检索结果-南通市图书馆

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Band-pass filtered velocity statistics in decaying turbulent box

在线全文

学校读者我要写书评

暂无评论

Theoretical & Applied Mechanics Letters 2011年第4期1卷 40-44页

作者： j.M.Lenoir S.Simoёns jean-Noel Gence UMR CNRS 5509 LMFAECLUCB LyonIINSALyon.France

For homogeneous isotropic turbulence study,the acquisition of band-pass filtered velocity increments(FVI) in a non-forced turbulent box is still a challenge both experimentally and *** and associated physical processes,at a given instant,are permanently contaminated by a forcing process which can seldom be *** situation tends to be the origin of intermittency and the non-Gaussian probability density distribution for acceleration and velocity *** reveal implied mechanism,grid turbulence is adapted to observe non-perturbed homogeneous isotropic *** velocity increments(VI) can be obtained following Comte-Bellot and Corrsin(GCBC) by means of two point-two time shifted velocity *** is difficult to obtain decaying turbulence(DT) at large turbulent Reynolds number without pollution coming from *** it is also significant to investigate DT in low Reynolds number regimes to determine non-polluted *** similarity of DT between particle image velocimetry(PIV) and hot wire anemometry measurements by GCBC are *** we focus our tendency on VI and FVI probability density function(PDF) shapes in this *** conclusion,the tendency to Gaussian shape in inertial zone wavenumbers,demonstrates that there will be no intermittency if turbulent cascade is not perturbed.

关键词： velocity increment velocity inertial zone homogeneous turbulence PDF shape

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

“Small is beautiful”-Examining reliable determination of low-abundant therapeutic antibody glycovariants

在线全文

学校读者我要写书评

暂无评论

journal of Pharmaceutical Analysis 2024年第10期14卷 1435-1449页

作者： Katharina Böttinger Christof Regl Veronika Schäpertöns Erdmann Rapp Therese Wohlschlager Christian G.Huber Department of Biosciences and Medical Biology Bioanalytical Research LabsUniversity of SalzburgSalzburg5020Austria Center for Tumorbiology and Immunology(CTBI) University of SalzburgSalzburg5020Austria glyXera GmbH MagdeburgSachsen-Anhalt39014Germany Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg39106Germany

Glycans associated with biopharmaceutical drugs play crucial roles in drug safety and efficacy,and therefore,their reliable detection and quantification is *** study introduces a multi-level quantification approach for glycosylation analysis in monoclonal antibodies(mAbs),focusing on minor abundant *** spectrometric data is evaluated mainly employing open-source software *** N-glycan and glycopeptide data form the basis for integrating information across different structural levels up to intact *** comparison showed that indeed,variations across structural levels were observed especially for minor abundant *** modification finder(MoFi),a tool for annotating mass spectra of intact proteins,we quantify isobaric glycosylation variants at the intact protein *** workflow's utility is demonstrated on NISTmAb,rituximab and adalimumab,profiling their minor abundant variants for the first time across diverse structural *** study enhances understanding and accessibility in glycosylation analysis,spotlighting minor abundant glycovariants in therapeutic antibodies.

关键词： Glycosylation Mass spectrometry Monoclonal antibodies Abundance profiling Minor glycovariants Multi-level analysis Data integration

Assessing phylogenetic relationships of Lycium samples using RAPD and entropy theory

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2005年第10期26卷 1217-1224页

作者： Ricky ns WONG Amber WY HA Department of Biology Hong Kong Baptist University Hong Kong China Department of Biology Hong Kong Baptist University Hong Kong China

Aim: To evaluate the phylogenetic relationships among related species of Lycium samples. Methods: Random amplified polymorphic DNA (RAPD) fingerprinting and lab-on-a-chip electrophoresis techniques were used to analyze the characteristics of Lycium species. Seven species and 3 varieties of Lycium were studied. Based on RAPD fingerprint data obtained from 11 primers, we proposed a new index, called dispersivity, using entropy theory and projection methods to depict the diversity of the DNA fingerprints. Results: Using the proposed dispersivity, primers were sorted and the dendrograms of the 7 species and 3 varieties of Lycium were constructed synthetically by merging primer information. Conclusion:Phylogenetic relationships among Lycium samples were constructed synthetically based on RAPD fingerprint data generated from 11 primers.

关键词： DNA fingerprinting RAPD technique lab-on-a-chip entropy UPGMA