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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Fluid-structure interaction in Z-shaped pipe with different supports

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Acta Mechanica Sinica 2020年第2期36卷 513-523页

作者： Q.Guo j.x.Zhou x.l.Guan College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China Highway Science and Technology Research Institute Xinjiang Production and Construction Corpsürümqi 830002China

Fluid-structure interaction(FSI)has a strong relation with layout of fluid delivery *** is liable to cause local ***,FSI analysis is necessary in many cases,especially for flexible pipe *** modeling consists of eight governing equations and then completely solved via the finite volume method(FVM).Friction,Poisson and joint couplings were discussed in detail to reveal the influence of a Z-shaped pipe with different supports and elbows on *** the feasibility of solving FSI by FVM was verified,the different effects of free,fixed and elastic supports on FSI in the commonly used and simplified Z-shaped pipe were further *** indicated that different support stiffness lead to various FSI *** coupling occurs at the elbow and less support is considered,then the pipe has a relatively large amplitude and complex pressure fluctuation.

关键词： Fluid-structure interaction Finite volume method Z-shaped pipe Support stiffness

Elastic-plastic behavior of a semicircular frame being pressed against a rigid plane

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Acta Mechanica Sinica 2008年第4期24卷 419-432页

作者： x.W.Zhang j.l.Yang T.x.Yu Institute of Solid Mechanics Beihang University Beijing 100083 China Department of Mechanical Engineering Hong Kong University of Science and Technology Kowloon Hong Kong China

As a simplified structural model, a semicircular frame is used to study the crashworthiness behavior of an aircraft fuselage. The quasi-static large elastic-plastic deformation of a semicircular frame in the process of its being pressed against a rigid ground is analyzed. First, based on the linear elastic assumption, the quasi-static large deformation contact process of the frame can be divided into three phases, i.e., point contact, line contact and post-buckling. By means of a shooting method, the relations between the displacement and contact force as well as the distribution of bending moment in the three phases are obtained. Then, by assuming an elastic, perfectly-plastic moment-curvature relationship for the semi-circular frame, the contact process is analyzed in detail to reveal the plastic collapse mechanism, the traveling of plastic hinge and the force-displacement relationship. In order to verify the analysis, a preliminary experiment was conducted, in which two types of half rings with clamped ends were pressed by a rigid plate. In addition, a numerical simulation is also conducted by employing ABAQUS to analyze both rectangular cross-sectional beam and I-beam. Finally, the theoretical predictions are compared with the experimental results and numerical solutions, showing that the elastic-plastic analysis can predict the contact process very well.

关键词： Elastic-plastic·large deformation ·Semicircular frame Contact ·Traveling hinge

High-magnetic-field induced charge order in high-T_c cuprate superconductors

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Chinese Physics B 2019年第11期28卷 25-42页

作者： l x Zheng j li T WU Hefei National laboratory for Physical Science at Microscale University of Science and Technology of ChinaHefei 230026China Key laboratory of Strongly-coupled Quantum Matter Physics University of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China CAS Center for Excellence in Superconducting Electronics(CENSE) Shanghai 200050China CAS Center for Excellence in Quantum Information and Quantum Physics Hefei 230026China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

In the last few years, charge order and its entanglement with superconductivity are under hot debate in high-Tc community due to the new progress on charge order in high-Tc cuprate superconductors YBa2Cu3O6+x. Here, we will briefly introduce the experimental status of this field and mainly focus on the experimental progress of high-field nuclear magnetic resonance(NMR) study on charge order in YBa2Cu3O6+x. The pioneering high-field NMR work in YBa2Cu3O6+x sets a new stage for studying charge order which has become a ubiquitous phenomenon in high-Tc cuprate superconductors.

关键词： charge order cuprates nuclear magnetic resonance YBa2Cu3O6+x superconductors competing order

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Development and Electrochemical Studies of Ruthenium Based Mixed Oxide Catalyst Electrodes for Chlorine Evolution

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Chemical Research in Chinese Universities 2002年第2期18卷 133-138页

作者： l.x.Yang j.P.G.Farr Department of Chemical and Processing Engineering University of Newcastle Merz CourtNewcastle upon Tyne NE17RU School of Metallurgy and Materials The University of Birmingham EdgbastonBirmingham B152TTUK

Experimental results are presented which allow comparison of the electrochemical performance of RuO 2/Ti, Ru 0 3 Sn 0 7 O 2/Ti and Ru 0 3 V 0 7 O 2/Ti catalysts prepared on a titanium substrate by thermal decomposition from respective precursors. The highest activity for chlorine evolution is observed on the Ru 0 3 V 0 7 O 2/Ti electrode, lower on Ru 0 3 Sn 0 7 O 2/Ti and least on RuO 2/Ti. Voltammograms obtained in the polarisable region are used to characterize the different electrodes. Further more an analysis of the catalytic activity and reaction kinetics of the developed electrodes in NaCl are presented.

关键词： Catalyst Cl_(2) evolution Ruthenium oxide

Machine learning guided automatic recognition of crystal boundaries in bainitic/martensitic alloy and relationship between boundary types and ductile-to-brittle transition behavior

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journal of Materials Science & Technology 2021年第25期84卷 49-58页

作者： x.C.li j.x.Zhao j.H.Cong R.D.K.Misra x.M.Wang x.l.Wang C.j.Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Department of Metallurgical Materials and Biomedical EngineeringUniversity of Texas at El Paso500 W.University AvenueEl PasoTX 79968USA

Gradient boosting decision tree(GBDT)machine learning(Ml)method was adopted for the first time to automatically recognize and conduct quantitative statistical analysis of boundaries in bainitic microstructure using electron back-scatter diffraction(EBSD)*** spite of lack of large sets of EBSD data,we were successful in achieving the desired accuracy and accomplishing the objective of recognizing the *** with a low model accuracy ofler angles or axis-angle pair as characteristic features,the accuracy of the model was significantly enhanced to about 88%when the Euler angle was converted to overall misorientation angle(OMA)and specific misorientation angle(SMA)and considered as important *** this model,the recall score of prior austenite grain(PAG)boundary was~93%,high angle packet boundary(OMA>40°)was~97%,and block boundary was~96%.The derived outcomes of Ml were used to obtain insights into the ductile-to-brittle transition(DBTT)***,Ml modeling approach suggested that DBTT was not determined by the density of high angle grain boundaries,but significantly influenced by the density of PAG and packet *** study underscores that Ml has a great potential in detailed recognition of complex multi-hierarchical microstructure such as bainite and martensite and relates to material performance.

关键词： Machine learning Feature engineering Automatic recognition lath structure Crystallography

STUDY ON PREPARATION, COMPlEx PERMITTIVITY,PERMEABIlITY AND MICROWAVE PROPERTIES OF BaZnzCo(2-z)Fe16O27/SiO2 MICROCRYSTAllINE GlASS CERAMICS

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Acta Metallurgica Sinica(English letters) 2003年第6期16卷 421-427页

作者： H.j.Zhang x.l.jia x.Yao l.Y.Zhang HighTemperatureCeramicsInstitute ZhengzhouUniversityZhengzhou450052China FunctionalMaterialsResearchlaboratory TongjiUniversityShanghai200092China

BaZnzCo2-zFe16O27/SiO2 microcrystalline glass ceramics with Z=0.0, 0.5, 0.8 and 1.1 were prepared at temperature 1200℃ for 5h by citrate sol-gel process. The complex dielectric constant and complex permeability of BaZnzCo2-zFe16 O27/SiO2-paraffin wax composites had been measured. Both the complex dielectric constant and dielectric loss exhibit almost no variation with frequency in 0.1-6.0GHz. The real part of permeability decreases with increasing frequency for all samples, and the imaginary part of permeability exhibits a clear resonance peak at 1.44GHz for Co2 W/SiO2, 1.32GHz for Zn0.5Co1.5 W/SiO2, 1.20GHz for Zn0.8Co1.2W/SiO2, and 1.08GHz for Zn1.1 Co0.9 W/SiO2. It is also showed that the content of zinc has a close effect on the magnetic properties of BaZnzCo2-zFe16O27/SiO2 microcrystalline glass ceramics, the greater the zinc content, the higher the values of imaginary part of permeability and magnetic loss.

关键词： BaZnz Co2-zFe16O27/SiO2 microcrystalline glass ceramics,sol-gel microwave property

Phase Selection in Solidi?cation of Undercooled Co–B Alloys

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journal of Materials Science & Technology 2017年第4期33卷 352-358页

作者： x.x.Wei W.xu j.l.Kang M.Ferry j.F.li State Key laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240.China Australian Research Council Centre of Excellence for Design in light Metals School of Materials Science and EngineeringThe University of New South WalesSydneyNSW 2052Australia

A series Co-（18.5–20.7） at.% B melts encompassing the eutectic composition（Co81.5B18.5） were solidified at different degrees of undercooling. It is found that the metastable Co23B6 phase solidifies as a substitute for the stable Co3 B phase in the alloy melts undercooled above a critical undercooling value of -60 *** Co23B6 and α-Co phases make up a metastable eutectic. The corresponding eutectic composition and temperature are Co80.4B19.6 and 1343 K, respectively. On exposure of the metastable Co23B6 phase at a given temperature above 1208 K, it does not decompose even after several hours. But it transforms by a eutectoid reaction to α-Co ＋ Co3 B at lower temperature.

关键词： Undercooling Rapid solidi?cation Metastable phase diagram Structure evolution