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HDPairFinder:A data processing platform for hydrogen/deuterium isotopic labeling-based nontargeted analysis of trace-level amino-containing chemicals in environmental water

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journal of Environmental Sciences 2024年第2期136卷 583-593页

作者： Tingting zhao Kristin Carroll Caley B.Craven Nicholas j.P.Wawryk Shipei Xing jian Guo Xing-Fang Li Tao Huan Department of Chemistry Faculty of ScienceUniversity of British ColumbiaVancouver Campus2036 Main MallVancouverBritish ColumbiaV6T 1Z1Canada Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6G 2G3Canada

The combination of hydrogen/deuterium(H/D)formaldehyde-based isotopic methyl labeling with solid-phase extraction and high-performance liquid chromatography–high resolution mass spectrometry(HPLC-HRMS)is a powerful analytical solution for nontargeted analysis of trace-level amino-containing chemicals in water *** the huge amount of chemical information generated in HPLC-HRMS analysis,identifying all possible H/Dlabeled amino chemicals presents a significant challenge in data *** address this,we designed a streamlined data processing pipeline that can automatically extract H/D-labeled amino chemicals from the raw HPLC-HRMS data with high accuracy and ***,we developed a cross-correlation algorithm to correct the retention time shift resulting from deuterium isotopic effects,which enables reliable pairing of H-and D-labeled ***,we implemented several bioinformatic solutions to remove false chemical features generated by in-source fragmentation,salt adduction,and natural13C ***,we used a data mining strategy to construct the AMINES library that consists of over 38,000 structure-disjointed primary and secondary amines to facilitate putative compound ***,we integrated these modules into a freely available R program,*** rationale of each module was justified and its performance tested using experimental H/D-labeled chemical standards and authentic water *** further demonstrated the application of HDPairFinder to effectively extract N-containing contaminants,thus enabling the monitoring of changes of primary and secondary N-compounds in authentic water *** is a reliable bioinformatic tool for rapid processing of H/D isotopic methyl labeling-based nontargeted analysis of water samples,and will facilitate a better understanding of N-containing chemical compounds in water.

关键词： Isotope labeling Nontargeted analysis Reactive N-compounds HPLC-HRMS Source water

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Study on thermal decomposition kinetics of azobenzene-4,4′-dicarboxylic acid by using compensation parameter method and nonlinear fitting evaluation

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Chinese journal of Chemical Engineering 2024年第6期70卷 269-279页

作者： Shuyi Shen Song Guo Sining Chen jinhua zhao Nanjing University of Science&Technology Nanjing 210094China China Academy of Safety Science and Technology Beijing 100012China

Recently,azobenzene-4,4'-dicarboxylic acid(ADCA)has been produced gradually for use as an organic synthesis or pharmaceutical intermediate due to its eminent *** large quantities put into application in the future,the thermal stability of this substance during storage,transportation,and use will become quite ***,in this work,the thermal decomposition behavior,thermal decomposition kinetics,and thermal hazard of ADCA were *** were conducted by using a SENSYS evo DSC device.A combination of differential iso-conversion method,compensation parameter method,and nonlinear fitting evaluation were also used to analyze thermal kinetics and mechanism of ADCA *** results show that when conversion rate α increases,the activation energies of ADCA's first and main decomposition peaks *** amount of heat released during decomposition varies between 182.46 and 231.16 j·g^(-1).The proposed kinetic equation is based on the Avrami-Erofeev model,which is consistent with the decomposition *** the Frank-Kamenetskii model,a calculated self-accelerating decomposition temperature of 287.0℃is obtained.

关键词： Azobenzene-4,4′-dicarboxylic acid Thermal decomposition behavior Kinetic mechanism Thermal hazard evaluation Compensation parameter effect

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Rice gene OsUGT75A regulates seedling emergence under deep-sowing conditions

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The Crop journal 2024年第1期12卷 133-141页

作者： jia zhao Siyu Liu Xiaoqian zhao Zhibo Huang Shan Sun Zixuan Zeng Yongqi He Zhoufei Wang The Laboratory of Seed Science and Technology Guangdong Key Laboratory of Plant Molecular BreedingNational Engineering Research Center of Plant Space BreedingSouth China Agricultural UniversityGuangzhou 510642GuangdongChina

Poor seedling emergence is a challenge for direct seeding of rice under deep-sowing field *** we reveal that UDP-glucosyltransferase OsUGT75A promotes rice seedling emergence under deepsowing conditions by increasing shoot *** of OsUGT75A was higher in the middle regions of the shoot and in shoots under deep-sowing *** of free abscisic acid(ABA)and jasmonates(jA)were higher in shoots of OsUGT75A mutants than in those of wild-type plants,and OsUGT75A mutants were more sensitive to ABA and jA *** shoot length was attributed to higher ABA INSENSITIVE 3(OsABI3)expression and lower jASMONATE-ZIM domain protein(OsjAZ)expression in *** extension by OsUGT75A is achieved mainly by promotion of cell *** elite haplotype of OsUGT75A associated with increased shoot length was identified among indica rice ***75A acts to increase seedling emergence under deep-sowing conditions.

关键词： Abscisic acid Deep-sowing jasmonic acid Rice Shoot length

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All-optical driven soft crawler with complexmotion capabilities

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International journal of Smart and Nano Materials 2024年第2期15卷 348-364页

作者： Chenchu Zhang jin Wang Linhan zhao Renfei Chen Qiangqiang zhao jie zhao Fating Liu Yucheng Bian Heng Zhang Yisen Wang Chaowei Wang Ying Hu Anhui Province Key Lab of Aerospace Structural Parts Forming Technology and Equipment Institute of Industry and Equipment TechnologyHefei University of TechnologyHefeiChina CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefeiChina GBA Branch of Aerospace Information Research Institute Chinese Academy of SciencesGuangzhouChina

The emergence of millimeter-scale soft actuators has signifi-cantly expanded the potential applications in areas such as search and rescue,drug delivery,and human assistance,due to their high *** these advancements,achieving precise control over the intricate movements of soft crawlers poses a significant *** this study,we have developed an all-optical approach that enables manipulation of propul-sive forces by simultaneously modifying the magnitude and direction of friction forces,thereby enabling complex motions of soft ***,the approach is not constrained by specific actuator shapes,and theoretically,any elongated photothermal actuator can be *** actuator was designed with an isosceles trapezoid shape,featuring a top width of 2mm,a bottom width of 4 mm,and a length of 8 *** our,manipulation approach,we showcase a proof-of-concept for complex soft robotic motions,including crawling(achieving speeds of up to 2.25 body lengths per minute),turning,avoiding obstacles,handling and trans-ferring objects approximately twice its own weight,and navi-gating narrow spaces along programmed *** results showcasethis all-optical manipulationapproach as a promising,yet unexplored tool for the precision and wireless control for the development of advanced soft actuators.

关键词： Light driven soft actuator all-optical manipulation laser manipulation

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Overlooked interaction between redox-mediator and bisphenol-A in permanganate oxidation

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Environmental Science and Ecotechnology 2024年第5期21卷 248-255页

作者： Honglong Zhang Qiaoqiao zhao Kangbao Zhong Ruopeng Bai jiaojiao Dong jun Ma jing Zhang Timothy j.Strathmann School of Environment Harbin Institute of TechnologyHarbin150090PR China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing100084PR China School of Chemistry and Chemical Engineering Chongqing Key Laboratory of Chemical Theory and MechanismChongqing UniversityChongqing401331PR China College of Environment and Ecology Chongqing UniversityChongqing400045PR China Department of Civil and Environmental Engineering Colorado School of Mines1500 Illinois StreetGoldenCO80401United States

Research efforts on permanganate(Mn(VII))combined with redox-mediator(RM),have received increasing attention due to their significant performance for bisphenol-A(BPA)***,the mechanisms underpinning BPA degradation remain *** we show the overlooked interactions between RM and BPA during permanganate oxidation by introducing an RMdN-hydroxyphthalimide(NHPI).We discovered that the concurrent generation of MnO_(2) and phthalimide-N-oxyl(PINO)radical significantly enhances BPA oxidation within the pH range of *** detection of radical cross-coupling products between PINO radicals and BPA or its derivatives corroborates the pivotal role of radical cross-coupling in BPA ***,we observed the formation of an NHPI-BPA complex,which undergoes preferential oxidation by Mn(VII),marked by the emergence of an electronrich domain in *** findings unveil the underlying mechanisms in the Mn(VII)/RM system and bridge the knowledge gap concerning BPA transformation via *** research paves the way for further exploration into optimizing complexation sites and RM dosage,significantly enhancing the system's efficiency in water treatment applications.

关键词： Permanganate Redox-mediator Bisphenol-A Radical cross-coupling Complexation

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Recent research progress in the mechanism and suppression of fusion welding-induced liquation cracking of nickel based superalloys

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International journal of Minerals,Metallurgy and Materials 2024年第5期31卷 1072-1088页

作者： Zongli Yi jiguo Shan Yue zhao Zhenlin Zhang Aiping Wu Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China College of Engineering China Agricultural UniversityBeijing 100091China State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China School of Material Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

Nickel-based superalloys are extensively used in the crucial hot-section components of industrial gas turbines,aeronautics,and astronautics because of their excellent mechanical properties and corrosion resistance at high *** welding serves as an effective means for joining and repairing these alloys;however,fusion welding-induced liquation cracking has been a challenging *** paper comprehensively reviewed recent liquation cracking,discussing the formation mechanisms,cracking criteria,and *** recent investigations,regulating material composition,changing the preweld heat treatment of the base metal,optimizing the welding process parameters,and applying auxiliary control methods are effective strategies for mitigating *** promote the application of nickel-based superalloys,further research on the combination impact of multiple elements on cracking prevention and specific quantitative criteria for liquation cracking is necessary.

关键词： nickel-based superalloy fusion welding liquation cracking cracking mechanism cracking suppression

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Development of a novel Eu^(3+)-doped tantalate red-emitting phosphor for w-LEDs application

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journal of Rare Earths 2024年第8期42卷 1479-1488,I0003页

作者： Fan Zeng jingjing Ru Bing zhao Feiyun Guo jianzhong Chen College of Chemistry and Materials Fujian Province University Key Laboratory of Green Energy and Environment CatalysisNingde Normal University.Ningde352100China School of Environment and Resources School of Carbon Neutral and Modern IndustryFujian Normal UniversityFuzhou350007China College of Information and Mechanical&Electrical Engineering Ningde Normal UniversityNingde352100China College of Chemistry Fuzhou UniversityFuzhou350108China

Two novel phosphors LiBa_(4(1-x))Eu_(4x)Ta_(3)O_(12)(H-LBTO:xEu^(3+)) and Li_(0.25)Ba_(1-x)Eu_(x)Ta_(0.75)O_(3)(C-LBTO:xEu^(3+))were prepared successfully by a molten salt *** transformation between these two structures was realized by changing the sintering temperature or changing the Eu^(3+) ions concentration,which was also demonstrated by the X-ray diffraction(XRD),scanning electron microscopy(SEM),diffuse reflectance spectra(DRS),and photoluminescence excitation(PLE) analyses,Both the sintering temperature and the Eu^(3+)ions doping concentration have significant impact on the formation of the crystal *** these phosphors sintered at 1023 K exhibit two major luminescence lines at 594 and 614 nm under nearUV light of 395 nm excitation,corresponding to Eu^(3+)ions typical transitions of ^(5)D_(0)→^(7)F_(1) and ^(5)D_(0)→^(7)F_(2).The optimum concentration of Eu^(3+) ions is 9 mol% for C-LBTO:xEu^(3+) samples and the quenching interaction type is the nearest-neighbor ion *** thermal stability of the C-LBTO:0.09Eu^(3+)sample was investigated in detail and the device application further suggests that C-LBTO:0.09Eu^(3+) can be used as a red phosphor for near-UV excited w-LEDs in lighting.

关键词： Phosphor Tantalate LED device Rare earths

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Impact of Mo/Ni alloying on microstructural modulation and low-temperature toughness of high-strength low-alloy steel

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journal of Iron and Steel Research International 2024年第7期31卷 1746-1762页

作者： Wei Liu Hong-li zhao Bing-xing Wang Yong Tian State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

The high-strength low-alloy steel plates with varying Ni/Mo contents were manufactured using the thermos-mechanical control *** investigation was conducted to explore the effect of Ni/Mo microalloying on microstructure evolution and mechanical properties of the *** results revealed that the increase in Ni content from 1 to 2 wt.%reduced the transition temperature of ferrite and the growth range of ferritic grain was narrowed,which promoted grain *** optimized combination of grain size,high-angle grain boundaries(HAGBs),and martensite-austenite(M-A)islands parameter contributed to the excellent impact toughness of S1 steel at-100℃(impact absorbed energy of 218.2 j at-100℃).As the Mo increases from 0 to 2 wt.%,the matrix structure changes from multiphase structure to granular bainite,which increases the average effective grain size to~4.62 pm and reduces HAGBs proportion to~36.22%.With these changes,the low-temperature impact toughness of S3 steel is *** addition,based on the analysis of the characteristics of crack propagation path,it was found that M-A islands with low content(~2.21%)and small size(~1.76 pm)significantly retarded crack propagation,and the fracture model of M-A islands with different morphologies was further ***,correlation between behaviour of delamination and toughness was further analysed by observing delamination size and impact energy parameters.

关键词： High-strength low-alloy steel Microstructural regulation Ni addition Mo addition Crack propagation Low-temperature toughness

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Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

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Bone Research 2024年第2期12卷 372-389页

作者： Longqing Wang Wenhao jiang Siyuan zhao Dong Xie Qing Chen Qi zhao Hao Wu jian Luo Lili Yang Spine Center Department of OrthopaedicsShanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003PR China Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Department of Orthopaedics No.905 Hospital of PLA NavyShanghaiPR China

Ossification of the Posterior Longitudinal Ligament(OPLL)is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone,resulting in limited spinal mobility and nerve *** both bulk and single-cell RNA sequencing,we elucidate the molecular characteristics,cellular components,and their evolution during the OPLL process at a single-cell resolution,and validate these findings in clinical *** study also uncovers the capability of ligament stem cells to exhibit endothelial cell-like phenotypes in vitro and in ***,our study identifies LOXL2 as a key regulator in this *** gain-and loss-of-function studies,we elucidate the role of LOXL2 in the endothelial-like differentiation of ligament *** acts via the HIF1A pathway,promoting the secretion of downstream VEGFA and *** function is not related to the enzymatic activity of ***,we identify sorafenib,a broad-spectrum tyrosine kinase inhibitor,as an effective suppressor of LOXL2-mediated vascular *** disrupting the coupling between vascularization and osteogenesis,sorafenib demonstrates significant inhibition of OPLL progression in both BMP-induced and enpp1 deficiency-induced animal models while having no discernible effect on normal bone *** findings underscore the potential of sorafenib as a therapeutic intervention for OPLL.

关键词： LOXL2 ligament finding

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BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

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Current Medical Science 2024年第2期44卷 333-345页

作者： jun-li zhao Lin zhao Qiu-nan ZHAN Miao LIU Ting ZHANG Wen-wen CHU Department of Nephrology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghai 201318China Orthopedic Department Guangming Traditional Chinese Medicine Hospital of Pudong New AreaShanghai 201399China

Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to ***:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6j mice were infused with 4.25%glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5%PDF group,2.5%PDF group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of *** and Masson staining were performed to evaluate the extent of *** therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function ***-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25%*** were divided into control group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 ***:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to *** RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD *** found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD *** with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious f

关键词： peritoneal fibrosis bone marrow mesenchymal stem cell-derived exosomes miR-27a-3p TP53 epithelialmesenchymal transition

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