We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high- grade basal cell carcinoma and malignant melanoma. some tumor cellsshowed a keratinocytic phenotype (cytokeratins, ...
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We describe two cases of a malignant cutaneous neoplasm with combined phenotypical features of high- grade basal cell carcinoma and malignant melanoma. some tumor cells showed a keratinocytic phenotype (cytokeratins, p63) and others a melanocytic phenotype (HMB- 45, mart- 1, Melan- A, s100- protein). We favor the hypothesis of a tumor with bidirectional keratinocytic and melanocytic differentiation, an exceptionally rare event.
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