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A Custom-Tailored Multi-TW Optical Electric Field for Gigawatt Soft-X-Ray Isolated Attosecond Pulses

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Ultrafast Science 2021年第1期1卷 48-60页

作者： Bing Xue Yuuki Tamaru Yuxi Fu Hua Yuan Pengfei Lan Oliver D.Mücke Akira Suda Katsumi Midorikawa Eiji j.takahashi RIKEN Center for Advanced Photonics RIKEN2-1 HirosawaWakoSaitama 351-0198Japan Tokyo University of Science 2641 YamazakiNoda-shiChiba-ken 278-8510Japan School of Physics and Wuhan National Laboratory of Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Center for Free-Electron Laser Science CFEL Deutsches Elektronen-Synchrotron DESYNotkestraße 8522607 HamburgGermany

Since the first isolated attosecond pulse was demonstrated through high-order harmonics generation(HHG)in 2001,researchers’interest in the ultrashort time region has ***,one realizes a limitation for related research such as attosecond *** bottleneck is concluded to be the lack of a high-peak-power isolated attosecond pulse ***,currently,generating an intense attosecond pulse would be one of the highest priority *** this paper,we review our recent work of a TW-class parallel three-channel waveform synthesizer for generating a gigawatt-scale soft-X-ray isolated attosecond pulse(IAP)using *** employing several stabilization methods,we have achieved a stable 50 mj three-channel opticalwaveform synthesizer with a peak power at the multi-TW *** optical-waveform synthesizer is capable of creating a stable intense optical field for generating an intense continuum harmonic beam thanks to the successful stabilization of all the ***,the precision control of shot-to-shot reproducible synthesized waveforms is *** the HHG process employing a loose-focusing geometry,an intense shot-to-shot stable supercontinuum(50–70 eV)is generated in an argon gas *** continuum spectrum supports an IAP with a transform-limited duration of 170 as and a submicrojoule pulse energy,which allows the generation of a GW-scale *** supercontinuum in the soft-X-ray region with higher photon energy of approximately 100–130 eV is also generated in neon gas from the *** transform-limited pulse duration is 106 ***,the enhancement of HHG output through optimized waveform synthesis is experimentally proved.

关键词： intense generating stabilization

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通气搅拌发酵罐加压时的氧吸收率

发酵科技通讯 1983年第1期 58-62页

作者： S·SATO S·MUKATAKA H·KATAOKA j.takahashi 张敏华

通气搅拌发酵罐加压至5.9大气压,以亚硫酸氧化法测定其氧吸收率,以说明压力对氧吸收率的影响。供给一定量流速的空气时,氧吸收率比例地增加至压力P的0.4～0.8次方,而容积氧传递系数随压力的增加而减低。供给相同表面线速度的空气时,氧... 详细信息

通气搅拌发酵罐加压至5.9大气压,以亚硫酸氧化法测定其氧吸收率,以说明压力对氧吸收率的影响。供给一定量流速的空气时,氧吸收率比例地增加至压力P的0.4～0.8次方,而容积氧传递系数随压力的增加而减低。供给相同表面线速度的空气时,氧吸收率比例地增加至压力的1.1次方,而容积氧传递系数比例地增加至P0.1。考虑到受压力影响下的容积氧传递系数（Kd）推荐下面的经验公式:Kd=2.8×10-8(P0.1(μGP0.35(N1.8)这里μGP是表面空气线速度,N是叶轮转速。

关键词：氧吸收率空气氧摄取率工业气体

Caspase-11 mediated inflammasome activation in macrophages by systemic infection of *** exacerbates arthritis

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International journal of Oral Science 2024年第3期16卷 499-514页

作者： Tokuju Okano Hiroshi Ashida Noriko Komatsu Masayuki Tsukasaki Tamako Iida Marie Iwasawa Yuto takahashi Yasuo Takeuchi Takanori Iwata Miwa Sasai Masahiro Yamamoto Hiroshi Takayanagi Toshihiko Suzuki Department of Bacterial Pathogenesis Infection and Host ResponseGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Lifetime Oral Health Care Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunoparasitology Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan

Clinical studies have shown that Aggregatibacter actinomycetemcomitans(***)is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis(RA).However,the mechanism is poorly ***,we show that systemic infection with *** triggers the progression of arthritis in mice anti-collagen antibody-induced arthritis(CAIA)model following IL-1βsecretion and cell infiltration in paws in a manner that is dependent on caspase-11-mediated inflammasome activation in *** administration of polymyxin B(PMB),chloroquine,and anti-CD11b antibody suppressed inflammasome activation in macrophages and arthritis in mice,suggesting that the recognition of lipopolysaccharide(LPS)in the cytosol after bacterial degradation by lysosomes and invasion via CD11b are needed to trigger arthritis following inflammasome activation in *** data reveal that the inhibition of caspase-11-mediated inflammasome activation potentiates aggravation of RA induced by infection with *** work highlights how RA can be progressed by inflammasome activation as a result of periodontitis-associated bacterial infection and discusses the mechanism of inflammasome activation in response to infection with ***.

关键词： CD11b inflam infection

钆塞酸二钠动态增强MRI对心率和血氧的影响

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国际医学放射学杂志 2015年第6期 578-578页

作者： T.Hayashi S.Saitoh Y.Tsuji j.takahashi N.Tagaya M.Hiramoto 高海军 Department of Radiological Technology Toranomon Hospital

摘要目的探讨在肝脏疾病病人中行动态增强(DCE)MRI,钆塞酸二钠是否影响周边的毛细血管血氧饱和度(Sp O2)和(或)心率(HR)。材料与方法此项回顾性研究通过

关键词：钆塞酸二钠动态增强 MRI 心率

Measurements of dihadron correlations relative to the event plane in Au+Au collisions at√^(S)NN=200 GeV

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Chinese Physics C 2021年第4期45卷 198-241页

作者： H.Agakishiev M.M.Aggarwal Z.Ahammed A.V.Alakhverdyants I.Alekseev j.Alford B.D.Anderson C.D.Anson D.Arkhipkin G.S.Averichev j.Balewski D.R.Beavis N.K.Behera R.Bellwied M.j.Betancourt R.R.Betts A.Bhasin A.K.Bhat H.Bichsel j.Bieleik j.Bielcikova B.Biritz L.C.Bland W.Borowski j.Bouchet E.Braidot A.V.Brandin A.Bridgeman S.G.Brovko E.Bruna S.Bueltmann I.Bunzarov T.P.Burton X.Z.Cai H.Caines M.Calderon de la Barca Sanchez D.Cebra R.Cendejas M.C.Cervantes Z.Chajecki P.Chaloupka S.Chattopadhyay H.F.Chen j.H.Chen j.Y.Chen L.Chen j.Cheng M.Cherney A.Chikanian K.E.Choi W.Christie P.Chung M.j.M.Codrington R.Corliss j.G.Cramer H.j.Crawford S.Dash A.Davila Leyva L.C.De Silvat R.R.Debbe T.G.Dedovich A.A.Derevschikov R.Derradi de Souza L.Didenko P.Djawotho S.M.Dogra X.Dong j.L.Drachenberg j.E.Draper j.C.Dunlop L.G Efimov M.Elnim j.Engelage G Eppley M.Estienne L.Eun O.Evdokimov R.Fatemi j.Fedorisin A.Feng R.G.Fersch P.Filip E.Finch V.Fine Y.Fisyak C.A.Gagliardi D.R.Gangadharan A.Geromitsos F.Geurts P.Ghosh Y.N.Gorbunov A.Gordon O.Grebenyuk D.Grosnick S.M.Guertin A.Gupta W.Guryn B.Haag O.Hajkova A.Hamed L-X.Han j.W.Harris j.P.Hays-Wehle M.Heinz S.Heppelmann A.Hirsch E.Hjort G.W.Hoffmann D.j.Hofiman B.Huang H.Z.Huang T.j.Humanic L.Huo G.Igo P.jacobs W.W.jacobs C.jena F.jin j.joseph E.G.judd S.Kabana K.Kang j.Kapitan K.Kauder H.Ke D.Keane A.Kechechyan D.Kettler D.P.Kikola j.Kiryluk A.Kisiel V.Kizka A.G.Knospe D.D.Koetke T.Kollegger j.Konzer I.Koralt L.Koroleva W.Korsch L.Kotchenda V.Kouchpil P.Kravtsov K.Krueger M.Krus L.Kumar P.Kurnadi M.A.C.Lamont j.M.Landgraf S.LaPointe j.Lauret A.Lebedev R.Lednicky j.H.Lee W.Leight M.j.LeVine C.Lil L.Li N.Li W.Li X.Li X.Li Y.Li Z.M.Li M.A.Lisa F.Liu H.Liu j.Liu T.Ljubicic W.j.Llope R.S.Longacre W.A.Love Y.Lu E.V.Lukashov X.Luo G.L.Ma Y.G.Mai D.P.Mahapatra R.Majka O.I.Mall L.K.Mangotra R.Manweiler S.Margetis C.Markert H.Masui H.S.Matis Yu.A.Matulenko D.MeDonald T.S.McShane A.Meschanin R.Milner N.G.Minaev S.Mioduszewski A.Mischke M.K.Mitrovski B.Mohanty M.M.Mondal B.Morozov D.A.Morozov M.G.Munhoz M Argonne National Laboratory Argonnellinois 60439USA Brookhaven National Laboratory UptonNew York 11973USA University of Califomia BerkeleyCaliformnia 94720USA University of California DavisCalifornia 95616USA University of Califormnia Los AngelesCalifomia 90095USA Universidade Estadual de Campinas Sao PauloBrazil University of Illinois at Chicago ChicagoIlinois 60607USA Creighton University OmahaNebraska 68178USA Czech Technical University in Prague FNSPEPrague11519Czech Republic Nuclear Physics Institute AS CR 25068 Rez/PragueCzech Republic University of Frankfurt FrankfurtGermany Institute of Physics Bhubaneswar 751005India Indian Institute of Technology MumbaiIndia Indiana University BloomingtonIndiana 47408USA Alikhanov Instiute for Theoretical and Experimental Physics MoscowRussia University of jammu Jammu 180001India joint Institute for Nuclear Research Dubna141980Russia Kent State University KentOhio 44242USA University of Kentucky LexingtonKentucky40506-0055USA Institute of Modern Physics LanzhouChina Lawrence Berkeley National Laboratory BerkeleyCalifornia 94720USA Massachusetts Institute of Technology CambridgeMA 02139-4307USA Mx-Planck-Institut fir Physik MunichGermany Michigan State University East LansingMichigan 48824USA Moscow Engineering Physics Institute Moscow Russia NIKHEF and Utrecht University AmsterdamThe Netherlands Ohio State University ColumbusOhio 43210USA Old Dominion University NorfolkVA23529USA Panjab University Chandigarh 160014India PennsyIvania State University University ParkPennsylvania 16802USA Institute of High Energy Physics ProtvinoRussia Purdue University West LafayetteIndiana 47907USA Pusan National University PusanRepublic of Korea University of Rajasthan Jaipur 302004India Rice University HoustonTexas 77251USA Universidade de Sao Paulo Sao PauloBrazil University of Science&Technology of China Hefei 230026.China Shandong University JinanShandong 250100China Shanghai Institute of Applied Physics Shanghai 201800Chi

Dihadron azimuthal correlations containing a high transverse momentum(pr)trigger particle are sensit-ive to the properties of the nuclear medium created at RHIC through the strong interactions occurring between the traversing parton and the medium,*** measurements revealed a strong modification to di-hadron azimuthal correlations in Au+Au collisions with respect to ptp and d+Au *** modification in-creases with the collision centrality,suggesting a path-length or energy density dependence to the je-quenching *** paper reports STAR measurements of dihadron azimuthal correlations in mid-central(20%-60%)Au+Au collisions at√^(S)NN=200 GeV as a function of the trigger particle's azimuthal angle relative to the event plane,Ф_(s)=|Ф_(t)-ψ_(Ep)|.The azimuthal correlation is studied as a function of both the trigger and associated particle *** subtractions of the combinatorial background and anisotropic flow,assuming Zero Yield At Minimum(ZYAM),are *** correlation results are first discussed with subtraction of the even harmonic(elliptic and quadrangu-lar)flow *** away-side correlation is strongly modifed,and the modification varies withФ_(s),with a double-peak structure for out-of-plane trigger *** near-side ridge(long range pseudo-rapidity△_(η)correla-tion)appears to drop with increasingФ_(s)while the jet-like component remains approximately *** correla-tion functions are further studied with the subtraction of odd harmonic triangular flow background arising from *** is found that the triangular flow,while responsible for the majority of the amplitudes,is not sufficient to explain theφs-dependence of the ridge or the away-side double-peak *** dropping ridge withФ_(s)could be attributed to aФ_(s)-dependent lliptie anisotropy;however,the physics mechanism of the ridge remains an open *** with aФ_(s)-dependent elliptic flow,the away-side correlation structure

关键词： relativistic heavy ion collisions dihadron correlations jet-medium interactions anisotropic flow background event plane

On a New Geometric Constant Related to the Modulus of Smoothness of a Banach Space

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Acta Mathematica Sinica,English Series 2014年第9期30卷 1526-1538页

作者： Yasuji takahashi Mikio KATO Department of System Engineering Okayama Prefectural University Department of Mathematics Faculty of EngineeringShinshu University

We shall introduce a new geometric constant A（X） of a Banach space X, which is closely related to the modulus of smoothness px （T）, and investigate it in relation with the constant As （X） by Baronti et al., the von Neumann-jordan constant CNj（X） and the james constant j（X）. A sequence of recent results on these constants as well as some other geometric constants will be strengthened and improved.

关键词： Constant A(X) von Neumann-jordan constant james constant modulus of smoothness modulus of convexity uniform non-squareness

CREB-binding proteins (CBP) as a transcriptional coactivator of GATA-2

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Science China(Life Sciences) 2008年第3期51卷 191-198页

作者： TOMOMI takahashi TORU Nakano Department of Pathology Medical School and Graduate School of Frontier Biosciences Osaka University Yamada-oka 2-2 Suita Osaka 565-0871 Japan

The GATA family consists of six members, GATA 1-6. In this study, we focused on GATA-2, which is expressed predominantly in hematopoietic progenitor cells and plays the key role in keeping these cells in the undifferentiated status. CREB-binding proteins (CBP) are essential transcriptional coacti- vators for a large number of regulated DNA-binding transcription factors, including GATA-1. But there have been no reports on whether CBP is still a co-activator of GATA-2. Here, we used the immunopre- cipitation and pull-down experiments to show that the GATA-2 and CBP were physically binding to- gether, and clarified the binding sites CH1, CH3 , CH452 and CT1430 in CBP and N-finger, C-finger and N-C-finger in GATA-2. Luciferase assay results in our experiment indicated that CBP could increase GATA-2 transcriptional activity in the dose-dependent manner. GATA-1 is mainly expressed in differen- tiated hematopoietic cells, but still has overlap expression with GATA-2. CBP is a coactivator of GATA-2 and GATA-1. The investigation on the mechanism that could decide whether CBP binds to GATA-2 to keep hematopoietic cells in the progenitor status or to GATA-1 to start differentiation will be a very in- teresting and very meaningful project in the near future.

关键词： CBP TATA-2 coactivator hematopoietic cells

Tunable deconfined quantum criticality and interplay of different valence-bond solid phases

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Chinese Physics B 2020年第5期29卷 52-65页

作者： Bowen Zhao jun takahashi Anders W.Sandvik Department of Physics Boston University590 Commonwealth AvenueBostonMassachusetts 02215USA Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China

We use quantum Monte Carlo simulations to study an S = 1/2 spin model with competing multi-spin interactions. We find a quantum phase transition between a columnar valence-bond solid(cVBS) and a Néel antiferromagnet(AFM), as in the scenario of deconfined quantum-critical points, as well as a transition between the AFM and a staggered valence-bond solid(sVBS). By continuously varying a parameter, the sVBS–AFM and AFM–cVBS boundaries merge into a direct sVBS–cVBS transition. Unlike previous models with putative deconfined AFM–cVBS transitions, e.g., the standard j–Q model,in our extended j–Q model with competing cVBS and sVBS inducing terms the transition can be tuned from continuous to first-order. We find the expected emergent U(1) symmetry of the microscopically Z4 symmetric cVBS order parameter when the transition is continuous. In contrast, when the transition changes to first-order, the clock-like Z4 fluctuations are absent and there is no emergent higher symmetry. We argue that the confined spinons in the sVBS phase are *** also present results for an SU(3) symmetric model with a similar phase diagram. The new family of models can serve as a useful tool for further investigating open questions related to deconfined quantum criticality and its associated emergent symmetries.

关键词： quantum phase transitions deconfined quantum criticality quantum spin systems quantum Monte Carlo simulations

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

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Cellular & Molecular Immunology 2020年第1期17卷 50-63页

作者： Atsushi takahashi-Kanemitsu Christopher T.Knight Masanori Hatakeyama Department of Microbiology Graduate School of MedicineThe University of TokyoTokyoJapan

Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for gastric *** cagA gene product,CagA,is delivered into gastric epithelial cells via the bacterial type IV secretion *** CagA then undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala(EPIYA)motifs in its C-terminal region and acts as an oncogenic scaffold protein that physically interacts with multiple host signaling proteins in both tyrosine phosphorylation-dependent and-independent *** of CagA using in vitro cultured gastric epithelial cells has indicated that the nonphysiological scaffolding actions of CagA cell-autonomously promote the malignant transformation of the cells by endowing the cells with multiple phenotypic cancer hallmarks:sustained proliferation,evasion of growth suppressors,invasiveness,resistance to cell death,and genomic *** expression of CagA in mice leads to in vivo oncogenic action of CagA without any overt *** in vivo oncogenic activity of CagA is further potentiated in the presence of chronic *** Helicobacter pylori infection triggers a proinflammatory response in host cells,a feedforward stimulation loop that augments the oncogenic actions of CagA and inflammation is created in CagA-injected gastric *** that Helicobacter pylori is no longer colonized in established gastric cancer lesions,the multistep nature of gastric cancer development should include a“hit-and-run”process of CagA ***,acquisition of genetic and epigenetic alterations that compensate for CagA-directed cancer hallmarks may be required for completion of the“hit-and-run”process of gastric carcinogenesis.

关键词： cagA/CagA Helicobacter pylori SHP2 PAR1 inflammation “hit-and-run”carcinogenesis