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出生前暴露于倍他米松是否对成年后的心理功能和健康相关生活质量产生不良影响

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 1-2页

作者： Dalziel S.R. Lim V.K. Lambert A. j.E. Harding 丁福 Liggins Institute University of Auckland Auckland New Zealand

Objectives: To determine if antenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome alters psychological functioning and health related quality of life in adulthood. Design: Follow-up of the first and largest double blind, placebo controlled, randomised trial of a single course of antenatal betamethasone for the prevention of neonatal respiratory distress syndrome. Setting: Tertiary obstetric hospital in Auckland, New Zealand. Participants: 192 adult offspring, mean age 31 years, of mothers who took part in a randomised controlled trial of antenatal betamethasone for the prevention of neonatal respiratory distress syndrome (87 exposed to betamethasone and 105 exposed to placebo). Interventions: Mothers received two doses of betamethasone or placebo 24 hours apart. Main outcome measures: Cognitive functioning assessed with Wechsler abbreviated scale of intelligence; working memory and attention assessed with Benton visual retention test, paced auditory serial addition test, and Brown attention deficit disorder scale; psychiatric morbidity assessed with beck depression inventory II, state-trait anxiety inventory, and schizotypy traits questionnaire; handedness assessed with Edinburgh handedness inventory; health related quality of life assessed with short form 36 health survey. Results: No differences were found between groups exposed to betamethasone and placebo in cognitive functioning, working memory and attention, psychiatric morbidity, handedness, or health related quality of life. Conclusions: Prenatal exposure to a single course of betamethasone does not alter cognitive functioning, working memory and attention, psychiatric morbidity, handedness, or health related quality of life in adulthood. Obstetricians should continue to use a single course of antenatal betamethasone for the prevention of neonatal respiratory distress syndrome.

关键词：倍他米松生活质量心理功能出生前安慰剂对照认知功能注意力缺陷精神病态韦氏智力量表抑郁

Light treatment for seasonal Winter depression in African-American vs Caucasian outpatients

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World journal of Psychiatry 2015年第1期5卷 138-146页

作者： Hyacinth N Uzoma Gloria M Reeves Patricia Langenberg Baharak Khabazghazvini Theodora G Balis Mary A johnson Aamar Sleemi Debra A Scrandis Sarah A Zimmerman Dipika Vaswani Gagan Virk Nijjar johanna Cabassa Manana Lapidus Kelly j Rohan Teodor T Postolache Department of Psychiatry University of Maryland School of MedicineBaltimoreMD 21201-1549United States Psychiatry Residency Training Program St.Elizabeth’s HospitalWashingtonDC 20032United States Department of Epidemiology and Preventive Medicine University of Maryland School of MedicineBaltimoreMD 21201-1549United States Department of Ophthalmology and Visual Science University of Maryland School of MedicineBaltimoreMD 21201-1549United States Family and Community Health University of Maryland School of NursingBaltimoreMD 21201-1549United States Department of Psychological Science University of VermontBurlingtonVT 05405-0134United States VISN 5 Capitol Health Care Network Mental Illness Research Education and Clinical Center BaltimoreMD 21201United States VISN 19 Rocky Mountain Mental Illness Research Education and Clinical Center DenverCO 80220United States 不详

AIM: To compare adherence, response, and remission with light treatment in African-American and Caucasian patients with Seasonal Affective ***: Seventy-eight study participants, agerange 18-64(51 African-Americans and 27 Caucasians)recruited from the Greater Baltimore Metropolitan area, with diagnoses of recurrent mood disorder with seasonal pattern, and confirmed by a Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-Ⅳ, were enrolled in an open label study of daily bright light treatment. The trial lasted6 wk with flexible dosing of light starting with 10000 lux bright light for 60 min daily in the morning. At the end of six weeks there were 65 completers. Three patients had Bipolar Ⅱ disorder and the remainder had Major depressive disorder. Outcome measures were remission(score ≤ 8) and response(50% reduction)in symptoms on the Structured Interview Guide for the Hamilton Rating Scale for Depression(SIGH-SAD)as well as symptomatic improvement on SIGH-SAD and beck Depression Inventory-Ⅱ. Adherence was measured using participant daily log. Participant groups were compared using t-tests, chi square, linear and logistic regressions. RESULTS: The study did not find any significant group difference between African-Americans and their Caucasian counterparts in adherence with light treatment as well as in symptomatic *** symptomatic improvement and rate of treatment response were not different between the two groups,African-Americans, after adjustment for age, gender and adherence, achieved a significantly lower remission rate(African-Americans 46.3%; Caucasians 75%; P =0.02).CONCLUSION: This is the first study of light treatment in African-Americans, continuing our previous work reporting a similar frequency but a lower awareness of SAD and its treatment in African-Americans. Similar rates of adherence, symptomatic improvement and treatment response suggest that light treatment is a feasible, acceptable,

关键词： Seasonal affective disorder Depression Light treatment African-American Black Remission gap Ethnicity Race

超声溶栓治疗rt-PA禁忌的急性缺血性卒中患者

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 60-61页

作者： Eggers j. Seidel G. Koch B. Knig I.R. 朱光明 Department of Neurology Univ. Hospital Schleswig-Holstein Campus Lübeck Ratzeburger Allee 160 23 438 Lübeck Germany Dr.

The authors studied the effect of transcranial ultrasound on patients with acu te middle cerebral artery occlusion and contraindications for thrombolysis. Fift een consecutive subjects were randomized for insonation over 1 hour or for inclusion in a control group. By day 4, recanalization and neurologic improvem ent occurred more frequently in the target group. Ultrasound-induced accelerati on of clot dissolution may be an option for patients with contraindications for recombinant tissue plasminogen activator.

关键词：急性缺血性卒中 rt-PA 大脑中动脉闭塞血管再通功能改善率

WONCA研究论文摘要汇编——基层医疗全科医生在随访中多次使用抑郁症自评量表监测抑郁症状严重程度的影响:随机对照研究

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中国全科医学 2017年第8期 917-917页

作者： WIKBERG C WESTMAN j PETERSSON E L 本刊编辑部

背景本文旨在评估以患者为本的反复全科医生咨询中,使用抑郁症自评量表是否影响患者的抑郁症状严重程度、生活质量、药物使用和病假频率。方法在3个月的干预期间,干预组患者定期拜访全科医生至少4次。除常规治疗(TAU)外,每次随访均采用... 详细信息

背景本文旨在评估以患者为本的反复全科医生咨询中,使用抑郁症自评量表是否影响患者的抑郁症状严重程度、生活质量、药物使用和病假频率。方法在3个月的干预期间,干预组患者定期拜访全科医生至少4次。除常规治疗(TAU)外,每次随访均采用抑郁症自评工具Montgomery-Asberg抑郁评定量表进行评价。对照组仅接受TAU,随访频率则根据全科医生和患者对护理需求的联合评估。采用beck抑郁量表Ⅱ评估抑郁症状严重程度,EQ-5D量表评估生活质量,GHQ-12量表评估心理良好状态,在治疗前和治疗3、6、12个月时进行量表调查。结果在12个月的随访期间,干预组与对照组抑郁症状严重程度减轻或缓解率、生活质量改变、心理良好状态、使用镇静剂的剂量和病假情况比较,差异均无统计学意义(P>0.05)。然而,在随访6个月时,干预组有更多的患者持续服用抗抑郁药(P<0.05)。结论在以患者为本的基层医疗咨询中频繁使用抑郁症自评量表对患者的抑郁症状、健康状况、病假情况和保健方面没有进一步的促进效应。

关键词：抑郁症状 WONCA 全科医生自评量表程度

患丙型肝炎老干部未进行抗病毒治疗:对生活质量造成影响的生理和社会心理因素

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 48-49页

作者： Rowan P.j. Al-jurdi R. Tavakoli-Tabasi S. H.B. El-Serag 陈瑜 Houston Veterans Affairs Medical Center (152) 2002 Holcombe Blvd. Houston TX 77030 United States Dr.

Background and Aims: Treatment-naive hepatitis C virus (HCV)infected patients report impaired health-related quality of life (HRQOL), although causes are unclear. Psychosocial factors may be major determinants of HRQOL. Methods: We administered a general (Short Form-36; SF-36) and a liver-specific (Chronic Liver Disease Questionnaire; CLDQ) HRQOL measure to 62 HCV-infected veterans being considered for antiviral therapy. Psychosocial assessment included the Structured Clinical Interview for DSM-IV Axis I Disorders/Non-Patient (SCID-VNP), beck Depression Inventory-II (BDI-II), beck Anxiety Inventory (BAI), Abbreviated Cook-Medley (ACM) anger measure, and Medical Outcomes Study Social Support Measure (SSM). We examined the potential determinants of HRQOL, including psychosocial measures, demographic measures (age, sex, race/ethnicity), clinical measures (presence of cirrhosis, comorbid medical conditions), and viral data (quantitative PCR). Results: SF-36 scores were significantly lower in HCV-infected patients than published U.S. population norms but similar to those reported by previous studies of HCV infected samples. CLDQ scores were very similar to those reported by previous studies. Demographic, clinical, and viral indicators were not statistically associated with HRQOL, and neither was the presence of a substance abuse or psychotic disorder. Lower BDI-II and BAI scores were associated with better general and disease-specific HRQOL. Lower SSM scores were associated with lower scores on SF-36 but not CLDQ; however, this effect did not persist in multiple linear regression analyses. In these, BDI-II was the strongest independent predictor of both SF-36 and CLDQ. Conclusions: Psychosocial factors, especially depression, are strong indicators of impaired HRQOL for HCV-infected veterans not receiving antiviral therapy. Screening and treatment of psychosocial factors is recommended.

关键词：丙型肝炎抗病毒生活质量病毒学指标心理因素慢性肝病社会支持疾病特异性药物滥用医学成果

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

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Translational Neurodegeneration 2019年第1期8卷 127-133页

作者： Franziska Hopfner Stefanie HMüller Dagmar Steppat joanna Miller Nele Schmidt Klaus-Peter Wandinger Frank Leypoldt Daniela Berg Andre Franke Wolfgang Lieb Lukas Tittmann Monika Balzer-Geldsetzer Simon Baudrexel Richard Dodel Ruediger Hilker-Roggendorf Elke Kalbe jan Kassubek Thomas Klockgether Inga Liepelt-Scarfone Brit Mollenhauer Petra Neuser Kathrin Reetz Oliver Riedel Claudia Schulte jörg BSchulz Annika Spottke Alexander Storch Claudia Trenkwalder Hans-Ulrich Wittchen Karsten Witt Ullrich Wüllner Günther Deuschl Gregor Kuhlenbäumer Department of Neurology University Hospital Schleswig HolsteinArnold-Heller Str.324105 KielGermany Center of Blood Transfusion University Hospital Schleswig HolsteinKiel&LübeckGermany Department of Clinical Chemistry University Hospital Schleswig-HolsteinKielGermany Institute of Clinical Molecular Biology University Hospital Schleswig-HolsteinKielGermany Institute of Epidemiology University Hospital Schleswig-HolsteinKielGermany Chair of Geriatric Medicine University Hospital EssenEssenGermany Department of Neurology Philipps-University MarburgMarburgGermany Department of Neurology Goethe UniversityFrankfurt/MainGermany Brain Imaging Center Goethe UniversityFrankfurt/MainGermany Department of Medical Psychology|Neuropsychology and Gender Studies&Center for Neuropsychological Diagnostics and Intervention(CeNDI) University Hospital CologneCologneGermany Psychological Gerontology Institute of GerontologyUniversity of VechtaVechtaGermany Department of Neurology University of UlmUlmGermany Department of Neurology University of Bonnand German Center for Neurodegenerative Diseases(DZNE)BonnGermany Center for Neurology Hertie Institute for Clinical Brain ResearchDepartment of Neurodegenerative DiseasesUniversity of TübingenTübingenGermany DZNE German Center for Neurodegenerative DiseasesTübingenGermany Paracelsus-Elena-Klinik KasselGermany Institute of Neuropathology and Department of Neurosurgery University Medical Center GöttingenGöttingenGermany Coordinating Centre for Clinical Trials Philipps-UniversityMarburgGermany Department of Neurology RWTH Aachen UniversityAachenGermany jARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum Jülich GmbH and RWTH Aachen UniversityAachenGermany Leibniz Institute for Prevention Research and Epidemiology-BIPS Achterstrasse 3028359 BremenGermany Department of Neurology Technische Universität Dresden01307 DresdenGermany German Center for Neurodegenerative Diseases(DZNE) Research Site Rostock18147 RostockGerma

Background:IgG-class autoantibodies to N-Methyl-D-Aspartate(NMDA)-type glutamate receptors define a novel entity of autoimmune *** examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting *** measured NMDA antibodies in a large,well phenotyped sample of Parkinson patients without and with cognitive impairment(n=296)and controls(n=295)free of neuropsychiatric *** phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive ***:NMDA antibodies were analysed in the serum of patients and controls using well established validated *** used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic ***:The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients(13%)than in controls(22%)and higher than in previous studies in both *** IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment,nor with quantitative indicators of disease severity and cognitive impairment.A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson ***:It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease *** Parkinson disease with dementia,while NMDA IgG antibodies define a separate disease of its own.

关键词： NMDA antibody NMDA IgA/IgM antibodies Parkinson disease Cognitive impairment

3T四维相位对比MRI分析主动脉弓二次血流的模式、几何形状及年龄的相关性

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国际医学放射学杂志 2012年第4期 398-399页

作者： A. Frydrychowicz A. Berger A.M. del Rio M.F. Russe j. Bock A. Harloff 郭雪梅 Clinic for Radiology and Nuclear Medicine University Hospital Schleswig -Holstein Campus LübeckRatzeburger Allee 160 Haus 40 23538 Lübeck Germany

摘要目的分析年龄、主动脉弓形状及大小对于二次血流模式,如流动敏感MRI(4D PC-MRI)显示的螺旋流和涡流的影响。方法研究由临床试验评审及管理委员会(IRB)批准并签署知情同意书;62例胸主动脉形态无异常改变[升主动脉(AAo)直径(3.2±0.6)... 详细信息

摘要目的分析年龄、主动脉弓形状及大小对于二次血流模式,如流动敏感MRI(4D PC-MRI)显示的螺旋流和涡流的影响。方法研究由临床试验评审及管理委员会(IRB)批准并签署知情同意书;62例胸主动脉形态无异常改变[升主动脉(AAo)直径(3.2±0.6)cm(范围2.2～5.1cm)]的受试者(年龄20～80岁)

关键词： MRI 血流动力学主动脉电影MRI MR血管成像血流

大骨节病关节软骨细胞形态及Ⅰ、Ⅱ、Ⅲ、Ⅹ型胶原表型和MMP-13表达的体外研究

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西安交通大学学报（医学版） 2008年第6期29卷 616-616页

作者：王伟卓郭雄陈君长许鹏 MIKKO j．LAMMI 西安交通大学医学院公共卫生系陕西西安710061 西安交通大学医学院第二附属医院骨科陕西西安710004 Institute of Biosciences Applied BiotechnologyUniversity of Kuopio芬兰

目的体外培养大骨节病(Kashin-beck disease,KBD)患者和正常对照的关节软骨细胞并对比观察细胞形态、Ⅰ、Ⅱ、Ⅲ和Ⅹ型胶原表型及基质金属蛋白酶13(MMP-13)的表达变化,以明确KBD软骨细胞的生长特性。方法依据我国"大骨节病临床诊断标准... 详细信息

目的体外培养大骨节病(Kashin-beck disease,KBD)患者和正常对照的关节软骨细胞并对比观察细胞形态、Ⅰ、Ⅱ、Ⅲ和Ⅹ型胶原表型及基质金属蛋白酶13(MMP-13)的表达变化,以明确KBD软骨细胞的生长特性。方法依据我国"大骨节病临床诊断标准"和病理学变化特征,选择KBD患者为KBD组(n=8),并设立正常对照组(n=8)。在无菌手术条件下采集关节软骨,胶原酶等消化、分离后进行软骨细胞培养,光镜及透射电子显微镜观察形态,免疫组织化学及流式细胞术观察细胞Ⅰ、Ⅱ、Ⅲ、Ⅹ型胶原和MMP-13的体外表达变化,对比研究KBD软骨细胞表型表达的特点。结果KBD软骨细胞内空泡及核变形现象较正常增多,并有绒毛及胶原纤维不规则排列等超微结构变化。两组间Ⅰ、Ⅱ、Ⅲ、Ⅹ型胶原表型表达差异显著,其中KBD组Ⅱ型胶原表型表达显著低于对照组(t=-5.54,P<0.001),而MMP-13表达显著增高(t=3.70,P<0.01)。结论KBD软骨细胞Ⅰ、Ⅱ、Ⅱ、Ⅹ型胶原表型和MMP-13的表达不同于正常对照组,以软骨细胞的退行性和增生性变化为著。

关键词：大骨节病患者软骨细胞胶原表型 MMP-13

先天性心血管异常检查中4D增强时间分辨MRA与3D MRA影像质量和诊断价值的比较

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国际医学放射学杂志 2013年第6期 592-593页

作者： F.M.Vogt j.M.Theysohn D.Michna P.Hunold U.Neudorf S.Kinner 魏璐吴梦琳 Clinic for Radiology and Nuclear Medicine University Hospital Schleswig-HolsteinCampus Lübeck Ratzeburger Allee 16023538 LübeckGermany

摘要目的比较时间分辨随机轨道(TWIST)4D增强磁共振血管成像(MRA)与3D扰相梯度回波(FLASH)MRA在先天性心血管异常检查中的优劣性。方法 26例先天性心血

关键词：先天性心脏病 MR血管成像传统3D MRA 动态4D MRA 诊断价值