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Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review

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World journal of Gastroenterology 2016年第29期22卷 6742-6756页

作者： Tyler j severson siddesh Besur Herbert L Bonkovsky Department of Gastroenterology and Hepatology Wake Forest University NC Baptist Medical Center Abdominal Transplant Program Aurora St Luke’s Medical Center

AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease (NAFLD) onset, severity, and outcome through systematic literature ***: The authors conducted both systematic and specific searches of PubMed through December 2015 with special emphasis on more recent data (from 2012 onward) while still drawing from more historical data for background. We identified several specific genetic polymorphisms that have been most researched and, at this time, appear to have the greatest clinical significance on NAFLD and similar hepatic diseases. These were further investigated to assess their specific effects on disease onset and progression and the mechanisms by which these effects ***: We focus particularly on genetic polymorphisms of the following genes: PNPLA3, particularly the p. I148M variant, TM6sF2, particularly the p. E167K variant, and on variants in FTO, LIPA, IFNλ4, and iron metabolism, specifically focusing on HFE, and HMOX-1. We discuss the effect of these genetic variations and their resultant protein variants on the onset of fatty liver disease and its severity, including the effect on likelihood of progression to cirrhosis and hepatocellular carcinoma. While our principal focus is on NAFLD, we also discuss briefly effects of some of the variants on development and severity of other hepatic diseases, including hepatitis C and alcoholic liver disease. These results are briefly discussed in terms of clinical application and future potential for personalized ***: Polymorphisms and genetic factors of several genes contribute to NAFLD and its end results. These genes hold keys to future improvements in diagnosis and management.

关键词： Genetic polymorphisms Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis PNPLA3 TM6sF2 FTO Cirrhosis Iron metabolism

毛乌素沙地的粉尘释放通量观测及DPM模型的野外验证

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科学通报 2006年第11期51卷 1326-1332页

作者：梅凡民 j．Rajot s．Alfaro L．Gomes 张小曳王涛中国科学院寒区旱区环境与工程研究所沙漠与沙漠化重点实验室 Laboratoire Interuniversitaire des systèmes Atmosphèriques Universitè de Paris 12 Paris 94010France 中国气象局大气成分观测与服务中心中国气象局大气化学重点开放实验室

目前关于中国粉尘源区的释放通量观测数据很少,被经常使用的DPM粉尘释放模型在中国源区的可靠性还没有得到验证．2002年春季在毛乌素沙地开展了野外观测实验,分别观测了跃移通量、<10μm的粉尘释放通量、温度和风速梯度．观测期间平均... 详细信息

目前关于中国粉尘源区的释放通量观测数据很少,被经常使用的DPM粉尘释放模型在中国源区的可靠性还没有得到验证．2002年春季在毛乌素沙地开展了野外观测实验,分别观测了跃移通量、s-1之间,实测的跃移通量约在0．07～8．00 g·m-1·s-1之间,实测和模拟的跃移通量较为一致,跃移通量方程经验系数取2．61比较合适;在3次局地的粉尘释放过程中,实测的粉尘释放通量约在1～3μg·m-2·s-1之间,模拟的粉尘释放通量偏高,说明该模型在低风速条件下还需要校正．通过与前人数据的比较,发现松散的砂质土的跃移通量大于具有物理结皮的砂质土和存在大土壤团块的壤质土,说明在相同摩阻风速条件下,松散的砂质土的粉尘释放通量最大,预示中国北方粉尘的主要源地在沙漠和沙漠化的土地．

关键词：毛乌素沙地粉尘释放通量观测模型验证

TROPICAL CYCLONEs AND CLIMATE CHANGE

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Tropical Cyclone Research and Review 2019年第4期8卷 240-250页

作者： K.j.E.Walsh s.j.Camargo T.R.Knutson j.Kossin T.-C.Lee H.Murakami C.Patricola school of Earth sciences University of MelbourneAustralia Lamont-Doherty Earth Observatory Columbia UniversityUSA NOAA/GFDL PrincetonUSA NOAA/National National Centers for Environmental Information USA Hong Kong Observatory Hong KongChina NOAA/GFDL Princeton UniversityUSA Lawrence Berkeley National Laboratory USA

since the Eighth International Workshop on Tropical Cyclones(IWTC-8), held in December 2014, progress has been made in our understanding of the relationship between tropical cyclone(TC) characteristics, climate and climate change. New analysis of observations has revealed trends in the latitude of maximum TC intensity and in TC translation speed. Climate models are demonstrating an increasing ability to simulate the observed TC climatology and its regional variations. The limited representation of air-sea interaction processes in most climate simulations of TCs remains an issue. Consensus projections of future TC behavior continue to indicate decreases in TC numbers, increases in their maximum intensities and increases in TC-related rainfall. Future sea level rise will exacerbate the impact of storm surge on coastal regions, assuming all other factors equal. studies have also begun to estimate the effect on TCs of the climate change that has occurred to date. Recommendations are made regarding future research directions.

关键词： tropical cyclone climate change climate variability

Afterword to semen Analysis in 21st Century Medicine special issue in Asian journal of Andrology

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Asian journal of Andrology 2010年第1期12卷 118-123页

作者： David j. Handelsman Trevor G. Cooper Reproductive Endocrinology ＆ Andrology Director ANZA C Research Institute Sydney Australia Andrology Laboratory Institute of Reproductive Medicine of the University Munster Germany

We summarise and comment on the topics discussed by the contributors to this special Issue. As an introduction, Ann jequier＇s [ 1 ] generally positive assessment of the new-look manual was tempered with her res- ervations about reference values, on which other chapters dwelt at length. Aspects of laboratory technique were discussed by Charlene Brazil [2], whose offering gives a rare insight into the actual workings of andrology laboratories and highlights the need for greater involvement of laboratory directors （often clinicians） in assessing the quality of data provided.

关键词： no english key word

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硫营养对绿茶产量和品质的影响

茶叶科学 2006年第3期26卷 177-180页

作者：李杰马立峰 jóska Gerendás 阮建云 Institute of Plant Nutrition and soil science University of Kiel 中国农业科学院茶叶科学研究所浙江杭州310008

研究了硫营养对绿茶产量和品质的影响及其可能的机理。试验设2个硫处理(0,50 kg ***-1.a-1),每个处理重复4次,完全随机区组设计。结果表明:施硫能够提高产量、增加氨基酸和抗坏血酸(AsA和DAsA)含量,降低茶多酚和酚氨比(TP/AA)。施硫对... 详细信息

研究了硫营养对绿茶产量和品质的影响及其可能的机理。试验设2个硫处理(0,50 kg ***-1.a-1),每个处理重复4次,完全随机区组设计。结果表明:施硫能够提高产量、增加氨基酸和抗坏血酸(AsA和DAsA)含量,降低茶多酚和酚氨比(TP/AA)。施硫对茶叶品质的改善与降低多酚氧化酶(PPO)的活性、提高硝酸还原酶(NR)和苯丙氨酸解氨酶(PAL)活性有关。

关键词：氨基酸抗坏血酸多酚氧化酶硝酸还原酶苯丙氨酸解氨酶

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簇毛麦抗白粉病基因的RAPD及RFLP标记

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中国农业科学 2005年第3期38卷 439-445页

作者：李辉陈孝施爱农孔凡晶 Leath s Murphy j P 贾旭 RaleighNC27695 中国农业科学院作物育种与栽培研究所中国科学院遗传与发育生物学研究所北京100081 北京100101 国家植物细胞与染色体工程重点实验室北京100081 河北省农林科学院粮油作物研究所河北省遗传育种重点实验室石家庄050031 美国北卡罗来纳州立大学

分析了来自苏联簇毛麦及其抗病衍生系的抗白粉病基因对不同生理小种的抗性反应。用 120 个随机引物对 6D/6V 代换系 Pm930640 进行 RAPD 分析,检测到 5 个引物 OPAN03、OPAI01、OPAL03、OPAD07 和 OPAG15,分别在大约 1 700、700、750、4... 详细信息

分析了来自苏联簇毛麦及其抗病衍生系的抗白粉病基因对不同生理小种的抗性反应。用 120 个随机引物对 6D/6V 代换系 Pm930640 进行 RAPD 分析,检测到 5 个引物 OPAN03、OPAI01、OPAL03、OPAD07 和 OPAG15,分别在大约 1 700、700、750、480 和 580 bp 处有区别于小麦亲本的多态性条带。对 Chancellor×Pm930640 F2群体进行 OPAN03、OPAI01 和 OPAL03 等 3 个 RAPD 标记与抗白粉病基因的连锁分析,表明这些标记同簇毛麦的抗白粉病基因是连锁的。对大部分分别含有 Pm1-Pm20 的已知抗病基因、含有簇毛麦抗病基因及其相关亲本的 29 个小麦品系进行RAPD标记分析。结果表明,这些标记不仅可以鉴定簇毛麦的抗病基因,而且可以判断其遗传背景。OPAL03750仅出现在含有苏联簇毛麦 6Vs 染色体的抗病材料中,可作为区别于 Pm21 的分子标记。RFLP 标记的结果也表明两个不同簇毛麦的 6Vs 染色体有明显的多态性。

关键词：簇毛麦 RAPD标记 RFLP标记抗白粉病基因

Fuzzy Logic Based Handover Authentication in 5g Telecommunication Heterogeneous Networks

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Computer systems science & Engineering 2023年第7期46卷 1141-1152页

作者： j.Divakaran Arvind Chakrapani K.srihari Vivekanandha College of Engineering for Women TiruchengodeNamakkal637205TamilnaduIndia Karpagam College of Engineering Coimbatore641032TamilnaduIndia sNs College of Technology Coimbatore641035TamilnaduIndia

Under various deployment circumstances,fifth-generation(5G)telecommunications delivers improved network compound management with fast communication *** to the introduction of the Internet of Things(IoT)in data management,the majority of the ultra-dense network models in 5G networks frequently have decreased spectral efficiency,weak handover management,and *** majority of traditional handover authentication models are seriously threatened,making them vulnerable to a variety of security *** authentication of networked devices is the most important ***,a model that incorporates the handover mechanism and authentication model must be *** article uses a fuzzy logic model to create a handover and key management system that focuses on cloud handover management and authentication *** order to decrease delays in 5G networks,the fuzzy logic is built with multiple criteria that aim to reduce the number of executed handovers and target cell *** simulation is run to evaluate the model’s performance in terms of latency,spatial complexity,and other metrics related to authentication attack validation.

关键词： Handover authentication mobility management fuzzy logic latency 5G IoT MATLAB 3gpp

A remark on Kac's scattering length formula

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science China Mathematics 2013年第2期56卷 331-338页

作者： FITZsIMMONs Patrick j. HE Ping YING jianGang Department of Mathematics University of California at San Diego Department of Applied Mathematics Shanghai University of Finance and Economics school of Mathematics Fudan University

The scattering length formula was formulated and proved in special cases by Kac in 1974 and *** was discussed by a series of authors,including Taylor 1976,Tamura 1992 and Takahashi *** formula was proved by Takeda 2010 in symmetric case and by He 2011 assuming weak *** this article,we shall use the powerful tool of Kutznetsov measures to prove this formula in the general framework of right Markov processes without further assumptions.

关键词： scattering length Kuznetsov measure capacity

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Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease

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World journal of Gastroenterology 2014年第27期20卷 8751-8763页

作者： Ahmed Tawfik Paul K Flanagan Barry j Campbell Department of Gastroenterology Institute of Translational Medicine University of Liverpool

Multiple studies have demonstrated alterations in the intestinal microbial community (termed the microbiome) in Crohn’s disease (CD) and several lines of evidence suggest these changes may have a significant role in disease pathogenesis. In active and quiescent disease, both the faecal and mucosa-associated microbiome are discordant with matched controls with reduced biodiversity, changes in dominant organisms and increased temporal variation described. Mucosa-associated adherent, invasive Escherichia coli (E. coli) (AIEC), pro-inflammatory and resistant to killing by mucosal macrophages, appear to be particularly important. AIEC possess several virulence factors which may confer pathogenic potential in CD. Type-1 pili (FimH) allow adherence to intestinal cells via cell-surface carcinoembryonic antigen-related cell adhesion molecules and possession of long polar fimbrae promotes translocation across the intestinal mucosa via microfold (M)-cells of the follicle-associated epithelium. Resistance to stress genes (htrA, dsbA and hfq) and tolerance of an acidic pH may contribute to survival within the phagolysosomal environment. Here we review the current understanding of the role of mucosa-associated E. coli in Crohn’s pathogenesis, the role of the innate immune system, factors which may contribute to prolonged bacterial survival and therapeutic strategies to target intracellular E. coli.

关键词： Crohn's disease Inflammatory bowel disease Escherichia coli Intra-macrophage survival and replication Phagolysosome Autophagy