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外阴糜烂性扁平苔藓:呈现少量基底膜带循环抗体

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世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 45-45页

作者： Cooper S.M Dean D Allen j 潘敏 Department of Dermatology Churchill Hospital HeadingtonOxford OX3 7LJ United Kingdom.Dr

The objective of this study was to investigate whether circulating basement membrane zone (BMZ) antibodies are present in erosive lichen planus (LP) of the vulva. In total, 56 consecutive women with biopsy-confirmed erosive LP of the vulva were recruited from a vulval clinic in a district general hospital and teaching hospital in Oxfordshire. Indirect immunofluorescence (IgG and IgA) was performed on 56 sera, and 15 were tested to IgG subclasses (1-4). Immunoblotting was carried out on salt-split and urea-extracted epidermal skin extracts on 11. The main outcome measure was the presence or absence of staining at the BMZ. Of the 56 sera, 34 (61%) had weak (neat or 1:5) epidermal-binding BMZ antibodies (25 had IgG, 5 had IgA, 4 had both IgG and IgA). All 15 sera tested to IgG showed epidermal binding to one or more IgG subclasses: IgG1 (7 sera), IgG2 (7),IgG3 (7) and IgG4 (0). Immunoblotting identified IgG antibodies to bullous pemphigoid (BP)180 (10/11) and BP230 (2/11).The majority (61%) of patients with vulval erosive LP had circulating serum IgG BMZ antibodies, chiefly reacting with BP180. There was subclass restriction of the IgG response to IgG1, 2 and 3. The significance of these antibodies is uncertain, but they may be a marker for the disease.

关键词：基底膜带糜烂性扁平苔藓循环抗体 IgG 免疫印迹间接免疫荧光大疱性类天疱疮女阴教学医院综合医院

相位对比MRI预测内镜下三脑室造瘘术预后的价值

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国际医学放射学杂志 2009年第6期 578-578页

作者： S.M.Stivaros D.Sinclair P.A.Bromiley j.Kim j.Thorne A.jackson 李树荣 Department of Imaging Science Wolfson Molecular Imaging CentreUniversity of Manchester27 Palatine RdWithingtonManchester M20 3LJEngland

目的探讨术前相位对比MRI测量脑血流及脑脊液流体动力学指标能否作为内镜下三脑室造瘘术疗效的生物预测指标。材料与方法本前瞻性研究经当地伦理委员会批准,并获得病人知情同意。对13例慢性梗阻性脑积水的病人进行相位对比1.5T MRI检查(女6

关键词：相位对比 MRI 脑室造瘘术脑室造口术内镜下

长期甲氨蝶呤治疗银屑病和杂合α1-抗胰蛋白酶缺乏诱导肝纤维化?

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 56-56页

作者： Mathew j. Igbokwe U.O. Morley N. Burt A.D. 周少娜 Department of Histopathology Royal Cornwall Hospital Truro Cornwall TR1 3LJ United KingdomDr.

Background: Dermatologists, or pathologists, occasionally need to decide whether or not to continue methotrexate therapy in a patient with an identifiable risk factor for liver fibrosis, in this instance heterozygous α1-antitrypsin deficiency. Case Presentation: We relate our experience with an elderly male patient, diagnosed as having α1-antitrypsin deficiency on a liver biopsy, genotypically confirmed as PiMZ. He had been receiving methotrexate for psoriasis for 17 years with a cumulative dose of 7,200 mg. He was monitored by biochemical profiling and interval (10) liver biopsies. Non-specific changes were seen on liver histology although grade 1 liver fibrosis was seen in his last 2 biopsies. Conclusion: We suggest that methotrexate therapy is relatively safe in patients with heterozygous α1-antitrypsin deficiency, with no other risk factor. We however advise that the risk of fibrosis should be monitored and that the patient receives appropriate counselling.

关键词：银屑病抗胰蛋白酶缺乏甲氨蝶呤肝纤维化杂合皮肤科医生肝组织学生化检测肝活检累积剂量

用间-四羟苯基-氯(Foscan~)对女阴表皮内肿瘤进行光动力治疗

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世界核心医学期刊文摘（皮肤病学分册） 2005年第4期1卷 13-13页

作者： Campbell S.M. Gould D.j. Salter L. 冯义国 Cornwall Dermatol. Research Project Royal Cornwall Hospital Truro Cornwall TR1 3LJUnitedKingdom

Background: Photodynamic therapy (PDT) has unique properties which make it suitable for the local treatment of superficial epithelial disorders; it has been suggested as a useful treatment for carcinoma in situ of the vulva. Objectives: To evaluate the effect of the systemic photosensitizing agent metatetrahydroxyphenyl-chlorin(mTHPC or temoporfin; Foscan., Biolitec, Edinburgh, U.K.) in vulval intraepithelial neoplasia type III (VIN III). Methods: PDT using mTHPC was performed in six patients with VIN III. A dose of 0.1 mg kg-1 body weight mTHPC was injected intravenously and the area of VIN irradiated 96 h later with 652-nm light from a diode laser. Patients were reviewed 1 week, 6 months and 2 years following treatment. Results: Patients experienced only minimal pain from the initial treatment but two patients subsequently developed severe pain at the treated site for up to 2 weeks following PDT. All patients developed oedema and slough formation at the treated site and one patient developed cellulitis. At 6 months two patients had developed small recurrences of VIN at the original site and one patient had an area of VIN at a new site. These were treated either with further PDT or with a small excision. At 2 years there was no recurrence of VIN at the original site in all patients reviewed. Conclusions: This small case series demonstrates that mTHPC-PDT is a useful initial treatment for VIN III. It is relatively selective, shows good cosmesis and conserves form and function. This is a major advantage over surgery. Repeat treatments are also possible, which is important in a condition such as VIN, which tends to be multifocal. Systemic mTHPC-PDT appears to have an advantage over topical 5-aminolaevulinic acid-PDT as the photosensitizer is distributedwidely in areas of disease and consequently identifies foci which may not be apparent clinically but become evident when illuminated.

关键词：光动力治疗 Foscan 羟苯基女阴光敏剂用间小样本研究氨基乙酰丙酸蜂窝织炎二极管激光器

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中枢神经系统淋巴瘤的毛细血管生理及给药

世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 17-17页

作者： Warnke P.C. Timmer j. Ostertag C.B. Kopitzki K. 郭俊 University of Liverpool Department of Neurological Science Clin. Sci. Ctr. for Res. and Educ. Lower Lane Liverpool L9 7LJ Merseyside United Kingdom Dr.

To evaluate whether the chemosensitivity of primary central nervous system ly mphomas to water soluble drugs could result from improved drug delivery, we qu antitatively assessed pharmacokinetic factors in seven patients. The capillary p ermeability surface product was found to be significantly increased in central n ervous system lymphomas compared with glioblastoma multiforme, medulloblastomas, and metastases. Tumoral blood flow was significantly greater than in normal whi te matter. Our results suggest favorable pharmacokinetics to water and lipid soluble drugs in primary central nervous system lymphomas.

关键词：髓母细胞瘤水溶性药物药物动力学脂溶性药物药物代谢动力学通透性药物给药血流量