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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard j.simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

Modern Corrosion Mapping of Storage Tank Bottoms--Notable Advancements in Critical Zone Coverage,Inspection Efficiency and Data Integrity

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journal of Civil Engineering and Architecture 2024年第3期18卷 148-153页

作者： Andrew j.simpson Matthew A.Boat Eddyfi Technologies-Eddyfi UK Ltd Clos Llyn CwmSwansea Enterprise ParkSwanseaSA68QYUK

Every day,an NDT(Non-Destructive Testing)report will govern key decisions and inform inspection strategies that could affect the flow of millions of dollars which ultimately affects local environments and potential risk to *** is a direct correlation between report quality and equipment *** more able the equipment is-in terms of efficient data gathering,signal to noise ratio,positioning,and coverage-the more actionable the report *** results in optimal maintenance and repair strategies providing the report is clear and well ***,when considering tank floor storage inspection it is essential that asset owners have total confidence in inspection findings and the ensuing *** floor inspection equipment must not only be efficient and highly capable,but data sets should be traceable and integrity maintained *** mapping of large surface areas such as storage tank bottoms is an inherently arduous and time-consuming ***(magnetic flux leakage)based tank bottom scanners present a well-established and highly rated method for *** are many benefits of using modern MFL technology to generate actionable *** among these includes efficiency of coverage while gaining valuable information regarding defect location,severity,surface origin and the extent of *** recent advancements in modern MFL tank bottom scanners afford the ability to scan and record data sets at areas of the tank bottom which were previously classed as dead zones or areas not scanned due to physical *** example of this includes scanning the CZ(critical zone)which is the area close to the annular to shell junction *** of these additional dead zones increases overall inspection coverage,quality and *** of the CZ areas allows engineers to quickly determine the integrity of arguably the most important area of the tank *** we discuss notable developments in CZ coverage

关键词： Storage tank tank bottom CZ MFL stars corrosion corrosion-mapping efficiency coverage paperless reporting data traceability

Biomechanics of ankle giving way:A case report of accidental ankle giving way during the drop landing test

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journal of Sport and Health Science 2019年第5期8卷 494-502页

作者： Yumeng Li jupil Ko Shuqi Zhang Cathleen N.Brown Kathy j.simpson Department of Kinesiology California State UniversityChicoCA 95928USA Department of Physical Therapy and Athletic Training Northern Arizona UniversityPhoenixAZ 85004USA Department of Kinesiology and Physical Education Northern Illinois UniversityDeKalbIL 60115USA Department of Athletic Training and Kinesiology Oregon State UniversityCorvallisOR 97331USA Department of Kinesiology University of GeorgiaAthensGA 30602USA

Background:Several case studies observed that the lateral ankle sprain resulted from a sudden increase in ankle inversion accompanied by internal ***,without sufficient ankle kinetics and muscle activity information in the literature,the detailed mechanism of ankle sprain is still *** purpose of our case report is to present 2 accidental ankle giving way incidents for participants with chronic ankle instability(CAI)and compare to their normal trials with data of kinematics,kinetics,and electromyography(EMG).Case description:Two young female participants accidentally experienced the ankle giving way when landing on a 25°lateral-tilted force plate.3 D kinematics,kinetics,and muscle activity were recorded for the lower *** comparisons were made between the giving way trials and normal trials for joint angles,angular velocities,moments,centers of pressure and EMG linear ***:One participant’s giving way trial displayed increased ankle inversion and internal rotation angles in the pre-landing phase and at initial contact compared to her normal *** participant’s giving way trial exhibited greater hip abduction angles and delayed activation of the peroneus longus muscle in the pre-landing phase versus her normal ***:A vulnerable ankle position(i.e.,more inverted and internally rotated),and a late activation of peroneus activity in the pre-landing phase could result in the ankle giving way or even sprains.A neutral ankle position and early activation of ankle evertors before landing may be helpful in preventing ankle sprains.

关键词： Chronic ankle instability EMG Kinematics Kinetics Lateral anlde sprain

Cross-cultural adaptation and validation of an ankle instability questionnaire for use in Chinese-speaking population

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journal of Sport and Health Science 2019年第6期8卷 555-560页

作者： Yumeng Li Li Guan jupil Ko Shuqi Zhang Cathleen N.Brown Kathy j.simpson Department of Kinesiology California State University ChicoChicoCA 95926USA Department of Psychology University of GeorgiaAthensGA 30605USA Department of Physical Therapy and Athletic Training Northern Arizona UniversityFlagstaffAZ 86011USA Department of Kinesiology and Physical Education Northern Illinois UniversityDekalbIL 60115USA Department of Athletic Training and Kinesiology Oregon State UniversityCorvallisOR 97331USA Department of Kinesiology University of GeorgiaAthensGA 30605USA

Background:The Identification of Functional Ankle Instability(IdFAI)is a valid and reliable tool to identify chronic ankle instability;however,it was developed in English,thus limiting its usage only to those who can read and write in *** objectives of our study were to(1)cross-culturally adapt a Chinese(Mandarin)version of the IdFAI and(2)determine the psychometric properties of the Chinese version ***:The cross-cultural adaptation procedures used by the investigators and translators followed previously published guidelines and included 6 stages:(1)initial translation,(2)synthesis of the translations,(3)back translation,(4)developing the pre-final version for field testing,(5)testing the pre-final version,and(6)finalizing the Chinese version of IdFAI(IdFAI-C).Five psychometric properties of the IdFAI-C were assessed from results of 2 participant groups:bilingual(n=20)and Chinese(n=625).Results:A high degree of agreement was found between the English version of IdFAI and IdFAI-C(intra-class correlation_(2,1)=0.995).An excellent internal consistency(Cronbach'sα=0.89),test—retest reliability(intra-class correlation_(2,1)=0.970),and construct validity(r(625)=0.67)was also found for the *** addition,the results of exploratory and confirmatory factor analysis indicated that ankle instability was the only construct measured from the ***:The IdFAI-C is a highly reliable and valid self-report questionnaire that can be used to assess ankle ***,we suggest that it can be used to effectively and accurately assess chronic ankle instability in clinical settings for Chinese-speaking individuals.

关键词： Ankle giving way Ankle sprain Chronic ankle instability Identification of functional instability Mandarin Translation

Comparison of the‘Seattle’and‘International’Criteria Electrocardiogram Interpretation in Division II Female Collegiate Athletes:A Preliminary Study

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journal of Science in Sport and Exercise 2023年第3期5卷 274-279页

作者： Ludmila Cosio-Lima N.Kumar Brooke L.Adlof j.simpson A.Crawley Y.Lee University of West Florida 11000 University Parkway#72/220PensacolaFL 32514USA

Purpose A 12-lead electrocardiogram(ECG)is a screening tool to detect abnormalities that may predispose athletes to sud-den cardiac *** standardized criteria have been introduced to better interpret ECG data,however this research has predominantly focused on male *** is important to include female athletes in research to better define ECG character-istics in this *** purpose of this study was to compare the Seattle and International Criteria ECG abnormalities in Division II female collegiate athletes of various *** Fifty-six females(age 20.2±1.4 years;height 1.70±0.7 m;weight 69.5±8.9 kg)completed a resting 12-lead ECG *** data was classified as‘normal’and‘abnormal’according to the parameters of each criterion and abnormal conditions were ***-square analysis was used to assess statistical comparisons between *** There was a significant difference in abnormal classifications as the total number of ECGs identified as abnormal using the Seattle Criteria decreased from 12(21.4%)to 2(3.6%)when using the International Criteria(P<0.05).African American athletes had a higher number of abnormal ECG’s compared to White and Latina athletes using the Seattle Criteria(P=0.03).Conclusions The International Criteria significantly reduces the total number of abnormal ECG readings in female collegiate athletes compared to the Seattle Criteria and did not overly identify African American athletes with *** research is necessary to expand on this study and clearly define criteria for female athletes of various ethnicities.

关键词： 12-lead ECG Female athletes Sudden cardiac death ECG abnormalities

Nutritional geometry framework of sucrose taste in Drosophila

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journal of Genetics and Genomics 2023年第4期50卷 233-240页

作者： An-Qi Li Sha-Sha Li Ruo-Xin Zhang Xin-Yuan Zhao Zhi-Ying Liu Yun Hu Bei Wang G Gregory Neely Stephen j.simpson Qiao-Ping Wang Laboratory of Metabolism and Aging School of Pharmaceutical Sciences(Shenzhen)Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdong 518107China The Dr.john and Anne Chong Laboratory for Functional Genomics Charles Perkins Centre and School of Life&Environmental SciencesThe University of SydneySydneyNSW2006Australia Charles Perkins Centre and School of Life&Environmental Sciences The University of SydneySydneyNSW2006Australia

Dietary protein(P)and carbohydrate(C)have a major impact on the sweet taste ***,it remains unclear whether the balance of P and C influences the sweet taste ***,we use the nutritional geometry framework(NGF)to address the interaction of protein and carbohydrates on sweet taste using Drosophila as a *** results reveal that high-protein,low-carbohydrate(HPLC)diets sensitize to sweet taste and low-protein,high-carbohydrate(LPHC)diets desensitize sweet taste in both male and female *** further investigate the underlying mechanisms of the effects of two diets on sweet taste using RNA *** compared to the LPHC diet,the m RNA expression of genes involved in the metabolism of glycine,serine,and threonine is significantly upregulated in the HPLC diet group,suggesting these amino acids may mediate sweet taste *** further find that sweet sensitization occurs in flies fed with the LPHC diet supplemented with serine and *** study demonstrates that sucrose taste sensitivity is affected by the balance of dietary protein and carbohydrates possibly through changes in serine and threonine.

关键词： Nutritional geometry framework Sweet taste Sweet taste sensitivity Micronutrient Dietary balance Protein Carbohydrates Drosophila

一次梳理及二次梳理对精梳落棉和纱线品质的影响

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国外纺织技术(纺织分册) 1985年第7期 14-17页

作者： j.simpson 钟毅芸

引言 1967年发表的一项研究结果表明,当梳棉产量增加时,梳棉网中的后弯钩大量减少,这样就改善了纤维的伸直平行度,降低了精梳过程中的落棉。落棉量少的精梳棉条中的纤维长度分布与落棉量多的精梳棉条中的纤维长度分布几乎相差无几。为此... 详细信息

引言 1967年发表的一项研究结果表明,当梳棉产量增加时,梳棉网中的后弯钩大量减少,这样就改善了纤维的伸直平行度,降低了精梳过程中的落棉。落棉量少的精梳棉条中的纤维长度分布与落棉量多的精梳棉条中的纤维长度分布几乎相差无几。为此,当时许多纺织厂增加了精梳纱的梳棉产量,但是梳棉产量的增加。势必使棉结杂质的排除量减少,从而使成纱棉杂增加。因此,一些纺织厂便增加了盖板速度以去除较多的盖板花,并把

关键词：精梳落棉经过棉卷落棉隔距双联梳棉机落棉率精梳条纤维长度分布精梳机梳理机

不同原棉和不同梳棉机加工的条子喂入不同气流纺纱机的比较

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国外纺织技术(纺织分册) 1984年第10期 11-15页

作者： j.simpson 周开宇

引言最初用于棉纺的气流纺纱机是无除杂装置的。由于纺纱杯内积杂,就必需使用非常洁净的原棉或者采用双联梳棉这类的棉条准备工序。第二代的气流纺纱机在开松辊或分梳辊部分加装了除杂装置。而且,也改进了纺纱杯的设计以最大限度地减... 详细信息

引言最初用于棉纺的气流纺纱机是无除杂装置的。由于纺纱杯内积杂,就必需使用非常洁净的原棉或者采用双联梳棉这类的棉条准备工序。第二代的气流纺纱机在开松辊或分梳辊部分加装了除杂装置。而且,也改进了纺纱杯的设计以最大限度地减少积杂。最新型的气流纺纱机能令人满意地加工含杂很多的棉条;但是,在确定开清棉、梳棉和纺纱

关键词：除杂装置开清棉分梳辊纺纱杯捻系数棉箱环锭纺纱机梳棉工序熟条均匀度试验仪

开清棉和梳棉的除杂作用对气流纺纱杯积杂的影响

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国外纺织技术 1981年第35期 2-6页

作者： j.simpson 朱德明

引言排除杂质,气流纺纱比环锭纺纱更加重要。因而,对于气流纺纱,开清棉除杂作用要加强,尤其要去除细小尘杂,还有在给棉罗拉与纺纱杯之间大多数气流纺机已经组合成刺辊型除杂器。梳理和除杂作用极好的双

关键词：纺纱杯机器纺织机械零部件除杂纺纱工艺开清棉气流纺机梳棉排杂原棉气流纺纱机转杯纺纱机纺纱机械批号生条定向度