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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Micro-synchrophasor based special protection scheme for distribution system automation in a smart city

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Protection and Control of Modern Power systems 2020年第1期5卷 97-110页

作者： Deepa s.Kumar savier j.s Biju s.s Dept of Electrical Engineering College of EngineeringTrivandrumKeralaIndia 400/220kV substation Powergrid Corporation of India Ltd.TrivandrumKeralaIndia Power system Operations Kerala State Electricity Board Ltd.KeralaIndia

Introduction:Aspects of power system protection which contributes to mal-operations and blackouts can be improved by supervision of system behavior and response based analysis rather than condition-based or event-based analysis using wide area measurements based on synchrophasor *** paper explores the application of micro-Phasor Measurement Unit for time synchronized real-time distribution network monitoring and agile decision support schemes for system prognosis and *** description:The scheme is proposed as part of a project on“Power system Voltage stability Analysis using synchrophasors in Distribution system of Kerala Grid”at Kerala state Electricity Board *** actual grid occurrence during the severe tropical cyclone Ockhi,is considered as the base case which motivated the *** and evaluation:A voltage stability index(VsI)based special protection scheme(sPs)for radial distribution network at a proposed smart city is presented in the present *** proposed special protection scheme on actual implementation can use data from proposed local micro-Phasor Measurement *** PMU is proposed to be placed at one of the key nodes of the distribution system network in the ***:The VsI is derived using local phasor values and is used to initiate a special Protection scheme for N-1 contingency at the key node,so as to ensure availability of the most essential feeder which provides supply to a hospital campus housing several health institutes of prime *** voltage stability index derived is tested and sPs is validated using real-time grid data.

关键词： Micro-phasor measurement unit Power system protection Voltage stability Power system stability Power distribution smart grids

Macrophage invasion:here,there and everywhere

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signal Transduction and Targeted Therapy 2022年第8期7卷 2634-2635页

作者： Lola C.Hernandez Pablo j.sáez Cell Communication and Migration Laboratory Institute of Biochemistry and Molecular Cell BiologyCenter for Experimental MedicineUniversity Medical Center HamburgEppendorfHamburgGermany

Recently Akhmanova et *** in science that cell division at specific locations in the tissue constitutes a novel strategy for macrophage infiltration.1 Cell infiltration or tissue invasion is a common migratory strategy used by highly motile *** cellular response is observed in tissue colonization during development,drives intra/extravasation of leukocytes during the immune response and is exploited by tumors for *** cells employ diverse mechanisms to invade tissues,including degradation or deformation of the extracellular matrix(ECM)and cell squeezing through small pores.2 Leukocytes are professional migrating cells able to find their way through tissues with different topologies and levels of *** their nucleus,the largest and stiffest organelle in a cell,leukocytes probe the microenvironment and choose the path of least resistance when moving through small pores.

关键词： invasion al. pores

Quantitative genetic studies with applications in plant breeding in the omics era

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The Crop journal 2020年第5期8卷 683-687页

作者： jiankang Wang j.sécrossa junyi Gai Institute of Crop sciences Chinese Academy of Agricultural SciencesBeijing 100081China International Maize and Wheat Improvement Center(CIMMYT) Carretera Mexico-Veracruz Km.45El BatanTexcocoMexico soybean Research Institute Nanjing Agricultural UniversityNanjing 210095JiangsuChina

Quantitative genetics is concerned with the inheritance of biological traits showing continuous(or quantitative)phenotypic *** traits are common and have been extensively investigated and studied in evolutionary and genetic studies and in plant and animal *** traits are normally controlled by multiple genes with various kinds of genetic effect,and their phenotypes are readily modified by environmental variation.

关键词： breeding inheritance traits

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing sMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller school of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

spinal muscular atrophy(sMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of sMA was understood in 1995 when loss or impairment of the survival motor neuron 1(sMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,sMN2,which can produce low levels(approximately 10%)of the full-length functional sMN protein,has led to the generation of sMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,sMN2 copy number is used as a proxy for the prediction of disease severity,with higher sMN2 copy number typically being associated with reduced severity of sMA,although this relationship is not absolute:some individuals with low sMN2 copy number have less severe sMA phenotypes and vice ***,the etiology of sMA is further complicated by other factors,such as non-typical nucleotide variants and sMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

The logically consistent relationship between cladograms and synapomorphies

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Zoological systematics 2024年第4期49卷 281-284页

作者： santiago j.sanchez-Pacheco Direccion Academica Universidad Nacional de ColombiaSede de La PazLa PazCesarColombia

Here I explore the biological relevance,origin and meaning of the concept of cladogram(rooted,directed branching diagrams representing the hypothesized phylogenetic relationships among the terminal taxa under study)and argue that cladograms do not necessarily entail synapomorphies,but synapomorphies are required to test and ultimately falsify cladograms.

关键词： meaning sized among