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Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2970-2983页

作者： Qi Yang Bao Xue Fengjiang Liu Yongzhi Lu jielin Tang Mengrong Yan Qiong Wu Ruyi Chen Anqi Zhou Lijie Liu junjun Liu Changbin qu Qingxin Wu Muqing Fu jiayi Zhong jianwei Dong Sijie Chen Fan Wang Yuan Zhou jie Zheng Wei Peng jinsai Shang Xinwen Chen Guangzhou National Laboratory Guangzhou 510005China State Key Laboratory of Respiratory Disease Guangzhou Medical UniversityGuangzhou 511436China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China GMUGIBH joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 511436China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmaceutical Science and Technology Hangzhou lnstitute for Advanced StudyUCASHangzhou 310024China

Respiratory syncytial virus(RSV)is the major cause of bronchiolitis and pneumonia in young children and the *** are currently no approved RSV-specific therapeutic small molecules *** high-throughput antiviral screening,we identified an oral drug,the prenylation inhibitor lonafarnib,which showed potent inhibition of the RSV fusion *** exhibited antiviral activity against both the RSV A and B genotypes and showed low cytotoxicity in HEp-2 and human primary bronchial epithelial cells(HBEC).Time-of-addition and pseudovirus assays demonstrated that lonafarnib inhibits RSV entry,but has farnesyltransferase-independent antiviral ***-electron microscopy revealed that lonafarnib binds to a triple-symmetric pocket within the central cavity of the RSV F metastable pre-fusion *** at the RSV F sites interacting with lonafarnib showed resistance to lonafarnib but remained fully sensitive to the neutralizing monoclonal antibody ***,lonafarnib dose-dependently reduced the replication of RSV in BALB/c ***,lonafarnib could be a potential fusion inhibitor for RSV infection.

关键词： neutral metastable approved

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体积脉动注塑rPE-HD/rPET混杂体系结构性能演变

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中国塑料 2024年第8期38卷 1-7页

作者：梁济峰瞿金平华南理工大学机械与汽车工程学院聚合物新型成型装备国家工程研究中心聚合物成型加工工程教育部重点实验室广东省高分子先进制造技术及装备重点实验室广州510640

以常见的废弃塑料制品组分高密度聚乙烯(PE-HD)、聚对苯二甲酸乙二醇酯(PET)为实验材料,设置两者的混杂比例为9/1、8/2和7/3,利用螺杆挤出机多次重复熔融再生,并利用体积脉动注塑成型工艺制备增强增韧的混杂塑料回收制品,实现多次回收... 详细信息

以常见的废弃塑料制品组分高密度聚乙烯(PE-HD)、聚对苯二甲酸乙二醇酯(PET)为实验材料,设置两者的混杂比例为9/1、8/2和7/3,利用螺杆挤出机多次重复熔融再生,并利用体积脉动注塑成型工艺制备增强增韧的混杂塑料回收制品,实现多次回收制品力学性能的显著提高。分析了不同注塑工艺对样品微观结构的影响机理,证明了体积脉动注塑成型引入的脉动应力场能有效提高不相容组分间的相容性,诱导掺杂相原位成纤和材料结晶形态的改变,构建互联杂化串晶结构。力学测试结果表明,在PE-HD和PET的混杂比例为9/1时,体积脉动注射成型制备的混杂回收材料屈服强度和冲击韧性达38.7 MPa和165 k j/m^(2),与稳态注射相比有54.8%和3675.7%的提升。混杂比例为7/3时,样品的屈服强度和冲击韧性为31.0 MPa和11.6 k j/m^(2),与稳态注射相比仍有14.8%和216.1%的提升。

关键词：体积脉动注塑成型物理回收高密度聚乙烯增强增韧脉动应力场

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顾及特征离散程度的SEaTH特征优化选择方法

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测绘学报 2024年第1期53卷 20-35页

作者：瞿伟王宇豪王乐李久元李达长安大学地质工程与测绘学院陕西西安 710054

特征选择是面向对象信息提取的关键步骤之一.本文针对分离阈值(separability and threshold,SEaTH)这一特征选择方法在实际应用中存在的不足,例如未考虑特征值的离散程度,仅利用j-M距离评判单一特征,特征间可能存在较强相关性,以及无法... 详细信息

特征选择是面向对象信息提取的关键步骤之一.本文针对分离阈值(separability and threshold,SEaTH)这一特征选择方法在实际应用中存在的不足,例如未考虑特征值的离散程度,仅利用j-M距离评判单一特征,特征间可能存在较强相关性,以及无法有效确定出分类顺序,提出了一种改进的SEaTH算法(optimized SEaTH,OPSEaTH).OPSEaTH 算法首先在j-M 距离基础上构建了一类特征评价指标(E值),有效解决了特征值的离散度问题;然后,基于E值构建出特征组合评价指标(C,值),可有效评估得到每种地物的最佳特征组合并自动确定出地物的分类顺序;最后基于eCognition等分类器可完成对地物对象的最终有效分类.利用高分二号遥感影像数据对本文方法进行了测试,并将结果分别与SEaTH算法、DPC、OIF和最近邻分类器的分类结果进行了对比,结果表明:OPSEaTH算法不仅能有效降低特征维数、优化特征空间,还能够对分类顺序进行自动化合理确定,总体精度和Kappa系数及其他精度指标,均显著优于基于SEaTH算法的特征选择结果.本文方法无论从特征降维效果、分类结果精度还是计算效率方面均优于DPC、OIF和最近邻分类器结果.OPSEaTH是一种更优的特征选择方法.

关键词： SEaTH算法特征选择离散系数特征组合分类顺序改进SEaTH算法

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One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*reaction reaction

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Nuclear Science and Techniques 2024年第6期35卷 120-129页

作者： Gao-Long Zhang Zhen-Wei jiao Guang-Xin Zhang E.N.Cardozo B.Paes Shi-Peng Hu jian-Qiang Qian Daniele Mengoni Wei-Wei qu Cong-Bo Li Yun Zheng Huan-Qiao Zhang Hui-Bin Sun Nan Wang Chun-Lei Zhang j.j.Valiente-Dobón D.Testov M.Mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou M.La Commara A.Goasduff D.Bazzacco D.R.Napoli F.Galtarossa F.Recchia A.Illana S.Bakes I.Zanon S.Aydin Gde Angelis M.Siciliano R.Menegazzo S.M.Lenzi S.Akkoyun L.F.Canto j.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil Laboratorio TANDAR Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for Advanced Study in Nuclear Energy and Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPaduaItaly Dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Laboratori Nazionali di Legnaro INFN35020 LegnaroItaly INFN Sezione di Napoli80126 NaplesItaly Dipartimento di Farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly Department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics Division Argonne National LaboratoryLemontILUSA Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li and^(209)Bi was studied at 28,30,and 34 MeV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)Li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 Li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)Li,^(5)Li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei Cross section

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Generating optical supercontinuum and frequency comb in tenuous plasmas

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Matter and Radiation at Extremes 2021年第5期6卷 13-22页

作者： Kenan qu Nathaniel j.Fisch Department of Astrophysical Sciences Princeton UniversityPrincetonNew Jersey 08544USA

There are several mechanisms by which the frequency spectrum of a laser broadens when it propagates at near-relativistic intensity in a tenuous *** on one-dimensional effects,we identify two strong optical nonlinearities,namely,four-wave mixing(FWM)and forward Raman scattering(FRS),for creating octave-wide *** dominates the interaction when the laser pulse is short and intense,and its combination with phase modulation produces a symmetrically broadened *** dominates when the laser pulse is long and relatively weak,and it broadens the laser spectrum mainly toward lower frequencies and produces a frequency *** frequency chirping combined with group velocity dispersion compresses the laser pulse,causing higher peak intensity.

关键词： optical spectra scattering

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风化过程中铼和硒的活动性及其对化石有机碳风化的指示

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中国科学：地球科学 2024年第3期54卷 760-770页

作者：张玉红汪进曲远馨朱超金章东中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710061 中国科学院大学北京100049 西安地球环境创新研究院西安710061 西安交通大学全球环境变化研究院西安710049

化石有机碳风化是地质时间尺度上重要的碳源,对全球碳循环和气候变化具有重要影响,但如何量化一直是个挑战.河水铼(Re)含量的变化被认为具有示踪流域化石有机碳风化强度的潜力,然而Re的来源及其与化石有机碳风化之间的关系还知之甚少.... 详细信息

化石有机碳风化是地质时间尺度上重要的碳源,对全球碳循环和气候变化具有重要影响,但如何量化一直是个挑战.河水铼(Re)含量的变化被认为具有示踪流域化石有机碳风化强度的潜力,然而Re的来源及其与化石有机碳风化之间的关系还知之甚少.为了更好地认识这一指标的有效性,本文选择重庆市城口县下寒武统水井沱组页岩风化剖面为研究对象,通过元素含量、逐级提取实验等分析,探讨页岩风化序列中Re和硒(Se)的活动性及其与化石有机碳风化的关系.结果表明,化学蚀变指数(CIA)从基岩到风化层逐步升高,指示增强的风化强度.根据逐级提取实验和质量迁移系数(τ)的变化发现,页岩中的Re和Se主要赋存于有机质相,风化过程中与化石有机碳同步流失,而与页岩中的硫化物矿物氧化无明显相关;风化过程中Re和Se不同的地球化学行为导致其与化石有机碳非等量流失.本研究支持Re作为示踪化石有机碳风化的指标,而Se是示踪化石有机碳风化的潜在指标.未来需要不同类型沉积岩剖面与流域相结合的研究,明确河水Re和Se的来源及其与流域化石有机碳风化之间的关系.

关键词： Re和Se 页岩活动性化石有机碳化学风化

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PREPARATION　AND　CHARACTERIZATION　OF　NIOBIUM－CONTAINING　DIMOLYBDO－15－TUNGSTODIPHOS－PHORIC　SALT

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Chinese Chemical Letters 1996年第2期7卷 199-200页

作者： Gong, j qu, LY NE NORMAL UNIV DEPT CHEMCHANGCHUN 130024PEOPLES R CHINA

Preparation of P2W15M15Mo2NbO627- was reported in the paper. It was characterized by elementry analysis, IR,UV, polarography, 183 W-NMR and XPD spectra. All results showed the structure of the heteropoly anion was the...

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Recent Trends in Satellite-Derived Chlorophyll and Aerosol Optical Depth Together with Simulated Dimethylsulfide in the Eastern China Marginal Seas

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journal of Ocean University of China 2022年第2期21卷 486-498页

作者： qu Bo GABRIC Albert j. School of Science Nantong UniversityNantong 266000China School of Environment and Science Griffith UniversityBrisbaneQLDAustralia

The biogenic compound dimethylsulfide(DMS)produced by a range of marine biota is the major natural source of re-duced sulfur to the atmosphere and plays a major role in the formation and evolution of aerosols,potentially affecting *** spatio-temporal distribution of satellite-derived chlorophyll_a(CHL)and aerosol optical depth(AOD)for the recent years(2011-2019)in the Eastern China Marginal Seas(ECMS)(25°-40°N,120°-130°E)are *** seasonal CHL peaks occurred during late April and the CHL distribution displays a clear zonal *** CHL was also observed along the northern and western coastlines during summer and winter *** analysis shows that mean CHL decreases by about 10%over the 9-year study period,while AOD was higher in south and lower in north during summertime.A genetic algorithm technique is used to calibrate the key model parameters and simulations are carried out for 2015,a year when field data was *** simulation results show that DMS seawater concentration ranges from 1.56 to 5.88 nmol L^(−1) with a mean value of 2.76 nmol L^(−1).DMS sea-air flux ranges from 2.66 to 5.00mmol m^(−2) d^(−1) with mean of 3.80mmol m^(−2) d^(−1).Positive correlations of about 0.5 between CHL and AOD were found in the study region,with higher correlations along the coasts of jiangsu and Zhejiang *** elevated CHL concentration along the west coast is correlated with increased sea-water concentrations of DMS in the *** results suggest a possible influ-ence of DMS-derived aerosol in the local ECMS atmosphere,especially along the western coastline of ECMS.

关键词： dimethylsulfide sea-to-air flux chlorophyll-a aerosol optical depth biogeochemical model Eastern China Marginal Seas

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改进粒子群算法在柔性车间调度问题的研究

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机械设计与制造 2024年第7期 227-231页

作者：曲鹏举唐向红贵州理工学院工程训练中心贵州贵阳550000 贵州大学现代制造教育部重点实验室贵州贵阳550000

为了减少柔性作业车间调度问题加工时间,通过前景理论构建柔性作业车间加工满意度数学模型,以降低加工时间为目标,设计了一种惯性权重幂函数调节的改进粒子群算法(PPSO),该算法惯性权重能够幂函数自适应调节,学习因子能够发生相应的递... 详细信息

为了减少柔性作业车间调度问题加工时间,通过前景理论构建柔性作业车间加工满意度数学模型,以降低加工时间为目标,设计了一种惯性权重幂函数调节的改进粒子群算法(PPSO),该算法惯性权重能够幂函数自适应调节,学习因子能够发生相应的递减或递增变化平衡算法的全局探索和局部开发能力。选取BRdata与Kacem经典算例,通过与人工免疫算法(AIA)和整合模拟退火算法(ISA)的进行仿真比较,PPSO加工时间较短;在工件数j=25、可用机器数M=16、迭代次数600情况下比较BRdata算例,PPSO加工时间相较AIA、ISA算法分别缩短了21.61%和4.32%,验证结果表明PPSO算法在柔性车间调度问题中降低产品加工时间的有效性。

关键词：改进粒子群算法柔性作业车间调度前景理论惯性权重幂函数加工时间

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Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 1-12页

作者： Chen, Si Zhang, Zhengyuan Wang, Qian Yang, Qi Yin, Li Ning, Lishan Chen, Zhilong Tang, jielin Deng, Weiqi He, Ping Li, Hengchun Shi, Linjing Deng, Yijun Liu, Zijian Bu, Hemeng Zhu, Yaohui Liu, Wenming qu, Linbing Feng, Liqiang Xiong, Xiaoli Sun, Baoqing Zhong, Nanshan Li, Feng Li, Pingchao Chen, Xinwen Chen, Ling Guangzhou Med Univ Guangzhou Peoples Hosp 8 Guangzhou Inst Infect Dis Guangzhou Peoples R China Guangzhou Natl Lab Guangzhou Peoples R China Chinese Acad Sci Guangzhou Inst Biomed & Hlth Ctr Cell Lineage Res State Key Lab Resp Dis Guangzhou Peoples R China Guangzhou Med Univ Affiliated Hosp 1 Guangzhou Inst Resp Hlth Natl Clin Res Ctr Resp DisState Key Lab Resp Dis Guangzhou Peoples R China Univ Chinese Acad Sci Beijing Peoples R China Xiamen United Inst Resp Hlth Xiamen Peoples R China

The upper respiratory tract is the initial site of SARS-CoV-2 infection. Nasal spike-specific secretory immunoglobulin A (sIgA) correlates with protection against Omicron breakthrough infection. We report that intranasal vaccination using human adenovirus serotype 5 (Ad5) vectored Omicron spike in people who previously vaccinated with ancestral vaccine could induce robust neutralizing sIgA in the nasal passage. Nasal sIgA was predominantly present in dimeric and multimeric forms and accounted for nearly 40% of total proteins in nasal mucosal lining fluids (NMLFs). A low-level IgG could also be detected in NMLFs but not IgM, IgD, and IgE. After a complete nasal wash, sIgA in the nasal passage could be replenished rapidly within a few hours. A comparison of purified paired serum IgA, serum IgG, and nasal sIgA from the same individuals showed that sIgA was up to 3-logs more potent than serum antibodies in binding to spikes and in neutralizing Omicron subvariants. Serum IgG and IgA failed to neutralize XBB and BA.2.86, while nasal sIgA retained potent neutralization against these newly emerged variants. Further analysis showed that sIgA was more effective than IgG or IgA in blocking spike-mediated cell-to-cell transmission and protecting hACE2 mice from XBB challenge. Using a sIgA monoclonal antibody as a reference, we estimated that the total nasal sIgA contains about 2.6-3.9% spike-specific sIgA in NMLFs collected approximately one month after intranasal vaccination. Our study provided insights for developing intranasal vaccines that can induce sIgA to build an effective and mutation-resistant first-line immune barrier against constantly emerging variants.

关键词： MUCOSAL IGA

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