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Removal of phenol by activated alumina bed in pulsed high-voltage electric field

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journal of Environmental Sciences 2007年第4期19卷 409-415页

作者： zhu Li-nan MA jun YAng Shi-dong School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China

A new process for removing the pollutants in aqueous solution-activated alumina bed in pulsed high-voltage electric field was investigated for the removal of phenol under different conditions. The experimental results indicated the increase in removal rate with increasing applied voltage, increasing pH value of the solution, aeration, and adding Fe^2＋. The removal rate of phenol could reach 72.1% when air aeration flow rate was 1200 ml/min, and 88.2% when 0.05 mmol/L Fe^2＋ was added into the solution under the conditions of applied voltage 25 kV, initial phenol concentration of 5 mg/L, and initial pH value 5.5. The addition of sodium carbonate reduced the phenol removal rate. In the pulsed high-voltage electric field, local discharge occurred at the surface of activated alumina, which promoted phenol degradation in the thin water film. At the same time, the space-time distribution of gas-liquid phases was more uniform and the contact areas of the activated species generated from the discharge and the pollutant molecules were much wider due to the effect of the activated alumina bed. The synthetical effects of the pulsed high-voltage electric field and the activated alumina particles accelerated phenol degradation.

关键词： pulsed high-voltage electric field hybrid gas-liquid electrical discharge activated alumina phenol Fenton's reaction water treatment

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基于共同体视角的高职院校实践育人模式探究

职业技术 2025年第1期24卷 55-61页

作者：张楠朱其志张龙江苏农牧科技职业学院江苏泰州225300

实践育人是新时代高职院校落实“三全育人”的重要举措,是培养全面发展的人才的有效途径。高职院校要深刻认识实践育人的本质内涵及其实践性、主体性、系统性、开放性、情境性、创造性、价值性等基本特征,客观分析近年来实践育人存在的... 详细信息

实践育人是新时代高职院校落实“三全育人”的重要举措,是培养全面发展的人才的有效途径。高职院校要深刻认识实践育人的本质内涵及其实践性、主体性、系统性、开放性、情境性、创造性、价值性等基本特征,客观分析近年来实践育人存在的现实问题,探索实施基于共同体视角的实践育人新模式,提出相应的策略选择,提升实践育人实效。

关键词：共同体实践育人基本特征育人模式

A novel particle filter approach for indoor positioning by fusing WiFi and inertial sensors

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Chinese journal of Aeronautics 2015年第6期28卷 1725-1734页

作者： zhu nan Zhao Hongbo Feng Wenquan Wang Zulin School of Electronics and Information Engineering Beihang University

WiFi fingerprinting is the method of recording WiFi signal strength from access points （AP） along with the positions at which they were recorded, and later matching those to new mea- surements for indoor positioning. Inertial positioning utilizes the accelerometer and gyroscopes for pedestrian positioning. However, both methods have their limitations, such as the WiFi fluctuations and the accumulative error of inertial sensors. Usually, the filtering method is used for integrating the two approaches to achieve better location accuracy. In the real environments, especially in the indoor field, the APs could be sparse and short range. To overcome the limitations, a novel particle filter approach based on Rao Blackwellized particle filter （RBPF） is presented in this paper. The indoor environment is divided into several local maps, which are assumed to be independent of each other. The local areas are estimated by the local particle filter, whereas the global areas are com- bined by the global particle filter. The algorithm has been investigated by real field trials using a WiFi tablet on hand with an inertial sensor on foot. It could be concluded that the proposed method reduces the complexity of the positioning algorithm obviously, as well as offers a significant improvement in position accuracy compared to other conventional algorithms, allowing indoor positioning error below 1.2 m.

关键词： Fusion algorithm Indoor positioning Inertial sensor Rao Blackwellized par ticle filter WiFi fingerprinting

Predictability and skill of convection-permitting ensemble forecast systems in predicting the record-breaking“21·7”extreme rainfall event in Henan Province,China

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Science China Earth Sciences 2022年第10期65卷 1879-1902页

作者： Kefeng zhu Chenyue ZHAng Ming XUE nan YAng Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China Key Laboratory of Mesoscale Severe Weather/Ministry of Education and School of Atmospheric Sciences Nanjing UniversityNanjing 210093China Center for Analysis and Prediction of Storms and School of Meteorology University of Oklahoma Norman Oklahoma 73072USA

During 19–21 july 2021,an extreme rainfall event occurred in Henan Province,China,during which a recordbreaking maximum hourly rainfall of 201.9 mm was recorded in Zhengzhou at 09 UTC july *** this study,the predictability of this extreme rainfall event is investigated using two convection-permitting ensemble forecast systems(CEFSs):one initialized from NCEP GEFS(named CEFS_GEFS)and the other initialized from time-lagged ERA5 data(named CEFS_ERA).Both are able to reproduce the daily heavy rainfall along the Taihang Mountains,but most members have significant position biases for the extreme rainfall in *** the hourly rainfall,a few members are able to capture the evolution and propagation of extreme ***,all ensemble members underestimate the extreme hourly rainfall and have position errors of a few tens to a few hundreds of *** results suggest that the predictability of the extreme hourly rainfall at the accuracy of city scale in Zhengzhou is low,especially by deterministic forecasting models,and the occurrence of the extreme requires many favorable conditions to happen *** terms of the Brier score,CEFS_GEFS performs better than CEFS_*** latter lacks spread,especially in regions with scarce rain,resulting in less dispersion in precipitation distributions and larger probability forecast *** a neighborhood is applied,the probability of precipitation(POP)is significantly increased over *** the traditional POP shows almost no skill for hourly rainfall≥25 mm h-1,the neighborhood POP significantly improves the forecast skill score,for both daily and hourly rainfall,suggesting higher predictability when spatial error among the ensemble members is allowed.

关键词： Convective-permitting ensemble forecasts Neighborhood precipitation probability Extreme rainfall

Hierarchical-Based Object Detection with Improved Locality Sparse Coding

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Chinese journal of Electronics 2016年第2期25卷 290-295页

作者： zhu Suguo DU junping REN nan LIAng Meiyu Beij.ng Key Laboratory of Intelligent Telecommunication software and Multimedia School of Computer ScienceBeijing University of Posts and Telecommunications

This paper proposes to extend the hierarchical method to be adapted to sequential frames, aiming at detecting the moving object in dynamic scenes. A novel two-layer model is proposed, in which dictionaries are learned through three different stages and the locality constrained sparse representation is improved. This leads more significant improvement for performance of both static image classification and moving object detection. The experimental results demonstrate that the proposed algorithm is efficient and robust compared with the state-of-the-art classification methods, and also able to detect moving object in the sequential frames accurately.

关键词： Hierarchical detection Sparse coding Classification Object detection

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li jianhua Huang Di Zhao Lemei zhu Zheyu Zhang Min Yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Coking wastewater increases micronucleus frequency in mouse in vivo via oxidative stress

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journal of Environmental Sciences 2013年第10期25卷 2123-2129页

作者： Na zhu Hongyan Li Guangke Li nan Sang College of Environment and Resource Center of Environmental Science and Engineering Shanxi University

Coking wastewater has caused serious health risk in coal-producing areas of China, however its toxic effects have not been well understood. The genotoxicity induced by coking wastewater on mice in vivo and its possible oxidative mechanisms were investigated via observing the induction of micronuclei in polychromatic erythrocytes of mouse bone marrow, and subsequently determining the antioxidative enzyme activities （superoxide dismutase Cu, Zn-SOD, Se-dependent glutathione peroxidase, and catalase）, thiobarbituric acid reactive substance contents and protein carbonyl levels in brains and livers of mice. Results showed that the tested coking wastewater caused a significant increase of micronucleus frequencies in a concentration-dependent manner. Also, the sample increased lipid peroxidation and protein oxidation levels, which was accompanied by changes in antioxidative status. Interestingly, pre-treatment with an antioxidant （vitamin C） led to a statistical reduction in the micronucleus frequency caused by coking wastewater. This implies that coking wastewater induces evident genetic damage in mammalian cells, and exposure to polluted areas might pose a potential genotoxic risk to human beings; in the process, oxidative stress played a crucial role.

关键词： micronucleus oxidative stress coking wastewater mouse bone marrow

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei zhu Lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： j.ng Li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan