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党史素材融入高职基础写作课程的价值意蕴与实践路径

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湖北开放职业学院学报 2024年第8期37卷 136-138页

作者：蒋红怡宜春幼儿师范高等专科学校江西宜春336000

党史素材融入高职基础写作课程,是落实立德树人根本任务的必然方案。其承载着推动党史素材学习常态化,也蕴含着提升高职写作教师素养及赋能高职基础写作课提质增效的价值意蕴。党史素材融入高职基础写作课程的问题主要有:融入内容机械... 详细信息

党史素材融入高职基础写作课程,是落实立德树人根本任务的必然方案。其承载着推动党史素材学习常态化,也蕴含着提升高职写作教师素养及赋能高职基础写作课提质增效的价值意蕴。党史素材融入高职基础写作课程的问题主要有:融入内容机械化、融入方式单一化、融入主题错位化、融入评价工具化。党史素材融入高职基础写作课程应挖掘课程教学内容与党史素材契合点,创新党史素材融入课程的教学方式,增强写作教师的党史学习理解能力、完善党史素材融入课程的价值评价。

关键词：党史素材高职基础写作课程价值意蕴实践路径

丙泊酚与瑞马唑仑对经无痛纤维支气管镜活检术患者的临床研究

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中国临床药理学杂志 2024年第12期40卷 1699-1703页

作者：黄志华王艳芳秦朝生蒋奕红桂林医学院附属医院麻醉科广西壮族自治区桂林541001 桂林医学院附属医院护理部广西壮族自治区桂林541001

目的观察丙泊酚与瑞马唑仑用于行无痛纤维支气管镜活检术患者的临床效果。方法选取2022年3月~2023年4月在我院行无痛纤维支气管镜活检术的患者为研究对象,随机分为2组。对照组用1 mg·kg^(-1)丙泊酚、3μg·kg^(-1)芬太尼、0.1 mg·kg^(... 详细信息

目的观察丙泊酚与瑞马唑仑用于行无痛纤维支气管镜活检术患者的临床效果。方法选取2022年3月~2023年4月在我院行无痛纤维支气管镜活检术的患者为研究对象,随机分为2组。对照组用1 mg·kg^(-1)丙泊酚、3μg·kg^(-1)芬太尼、0.1 mg·kg^(-1)顺式阿曲库铵进行麻醉诱导,并以4~6 mg·kg^(-1)·h^(-1)丙泊酚进行麻醉维持。试验组用0.2 mg·kg^(-1)瑞马唑仑、3μg·kg^(-1)芬太尼、0.1 mg·kg^(-1)顺式阿曲库铵进行麻醉诱导,并以0.2~0.4 mg·kg^(-1)·h^(-1)瑞马唑仑进行麻醉维持。比较2组患者的苏醒时间、拔喉罩时间、镜检时间、追加麻醉药物比例,检测2组患者的术前、术后24 h的S100β、神经元特异性烯醇化酶(NSE)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,统计2组患者药物不良反应发生情况。结果试验组与对照组均入组80例患者。试验组拔喉罩时间显著低于对照组,而镜检时间、苏醒时间、追加麻醉药物比例与对照组比较,在统计学上差异均无统计学意义(均P>0.05)。试验组整体麻醉效果分级与对照组比较,在统计学上差异无统计学意义(P>0.05)。试验组和对照组术后24 h时S100β分别为(0.66±0.17)和(0.78±0.21)μg·L^(-1);NSE分别为(8.47±1.78)和(11.47±2.06)μg·L^(-1);IL-6分别为(8.64±1.21)和(12.89±1.47)pg·mL^(-1);TNF-α分别为(6.27±1.07)和(9.13±1.41)pg·mL^(-1),组间比较在统计学上差异均有统计学意义(均P0.05)。结论瑞马唑仑应用于无痛纤维支气管镜活检术对神经系统损伤较小,可稳定血流动力学。

关键词：瑞马唑仑丙泊酚无痛纤维支气管镜血流动力学药物不良反应

Neutrophil rich anaplastic large cell lymphoma presented as cutaneous nodules in an adolescent

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Chinese Medical Journal 2008年第3期121卷 283-285页

作者： DU Hua-ping jiang Hao WANG yi-hong HUANG Jin-wen Department of Hematology Sir Run Run Shaw Hospital School ofMedicine Zhejiang University Hangzhou Zhejiang 310016China

Anaplastic large cell lymphoma （ALCL）, a type of lymphoma, was first described by Stain in 1985 and included in non-Hodgkin lymphoma according to REAL classification since 1998. In the absence of necrosis, neutrophils infiltration in non-Hodgkin lymphoma is uncommon. Mann et alI had previously reported neutrophil rich ALCL as a variant of ALCL. In this paper, we describe a neutrophil rich, anaplastic large cell lymphoma （ALCL） which presented as cutaneous nodules in an adolescent.

关键词： anaplastic large cell lymphoma neutrophil

膝骨性关节炎超声测量与临床表现的相关性研究

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中国矫形外科杂志 2024年第15期32卷 1379-1384页

作者：王开乐张洪翠周佳华姜怡宏周纪平仲春光山东省文登整骨医院山东威海264400

[目的]探讨膝骨性关节炎(knee osteoarthritis,KOA)内侧稳定结构超声形态与膝关节功能和稳定性的关系。[方法]2023年3月—2024年3月在本院住院的202例单侧KOA患者纳入本研究,收集患者的超声形态参数及临床数据。分析超声测量指标与KOA... 详细信息

[目的]探讨膝骨性关节炎(knee osteoarthritis,KOA)内侧稳定结构超声形态与膝关节功能和稳定性的关系。[方法]2023年3月—2024年3月在本院住院的202例单侧KOA患者纳入本研究,收集患者的超声形态参数及临床数据。分析超声测量指标与KOA功能和稳定性的相关性。[结果]依据自我报告的膝关节不稳定性评分,将患者分为两组,其中,不稳组140例,占69.3%;稳定组62例,占30.7%。不稳组WOMAC[(45.2±4.8)vs(29.8±3.8),P0.05)。两两相关分析表明:股内侧肌厚度和横截面积,与自报膝不稳评分、HSS评分、HKA角、膝伸屈ROM呈显著正相关(P<0.05),与WOMAC、VAS、JLCA呈显著负相关(P<0.05)。相反,内侧副韧带厚度和内侧半月板外凸厚度,与自报膝不稳评分、HSS评分、HKA角、膝伸屈ROM评分呈显著负相关(P<0.05),而与WOMAC、VAS、JLCA呈显著正相关(P<0.05)。上述超声指标与K-L评级之间无相关性。多元线性逐步回归表明:股内侧肌横截面积(B=-0.101,P<0.05)、内侧副韧带厚度(B=0.112,P<0.05)、内侧半月板外凸(B=0.132,P<0.05)是影响膝关节功能的因素。[结论]对于自报膝关节不稳患者,行超声检测膝关节内侧结构有临床指导意义。

关键词：膝骨关节炎肌骨超声内侧副韧带内侧半月板外凸自报膝关节不稳

Global-local combined features to detect pain intensity from facial expression images with attention mechanism

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Journal of Electronic Science and Technology 2024年第3期22卷 80-93页

作者： jiang Wu yi Shi Shun Yan hong-Mei Yan Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China MOE Key Laboratory for Neuroinformation School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu611731China College of Engineering University of California at Santa BarbaraSanta Barbara93106USA

The estimation of pain intensity is critical for medical diagnosis and treatment of *** the development of image monitoring technology and artificial intelligence,automatic pain assessment based on facial expression and behavioral analysis shows a potential value in clinical *** paper reports a framework of convolutional neural network with global and local attention mechanism(GLA-CNN)for the effective detection of pain intensity at four-level thresholds using facial expression ***-CNN includes two modules,namely global attention network(GANet)and local attention network(LANet).LANet is responsible for extracting representative local patch features of faces,while GANet extracts whole facial features to compensate for the ignored correlative features between *** the end,the global correlational and local subtle features are fused for the final estimation of pain *** under the UNBC-McMaster Shoulder Pain database demonstrate that GLA-CNN outperforms other state-of-the-art ***,a visualization analysis is conducted to present the feature map of GLA-CNN,intuitively showing that it can extract not only local pain features but also global correlative facial *** study demonstrates that pain assessment based on facial expression is a non-invasive and feasible method,and can be employed as an auxiliary pain assessment tool in clinical practice.

关键词： Attention Convolutional neural network Facial expression Pain intensity

To improve robustness of mechanical properties of semi-solid cast A356 alloy using taguchi design method

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China Foundry 2024年第2期21卷 175-184页

作者： yi-wu Xu hong-yi Zhan Wei Tong Jin-ping Li Le-peng Zhang De-jiang Li Xiao-qin Zeng School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China China Science Lab General Motors Global Research&DevelopmentShanghai 201206China General Motors(China)Investment Co. Ltd.Shanghai 201206China China International Intellectech Corporation(CIIC) Beijing 100004China

Mechanical properties of semi-solid casting are dependent on multiple processing parameters,and improper processing parameters will not only reduce mean data but also increase *** present study investigated the impact of parameters in slurry preparation and heat treatment on the yield strength and ductility of T6 heat-treated A356 Al-Si alloy using rapid slurry forming(RSF)semi-solid *** focus was primarily on the robustness of mechanical properties based on Taguchi design *** analyzing signal-to-noise ratio and minimum value calculated from-3S,the optimum slurry preparation parameters and heat treatment parameters were determined to be no quench,enthalpy exchange material(EEM)temperature of 140℃,EEM-to-melt ratio of 6mass%,stirring time of 18 s,solution heat treated at 520℃ for 2 h,and ageing heat treated at 190℃ for 6 *** a small batch validation,the-3S yield strength and-3S elongation reach 256.1 MPa and 5.03% respectively,showing a satisfactory *** hardness and microstructure of heat-treated samples with the best and worst properties were characterized to gain insight into the underlying mechanisms affecting the mean value and variations of mechanical properties.

关键词： semi-solid casting taguchi design method signal-to-noise ratio mechanical property microstructure

Molecular cloning, sequence analysis, and cadmium stress-rated expression changes of BTG1 in freshwater pearl mussel(Hyriopsis schlegelii)

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Zoological Research 2014年第5期35卷 389-397页

作者： Kou PENG Cheng-Yuan WANG Jun-Hua WANG Jun-Qing SHENG Jian-Wu SHI Jian LI yi-jiang hong School of Life Sciences and Food Engineering Nanchang University Institute of Life Science Nanchang University

The B cells translocation gene 1 （BTG1） is a member of the BTG/TOB family of anti-proliferative genes, which have recently emerged as important regulators of cell growth and differentiation among vertebrates. Here, for the first time we cloned the full-length eDNA sequence of Hyriopsis schlegelii （Hs-BTG1）, an economically important freshwater shellfish and potential indicator of environmental heavy metal pollution, for the first time. Using rapid amplification of eDNA ends （RACE） together with splicing the EST sequence from a haemocyte eDNA library, we found that Hs-BTG1 contains a 525 bp open reading frame （ORF） encoding a 174 amino-acid polypeptide, a 306 bp 5＇ untranslated region （5＇ UTR）, and a 571 bp 3＇ UTR with a Poly（A） tail as well as a transcription termination signal （AATAAA）. Homologne searching against GenBank revealed that Hs-BTG1 was closest to Crassostrea gigas BTG1, sharing 50.57% of protein identities. Hs-BTG1 also shares some typical features of the BTG/TOB family, possessing two well-conserved A and B boxes. Clustering analysis of Hs-BTG1 and other known BTGs showed that Hs-BTG1 was also closely related to BTG1 of C. gigas from the invertebrate BTG1 clade. Function prediction via homology modeling showed that both Hs-BTG1 and C. gigas BTG1 share a similar three-dimensional structure with Homo sapiens BTG1. Tissue-specific expression analysis of the Hs-BTG1 via real-time PCR showed that the transcripts were constitutively expressed, with the highest levels in the hepatopancreas and gills, and the lowest in both haemocyte and muscle tissue. Expression levels of Hs-BTG1 in hepatopancreas （2.03-fold）, mantle （2.07-fold）, kidney （2.2-fold） and haemocyte （2.5-fold） were enhanced by cadmium （Cd2＋） stress, suggesting that Hs-BTG 1 may have played a significant role in H, schlegelii adaptation to adverse environmental conditions.

关键词： Hyriopsis schlegelii BTG1 Gene cloning mRNA expression Cadmium stress

Characterization of cyclophilin D in freshwater pearl mussel (Hyriopsis schlegelii)

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Zoological Research 2017年第2期38卷 103-109页

作者： Xiu-Xiu Liu Cheng-Yuan Wang Chun Luo Jun-Qing Sheng Di Wu Bei-Juan Hu Jun-Hua Wang yi-jiang hong School of Life Sciences Nanchang University Nanchang Jiangxi 330031 China Key Laboratory of Aquatic Animals Resources and Utilization of jiangxi Nanchang University Nanchang Jiangxi 330031 China

Cyclophilin D （referred to as HsCypD） was obtained from the freshwater pearl mussel （Hyriopsis schlegelil）. The full-length cDNA was 2 671 bp, encoding a protein consisting of 367 amino acids. HsCypD was determined to be a hydrophilic intracellular protein with 10 phosphorylation sites and four tetratricopeptide repeat （TPR） domains, but no signal peptide. The core sequence region YKGCIFHRIIKDFMVQGG is highly conserved in vertebrates and invertebrates. Phylogenetic tree analysis indicated that CypD from all species had a common origin, and HsCypD had the closest phylogenetic relationship with CypD from Lottia gigantea. The constitutive mRNA expression levels of HsCypD exhibited tissue-specific patterns, with the highest level detected in the intestines, followed by the gonads, and the lowest expression found in the hemocytes.

关键词： Hyriopsis schlegelii Cyclophilin D Sequence analysis

Development and validation of a new prognostic model for patients with acute-on-chronic liver failure in intensive care unit

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World Journal of Gastroenterology 2024年第20期30卷 2657-2676页

作者： Zong-yi Zhu Xiu-hong Huang Hui-Qing jiang Li Liu Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Weixian People's HospitalXingtai 054700Hebei ProvinceChina

BACKGROUND Cirrhotic patients with acute-on-chronic liver failure(ACLF)in the intensive care unit(ICU)have a poor but variable *** prognosis evaluation can guide the rational management of patients with ***,existing prognostic scores for ACLF in the ICU environment lack sufficient *** To develop a new prognostic model for patients with ACLF in *** Data from 938 ACLF patients in the Medical Information Mart for Intensive Care(MIMIC)database were used to develop a new prognostic model(MIMIC ACLF)for ***,calibration and clinical utility of MIMIC ACLF were assessed by area under receiver operating characteristic curve(AUROC),calibration curve and decision curve analysis(DCA),*** ACLF was then externally validated in a multiple-center cohort,the Electronic Intensive Care Collaborative Research Database and a single-center cohort from the Second Hospital of Hebei Medical University in *** The MIMIC ACLF score was determined using nine variables:ln(age)×2.2+ln(white blood cell count)×0.22-ln(mean arterial pressure)×2.7+respiratory failure×0.6+renal failure×0.51+cerebral failure×0.31+ln(total bilirubin)×0.44+ln(internationalized normal ratio)×0.59+ln(serum potassium)×*** MIMIC cohort,the AUROC(0.81/0.79)for MIMIC ACLF for 28/90-day ACLF mortality were significantly greater than those of Chronic Liver Failure Consortium ACLF(0.76/0.74),Model for End-stage Liver Disease(MELD;0.73/0.71)and MELD-Na(0.72/0.70)(all P<0.001).The consistency between actual and predicted 28/90-day survival rates of patients according to MIMIC ACLF score was excellent and superior to that of existing *** net benefit of MIMIC ACLF was greater than that achieved using existing scores within the 50%threshold *** superior predictive accuracy and clinical utility of MIMIC ACLF were validated in the external *** We developed and validated a new prognostic model with satisfactory accuracy

关键词： Acute-on-chronic liver failure Cirrhosis Risk stratification Prognosis Model Scores