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Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning

Signal Transduction and Targeted Therapy 2019年第1期4卷 636-647页

作者： Eliseos j.Mucaki j.nathan z.l.zhao Daniel j.lizotte Peter K.Rogan Department of Biochemistry Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Department of Computer Science Faculty of ScienceWestern UniversityLondonON N6A 2C1Canada Department of Epidemiology&Biostatistics Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada Cytognomix Inc.LondonON N5X 3X5Canada Department of Oncology Schulich School of Medicine and DentistryWestern UniversityLondonON N6A 2C1Canada

The selection of effective genes that accurately predict chemotherapy responses might improve cancer *** compare optimized gene signatures for cisplatin,carboplatin,and oxaliplatin responses in the same cell lines and validate each signature using data from patients with *** support vector machine learning is used to derive gene sets whose expression is related to the cell line GI 50 values by backwards feature selection with *** genes and functional pathways distinguishing sensitive from resistant cell lines are identified by contrasting signatures obtained at extreme and median GI 50 *** of gene signatures at different thresholds are combined to reduce the dependence on specific GI 50 values for predicting drug *** most accurate gene signatures for each platin are:cisplatin:BARD1,BCl2,BCl2l1,CDKN2C,FAAP24,FEN1,MAP3K1,MAPK13,MAPK3,NFKB1,NFKB2,SlC22A5,SlC31A2,TlR4,and TWIST1;carboplatin:AKT1,EIF3K,ERCC1,GNGT1,GSR,MTHFR,NEDD4l,NlRP1,NRAS,RAF1,SGK1,TIGD1,TP53,VEGFB,and VEGFC;and oxaliplatin:BRAF,FCGR2A,IGF1,MSH2,NAGK,NFE2l2,NQO1,PANK3,SlC47A1,SlCO1B1,and *** from The Cancer Genome Atlas(TCGA)patients with bladder,ovarian,and colorectal cancer were used to test the cisplatin,carboplatin,and oxaliplatin signatures,resulting in 71.0%,60.2%,and 54.5%accuracies in predicting disease recurrence and 59%,61%,and 72%accuracies in predicting remission,*** cisplatin signature predicted 100%of recurrence in non-smoking patients with bladder cancer(57%disease-free;N=19),and 79%recurrence in smokers(62%disease-free;N=35).This approach should be adaptable to other studies of chemotherapy responses,regardless of the drug or cancer types.

关键词： bladder chemotherapy signature

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PREPARATION AND CORROSION RESISTANCE OF NiP/TiO_2 COMPOSITE FIlM ON CARBON STEEl IN SUlFURIC ACID SOlUTION

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Acta Metallurgica Sinica(English letters) 2006年第2期19卷 117-123页

作者： l.z. Song S.z. Song j. zhao School of Environment ＆ Chemical Engineering Yanshan University Qinhuangdao 066004 China School of Materials Science and Engineering Tianjin University Tianjin 300072 China

A NiP/TiO2 composite film on carbon steel was prepared by electroless plating and sol-gel composite process. An artificial neural network was applied to optimize the prepared condition of the composite film. Corrosion behavior of the NiP/TiO2 composite film was investigated by polarization resistance measurement, anode polarization, ESEM （environmental scanning electron microscopy） and EIS （electrochemical impedance spectroscopy） measurements. Results showed that the NiP/ TiO2 composite film has a good corrosion resistance in 0.5mol/l H2SO4 solution. The element valence of the composite film was characterized by XPS （X-ray photoelectron spectroscopy） spectrum, and an anticorrosion mechanism of the composite film was discussed.

关键词： electroless plating and sol-gel composite process artificial neural network NiP/TiO2 composite film corrosion resistance

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Numerical study of the circular opening effect on mechanical behaviour of rock under confinement

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journal of Rock Mechanics and Geotechnical Engineering 2019年第6期11卷 1201-1210页

作者： Y.l.Gui j.l.Shang j.j.Ma z.Y.zhao school of engineering newcastle universitynewcastle upon tynene17ruunited kingdom school of civil and environmental engineering nanyang technological university639798singapore school of civil engineering sun yat-sen universityguangzhou510275china

Opening holes in rock including their size and distribution can affect the performance of rock-related structures.A good understanding on this will contribute to,for example,rock cavern design,and construction,tunnelling,and mining *** improve the understanding,a comprehensive investigation of the opening hole effect on the rock mechanical behaviour under biaxial loading condition is carried out by virtue of a hybrid continuum-discrete element *** specimens with both single hole and multi-hole of various radii are investigated and compared with the cases subjected to uniaxial *** is demonstrated that the confining pressure can increase both the stiffness and strength due to delaying the crack initiation and *** increase due to the confining pressure is more evident for the compressive *** single hole specimens with 0.75 mm radius hole,the increase ratio of the compressive strength is a linear increasing function with width and the increase ratio ranges from 2.15 for the specimen with 3.5 mm width to 2.45 for 10 mm *** the single hole specimen with 10 mm width,the increase ratio starts at 2.13 for the specimen with 0.75 mm radius hole,ascending to the peak of 2.37 for the specimen with 1 mm radius hole,followed by a decline to 2.2 for the specimen with 1.25 mm radius ***,for the multi-hole specimens,the increase ratio varies from 1.66 to *** addition,to verify the influence of confining pressure magnitude on the performance of the rock specimens,totalling 10 confining pressure levels are applied and *** simulation results show that even though there are opening holes in the specimens,the simulated compressive strength generally follows the generalised Hoek-Brown model.

关键词： Rock with opening Simulation Biaxial loading Strength Stiffness

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Phase transition and dynamics of iron under ramp wave compression

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Acta Mechanica Sinica 2018年第5期34卷 902-909页

作者： T.Chong z.P.Tang F.l.Tan G.j.Wang j.H.zhao Department of Modern Mechanics University of Science and Technology of ChinaHefei 230027China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621999China

The ramp wave compression experiments of iron with different thicknesses were performed on the magnetically driven ramp loading device *** simulations of this process were done with Hayes multi-phase equation of state (H-MEOS) and dynamic equations of phase *** calculated results of H-MEOS are in good agreement with those of shock phase transition,but are different from those under ramp wave *** reason for this is that the bulk modulus of the material in the Hayes model and the wave velocity are considered *** compression is a jump from the initial state to the final state,and the sound speed is related to the slope of the Rayleigh ***,ramp compression is a continuous process,and the bulk modulus is no longer a constant but a function of pressure and *** on Mumaghan equation of state,the first-order correction of the bulk modulus on pressure in the Hayes model was carried *** numerical results of the corrected H-MEOS agree well with those of pure iron in both ramp and shock compression phase transition *** calculated results show that the relaxation time of iron is about 30 ns and the phase transition pressure is about 13 *** are obvious differences between the isentropic and adiabatic process in terms of pressure-specific volume and *** fluctuation of the sound speed after 13 GPa is caused by the phase transition.

关键词： Ramp wave compression Polymorphic phase transition Multiphase equation of state Sound speed

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Microstructural softening induced adiabatic shear banding in Ti-23Nb-0.7Ta-2zr-O gum metal

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journal of Materials Science & Technology 2020年第19期54卷 31-39页

作者： Silu liu Y.z.Guo z.l.Pan X.z.liao E.j.lavernia Y.T.zhu Q,M,Wei Yonghao zhao Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Engineering University of North Carolina at CharlotteNC 28223-0001USA School of Aerospace Mechanical and Mechatronic EngineeringThe University of SydneyNSW 2006Australia Department of Materials Science and Engineering University of Californi1IrvineCA 92697USA Department of Materials Science and Engineering North Carolina State UniversityNC 27695USA

Ti-23Nb-0.7Ta-2zr-O gum metal(GM)is an attractive candidate material for applications that require superior mechanical *** our earlier investigation of the GM[1],geometrical softening and the generation of adiabatic shear bands(ASBs)were proposed as primary reasons for the documented anisotropic impact *** the present study,electron backscattered diffraction(EBSD)analysis reveals two different deformed microstructures,i.e.,deformed ultrafine grains(UFGs)and dynamically recrystallized UFGs,formed in the ASBs of GM samples processed by extrusion equal channel angular pressing(ECAP),*** calculation of temperature rise during dynamic compression suggests that the above microstructure differences in the ASBs was originated from their different maximum ASB temperatures(608 K for extruded GM and 1159 K for ECAP-processed GM).Moreover,our calculation on the temperature at the onset of ASBs indicates that microstructural softening is the primary cause for the development of ASBs in both extruded GM(321 K)and ECAP-processed GM(331 K).

关键词： Gum metal Split hopkinson bar Adiabatic shear band Microstructures

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Effects of Growth Temperature on Structural and Electrical Properties of li-N-H Codoped znO

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journal of Materials Science & Technology 2013年第2期29卷 154-156页

作者： Y.F. lu z.z. Ye l.P. zhu Y.j. zeng j.Y. Huang B.H. zhao State Key laboratory of Silicon Materials Department of Materials Science and Engineering Zhejiang University

Effects of growth temperature on the structural and electrical properties of li-N-H codoped znO thin films grown by DC reactive magnetron sputtering were investigated. Scanning electron microscopy and X-ray diffraction results showed that increasing growth temperature could improve the crystalline quality. But Hall measurement results showed that growth temperature had a nonlinear influence on the electrical property. The variation of electrical properties with the growth temperature was found to be related to the activated concentration of N in znO and the evaporation of li during the growth process, derived from the Hall measurement and the second ion mass spectroscopy measurement.

关键词： znO Codoped Growth temperature Structural property Electrical property

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MODElING OF DYNAMIC RECRYSTAllIzATION OF Ti6A14V AllOY USING A CEllUlAR AUTOMATON APPROACH

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Acta Metallurgica Sinica(English letters) 2008年第4期21卷 260-268页

作者： j.W. zhao H. Ding W.j. zhao F.R. Cao H.l. Hou z.Q. li School of Materials and Metallurgy Northeastern University Shenyang 110004 China Beijing Aeronautical Manufacturing Technology Research Institute Beijing 100024 China

A cellular automaton （CA） model is established to simulate dynamic recrystallization （DRX） in the β single-phase field of Ti6Al4 V alloy, and the kinetics during DRX processing has been analyzed. The model employed considers the influences of dynamic recovery, nucleation rate, strain rate and dislocation density on DRX, and practical deformation parameters, such as temperature, strain and strain rate on DRX have been considered in the simulation. The simulated DRX grain size and DRX grain shape agree well with the experimental results, which shows the availability and lea- sibility of the cellular automaton method for the simulation of DRX. The result of kinetics analysis of DRX reveals that the Avrami exponent is variable ranging from 2.4 to 2.9, which increases with the increase of strain rate.

关键词： Ti6A4 V alloyi Dynamic recrystallization Kinetics Modeling Cellular automaton

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Magneto-Impedance Effect of Composite Wires Prepared by Chemical Plating under DC Current

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Nano-Micro letters 2014年第3期6卷 227-232页

作者： D.l.Chen X.li H.l.Pan H.Y.luan z.j.zhao Department of Physics Engineering Research Center for Nanophotonics & Advanced Instrument Ministry of Education East China Normal University

CuBe composite wires of 100 μm in diameter coated with a layer of NiCoP were prepared by a chemical plating method under DC current(CPUDC). The influences of DC current on coating morphology,deposition rate, composition, giant magneto-impedance(GMI) effect and magnetic properties were *** was shown that the circumferential domain structure of coating layer was induced by the DC current going through the wires. A maximum GMI ratio of 870% was obtained in the composite wire prepared under 150 m A and tested at 180 k Hz. It is 30 times higher than that of the composite wire plated in the same condition by conventional chemical plating method, indicating that CPUDC is an easy and effective approach to obtain composite wires and its applications will be further extended on magnetic sensors.

关键词： GMI Chemical plating Magnetic properties

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Deformation behaviors of as-built and hot isostatically pressed Ti-6Al-4V alloys fabricated via electron beam rapid manufacturing

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journal of Materials Science & Technology 2019年第11期35卷 2552-2558页

作者： z.liu z.B.zhao j.R.liu l.Wang S.X.zhu G.Yang S.l Gong Q.j.Wang R.Yang institute of metal research chinese academy of sciencesshenyang110016china school of materials science and engineering university of science and technology of chinahefei230000china avic manufacturing technology institute beijing100024china

The deformation behavior of as-built and hot isostatically pressed(HIP)Ti-6Al-4V alloys fabricated using electron beam rapid manufacturing(EBRM)were investigated in this *** deformation characteristics were characterized using a laser scanning confocal microscope and electron back-scattered diffraction(EBSD).In the as-built sample,prismatic slip was the main mode of deformation,as well as a small amount of basal slip and *** planar slip lines with large length scales were observed across severalα*** hot isostatical pressing,prismatic and basal slip were the main mode of deformation,accompanied by abundant cross-slip and multiple slip,and most of the slip lines were blocked within an a *** differences in deformation behavior were associated with the coarsening of a laths and the more retained p phase after HIP compared to the as-built *** cross-slip and multiple slip can lead to superior elongation-to-failure and a greater strain hardening effect in the HIP alloy compared to the as-built sample.

关键词： Electron beam rapid manufacturing Ti-6Al-4V Hot isostatic pressure Mechanical properties Slip behavior

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Giant Magneto-impedance Effect in Composite Wires with Different Core layer

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Nano-Micro letters 2013年第2期5卷 140-144页

作者： R.l.Wang X.li X.H.Kong Y.X.Guo j.z.Ruan z.j.zhao Department of Physics Engineering Research Center for Nanophotonics & Advanced Instrument Ministry of Education East China Normal University Experimental Teaching Center of Physics Shanghai Ocean University

Composite structure materials were potential sensing elements for magnetic sensors due to Giant magnetoimpedance(GMI) effect. Two kinds of composite wires with different magnetic/non-magnetic structures were fabricated by using electroless deposition methods and the magnetoimpedance properties were investigated. The maximum GMI ratio of 114% was acquired at 60 MHz in the composite wires with a ferromagnetic core, whereas, 116% of maximum GMI ratio was found in the composite wires with a conductive core at low frequency of 600 k Hz. These results exhibit that the GMI ratio reaches the maximum when magnetoresistance ratio ?R/R and magnetoinductance ratio ?X/X make the comparative contributions to the total magnetoimpedance(MI). The obvious GMI effect obtained in the composite wires with conductive core frequency may provide a candidate for applications in magnetic sensors, especially at low frequencies.

关键词： Composite wires Electroless deposition Giant Magnetoimpedance effect Resistivity

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