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Lactobacillus salivarius HHuMin-U Activates Innate Immune Defense against Norovirus Infection through TBK1-IRF3 and NF-κB Signaling Pathways

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Research 2023年第3期2022卷 229-241页

作者： Da Hyun Kim Minju jeong jae Hwan Kim joe Eun son john jYLee Sang-jun Park juyeon Lee Minwoo Kim jong-Won Oh Myeong Soo Park Sanguine Byun Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea Program in Developmental and Stem Cell Biology The Hospital for Sick ChildrenTorontoOntarioCanada Research Center BIFIDO Co.Ltd.Hanam 12930Republic of Korea

The composition of commensal bacteria plays a critical role in controlling immune responses in the *** have shown that specific bacterial strains may have the capacity to enhance host immune defense against gastrointestinal viral *** norovirus is known to be the most common cause of gastroenteritis,leading to an estimated 200,000 deaths every year,identification of bacterial strains with protective effects against norovirus infection remains ***,we discovered Lactobacillus salivarius HHuMin-U(HHuMin-U)as a potent antiviral strain against norovirus ***-U significantly suppressed murine norovirus replication and lowered viral RNA titers in *** transcriptome sequencing(RNA sequencing)analysis revealed that HHuMin-U markedly enhanced the expression level of antiviral interferon-stimulated genes compared to mock ***-U treatment dose-dependently induced type I interferons(IFN-αand IFN-β)and tumor necrosis factor-αproduction in mouse and human macrophages,promoting antiviral innate responses against norovirus *** on the molecular mechanism demonstrated that HHuMin-U can activate nuclear factorκB and TANK-binding kinase 1(TBK1)–interferon regulatory factor 3 signaling pathways,leading to the phosphorylation of signal transducer and activator of transcription 1 and signal transducer and activator of transcription 2,the key mediators of interferon-stimulated ***,oral administration of HHuMin-U increased IFN-βlevels in the ileum of mice and altered the gut microbiome *** results suggest the species/strain-specific importance of gut microbial composition for antiviral immune responses and the potential use of HHuMin-U as a probiotic agent.

关键词： TBK1 interferon protective

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j-F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS jET QUARK GLUON TAGGING

Reimagining large river management using the Resist–Accept–Direct(RAD) framework in the Upper Mississippi River

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Ecological Processes 2023年第4期12卷 3-22页

作者： Nicole K.Ward Abigail j.Lynch Erik A.Beever joshua Booker Kristen L.Bouska Holly Embke jeffrey N.Houser john F.Kocik joshua Kocik David j.Lawrence Mary Grace Lemon Doug Limpinsel Madeline R.Magee Bryan M.Maitland Owen Mc Kenna Andrew Meier john M.Morton jeffrey D.Muehlbauer Robert newman Devon C.Oliver Heidi M.Rantala Greg G.Sass Aaron Shultz Laura M.Thompson jennifer L.Wilkening National Park Service Climate Change Response Program Habitat Conservation Division NOAA Wisconsin Department of Natural Resources Aquatic Sciences Center Center for Limnology U.S. Geological Survey Northern Prairie Wildlife Research Center and Midwest Climate Adaptation Science Center U.S. Army Corps of Engineers Alaska Wildlife Alliance U.S. Geological Survey Alaska Cooperative Fish and Wildlife Research Unit University of Alaska Fairbanks University of North Dakota Great Lakes Indian Fish and Wildlife Commission (GLIFWC) Minnesota Department of Natural Resources U.S. Geological Survey National Climate Adaptation Science Center and School of Natural Resources University of Tennessee U.S. Geological Survey National Climate Adaptation Science Center U.S. Geological Survey Northern Rocky Mountain Science Center Department of Ecology Montana State University U.S. Fish and Wildlife Service National Wildlife Refuge System U.S. Geological Survey Upper Midwest Environmental Sciences Center U.S. Geological Survey Midwest Climate Adaptation Science Center NOAA NEFSC Orono University of Nebraska-Lincoln

Background Large-river decision-makers are charged with maintaining diverse ecosystem services through unprecedented social-ecological transformations as climate change and other global stressors intensify. The interconnected, dendritic habitats of rivers, which often demarcate jurisdictional boundaries, generate complex management challenges. Here, we explore how the Resist–Accept–Direct(RAD) framework may enhance large-river management by promoting coordinated and deliberate responses to social-ecological trajectories of change. The RAD framework identifies the full decision space of potential management approaches, wherein managers may resist change to maintain historical conditions, accept change toward different conditions, or direct change to a specified future with novel conditions. In the Upper Mississippi River System, managers are facing social-ecological transformations from more frequent and extreme high-water events. We illustrate how RAD-informed basin-, reach-, and site-scale decisions could:(1) provide cross-spatial scale framing;(2) open the entire decision space of potential management approaches; and(3) enhance coordinated inter-jurisdictional management in response to the trajectory of the Upper Mississippi River *** The RAD framework helps identify plausible long-term trajectories in different reaches(or subbasins) of the river and how the associated social-ecological transformations could be managed by altering site-scale conditions. Strategic reach-scale objectives may reprioritize how, where, and when site conditions could be altered to contribute to the basin goal, given the basin's plausible trajectories of change(e.g., by coordinating action across sites to alter habitat connectivity, diversity, and redundancy in the river mosaic).Conclusions When faced with long-term systemic transformations(e.g., > 50 years), the RAD framework helps explicitly consider whether or when the basin vision or goals may no longer be achievable,

关键词： Ecosystem Management Transformation Social-ecological system Anthropocene Climate change Basin planning Cross-scale interactions

From older toxic natural products to current drugs and drug candidates

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中国药理学与毒理学杂志 2019年第10期 932-932页

作者： David j newman Natural Products Branch US National Cancer Institute

Currently, and ignoring marine-sourced fatty acids/esters, there are 8 approved drugs(US FDA and Australia) that can be traced back to marine natural products initially isolated from a variety of sources. Six are directed towards cancers of man, one is for pain relief and one is an anti-HIV agent. These have come from the approximately 25,000 compounds currently reported from marine sources from approximately 1965. However,there are a substantial number of "toxic" agents that are either in clinical trials(as the initial compound or a derivative) or are potential "warheads" to be used with specific monoclonal antibodies. The 8 approved agents will be noted with brief comments, but the majority of the available time will be devoted to discussing agents from a variety of marine sources, that are either candidates for warheads, and/or have proceeded to PhaseⅡand Ⅲ trials in man against various cancers. The influence of older compounds that can be modified chemically to provide "interesting leads" will be one of the fundamental areas noted.

关键词： marine natural products cancers fatty acids

Stability of Semi-implicit Finite Volume Scheme for Level Set Like Equation

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Communications in Mathematical Research 2015年第4期31卷 351-361页

作者： Kim Kwang-il son Yong-chol Ma Fu-ming School of Mathematics Jilin University Department of Mathematics University of Science

We study numerical methods for level set like equations arising in image processing and curve evolution problems. Semi-implicit finite volume-element type schemes are constructed for the general level set like equation （image selective smoothing model） given by Alvarez et al. （Alvarez L, Lions P L, Morel j M. Image selective smoothing and edge detection by nonlinear diffusion II. SIAM j. Numer. Anal., 1992, 29： 845-866）. Through the reasonable semi-implicit discretization in time and co-volume method for space approximation, we give finite volume schemes, unconditionally stable in L∞ and W1＇2 （W1＇1） sense in isotropic （anisotropic） diffu- sion domain.

关键词： level set like equation semi-implicit finite volume scheme stability

The Global HIV Archive: Facilitating the Transition from Science to Practice of Efficacious HIV Prevention Interventions

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World journal of AIDS 2013年第1期3卷 41-56页

作者： josefina j. Card, Emily N. newman Emily N. newman Rachel E. Golden Tamara Kuhn Carmela Lomonaco Sociometrics Corporation Los Altos USA Sociometrics Corporation Los Altos USA.

This paper describes the development, content, and capabilities of the online Global HIV Archive (GHA). With the goal of facilitating widespread adaptation and appropriate use of efficacious HIV prevention programs throughout the globe, GHA has: 1) expanded and updated the search for HIV prevention programs originating in low-resource countries;2) identified those meritorious HIV prevention programs meeting established efficacy criteria of technical merit, replicability, and positive outcomes;3) prepared both implementation and evaluation materials from the efficacious programs for public use;4) developed interactive wizards or capacity-building tools to facilitate appropriate program selection, implementation, and adaptation;5) made the efficacious programs and accompanying wizards available to health practitioners throughout the globe in both printed and online formats.

关键词： HIV Evidence-Based Intervention Prevention Dissemination International

3D Fluorescence Characterization of Synthetic Organic Dyes

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American journal of Analytical Chemistry 2012年第9期3卷 622-631页

作者： Leonard j. Soltzberg Sandy Lor Nnennaya Okey-Igwe Richard newman Department of Chemistry & Physics Simmons College Boston USA Scientific Research Lab Boston Museum of Fine Arts Boston USA

The identification of dyes is important in research on museum artefacts as well as in forensic applications. UV-visible absorption spectroscopy cannot unambiguously distinguish dyes with similar hues, while mass spectrometry may fail to distinguish isobaric dyes. The detailed patterns produced by 3D fluorescence spectroscopy appear to be virtually unique, even among dyes that are closely related positional isomers. We report these patterns for 65 dyes from the Schweppe Library of Synthetic Organic Dyes as well as measurements suggesting both the capabilities and limitations of this method.

关键词： Fluorescence Spectrophotometry Dye Analysis MALDI-TOF Mass Spectrometry

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广大广工称雄GCCG2005

数码先锋 2006年第2期 76-76页

作者： SCEC j.son

在2006年新年的第一天,2005GCCG 终于完满结束。经过激烈的角逐。

关键词：李杰锋 GCCG2005 软件学院广州体育学院车士大资胡仁口强卜人二万

Characterizing and controlling infrared phonon anomaly of bilayer graphene in optical-electrical force nanoscopy

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Light(Science & Applications) 2023年第12期12卷 2700-2710页

作者： junghoon jahng Sunho Lee Seong-Gu Hong Chang jun Lee Sergey G.Menabde Min Seok jang Dong-Hyun Kim jangyup son Eun Seong Lee Hyperspectral Nano-imaging Team Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Aerospace Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Multiscale Mechanical Properties Measurement Team Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea School of Mechanical Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Functional Composite Materials Research Center Korea Institute of Science and TechnologyJeonbuk 55324Republic of Korea SKKU Advanced Institute of Nanotechnology Sungkyunkwan UniversitySuwon 16419Republic of Korea Division of Nano&Information Technology KIST SchoolUniversity of Science and TechnologySeoul 02792Republic of Korea

We,for the first time,report the nanoscopic imaging study of anomalous infrared(IR)phonon enhancement of bilayer graphene,originated from the charge imbalance between the top and bottom layers,resulting in the enhancement of E1u mode of bilayer graphene near 0.2 *** modified the multifrequency atomic force microscope platform to combine photo-induced force microscope with electrostatic/Kelvin probe force microscope constituting a novel hybrid nanoscale optical-electrical force imaging *** enables to observe a correlation between the IR response,doping level,and topographic information of the graphene *** the nanoscale spectroscopic image measurements,we demonstrate that the charge imbalance at the graphene interface can be controlled by chemical(doping effect via Redox mechanism)and mechanical(triboelectric effect by the doped cantilever)***,we can also diagnosis the subsurface cracks on the stacked few-layer graphene at nanoscale,by monitoring the strain-induced IR phonon *** approach provides new insights into the development of graphene-based electronic and photonic devices and their potential applications.

关键词： electrical force optical