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Validation of the functional rating index for the assessment of athletes with neck pain

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World journal of Orthopedics 2016年第8期7卷 507-512页

作者： Soofia Naghdi Noureddin Nakhostin Ansari Somaye Shams Salehi Ronald j Feise Ebrahim Entezary Department of Physiotherapy School of Rehabilitation Tehran University of Medical Sciences Institute of Evidence-Based Chiropractic

AIM: To validate the culturally-adapted Persian Functional Rating Index(PFRI) for assessing neck pain(NP) in athletes. METHODS: In this cross-sectional study, 100 athletes with NP and 50 healthy athletes participated and responded to the PFRI. Fifty athletes with NP completed the PFRI for at least 7 d later to establish test-retest reliability. RESULTS: The athletes with NP responded to all items, indicating excellent clinical utility. No floor and ceiling effects were found, indicating content validity and responsiveness. The PFRI revealed capability to discriminate between the athletes with NP and healthy athletes. The PFRI demonstrated strong correlation with the Numerical Rating Scale(Spearman's rho = 0.94), and the Persian Neck Disability Index(Pearson r = 0.995), supporting criterion and construct validity. Internal consistency reliability was high(Cronbach's α coefficient: 0.97). The test-retest reliability was excellent(ICCagreement = 0.96). The absolute reliability values of standard error of measurement and smallest detectable change were 3.2 and 8.84, respectively. An exploratory factor analysis yielded one factor explaining 78.03% of the total variance. CONCLUSION: The PFRI is a valid and reliable measure of functional status in athletes with NP.

关键词： Athletes Neck pain Functional rating index Reliability Validity

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细菌如何导致肿瘤

生物技术通讯 2003年第2期14卷 173-174页

作者： Alistair j. Lax Warren Thomas 黄海力

Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy

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World journal of Diabetes 2015年第7期6卷 943-960页

作者： Mark T Waddingham Amanda j Edgley Hirotsugu Tsuchimochi Darren j Kelly Mikiyasu Shirai james T Pearson Department of Medicine St Vincent’s HospitalUniversity of Melbourne Department of Physiology Monash University Department of Cardiac Physiology National Cerebral and Cardiovascular Center Research Institute Monash Biomedical Imaging Facility Monash University Australian Synchrotron

Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure in *** of hypertension and coronary artery disease,diabetes is associated with a specific cardiomyopathy,known as diabetic cardiomyopathy(DCM).Four decades of research in experimental animal models and advances in clinical imaging techniques suggest that DCM is a progressive disease,beginning early after the onset of type 1 and type 2 diabetes,ahead of left ventricular remodeling and overt diastolic *** the molecular pathogenesis of early DCM still remains largely unclear,activation of protein kinase C appears to be central in driving the oxidative stress dependent and independent pathways in the development of contractile *** subcellular alterations to the cardiomyocyte are now being highlighted as critical events in the early changes to the rate of force development,relaxation and stability under pathophysiological *** changes include perturbed calcium handling,suppressed activity of aerobic energy producing enzymes,altered transcriptional and posttranslational modification of membrane and sarcomeric cytoskeletal proteins,reduced actin-myosin cross-bridge cycling and dynamics,and changed myofilament calcium *** this review,we will present and discuss novel aspects of the molecular pathogenesis of early DCM,with a special focus on the sarcomeric contractile apparatus.

关键词： Diabetes Prediabetes Insulin resistance Myocardium Sarcomere Protein kinase C rho kinase

英国人群中乳糜泻患者MYO9B基因变异体的联合缺失

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世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 32-33页

作者： Hunt K.A. Monsuur A.j. McArdle W.L. D.A. Van Heel 尹勇 Institute of Cell and Molecular Science Barts and The London Queen Mary's School of Medicine and Dentistry Turner St London E1 2AD United Kingdom Prof.

Background and aims: Development of coeliac disease involves an interaction between environmental factors (especially dietary wheat, rye, and barley antigens) and genetic factors (there is strong inherited disease susceptibility). The known human leucocyte antigen (HLA)-DQ2 and -DQ8 association explains only a minority of disease heritability. A recent study in the Dutch population suggested that genetic variation in the 3′region of myosin IXB (MYO9B) predisposes to coeliac disease. MYO9B is a rho family GTPase activating protein involved in epithelial cell cytoskeletal organisation. MYO9B is hypothesised to influence intestinal permeability and hence intestinal antigen presentation. Methods: Four single nucleotide polymorphisms were chosen to tag all common haplotypes of the MYO9B 3′haplotype block (exons 15-27). We genotyped 375 coeliac disease cases and 1366 controls (371 healthy and 995 population based). All individuals were of White UK Caucasian ethnicity. Results: UK healthy control and population control allele frequencies were similar for all MYO9B variants. Case control analysis showed no significant association of any variant or haplotype with coeliac disease. Conclusions: Genetic variation in MYO9B does not have amajor effect on coeliac disease susceptibility in the UK population. Differences between populations, a weaker effect size than originally described, or possibly a type I error in the Dutch study might explain these findings.

关键词：乳糜泻 MYO9B 变异体递呈人类白细胞抗原疾病易感性肠道通透性肌球蛋白活化蛋白对照分

血管免疫母细胞性T细胞淋巴瘤:rhoA G17V突变

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临床与实验病理学杂志 2016年第11期32卷 1311-1311页

作者： Nagao R Kikuti Y Y Carreras j 杨海玉刘勇江西省人民医院临床医学研究所南昌330006

血管免疫母细胞性T细胞淋巴瘤（AITL）是一种较为少见的外周T细胞淋巴瘤亚型（占15—20％），起源于滤泡辅助T细胞。AITL是一种表现预后不良的侵袭性淋巴瘤，多数患者年龄超过50岁且表现为进展期病变，其中位生存期不到3年。AITL以多形... 详细信息

血管免疫母细胞性T细胞淋巴瘤（AITL）是一种较为少见的外周T细胞淋巴瘤亚型（占15—20％），起源于滤泡辅助T细胞。AITL是一种表现预后不良的侵袭性淋巴瘤，多数患者年龄超过50岁且表现为进展期病变，其中位生存期不到3年。AITL以多形性细胞浸润伴透明T细胞聚集为形态特征表现，但目前对其特异性分子遗传学特征的研究尚不清楚。rhoAG17V是一种体细胞突变，该突变可干扰rhoA蛋白与rho-结合区的结合，使rhoA蛋白失去GTP酶活性，从而影响细胞增殖及侵袭行为。

关键词：血管免疫母细胞性T细胞淋巴瘤 rhoA蛋白体细胞突变外周T细胞淋巴瘤侵袭性淋巴瘤 AITL 辅助T细胞中位生存期

对患呼吸窘迫综合征新生儿进行出生后连续心肌肌钙蛋白T测定及其与心肌作功能力的关系

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世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 17-18页

作者： Clark S.j. Newland P. Yoxall C.W. Subhedar N.V. 刘莉 jessop Wing Royal Hallamshire Hospital Tree Root Walk Sheffield S10 2SF United Kingdom

We measured serial cardiac troponin T in babies with respiratory distress syndrome and in “healthy”controls (no cardiorespiratory support required). We investigated relationships between cardiac troponin T and myocardial performance in respiratory distress syndrome. This was a prospective observational study at a large tertiary maternity unit that recruited 104 “healthy”babies from whom individual samples were collected. A further 24 infants with respiratory distress syndrome and 14 “healthy”preterm infants had serial sampling over the first three days. We measured fractional shortening in 14 of the infants with respiratory distress syndrome. Cardiac troponin T rose from a median (interquartile range) of 10 (10-11) pgmL on day one to 34 (22-46) pgmL by day three, p=0.005, in “healthy”babies. In respiratory distress syndrome levels were higher, 91 (46-135) pgmL at 6 (5-7) hours of age, Prho=-0.831, P < 0.001, but this correlation did not persist. In “healthy”babies there is a minimal rise of cardiac troponin T by day 3. In respiratory distress syndrome there is an early and sustained elevation of cardiac troponin T, with a negative relationship with fraction shortening, suggesting significant myocardial damage of antenatalintrapartum origin, giving rise to measurable dysfunction.

关键词：心肌肌钙蛋白T 呼吸窘迫综合征新生儿患者列测定出生后能力作功心脏肌钙蛋白T 观察研究产科医院

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甘肃东部下石炭纪植物群

古生物学报 1956年第4期 641-646页

作者：张善桢中国科学院古生物研究所

本文所描述的材料,系石油工业部地质调查队最近采集的。标本产于甘肃东部中卫及景泰二县之间,详细地层状况,我们还不明白,但根据其产有Sphenopteris(rho-dea?)sp.,Triphyllopteris collumbiana Schimper 和Cardiopteridium spetsbergenseNathorst 等植物的事实,我们相信这一个含植物化石的地层是属于下石炭纪的。Sphenopteris(rhodea?)sp.(图版Ⅰ,图1,1a)在图版Ⅰ,图1,1a 所表示的一块Sphenopteris 型的碎片是非常别致的。这一块碎

关键词：陆相位下沉积相甘肃东部斯行健植物化石植物区系植物群

儿童湿疹和哮喘对双亲睡眠和身心健康的影响:一项前瞻性比较研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 43-44页

作者： Moore K. David T.j. Murray C.S. P.D. Arkwright 李政霄 Academic Unit of Child Health University of Manchester Manchester United Kingdom

Background: The psychological impact of childhood atopic eczema on parents and carers is poorly quantified. Objectives: To compare the impact of caring for a child with atopic eczema vs. asthma on parents’sleep and well-being. Methods: Ninety two parents of 55 children who had moderate to severe atopic eczema or asthma took part in this prospective, questionnaire based study. It was conducted at regional eczema and asthma outpatient clinics within a U.K. tertiary paediatric hospital. The main outcome measures were the number and duration of parents’sleep disturbances, as well as their anxiety and depression scores. Results: Mothers caring for children with atopic eczema lost a median of 39 min of sleep per night and fathers lost 45 min sleep per night. This compared with a median of 0 min sleep lost by parents who had children with asthma (P rho = 0.58; P = 0.002) and depression (rho = 0.73; P rho = 0.59; P = 0.01). Conclusions: Compared with looking after a child with chronic asthma, caring for a child with chronic atopic eczema was associated with greater parental sleep disturbances. Disruption to parental sleep correlated with anxiety levels and, in the case of mothers, depression scores.

关键词：儿童湿疹慢性哮喘睡眠障碍身心健康前瞻性比较双亲焦虑水平父母亲中位时间照顾者

血管紧张素Ⅱ激活人类rhoA交换因子Arhgef

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中华高血压杂志 2015年第5期23卷 451-451页

作者：赵狄练桂丽 Carbone ML Brégeon j Devos N Chadeuf G Blanchard A Azizi M Pacaud P jeunemaitre X Loirand G

已有研究表明rhoA-rho激酶在人类高血压发展中的病理作用，但其分子机制以及rhoA鸟嘌呤交换因子在rhoA过度激活中的作用仍不清楚。

关键词： rhoA 血管紧张素Ⅱ激活交换因子人类 rho激酶病理作用过度激活分子机制