出了一个单位增广矩阵,并在此基础上给出了具体算法。该方法若用单个数位信息,在n=2m-1时,嵌入效率可达到m,有较高的数据嵌入效率;若用多个数位组合信息,可在保持嵌入效率不变的条件下,数据嵌入率近似等于1(n较大时),在相同比特数的宿主信息中,可嵌入较多的隐藏信息,可用于流媒体等信息量较大信息的隐藏。文中所述的方法,计算复杂度不高,易于硬件实现,已用微型计算机在局域网上进行了模拟实验,获得了较好的实验结果。

关键词：单位增广矩阵流媒体嵌入效率嵌入率 “异或”运算

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制备工艺对C／C-SiC复合材料滑动摩擦特性的影响

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中国有色金属学报 2008年第11期18卷 2008-2013页

作者：葛毅成易茂中彭可杨芸芸 f中南大学粉末冶金国家重点实验室长沙410083

分别采用熔渗硅(MSI)、前驱体裂解(PIP)技术制备4种C/C-SiC复合材料。在M2000型实验机上测试材料的摩擦磨损特性。结果表明:采用MSI制备的2种C/C-SiC摩擦因数高、不稳定,摩擦因数在0.404～0.906之间波动;随载荷增加,MSI-SiC质量分数为40... 详细信息

分别采用熔渗硅(MSI)、前驱体裂解(PIP)技术制备4种C/C-SiC复合材料。在M2000型实验机上测试材料的摩擦磨损特性。结果表明:采用MSI制备的2种C/C-SiC摩擦因数高、不稳定,摩擦因数在0.404～0.906之间波动;随载荷增加,MSI-SiC质量分数为40.9%的材料B的摩擦因数变化幅度低于SiC质量分数18.9%的材料A的摩擦因数,但其随时间延长的波动幅度大;随时间延长和载荷增加,采用PIP制备的2种C/C-SiC材料的摩擦因数变化小,在0.08～0.14之间波动;其中,随载荷增加,PIP-SiC质量分数为18.0%的材料C的摩擦因数波动幅度稍大于SiC质量分数为6.0%的材料D的。EDAX分析表明:材料A的部分磨损表面未发现碳元素;而材料C磨损表面的碳硅摩尔比大于1,使其有足够的炭形成自润滑膜,从而降低材料的摩擦因数。SEM形貌表明:MSI技术制备的材料摩擦表面粗糙,未形成完整的摩擦膜,而采用PIP技术制备的材料摩擦表面较完整且致密。

关键词： C/C—SiC复合材料制备工艺滑动摩擦摩擦特性

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针刺对家兔超负荷运动骨骼肌细胞内钙离子活度的影响

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中国临床康复 2005年第28期9卷 211-213页

作者：易学马国义河北体育学院教学实验中心河北省石家庄市050041

目的:应用钙离子敏感微电极技术,分析肌肉损伤与细胞内Ca2+浓度的关系及针刺对骨骼肌细胞内Ca2+活度的影响。方法:实验于2000-09/2001-05在河北医科大学中医学院实验针灸实验室完成。选用同种健康青紫蓝家兔70只,随机数字表法进行分组,... 详细信息

目的:应用钙离子敏感微电极技术,分析肌肉损伤与细胞内Ca2+浓度的关系及针刺对骨骼肌细胞内Ca2+活度的影响。方法:实验于2000-09/2001-05在河北医科大学中医学院实验针灸实验室完成。选用同种健康青紫蓝家兔70只,随机数字表法进行分组,分1次针刺处理组和4次针刺处理组,1次针刺处理组30只,分为3个亚组,即针刺组10只,对照组11只,空白组9只。4次针刺处理组40只,分为3个亚组,即针刺组15只,对照组13只,空白组12只。针刺组和对照组通过固定在兔左后肢的表面电极使股四头肌反复被动强直收缩运动,空白组不予电刺激。制造超负荷运动状态的疲劳模型。同时针刺组选取家兔股外侧肌局部(相当于伏兔和梁丘穴位置)于第4天刺激运动结束后即刻进行第1次针刺,4次针刺处理组还将于其后的第1天上,下午,第2天上午各针刺1次,对照组和空白组除不针刺外,亦以同样方式固定于实验架上。标本经处理后通过自制并测定的钙离子敏感微电极进行细胞膜电位的测定,同时测定细胞内外Ca2+有效浓度的电位差,计算细胞内钙离子活度。组间比较采用t检验。结果:70只实验动物最终进入结果分析51只。包括1次针刺处理组中针刺组7只,对照组8只,空白组7只。4次针刺处理中针刺组12只,对照组7只,空白组10只。①家兔过度运动后,针刺组及对照组与空白组相比,骨骼肌膜电位的绝对值均显著降低(64.3±1.38),(64.1±1.13),(80.7±3.09)-mV,P0.05)。②运动结束后46h,针刺组膜电位绝对值与对照组比较,显著升高(79.0±2.59),(67.6±1.58)-mV,P0.05。细胞内钙离子活度值针刺组均细胞内钙离子活度值比对照组显著降低,但仍高于空白组,差别显著(P<0.01)。结论:超负荷运动导致肌细胞超微结构的改变;细胞内钙离子活度升高;骨骼肌膜电位的绝对值均显著降低,可能是肌肉的损伤所致。针刺能够改善细胞内钙离子的代谢,从而促进超微结构损伤的修复。

关键词：肌收缩/针灸效应钙/代谢运动过度/针灸疗法

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Correction to “Maturity of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model [World J Gastroenterol 2018 March 14; 24(10): 1107-1119]”

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World Journal of Gastroenterology 2018年第39期24卷 4517-4518页

作者： yi-Fan Tong Xiu-Jun Cai Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

Correction to:Tong YF,Meng n,Chen MQ,ying Hn,Xu M,Lu B,Hong JJ,Wang YF,Cai *** of associating liver partition and portal vein ligation for staged hepatectomy-derived liver regeneration in a rat model(World J Gastroenterol 2017;24(10):1107-1119)[1].Erratum:In the“Conclusion of Abstract”,“Core tip”,“Discussion”and“Research perspectives”,the description regarding the relationship between the volumetric and functional proliferation during ALPPS-derived liver regeneration should be ***,the sentence that reads“as the ALPPS-derived proliferation in volume lags behind the functional regeneration”should be revised to“as the ALPPS-derived functional regeneration lags behind the proliferation in volume”.

关键词： liver Cai tip be

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An Inclusion-Exclusion Algorithm for network Reliability with Minimal Cutsets

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American Journal of Computational Mathematics 2012年第4期2卷 316-320页

作者： Yan-Rui Sun Wei-yi Zhou School of Electronic Information Wuhan University Wuhan China School of Sciences Northeastern University Shenyang China

The inclusion-exclusion formula (IEF) is a fundamental tool for evaluating network reliability with known minimal paths or minimal cuts. However, the formula contains many pairs of terms which cancel. Using the notion of comparable node partitions some properties of canceling terms in IEF are given. With these properties and the thought of “dynamic programming” method, a simple and efficient inclusion-exclusion algorithm for evaluating the source-to-terminal reliability of a network starting with cutsets is presented. The algorithm generates all the non-canceling terms in the unreliability expression. The computational complexity of the algorithm is O(n+m3+M), where n and m are the numbers of nodes and minimal cuts of the given network respectively, M is the number of terms in the final symbolic unreliability expression that generated using the presented algorithm. Examples are shown to illustrate the effectiveness of the algorithm.

关键词： Inclusion-Exclusion Formula network Reliability Minimal Cutset Dynamic Programming

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