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Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis

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World journal of Gastroenterology 2017年第18期23卷 3322-3329页

作者： Basavaraj Kerur Heather j Litman julia Bender Stern Sarah Weber j.nifer r lightdale Paul A rufo Athos Bousvaros Pediatric Gastroenterology Hasbro Children's Hospital Corrona LLC Southborough Inflammatory Bowel Disease Center Children's Hospital Boston Division of Pediatric Gastroenterology UMass Memorial Medical CenterUniversity Campus Worcester

To investigate of pediatric ulcerative colitis activity index (PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity (Mayo endoscopic score).METHODSWe reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d (either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions (such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayo endoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was *** identified 99 patients (53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity (62%), consideration of medication change (10%), assessment of medication efficacy (14%), and cancer screening (14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was “moderate-substantial” agreement between the two reviewers in assessing rectal Mayo scores (kappa = 0.54, 95%CI: 0.41-0.68).CONCLUSIONEndoscopic disease severity (Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies.

关键词： Ulcerative colitis Pediatric ulcerative colitis activity index Mayo score

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EUS临床实践的国际性调查

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 46-47页

作者： Das A. MouradW. lightdale C.j. 李翔

No comparative information exists regarding clinical variations in EUS practice patterns among American and international endosonographers. Eligible attendees of the XIIIth International Symposium on EUS, October 4-6 2002, New York, New York, were asked to complete a 2-page survey questionnaire on clinical practice of EUS. A total of 191 of 391 eligible attendees (48.9%) participated in the survey (110 from the United States, 81 from 30 different countries). The meanage of participants was 40.5 (10.6) years, and 171 (89.5%) were men. A total of 10 2 endosonographers (53.4%) were in academic practice. The majority (150, 78.5% ) also performed ErCP. Seventyeight (40.8%) had performed EUS for more than 5 years and 21 (11%) for l ess than 1 year. Only 36 (18.8%) had more than 6 months of dedicated hands-on EUS training, and more than a third of the respondents learned to perform EUS by observing others or they were self-taught. Compared with respondents from the United States, relatively fewer international respondents were performing open-access EUS, pancreatobiliary EUS procedures, and interventions such as EUS-guid ed FNA and celiac plexus neuralysis. This survey provides insight into the statu s of EUS as practiced in the United States and internationally. Although it appe ars that over the last decade EUS has become disseminated fairly uniformly on a global basis, a lack of consistent training standards and also inadequate opport unities for EUS training remain important areas of concern.

关键词：临床实践 EUS 超声内镜理论培训胰胆介入治疗比较性问卷调查训练标准抽吸术

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Identification of the Profile of Vulnerable Population to Elaborate Efficient Employment Strategy:Proposition of a Quantitative-creative Approach

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journal of Management Science & Engineering research 2021年第2期4卷 16-27页

作者： j.nifer ribeiro Dona Istefani Carisio de Paula Alceu Terra do Nascimento Aline Cafruni Gularte Federal University of rio Grande do Sul Brazil Intelligence core for projects and systems research group Brazil Mãos Verdes Work Cooperative Brazil

Brazilian public managers have been structuring and updating policies to support workers’employment and income ***,when the vulnerable individual has social,emotional,or technical limitations,success in this operation becomes *** research aim was to propose a methodology to identify profiles in vulnerable populations,viewing to promote the efficient elaboration of employment and income *** unit of analysis was vulnerable population of waste pickers,in a large city from South Brazil,in the scope of a municipal program named"All of us are Porto Alegre".A literature review allowed the identification of tools from marketing,economy and design adequate to profile analysis.A workshop with social educators responsible for giving support to the *** from workshop and the literature allowed the proposition of a methodology including cluster analysis and the creative tool named *** methodological approach suggests it is adequate in confirming the differences in *** theoretical contribution lies in the use of quantitative-creativity tools to support *** practical contribution is to provide consistent information for governmental decision-making at the labor access market.

关键词： Labor policy Vulnerable population Persona Cluster analysis

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食物蛋白诱导性小肠结肠炎综合征诊断和治疗国际共识指南

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中华临床免疫和变态反应杂志 2018年第1期12卷 109-123页

作者： Anna Nowak-We.grzyn MirnaChehade Marion E.Groetch jonathan M.Spergel robert A.Wood Katrina Allen Dan Atkins Sami Bahna Ashis V.Barad Cecilia Berin Terri Brown Whitehorn A.Wesley Burks jean-Christoph Caubet Antonella Cianferoni Marisa Conte Carla Davis Alessandro Fiocchi Kate Grimshaw rNutr ruchi Gupta Brittany Hofmeister j.B.Hwang Yitzhak Katz George N.Konstantinou Stephanie A.Leonard jennifer lightdale Sean McGhee Sami Mehr Stefano MiceliSopo Giovanno Monti Antonella Muraro Stacey Katherine Noel Ichiro Nomura Sally Noone Hugh A.Sampson Fallon Schultz Scott H.Sicherer Cecilia C.Thompson Paul j.Turner Carina Venter A.Amity Westcott-Chavez Matthew Greenhawt 李丽莎钱家鸣杨红不详中国医学科学院北京协和医学院北京协和医院变态(过敏)反应科中国医学科学院北京协和医学院北京协和医院消化内科

食物蛋白诱导性小肠结肠炎综合征（food protein-induced enterocolitis, FPIES）是一种非IgE,细胞介导的食物过敏反应,其表现可以很严重,甚至导致休克。虽然该类过敏反应有潜在的严重性,但FPIES 的知晓率却较低；而且有关FPIES 病理生... 详细信息

食物蛋白诱导性小肠结肠炎综合征（food protein-induced enterocolitis, FPIES）是一种非IgE,细胞介导的食物过敏反应,其表现可以很严重,甚至导致休克。虽然该类过敏反应有潜在的严重性,但FPIES 的知晓率却较低；而且有关FPIES 病理生理学,诊断和治疗的高质量研究数据缺乏；其临床预后尚不明确。这篇国际共识由美国变态反应、哮喘和免疫学会（AAAAI）食物不良反应委员会和国际FPIES 协会宣传组召集组织国际工作组总结撰写。这是第一部基于临床证据的FPIES 国际指南,有助于提高FPIES 的临床诊治水平。当然未来还需要更多有关FPIES 患病率,病理生理学,诊断标志物和未来治疗方法的研究,以便为FPIES 患者提供更好的医疗服务。这些指南内容将会在获得更多证据后定期更新。

关键词：食物蛋白诱导性小肠结肠炎综合征指南非IgE 介导的食物过敏

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