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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily lee William j.Mack Department of Integrative Anatomical sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

ON A ClAss OF ANAlYTIC FUNCTIONs RElATED TO CONIC DOMAINs AND AssOCIATED WITH CARlsON-sHAFFER OPERATOR

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Acta Mathematica scientia 2012年第4期32卷 1399-1407页

作者： s.Hussain j.sokól Mathematics Department COMSATS Institute of Information TechnologyAbbottabadPakistan Department of Mathematics Rzeszów University of Technologyul.W.Pola 235-959 RzeszówPoland

Making use of the Carlson-shaffer convolution operator, we introduce and study a new class of analytic functions related to conic domains. The main object of this paper is to investigate inclusion relations, coefficient bound for this class. We also show that this class is closed under convolution with a convex function. some applications are also discussed.

关键词： Hadamard product (or convolution) differential subordination Carlson-shaffer operator k-starlike functions k-uniformly convex function

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira M.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Effect of dietary near ideal amino acid profile on heat production of lactating sows exposed to thermal neutral and heat stress conditions

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journal of Animal science and Biotechnology 2021年第2期12卷 739-754页

作者： s.Zhang j.s.johnson N.l.Trottier Department of Animal science Michigan State UniversityEast Lansing 48824USA UsDA-ARs livestock Behavior Research Unit West Lafayette 47907USA

Background:Reduced protein diet manifested potential to mitigate heat production based on the concept of ideal amino acid *** hypothesis of this study was that lactating sows fed a low crude protein(lCP)diet with supplemental amino acid produce less heat compared to those fed a high crude protein(HCP)diet under both thermal neutral(TN)and heat stress(Hs)***:Thirty-two lactating sows were allotted to HCP(193 g CP/kg)and lCP(140 g CP/kg)diets under thermal neutral(TN,21±1.5°C)or cycling heat stress(Hs,32±1.5°C daytime and 24±1.5°C nighttime)*** contained 0.90%sID lysine and 10.8 Mj/kg net *** pressure indirect calorimeters were used to measure gas exchange in individual sows with litters,and individual piglets on days 4,8,14 and *** and litter weights were recorded on days 1,10 and ***:sow total heat production(THP)was calculated by subtracting litter THP from sow+litter THP based on *** BW and body protein(BP)loss was greater for lCP diet compared to HCP diet in peak lactation(Pspectively)and throughout the entire lactation period(Pspectively)under Hs ***-stressed sows fed HCP diet had higher(Pl temperature at 13:00(Pspiration rate at 07:00(Psows fed HCP *** sows fed lCP diet,those under Hs tended to have higher(P=0.098)rectal temperature at 13:00 and had higher(Pspiration rate at 07:00,13:00 and 19:00 compared to TN *** relationship between daily THP and days in lactation of sows fed lCP diet was quadratic(Pscending trend until day 14 and a descending trend from days 14 to *** fed lCP diet had lower daily THP at day 18(Pse fed the HCP diet under Hs ***:Reduction in THP in sows fed lCP diet was largely associated with THP on day 18 of lactation under Hs *** lCP die

关键词： Amino acid Heat stress lactating sows low protein diet Total heat production

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger samantha j.Holdsworth Alistair j.Gunn laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

A mild, configurable, flexible CoNi-lDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei lv sam s.Yoon Qufu Wei Key laboratory of Eco-textiles Ministry of Education Jiangnan University school of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-lDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-lDH nanosheets enriched with H vacancies (CoNi-lDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-lDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnsO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-lDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias schwab Alexandra Kretz Computational Biology and systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(Als)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fAls),most cases are considered sporadic(sAls).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Analysis of antisym metric cross-ply laminates using high-order shear deformation theories:a meshless approach

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Acta Mechanica sinica 2020年第5期36卷 1078-1098,I0003页

作者： D.E.s.Rodrigues j.Belinha l.M.j.s.Dinis R.M.Natal jorge Institute of science and Innovation in Mechanical and Industrial Engineering 4200-465 PortoPortugal Department of Mechanical Engineering School of EngineeringPolytechnic of Porto(ISEP)4200-072 PortoPortugal Department of Mechanical Engineering Faculty of EngineeringUniversity of Porto(FEUP)4200-465 PortoPortugal

For many years finite element method(FEM)was the chosen numerical method for the analysis of composite ***,in the last 20 years,the scientific community has witnessed the birth and development of several meshless methods,which are more flexible and equally accurate numerical *** meshless method used in this work is the natural neighbour radial point interpolation method(NNRPIM).In order to discretize the problem domain,the NNRPIM only requires an unstructured nodal ***,using the Voronoi mathematical concept,it enforces the nodal connectivity and constructs the background integration *** NNRPIM shape functions are constructed using the radial point interpolation *** this work,the displacement field of composite laminated plates is defined by high-order shear deformation *** the end,several antisymmetric cross-ply laminates were analysed and the NNRPIM solutions were compared with the *** obtained results show the efficiency and accuracy of the NNRPIM formulation.

关键词： Antisymmetric cross-ply laminates High-order shear deformation theories Meshless methods Naturalneighbour radial point interpolation method(NNRPIM)

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn sua jo jonggeol Na j.jay liu Young-ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as strategy A. To compare the impacts of lignin upgrading and feedstock, strategy B, which co-produces tetrahydrofuran alone, and strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in strategy A. The market competitiveness of strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（lCAs）.strategy A was found to be the most favorable both economically（UsRDsCHARDOllAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

Constructing two-scale network microstructure with nano-Ti5si3 for superhigh creep resistance

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journal of Materials science & Technology 2019年第8期35卷 1532-1542页

作者： Y.jiao l.j.Huang s.l.Wei H.X.Peng Q.An s.jiang l.Geng state Key laboratory of Advanced Welding and joining Harbin Institute of TechnologyHarbin 150001 China Center of Analysis and Measurement Harbin Institute of TechnologyHarbin 150001 China Department of Materials science and Engineering Massachusetts Institute of TechnologyCambridge MA02139 USA Institute for Composites science Innovation (InCsI) School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027 China

The improvement of mechanical properties must be achieved by designing and constructing more suitable microstructure,such as hierarchical *** order to significantly enhance the creep resistance of titanium matrix composites(TMCs),two-scale network microstructure was constructed including the first-scale network(sker(TiBw)reinforcement and the second-scale network(si3 reinforcement by powder metallurgy and in-situ *** results showed that the creep rate of the composite was remarkably reduced by an order of magnitude compared with the Ti6Al4V alloy at 550℃,600℃,650℃ under the stresses between 100 MPa and 350 ***,the rupture time of the composite was increased by 20 times,compared with that of the Ti6Al4 Valloy at 550℃/300 *** superior creep resistance could be attributed to the hierarchical *** micro-TiBw reinforcement in the first-scale network boundary contributed to creep resistance primarily by blocking grain boundary sliding,while the nano-Ti5si3 particle in the second-scale network boundary mainly by hindering phase boundary *** addition,the nano-Ti5si3 particle was dissolved,and precipitated with smaller size than the primary *** phenomenon was attributed to si element diffusion under high temperature and external stress,which could further continuously enhance the creep ***,the creep rate during steady-state stage was significantly decreased,which manifested superior creep resistance of the composite.

关键词： Titanium matrix composite Two-scale network microstructure Nano-Ti5si3 Creep Powder metallurgy