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restoring the gut microbiome for the treatment of inflammatory bowel diseases

World journal of Gastroenterology 2014年第13期20卷 3468-3474页

作者： j.ssica r allegretti Matthew j Hamilton Division of Gastroenterology Brigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02115United States

Fecal microbiota transplantation (FMT) is considered to be a highly successful therapy for recurrent and refractory Clostridium difficile infection (CDI) based on recent clinical trials. The pathogenesis of inflammatory bowel diseases (IBD) is thought to be due in part to perturbations in the gut microflora that disrupt homeostasis. FMT restores essential components of the microflora which could reverse the inflammatory processes observed in IBD. Case reports and series for the treatment of IBD by FMT have shown promise with regards to treatment success and safety despite the limitations of the reporting. Future studies will determine the optimal delivery and preparation of stool as well as the conditions under which the recipient will derive maximal benefit. The long term consequences of FMT with regards to infection, cancer, auto-immune, and metabolic diseases are not known and will require continued regulation and study. Despite these limitations, FMT may be beneficial for the treatment of ulcerative colitis and Crohn’s disease, particularly those with concurrent CDI or with pouchitis.

关键词： Crohn’ s, Ulcerative colitis, Microbiota, Fecal transplantation, Dysbiosis, Pouchitis, Clostridium difficile, Probiotic

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Substituent, Temperature and Solvent Effects on the Keto-Enol EQUILIBrIUM in <i>β</i>-Ketoamides: A Nuclear Magnetic resonance Study

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Open journal of Physical Chemistry 2013年第4期3卷 138-149页

作者： Sergio L. Laurella Manuel González Sierra jorge j. P. Furlong Patricia E. allegretti Laboratorio LADECOr División Química Orgánica Departamento de Química Facultad de Ciencias Exactas Universidad Nacional de La Plata (UNLP) La Plata Argentina

Substituent, temperature and solvent effects on tautomeric equilibria in several β-ketoamides have been investigated by means of nuclear magnetic resonance spectroscopy (NMr). Keto-enol equilibrium predominates over the amide-imidol one. The relative stability of the individual tautomers and the corresponding equilibrium shifts are explained considering electronic and steric effects and tautomer stabilization via internal hydrogen bonds. In solution, these compounds exist mainly as ketoamide and Z-enolamide tautomers, both presenting intramolecular hydrogen bonds.

关键词： β-Ketoamides Keto-Enol Equilibrium Nuclear Magnetic resonance Spectroscopy

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