检索结果-南通市图书馆

Concentrated Extract of Green Tea Polyphenols Enhances the Toxicity of the Elderberry Lectin Nigrin b to Mice

Food and Nutrition Sciences 2014年第5期5卷 466-471页

作者： Pilar jiménez Patricia Cabrero jesús Tejero Manuel j. Gayoso Manuel Garrosa Damián Cordoba-diaz Manuel Cordoba-diaz Tomás Girbés Biología Celular Histología y Farmacología Facul- tad de Medicina and INCYL (Instituto de Neurociencias de Castilla y León) Universidad de Valladolid Valladolid Spain Farmacia y Tecnología Farmacéutica Facultad de Farmacia and IUFI (Instituto Universitario de Farmacia Industrial) Universidad Complu- tense de Madrid Madrid Spain Nutrición y Bromatología Facultad de Medicina and CINAD (Centro de Investigación en Nutrición Alimentación y Dietética Edi- ficio LUCIA-Parque Científico) Universidad de Valladolid Valladolid Spain Nutrición y Bromatología Facultad de Medicina and CINAD (Centro de Investigación en Nutrición Alimentación y Dietética Edi- ficio LUCIA-Parque Científico) Universidad de Valladolid Valladolid Spain

The effect of the administration of large amounts of green tea polyphenols is a matter of controversy. We explored whether a polyphenol mixture from a concentrated green tea extract (Polyphenon 60) could alter the effects on mice of the type 2 (two chains) ribosome-inactivating protein nigrin b isolated from Sambucus nigra L. Nigrin b triggers specific reversible toxic effects on the mouse intestines featured by apoptosis of mice Lieberkühn crypt cells upon parenteral administration of sub-lethal amounts. Independent administration to mice of 30 mg/kg body weight of Polyphenon 60 by oral gavage or 10 mg/kg body weight of nigrin b administered via the intraperitoneal route (i.p.) did not affect survival. In contrast, the simultaneous treatment greatly enhanced nigrin b toxicity leading to the death of some animals. The histological analysis revealed that the most serious injury was inflicted on the small intestine crypts, which disappeared, and on the liver, which evidenced hepatotoxicity showing haemorrhagic areas. These findings raise concerns about the abuse of high concentrations of green tea polyphenols especially when the intestinal mucosa is damaged, for instance by toxins or therapeutic drugs.

关键词： Green Tea Polyphenols Nigrin b Model Ribosome-Inactivating Protein Lectin Small Intestine Liver Apoptosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Compliant lightweight non-invasive standalone“Marine Skin”tagging system

引用

npj Flexible Electronics 2018年第1期2卷 97-105页

作者： joanna M.Nassar Sherjeel M.Khan Seneca j.Velling Andrea diaz-Gaxiola Sohail F.Shaikh Nathan R.Geraldi Galo A.Torres Sevilla Carlos M.Duarte Muhammad M.Hussain mmh Labs Computer Electrical Mathematical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Material&Nanoscience Program Faculty of ScienceUniversity of WaterlooWaterlooON N2L-3G1Canada Red Sea Research Center(RSRC) Biological and Environmental Sciences and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

Current marine research primarily depends on weighty and invasive sensory equipment and telemetric network to understand the marine environment,including the diverse fauna it contains,as a function of animal behavior and size,as well as equipment *** match animal morphology and activity within the surrounding marine environment,here we show a physically flexible and stretchable skin-like and waterproof autonomous multifunctional system,integrating Bluetooth,memory chip,and high performance physical *** sensory tag is mounted on a swimming crab(Portunus pelagicus)and is capable of continuous logging of depth,temperature,and salinity within the harsh ocean *** fully packaged,ultra-lightweight(<2.4 g in water),and compliant“Marine Skin”system does not have any wired connection enabling safe and weightless cuttingedge approach to monitor and assess marine life and the ecosystem’s health to support conservation and management of marine ecosystems.

关键词： Marine system Skin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Accumulations of Vitamin B6 from an Oral Dose in a New Reversible Model for Mouse Gut Injury and Regeneration

引用

Food and Nutrition Sciences 2013年第9期4卷 908-917页

作者： Pilar jiménez Damián Cordoba-diaz Patricia Cabrero Mónica Aracil Manuel j. Gayoso Manuel Garrosa Manuel Cordoba-diaz Tomás Girbés Biología Celular Histología y Farmacología Facultad de Medicina and INCYL (Instituto de Neurociencias de Castilla y León) Universidad de Valladolid Valladolid Spain. Farmacia y Tecnología Farmacéutica Facultad de Farmacia and IUFI (Instituto Universitario de Farmacia Industrial) Universidad Complutense de Madrid Madrid Spain Nutrición y Bromatología Facultad de Medicina and CINAD (Centro de Investigación en Nutrición Alimentación y Dietética- Edificio LUCIA-Parque Científico) Universidad de Valladolid Valladolid Spain

Chemically based rodent models are used to assess the positive effects promoted by foods and gut microbiota on gut health. Lectins with enzymatic activity, such as type 2 ribosome-inactivating proteins, might also prove useful for exploring these issues. Sub-lethal doses of the lectin nigrin from Sambucus nigra L. to mice promoted reversible derangement of gut epithelium by induction of apoptosis of transit amplifying cells of the small intestine crypts in a time-dependent course. The present work seeks to study vitamin B6 accumulation in plasma from an oral bolus in a mouse nigrin model. 24 h after sub-lethal nigrin b treatment, there was clear body weight reduction associated to a notable increase in Evan’s blue stain accumulation in excised small intestine, an increase in myeloperoxidase activity, and a near 50% reduction in plasma accumulation of vitamin B6. Histological analysis of small intestine sections of nigrin b-treated animals also revealed significant derangement of intestinal crypts. Seventy two hours after nigrin b treatment, stain uptake decreased and vitamin B6 accumulation was almost restored despite villi derangement. Large intestine crypts were scarcely or not at all affected. Eight days after nigrin b treatment, vitamin B6 uptake and intestinal crypt structure had fully recovered. The nigrin b mice model supports the view that, under these conditions, the carrier-mediated vitamin B6 uptake component of the small intestine crypts is probably the most active when the vitamin is administered orally as a bolus. The findings provide insights into the suitability of the present mice model for nutritional or drug absorption studies in conditions of partially altered or injured intestinal mucosa.

关键词： Vitamin B6 Nigrin b Ribosome-Inactivating Protein Sambucus Ricin Intestines Mice Model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

灯光、无人机准备……开拍

引用

科技纵览 2015年第7期 34-39页

作者： T.j.diaz

摄像机向着高于周围灌木一百多米的悬崖俯冲而下。镜头中呈现了一位穿着橙色荧光背心的年轻女性，靠在赭色石英岩的半山岩壁上休息。之后，摄像机飞到离岩石几米远的距离，近到足以顺着这名女子的目光，看到她可以用手支撑的下一个地方。

关键词：无人机灯光摄像机石英岩

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant adaptation to low phosphorus availability:Core signaling,crosstalks,and applied implications

引用

Molecular Plant 2022年第1期15卷 104-124页

作者： javier Paz-Ares Maria Isabel Puga Monica Rojas-Triana Iris Martinez-Hevia Sergio diaz Cesar Poza-Carrión Miguel Mi(n)ambres Antonio Leyva Department of Plant Molecular Genetics Centro Nacional de Biotecnología(CNB-CSIC)Darwin 3Campus Universidad Autónoma28049 MadridSpain Institute of Plant Biochemistry Institute of Synthetic Biology and CEPLASUniversity of Düsseldorf40225 DüsseldorfGermany

Phosphorus(P)is an essential nutrient for plant growth and *** preferentially absorb P as orthophosphate(Pi),an ion that displays low solubility and that is readily fixed in the soil,making P limita-tion a condition common to many soils and Pi fertilization an inefficient *** cope with Pi limitation,plants have evolved a series of developmental and physiological responses,collectively known as the Pi starvation rescue system(PSR),aimed to improve Pi acquisition and use efficiency(PUE)and protect from Pi-starvation-induced *** research has been carried out during the last 20 years to un-ravel the mechanisms underlying the control of the PSR in *** we review the results of this research effort that have led to the identification and characterization of several core Pi starvation signaling components,including sensors,transcription factors,microRNAs(miRNAs)and miRNA inhibitors,kinases,phosphatases,and components of the proteostasis *** also refer to recent results revealing the existence of intricate signaling interplays between Pi and other nutrients and antagonists,N,Fe,Zn,and As,that have changed the initial single-nutrient-centric view to a more integrated view of nutrient ***,we discuss advances toward improving PUE and future research priorities.

关键词： inositol pyrophosphate plant nutrient PHR1 transcription factor PUE(phosphorus acquisition and use efficiency) SPX sensor and STOP1 transcription factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanoencapsulation of antioxidant peptides from Lupinus mutabilis in chitosan nanoparticles obtained by ionic gelling and spray freeze drying intended for colonic delivery

引用

Food Bioscience 2022年第6期50卷 603-613页

作者： Arturo Intiquilla Karim jiménez-Aliaga Amparo Iris Zavaleta Alexander Gamboa Nelson Caro Mario diaz Martin Gotteland Lilian Abugoch Cristian Tapia Laboratorio de Biología Molecular Facultad de Farmacia y BioquímicaUniversidad Nacional Mayor de San MarcosJirón Puno1002Lima 1Peru Departamento de Ciencia de los Alimentos y Tecnología Química Facultad de Ciencias Químicas y FarmacéuticasUniversidad de ChileSantos Dumont 964SantiagoChile Centro de investigación Austral Biotech Universidad de Santo TomasSantiago de ChileChile Facultad de Odontología Universidad de ChileSantiagoChile Departamento de Nutrición Facultad de MedicinaUniversidad de ChileChile.y Laboratorio de Microbiología y ProbióticosInstituto de Nutrición y Tecnología de Alimentos (INTA)Universidad de ChileChile y Núcleo Milenio en la Biología de la Microbiota IntestinalSantiagoChile

Oxidative stress has long been associated with the pathogenesis of inflammatory bowel disease(IBD),and it has been suggested that the combined administration of antioxidants and anti-inflammatory agents may be helpful for its *** from plant proteins,such as soybean glycinin tripeptide VPY,effectively inhibit pro-inflammatory mediators in intestinal epithelial and immune cells,which are both involved in the pathogenesis of *** study aimed to produce antioxidant biopeptides from proteins of Lupinus mutabilis seeds and then encapsulate them in chitosan nanoparticles(NPs)for colonic *** antioxidant peptide fraction of less than three kDa(UF3)was obtained and added at different concentrations(0.1–0.4 mg/ml)in chitosan *** NPs were prepared by gelation with tripolyphosphate(CTPP-UF3)or spray freeze-drying of the chitosan solution(SFDC-UF3).Sizes of 332±13 and 465±58 nm and maximum encapsulation efficiencies of 63.80 and 71.75%,respectively,were ***3 maintained its antioxidant capacity(>80%)and showed different release profiles in 1X PBS buffer at pH 7.4,depending on the encapsulation ***-IR showed hydrogen bonding and electrostatic interactions between the peptide and *** nanosystems maintained cell viability greater than 70%in colonic cell lines *** results show that both methods are appropriate for the nanoencapsulation of UF3 and can be used to design nanoparticles for colonic delivery.

关键词： Antioxidant Peptidic fraction Lupinus mutabilis,chitosan nanoparticles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The nature of the companion of PSR j1719-1438: a white dwarf or an exotic object?

引用

Research in Astronomy and Astrophysics 2012年第7期12卷 813-816页

作者： j. E. Horvath Instituto de Astronomia Geofísica e Ciências Atmosfricas - Universidade de So Paulo

We raise the possibility that the very dense, compact companion of PSR j1719-1438, which has a jupiter-like mass, is an exotic quark object rather than a light helium or carbon white dwarf. The exotic hypothesis naturally explains some of the observed features, and provides quite strong predictions for this system, to be confirmed or refuted in feasible future studies.

关键词： binary pulsars -- exotic matter-- pulsars: individual (PSR j1719-1438)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

放电等离子超快速烧结SiC-Al_2O_3纳米复相陶瓷

引用

无机材料学报 1999年第1期14卷 55-60页

作者：高濂王宏志洪金生宫本大树 diaz DE LA TORRE SEBASTIAN 中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室上海200050 日本大阪府立产业技术综合研究所

本文介绍用非均相沉淀法制备的纳米SiC－Al2O3复合粉体经放电等离子超快速烧结得到晶内型的纳米复相陶瓷，超快速烧结的升温速率为600℃／min，在烧结温度不保温，迅即在3min内冷却至600℃以下．与热压烧结相比，可降低烧结温度200℃以... 详细信息

本文介绍用非均相沉淀法制备的纳米SiC－Al2O3复合粉体经放电等离子超快速烧结得到晶内型的纳米复相陶瓷，超快速烧结的升温速率为600℃／min，在烧结温度不保温，迅即在3min内冷却至600℃以下．与热压烧结相比，可降低烧结温度200℃以上．力学性能研究结果表明，在1450℃超快速烧结得到的纳米复相陶瓷的抗弯强度高达1000MPa，维氏硬度为19GPa，断裂韧性也比Al2O3有所提高．TEM像显示纳米SiC颗粒大多分布在Al2O3母体晶粒内，而断裂表面的SEM像表明，穿晶断裂是其主要的断裂模式，这是所制备的纳米复相陶瓷力学性能大幅提高的主要原因．

关键词：碳化硅施电等离子烧结纳米粉体复合陶瓷

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Perturbation Experiments in Community Plant Species during Recovery from Agricultural Abandonment in a Semi-Arid Region of Central-Western Spain

引用

journal of Environmental Protection 2016年第11期7卷 1618-1644页

作者： j. E. Alvarez-diaz M. C. Santa-Regina I. Santa-Regina Universidad de Antioquía Medellín Colombia Instituto Arcipreste de Hita Madrid Spain IRNASA-CSIC Cordel de Merinas Salamanca Spain

Background: Can high diversity mixtures of later succession plant species be able to suppress early successional (arable weed) species than low diversity species mixtures? Can the removal of plant functional groups have important consequences on the sys-tem stability? Location: The study area was located at 850 m a.s.l., fifteen kilometers (15 km) to the west of Salamanca city, Spain, in a dehesa-like woodland. Methods: The field experiment was installed in Spring 1996 (May). The plots represented former agricultural lands cropped with (a rotation of) monocultures and abandoned right at the beginning of the experiment after the last crop was harvested in 1995. Before in-stalling plots, the fields were harrowed and equalized. The treatments (NC-natural colonization, LD-low diversity seed mixture and HD-high diversity seed mixture) were randomly allocated to the plots in each block. The experiment was organised accord-ing to a block design with five replicate blocks. Within each block, four plots measur-ing 10 × 10 m were marked out and each of the three treatments was randomly as-signed to one plot. All plots were separated by 2 m walkways. Results: The competitive ability of the sown species in different mixtures in LD, valued on the basis of their performance in HD, is a good predictor of their ability to suppress the weed crops spe-cies. This was also corroborated by the high relationship between the efficiency of the sown species in both treatments of species mixture (R2 = 0.51, F (1, 33) = 34.56, P < 0.001). Conclusions: The increase of colonizing species cover was significantly lower in LD, which again supported the increase of biomass in 1998, being also lower in HD. Therefore, this increase in the community is more prominent in LD treatments. The effect of sown species was not so important in this increase.

关键词： Colonization Ecosystem Functioning Invasibility Restoration Sowing Experiment Species Richness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessing the performance of YOLOv5 algorithm for detecting volunteer cotton plants in corn fields at three different growth stages

引用

Artificial Intelligence in Agriculture 2022年第1期6卷 292-303页

作者： Pappu Kumar Yadav j.Alex Thomasson Stephen W.Searcy Robert G.Hardin Ulisses Braga-Neto Sorin C.Popescu Daniel E.Martin Roberto Rodriguez Karem Meza juan Enciso jorge Solórzano diaz Tianyi Wang Department of Biological&Agricultural Engineering Texas A&M UniversityCollege StationTXUnited States of America Department of Agricultural&Biological Engineering Mississippi State UniversityMississippi StateMSUnited States of America Department of Electrical&Computer Engineering Texas A&M UniversityCollege StationTXUnited States of America Department of Ecology&Conservation Biology Texas A&M UniversityCollege StationTXUnited States of America Aerial Application Technology Research U.S.D.A.Agriculture Research ServiceCollege StationTXUnited States of America U.S.D.A.-APHIS PPQ S&T Mission LabEdinburgTXUnited States of America Department of Civil&Environmental Engineering Utah State UniversityLoganUTUnited States of America Texas A&M AgriLife Research&Extension Center WeslacoTXUnited States of America College of Engineering China Agricultural UniversityBeijingChina

The feral or volunteer cotton(VC)plants when reach the pinhead squaring phase(5–6 leaf stage)can act as hosts for the boll weevil(Anthonomus grandis L.)*** Texas Boll Weevil Eradication Program(TBWEP)employs people to locate and eliminate VC plants growing by the side of roads or fields with rotation crops but the ones growing in the middle of fields remain *** this paper,we demonstrate the application of computer vision(CV)algorithm based on You Only Look Once version 5(YOLOv5)for detecting VC plants growing in the middle of corn fields at three different growth stages(V3,V6 and VT)using unmanned aircraft systems(UAS)remote sensing *** the four variants of YOLOv5(s,m,l,and x)were used and their performances were compared based on classification accuracy,mean average precision(mAP)and *** was found that YOLOv5s could detect VC plants with maximum classification accuracy of 98%and mAP of 96.3%at V6 stage of corn while YOLOv5s and YOLOv5m resulted in the lowest classification accuracy of 85%and YOLOv5m and YOLOv5l had the least mAP of 86.5%at VT stage on images of size 416×416 *** developed CV algorithm has the potential to effectively detect and locate VC plants growing in the middle of corn fields as well as expedite the management aspects of TBWEP.

关键词： Boll weevil Volunteer cotton plant Computer vision YOLOv5 Unmanned aircraft systems(UAS) Remote sensing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：