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Structural insights into AtABCG25,an angiosperm-specific abscisic acid exporter

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Plant Communications 2024年第1期5卷 284-295页

作者： jian Xin yeling Zhou yichun Qiu He Geng yuzhu wang yi Song jiansheng Liang Kaige yan Department of Chemical Biology School of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Institute of Plant and Food Science Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China Max Planck Institute of Molecular Plant Physiology Potsdam-GolmGermany Institute for Biological Electron Microscopy Southern University of Science and TechnologyShenzhenGuangdongChina

Cellular hormone homeostasis is essential for precise spatial and temporal signaling responses and *** acid(ABA)plays pivotal roles in orchestrating various developmental and stress re-sponses and confersfitness benefits over ecological and evolutionary timescales in terrestrial *** ABA level is regulated by complex processes,including biosynthesis,catabolism,and ***25 is thefirst ABA exporter identified through genetic screening and affects diverse ABA *** the structural basis of ABA export by ABCG25 is critical for further manipulations of ABA homeostasis and *** used cryo-electron microscopy to elucidate the structural dynamics of AtABCG25 and successfully characterized different states,including apo AtABCG25,ABA-bound AtABCG25,and ATP-bound AtABCG25(E232Q).Notably,AtABCG25 forms a homodimer that fea-tures a deep,slit-like cavity in the transmembrane domain,and we precisely characterized the critical residues in the cavity where ABA *** binding triggers closure of the nucleotide-binding domains and conformational transitions in the transmembrane *** show that AtABCG25 belongs to a conserved ABCG subfamily that originated during the evolution of *** subfamily neofunctionalized to regulate seed germination via the endosperm,in concert with the evolution of this angio-sperm-specific,embryo-nourishing ***,thesefindings provide valuable insights into the intricate substrate recognition and transport mechanisms of the ABA exporter AtABCG25,paving the way for genetic manipulation of ABA homeostasis and plantfitness.

关键词： AtABCG25 abscisic acid ABC transporters cryo-EM structure

Stresses State and Mechanical Behaviors of the Green Body During Die Compaction and Ejection Process

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Acta Metallurgica Sinica(English Letters) 2020年第4期33卷 605-614页

作者： S.M.wang y.wang y.X.wang F.P.Liu j.Cao Department of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Welding and joining Harbin Institute of TechnologyHarbin 15001China

Finite element simulations for metal powder compaction of a clutch plate were performed to examine the stresses during compaction,unloading,and *** describe the mechanical behavior of compacted green body,a modified densitydependent Drucker-Prager Cap model was utilized to predict the stress and density distribution of the compacted clutch plate during loading and ejection *** results indicate that maximum tensile principal stress was a main driving force for the tensile crack initiation during ejection stage,and shear stress may be another driving force in both compaction and ejection stages for shear crack *** were peak value of the stresses during ejection stage,and the stresses are in compressive state only during compaction ***,the tensile crack initiation is not possible during compaction except shear *** stress in the clutch plate is of less contribution to the crack initiation during compaction,unloading and *** of criteria of the crack initiation and fracture is necessary in order to obtain uniform density and crackfree components in the manufacturing of metal powder compaction.

关键词： Powder compaction Finite element simulation Stress history Cap model Green body

Quantified evaluation of particle shape effects from micro-to-macro scales for non-convex grains

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Particuology 2016年第2期14卷 23-35页

作者： y. yang j.F. wang y.M. Cheng Department of Civil and Environmental Engineering The Hong Kong Polytechnic University Hong Kong China Department of Civil and Architectural Engineering City University of Hong Kong Hong Kong China

Particle shape plays an important role in both the micro and macro scales responses of a granular assem- bly. This paper presents a systematic way to interpret the shape effects of granular material during quasi-static shearing. A more suitable shape descriptor is suggested for the quantitative analysis of the macroscale strength indexes and contact parameters for non-convex grains, with special consid- eration given to the peak state and critical state. Through a series of numerical simulations and related post-processing analysis, particle shape is found to directly influence the strain localisation patterns, microscale fabric distributions, microscale mobilisation indexes, and probability distribution of the nor- malised contact normal force. Additionally, the accuracy of the stress-force-fabric relationship can be influenced by the average normal force and the distribution of contact vectors. Moreover, particle shape plays a more important role than do the confining pressures in determining the friction angle. Strong force chains and the dilation effect are also found to be strongly influenced by the high confinin~ oressure.

关键词： Quantitative analysis Shape factor Statistical analysis Micro-macro indexes

Storylines of family medicine Ⅸ:people and places—diverse populations and locations of care

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Family Medicine and Community Health 2024年第S3期12卷 79-88页

作者： William B Ventres Leslie A Stone Emad R Abou-Arab julio Meza David S Buck jerome W Crowder jennifer y C Edgoose Alexander Brown Ellen j Plumb Amber K Norris jay j Allen Lauren E Giammar john E Wood Scott M Dickson G Austin Brown Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family Medicine University of California Los AngelesDavid Geffen School of MedicineLos AngelesCaliforniaUSA Community Medicine University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Social and Behavioral Sciences University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA NH Dartmouth Family Medicine Residency ConcordNew HampshireUSA San Francisco VA Medical Center San FranciscoCaliforniaUSA Duluth Family Medicine Residency Program University of Minnesota Medical School Duluth CampusDuluthMinnesotaUSA UAMS Northeast Regional Campus Family Medicine Residency Program JonesboroArkansasUSA Cascades East Family Medicine Residency Program Oregon Health&Science University School of MedicineKlamath FallsOregonUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅸ:people and places—diverse populations and locations of care’,authors address the following themes:‘LGBTQIA+health in family medicine’,‘A family medicine approach to substance use disorders’,‘Shameless medicine for people experiencing homelessness’,“Difficult”encounters—finding the person behind the patient’,‘Attending to patients with medically unexplained symptoms’,‘Making house calls and home visits’,‘Family physicians in the procedure room’,‘Robust rural family medicine’and‘Full-spectrum family medicine’.May readers appreciate the breadth of family medicine in these essays.

关键词： illustration family dimensions

Unraveling the role of iron on Ni-Fe alloy nanoparticles during the electrocatalytic ethanol-to-acetate process

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Nano Research 2024年第4期17卷 2328-2336页

作者： junshan Li Luming Li Xinyu Ma jun wang jun Zhao yu Zhang Ren He yaoyue yang Andreu Cabot yongfa Zhu Institute for Advanced Study Chengdu University610106 ChengduChina State Key Laboratory of Environmental-Friendly Energy Materials Southwest University of Science and TechnologyMianyang 621010China College of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Chemistry and Environment Southwest Minzu UniversityChengdu 610041China Hebei Key Laboratory of Photoelectric Control on Surface and Interface College of ScienceHebei University of Science and TechnologyShijiazhuang 050018China Catalonia Institute for Energy Research-IREC Sant Adriàde BesòsBarcelona 08930CataloniaSpain ICREA Pg.Lluís Companys 23Barcelona 08010CataloniaSpain Department of Chemistry Tsinghua UniversityBeijing 100084China

The anodic electrooxidation of ethanol to value-added acetate is an excellent example of replacing the oxygen evolution reaction to promote the cathodic hydrogen evolution reaction and save ***,we present a colloidal strategy to produce Ni-Fe bimetallic alloy nanoparticles(NPs)as efficient electrocatalysts for the electrooxidation of ethanol in alkaline ***-Fe alloy NPs deliver a current density of 100 mA·cm^(-2) in a 1.0 M KOH solution containing 1.0 M ethanol merely at 1.5 V *** hydrogen electrode(RHE),well above the performance of other electrocatalysts in a similar *** continuous 10 h testing at this external potential,this electrode is able to produce an average of 0.49 mmol·cm^(-2)·h^(-1) of acetate with an ethanol-to-acetate Faradaic efficiency of 80%.A series of spectroscopy techniques are used to probe the electrocatalytic process and analyze the ***,density functional theory(DFT)calculations demonstrate that the iron in the alloy NPs significantly enhances the electroconductivity and electron transfer,shifts the rate-limiting step,and lowers the energy barrier during the ethanol-to-acetate reaction pathway.

关键词： electrocatalysis ethanol oxidation reaction alloy nanoparticle acetate biorefinery

Organoids as preclinical models of human disease:progress and applications

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Medical Review 2024年第2期4卷 129-153页

作者： Baodan Chen Cijie Du Mengfei wang jingyi Guo Xingguo Liu CAS Key Laboratory of Regenerative Biology Joint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative MedicineChina-New Zealand Joint Laboratory on Biomedicine and HealthCUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative MedicineGIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research CentreInstitute for Stem Cell and RegenerationGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina University of Chinese Academy of Sciences BeijingChina Innovation Centre for Advanced Interdisciplinary Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Centre for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong SARChina

In the field of biomedical research,organoids represent a remarkable advancement that has the potential to revolutionize our approach to studying human diseases even before clinical *** are essentially miniature 3D models of specific organs or tissues,enabling scientists to investigate the causes of diseases,test new drugs,and explore personalized medicine within a controlled laboratory *** the past decade,organoid technology has made substantial progress,allowing researchers to create highly detailed environments that closely mimic the human *** organoids can be generated from various sources,including pluripotent stem cells,specialized tissue cells,and tumor tissue *** versatility enables scientists to replicate a wide range of diseases affecting different organ systems,effectively creating disease replicas in a laboratory *** exciting capability has provided us with unprecedented insights into the progression of diseases and how we can develop improved *** this paper,we will provide an overview of the progress made in utilizing organoids as preclinical models,aiding our understanding and providing a more effective approach to addressing various human diseases.

关键词： organoids human disease regenerative medicine drug screening tumor

Europium recovery process by means of polymeric nanoparticles functionalized with acrylic acid,curcumin and fumaramide

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journal of Rare Earths 2024年第10期42卷 1950-1959页

作者： P.A.Martínez-Montoya j.M.del Río A.de j.Morales-Ramirez M.Corea Escuela Superior de Ingeniería Química e Industrias Extractivas ESIQIE-IPNDepartamento de Ingeniería Metalúrgica UPALM S/N Col.Lindavista Escuela Superior de Ingenieria Química e Industrias Extractivas ESIQIE-IPNLaboratorio de Investigación en Polímeros y NanomaterialesUPALM S/N Col.Lindavista Centra de Investigación e Innovación Tecnológica CIITEC-IPNCda.de CECATIs/n

Polymeric nanoparticles of poly(methyl methacrylate) were obtained by emulsion polymerization techniques in a proce ss of two *** particles were functionalized with acrylic acid,curcumin,and fumaramide and three series of polymeric particles were *** incorporation of functional groups was confirmed by Fourier transform-infrared spectrosocopy(FT-IR) and ultraviolet-visible(UV-Vis) *** spherical morphology of particles with an average diameter of 100 nm was observed by scartning electron microscopy(SEM).The polymeric materials were used for recovery of [Eu]from synthetic *** nanoparticles show excellent chelation capacity to trap rare-earth ions,because they recover more than 85% of [Eu] at pH of *** images of SEM after extraction process show arrays between particles with larger average particle sizes to 1.5 *** addition,the particles have a good stripping capacity,exceeding 50% of it,maintaining their homogeneity in morphology and good stability in dispersion for the recovery and stripping processes.A pseudo-second model order is obtained for the extraction and stripping processes while the best results of stripping process are obtained at pH of6.

关键词： Chelating effect Emulsion polymerization Extraction process Rare earths Stripping process [Eu]recovery

Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization

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Bone Research 2024年第2期12卷 372-389页

作者： Longqing wang Wenhao jiang Siyuan Zhao Dong Xie Qing Chen Qi Zhao Hao Wu jian Luo Lili yang Spine Center Department of OrthopaedicsShanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003PR China yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji University School of MedicineShanghaiPR China Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiPR China Department of Orthopaedics No.905 Hospital of PLA NavyShanghaiPR China

Ossification of the Posterior Longitudinal Ligament(OPLL)is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone,resulting in limited spinal mobility and nerve *** both bulk and single-cell RNA sequencing,we elucidate the molecular characteristics,cellular components,and their evolution during the OPLL process at a single-cell resolution,and validate these findings in clinical *** study also uncovers the capability of ligament stem cells to exhibit endothelial cell-like phenotypes in vitro and in ***,our study identifies LOXL2 as a key regulator in this *** gain-and loss-of-function studies,we elucidate the role of LOXL2 in the endothelial-like differentiation of ligament *** acts via the HIF1A pathway,promoting the secretion of downstream VEGFA and *** function is not related to the enzymatic activity of ***,we identify sorafenib,a broad-spectrum tyrosine kinase inhibitor,as an effective suppressor of LOXL2-mediated vascular *** disrupting the coupling between vascularization and osteogenesis,sorafenib demonstrates significant inhibition of OPLL progression in both BMP-induced and enpp1 deficiency-induced animal models while having no discernible effect on normal bone *** findings underscore the potential of sorafenib as a therapeutic intervention for OPLL.

关键词： LOXL2 ligament finding

The role of ginseng as an anti-asthmatic agent

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Acupuncture and Herbal Medicine 2024年第3期4卷 358-366页

作者： Kailynn j.yang Liana y.A.Bautista Danielle G.Iben Dana H.Tran Loyola University of Chicago Stritch School of Medicine MaywoodILUSA

Introduction Asthma is an inflammatory obstructive respiratory lung disease characterized by limited *** is estimated that more than 300 million people worldwide are affected by asthma,and this number is expected to increase over the next few years[1].Uncontrolled asthma is associated with a severely impaired quality of life and increased mortality rates[2].Other adverse effects of poorly controlled asthma include obesity,pneumonia.

关键词： asthma impaired mortality