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Author Correction:Protein-based profiling of the human IgA1 clonal repertoire revealed shared clones of serum polymeric IgA1 and milk secretory IgA1

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Cellular & Molecular Immunology 2023年第3期20卷 310-310页

作者： jan Novak Matthew B.Renfrow R.Glenn King Colin Reily todd j.Green department of Microbiology University of Alabama at Birmingham Birmingham AL USA department of Medicine University of Alabama at Birmingham Birmingham AL USA department of Biochemistry and Molecular Genetics University of Alabama at Birmingham Birmingham AL USA

In the sentence beginning"H chain genes are assembled from one functional variable(B),one diversity(d),and.."in this article,the text should have read"H chain genes are assembled from one functional variable(M),one di... 详细信息

关键词： IgA1 secretory serum

儿童阑尾穿孔以及阴性阑尾切除术的危险与医院、患者特征

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美国医学会杂志（中文版） 2006年第1期25卷 11-16页

作者： todd A. Ponsky Zhihuan j. Huang Kory Kittle Martin R. Eichelberger james C. Gilbert Fredrick Brody Kurt d, Newman 周静（译）祝学光（校） departments of Surgery departments of Surgery and Biostatistics Children＇s National Medical Center and George Washington University Medical Center Washington DC and Child Health Corporation of America Overland Park Kan 不详

背景：即使作了努力，儿童阑尾穿孔和阴性阑尾切除术的发生率依然居高不下。这两种结局均被用作衡量医院质量的指标。对影响其发生率的因素还知之甚少。目的：研究儿童阑尾穿孔和阴性阑尾切除术的发生率与医院、患者特征的相关性。设计... 详细信息

背景：即使作了努力，儿童阑尾穿孔和阴性阑尾切除术的发生率依然居高不下。这两种结局均被用作衡量医院质量的指标。对影响其发生率的因素还知之甚少。目的：研究儿童阑尾穿孔和阴性阑尾切除术的发生率与医院、患者特征的相关性。设计、地点和患者：利用儿童健康信息系统数据库，对1997～2002年美幽36家儿童医院24411例5—17岁行阑尾切除术患者的资料进行同顾性分析。主要结局指标：阴性阑尾切除术和阑尾穿孔的发生率；不同医院、年龄、种族、健康保险状况以及医院财政年度和阑尾切除术数量下，阴性阑尾切除术、阑尾穿孔的优势比（odds ratio，OR）。阴性阑尾切除率的定义为行阑尾切除术但无阑尾炎的例数除以阑尾切除的总例数。结果：中位阴性阑尾切除率为3．06％（范围1％-12％），中位阑尾穿孔的发生率为35．08％（范围22％-62％）。与白种患儿比较，亚洲裔患儿（OR，1．66；95％可信区间[CI]，1．24—2．23）和黑种患儿（OR，1．13；95％CI，1.01—1.30）发生阑尾穿孔的校正后优势比均较高。与拥有个人健康保险的儿童相比较，没有健康保险的患儿以及只有公共保险儿童的阑尾穿孔比例增高（自我保险者：校正后OR，1．36；95％CI，1．22—1．53；公共保险者：校正后OR，1．48；95％CI，1．34—1．64）。阴性阑尾切除率与种族、健康保险状况或医院阑尾穿孔发生率没有相关性。阴性阑尾切除率随着医院阑尾切除数量的增多而有所改善。结论：学龄儿童的阑尾穿孔发生率与种族和健康保险状况相关，而与阴性阑尾切除率无关，因此更可能与某些入院前因素，如是否能得到治疗、治疗的质量以及患者或医生受教育的情况等相关。

关键词：阑尾切除术阑尾穿孔医院质量儿童健康患者特征阴性阑尾切除率健康保险信息系统数据库发生率

Participation in STEM Fields and 2d：4d in University Facultt

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Psychology Research 2015年第9期5卷 497-503页

作者： nathan Omasta Sharon Bertsch Bryan j. Pesta Carlow University Pittsburgh USA University of Pittsburgh atjohnstown Johnstown USA Cleveland State University Cleveland USA

Environmental Stresses Modulate Abundance and Timing of Alternatively Spliced Circadian Transcripts in Arabidopsis

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Molecular Plant 2015年第2期8卷 207-227页

作者： Sergei A. Filichkin jason S. Cumbie Palitha dharmawardhana Pankaj jaiswal jeff H. Chang Saiprasad G. Palusa A.S.N. Reddy Molly Megraw todd C. Mockler department of Botany and Plant Pathology Oregon State University Corvallis OR 97331 USA Center for Genome Research and Biocomputing Oregon State University Corvallis OR 97331 USA department of Biology and Program in Molecular Plant Biology Colorado State University Fort Collins CO 80523 USA donald danforth Plant Science Center Saint Louis MO 63132 USA Co-corresponding author

Environmental stresses profoundly altered accumulation of nonsense mRNAs including intron-retaining （IR） transcripts in Arabidopsis. Temporal patterns of stress-induced IR mRNAs were dissected using both oscillating and non-oscillating transcripts. Broad-range thermal cycles triggered a sharp increase in the long IR CCA1 isoforms and altered their phasing to different times of day. Both abiotic and biotic stresses such as drought or Pseudomonas syringae infection induced a similar increase. Thermal stress induced a time delay in accumulation of CCA1 14Rb transcripts, whereas functional mRNA showed steady oscillations. Our data favor a hypothesis that stress-induced instabilities of the central oscillator can be in part compensated through fluctuations in abundance and out-of-phase oscillations of CCA1 IR transcripts. Taken together, our results support a concept that mRNA abundance can be modulated through altering ratios between functional and nonsense/IR transcripts. SR45 protein specifically bound to the retained CCA1 intron in vitro, suggesting that this sp!icing factor could be involved in regulation of intron retention. Transcriptomes of nonsense-mediated mRNA decay （NMd）-impaired and heat-stressed plants shared a set of retained introns associated with stress- and defense-inducible transcripts. Constitutive activation of certain stress response networks in an NMd mutant could be linked to disequilibrium between functional and nonsense mRNAs.

关键词： Arabidopsis alternative splicing circadian clock intron retention nonsense-mediated mRNA decay(NMd) environmental stress

Search for two-neutrino double-beta decay of 136Xe to the 01+excited state of136Ba with the complete EXO-200 dataset

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Chinese Physics C 2023年第10期47卷 5-13页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau d.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.F.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Craycraft T.daniels L.darroch S.j.daugherty j.davis S.delaquis A.der Mesrobian-Kabakian R.de Voe j.dilling A.dolgolenko M.j.dolinski j.Echevers W.Fairbank jr. d.Fairbank j.Farine S.Feyzbakhsh P.Fierlinger Y.S.Fu d.Fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen j.Hoessl P.Hufschmidt M.Hughes A.Iverson A.jamil C.jessiman M.j.jewell A.johnson A.Karelin L.j.Kaufman T.Koffas R.Krücken A.Kuchenkov K.S.Kumar Y.Lan A.Larson B.G.Lenardo d.S.Leonard G.S.Li S.Li Z.Li C.Licciardi Y.H.Lin R.Mac Lellan T.Mc Elroy T.Michel B.Mong d.C.Moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar F.Retière A.L.Robinson P.C.Rowson j.Runge S.Schmidt d.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.Tarka S.Thibado j.todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel j.-L.Vuilleumier M.Wagenpfeil j.Watkins M.Weber L.j.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia d.R.Yahne L.Yang Y.-R.Yen O.Ya.Zeldovich T.Ziegler EXO-200 Collaboration Physics department McGill University Erlangen Centre for Astroparticle Physics (ECAP) Friedrich-Alexander-University Erlangen-Nürnberg Physics department Carleton University King Abdulaziz City for Science and Technology department of Physics Duke University and Triangle Universities Nuclear Laboratory (TUNL) Physics department University of Illinois Institute for Theoretical and Experimental Physics named by A.I.Alikhanov of National Research Centre “Kurchatov Institute” a division of National Research Center “Kurchatov Institute” department of Physics University of South Dakota department of Physics and Astronomy University of Kentucky SLAC National Accelerator Laboratory TRIUMF Institute of High Energy Physics Witmem Technology Co. Ltd. department of Physics Laurentian University Also at SNOLAB Physics department Colorado State University department of Physics and Physical Oceanography University of North Carolina at Wilmington Physics department and CEEM Indiana University Carleton University Commissariat àl’Energie Atomique et auxénergies alternatives Physics department Stanford University department of Physics Drexel University University of California Amherst Center for Fundamental Interactions and Physics department University of Massachusetts Technische Universit?t München Physikdepartment and Excellence Cluster Universe Qventus department of Physics University of Virginia Physics department University of Maryland department of Physics at the University of California department of Physics and Astronomy University of Alabama Wright Laboratory Department of Physics Yale University department of Physics Princeton University IBS Center for Underground Physics Physics department University of California SNOLAB department of Physics and Astronomy Stony Brook University SUNY SCIPP University of California Institute for Experimental Physics Hamburg University department of Physics and Astronomy Iowa State University Kellogg Lab Caltech LHEP Albert Einstein Center University of Ber

A new search for two-neutrino double-beta(2vββ) decay of136Xe to the 01+excited state of136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase Ⅱ dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2vββ decay to the 01+state of136Ba is 2.9 × 1024yr using a total136Xe exposure of 234.1 kg *** statistically significant evidence for 2vββ decay to the 01+state is observed,leading to a lower limit of T1/22v(0+→01+)>1.4×1024yr at 90% confidence level,improved by 70% relative to the current world’s best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

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婴儿和年长儿童输血指征(续)

国际输血及血液学杂志 2004年第1期27卷 82-87页

作者： Gibson BES,Bolton-Maggs PHB,Pamphilon d,Roberts I,todd A,Rodeck C,durbin duguid j,Boulton F,Cohen H,McClelland dBL,Rowley M,Smith N,Turner G,洪缨英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会英国血液学输血工作委员会成都市血液中心

5 对造血干细胞移植(SCT)、再生障碍性贫血和恶性肿瘤的输血支持5.1 一般观点经高剂量化疗/放疗治疗或所有再生障碍性贫血儿童,可能在将来的某个时候作为SCT的候选人。普遍认为制品白细胞去除低于 5×10～6/单位,CMV 是安全的(见 1.1... 详细信息

5 对造血干细胞移植(SCT)、再生障碍性贫血和恶性肿瘤的输血支持5.1 一般观点经高剂量化疗/放疗治疗或所有再生障碍性贫血儿童,可能在将来的某个时候作为SCT的候选人。普遍认为制品白细胞去除低于 5×10～6/单位,CMV 是安全的(见 1.1.3)。并非所有SCT中心同意。

关键词：输注辐照未足月输血指征心脏外科手术心脏手术浓缩血小板儿童供者血型

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颅内动脉粥样硬化血管内治疗的实践标准

国际脑血管病杂志 2012年第12期20卷 893-904页

作者： M Shazam Hussain justin F Fraser todd Abruzzo Kristine A Blackham Ketan R Bulsara Colin P derdeyn Chirag d Gandhi joshua AHksch daniel P Hsu Mahesh V jayaraman Philip M M eYers Sandra Narayanan Charles j Prestigiacomo Peter A Rasmussen 蔡乾昆(译) 李永坤(译) 刘新峰(译) 代表神经介入外科学学会南方医科大学南京临床医学院南京军区南京总医院神经内科 210002

背景有症状颅内动脉粥样硬化性疾病（intraeranial atherosclerotic disease，ICAd）是全世界范围内最常见的卒中原因之一。研究显示，严重ICAd患者的复发性卒中风险很高，亟需有效的预防手段。药物治疗是治疗ICAd的基础，对所有患者都... 详细信息

背景有症状颅内动脉粥样硬化性疾病（intraeranial atherosclerotic disease，ICAd）是全世界范围内最常见的卒中原因之一。研究显示，严重ICAd患者的复发性卒中风险很高，亟需有效的预防手段。药物治疗是治疗ICAd的基础，对所有患者都至关重要。血管内治疗也是一种潜在的治疗选择，但在最佳的技术和患者选择方面仍需进一步探索。本指南旨在为ICAd患者提供诊断和血管内治疗的推荐意见。方法进行文献回顾，以选#2000年至2011年期间发表的有关ICAd的文献。根据美国心脏协会（AmericanHeartAssociation，AHA）庄荚国卒中协会标准对证据进行评估和分类。在神经介入外科学学会标准委员会对现有证据进行评价的基础上制定推荐意见。按照美国神经病学学会（AmericanAcademyofNeurology，AAN）、AHA卒中委员会以及牛津大学循证医学中心（CentreforEvidenceBasedMedicine，CEBM）建议的循证医学指南进行评估。结果总共选定59篇文献。支架置人术与强化药物治疗预防颅内动脉狭窄患者复发性卒中（StentingversusAggressiveMedicalManagementforPreventingRecurrentStrokeinIntracranial＆enosis。SAMMPRIS）研究是现有的唯一一项前瞻性随机对照试验，文献的证据级别被归类为AHA B级、AANⅡ级和CEBM1b级。有症状椎动脉或颅内动脉粥样硬化性疾病支架置人术（StentingofSymptomaticAtheroscleroticLesionsintheVertebralorIntracranialarteries，SSYLVtA）试验是由独立的神经科医生进行转归评价的一项前瞻性非随机研究，文献的证据级别被归类为AHAB级、AANⅢ级和CEBM2级。其他研究均为非对照性或未进行客观的转归评价，因此证据级别被归类为AHAC级、AAHIV级和CEBM4级。结论对于有症状ICAd患者，阿司匹林＋氯毗格雷联合治疗3个月和强化控制危险因素是一线治疗方案。对于经过选择的有症状ICAd患者，球囊血管成形／支架置入术是一种可供选择的治疗方案。需要进一步研究，以确定合适的患者选择标准以及针对各种亚组患者的最佳治疗方案。

关键词：颅内动脉粥样硬化血管内治疗标准动脉粥样硬化性疾病美国神经病学学会最佳治疗方案复发性卒中随机对照试验

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An Earth-mass planet in a time of COVId-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael d.Albrow Sun-ju Chung Kyu-Ha Hwang Youn Kil jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha dong-jin Kim Hyoun-Woo Kim Seung-Lee Kim dong-joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge john drummond Thiam-Guan Tan josédias do Nascimento júnior dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry david P.Bennett Aparna Bhattacharya Martin donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas j.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi daisuke Suzuki Yuzuru Tanaka Paul j.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric todd Burdullis Pascal Fouqué department of Astronomy Tsinghua UniversityBeijing 100084China department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA department of Astronomy University of MarylandCollege ParkMD 20742USA department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 Mj),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance dL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVId-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

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Twenty years of human immunodeficiency virus care at the Mayo Clinic:Past,present and future

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World journal of Virology 2016年第2期5卷 63-67页

作者： nathan W Cummins Andrew d Badley Mary j Kasten Rahul Sampath Zelalem Temesgen jennifer A Whitaker john W Wilson joseph d Yao john Zeuli Stacey A Rizza division of Infectious diseases Mayo ClinicRochester

The Mayo human immunodeficiency virus(HIV) Clinic has been providing patient centered care for persons living with HIV in Minnesota and beyond for the past 20 years. Through multidisciplinary engagement, vital clinical outcomes such as retention in care, initiation of antiretroviral therapy and virologic suppression are maximized. In this commentary, we describe the history of the Mayo HIV Clinic and its best practices, providing a "Mayo Model" of HIV care that exceeds national outcomes and may be applicable in other settings.

关键词： Human immunodeficiency virus/acquired immune deficiency syndrome Patient engagement Care Cascade Multidisciplinary care Minimally disruptive medicine