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The impact of maternal immune activation on the morphology and electrophysiological properties of postnatally-born neurons in the offspring

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neural Regeneration Research 2024年第2期19卷 399-400页

作者： Emilio j.Galván Angelica Zepeda Departamento de Farmacobiología CINVESTAV Unidad Sur CdMxMéxico、Centro de Investigaciones sobre el EnvejecimientoCIE-CinvestavCdMxMéxico Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoUNAMCdMxMéxico

Pregnancy comes with a combination of physical changes and physiological immunosuppression that increases the susceptibility of women to pathogens and in turn,rises the prevalence of infectious diseases.

关键词： prevalence activation impact

Tensile ductility and deformation mechanisms of a nanotwinned 316L austenitic stainless steel

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journal of Materials Science & Technology 2020年第1期36卷 65-69页

作者： Y.Z.Zhang j.j.Wang n.R.Tao Shenyang national Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100049China

A nanotwinned 316 L austenitic stainless steel was prepared by means of surface mechanical grinding *** recovery annealing,the density of dislocations decreases obviously while the average twin/matrix lamella thickness still keeps in the nanometer *** annealed nanotwinned sample exhibits a high tensile yield strength of 771 MPa and a considerate uniform elongation of 8%.TEM observations showed that accommodating more dislocations and secondary twinning inside the nanotwins contribute to the enhanced ductility and work hardening rate of the annealed nanotwinned sample.

关键词： nanotwinned Stainless steel Ductility Deformation mechanism

Combinatorial therapies for spinal cord injury repair

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neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António j.Salgado nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

nanoscale strained-Si MOSFET physics and modeling approaches:a review

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journal of Semiconductors 2010年第10期31卷 19-23页

作者： Amit Chaudhry j.n.Roy Garima joshi University Institute of Engineering and Technology Panjab University Solar Semiconductor Private Limited

An attempt has been made to give a detailed review of strained silicon technology. Various device models have been studied that consider the effect of strain on the devices, and comparisons have been drawn. A review of some modeling issues in strained silicon technology has also been outlined. The review indicates that this technology is very much required in nanoscale MOSFETs due to its several potential benefits, and there is a strong need for an analytical model which describes the complete physics of the strain technology.

关键词： mobility SiGe strained-Si technology CAD

Better together? Treating traumatic brain injury with minocycline plus n-acetylcysteine

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neural Regeneration Research 2022年第12期17卷 2589-2592页

作者： Siobhán Lawless Peter j.Bergold Graduate Program in neural and Behavioral Sciences State University of New York-Downstate Health Sciences UniversityBrooklynNYUSA Department of Physiology and Pharmacology State University of New York-Downstate Health Sciences UniversityBrooklynNYUSA

Traumatic brain injury has a complex pathophysiology that produces both rapid and delayed brain damage. Rapid damage initiates immediately after injury. Treatment of traumatic brain injury is typically delayed many hours, thus only delayed damage can be targeted with drugs. Delayed traumatic brain injury includes neuroinflammation, oxidative damage, apoptosis, and glutamate toxicity. Both the speed and complexity of traumatic brain injury pathophysiology present large obstacles to drug development. Repurposing of Food and Drug Administration-approved drugs may be a highly efficient approach to get therapeutics to the clinic. This review examines the preclinical outcomes of minocycline and n-acetylcysteine as individual drugs and compares them to the minocycline plus n-acetylcysteine combination. Both minocycline and n-acetylcysteine are Food and Drug Administration-approved drugs with pleiotropic therapeutic effects. As individual drugs, minocycline and n-acetylcysteine are well tolerated, with known pharmacokinetics, and enter the brain through an intact blood-brain barrier. At concentrations greater than needed for antimicrobial action, minocycline is a potent anti-inflammatory minocycline, also acts as an antioxidant and inhibits multiple enzymes that promote brain injury including metalloproteases, caspases, and polyADP-ribose-polymerase-1. n-acetylcysteine alone is also an antioxidant. It increases brain glutathione, prevents lipid oxidation, and protects mitochondria. n-acetylcysteine also acts as an anti-inflammatory as well as increases extracellular glutamate by activating the X;cystine-glutamate antitransporter. These multiple actions of minocycline and n-acetylcysteine have made them attractive candidates to treat traumatic brain injury. When first dosed within the one hour after injury, either minocycline or n-acetylcysteine improves a diverse set of therapeutic outcome measures in multiple traumatic brain injury animal models. A small number of clinical

关键词： clinical trial outcome measures preclinical testing rodent models of traumatic brain injury therapeutic time window

Algebraic and group treatments to nonlinear displaced number states and their nonclassicality features:A new approach

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Chinese Physics B 2015年第6期24卷 334-340页

作者： n Asili Firouzabadi M K Tavassoly M j Faghihi Atomic and Molecular Group Faculty of PhysicsYazd University The Laboratory of Quantum Information Processing Yazd University Physics and Photonics Department Graduate University of Advanced Technology

Recently, nonlinear displaced number states （nDnSs） have been manually introduced, in which the deformation function f（n） has been artificially added to the previously well-known displaced number states （DnSs）. Indeed, just a simple comparison has been performed between the standard coherent state and nonlinear coherent state for the formation of nDnSs. In the present paper, after expressing enough physical motivation of our procedure, four distinct classes of nDnSs are presented by applying algebraic and group treatments. To achieve this purpose, by considering the DnSs and recalling the nonlinear coherent states formalism, the nDnSs are logically defined through an algebraic consideration. In addition, by using a particular class of Gilmore-Perelomov-type of SU（1,1） and a class of SU（2） coherent states, the nDnSs are introduced via group-theoretical approach. Then, in order to examine the nonclassical behavior of these states, sub-Poissonian statistics by evaluating Mandel parameter and Wigner quasi-probability distribution function associated with the obtained nDnSs are discussed, in detail.

关键词： displaced number state nonlinear coherent state Wigner function nonclassical state

SPICE compatible analytical electron mobility model for biaxial strained-Si-MOSFETs

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journal of Semiconductors 2011年第5期32卷 36-41页

作者： Amit Chaudhry j.n.Roy S.Sangwan UIET Panjab UniversityChandigarhIndia Solar Semiconductro Pvt.Ltd HyderabadIndia

This paper describes an analytical model for bulk electron mobility in strained-Si layers as a function of strain. Phonon scattering, columbic scattering and surface roughness scattering are included to analyze the full mobility model. Analytical explicit calculations of all of the parameters to accurately estimate the electron mobility have been made. The results predict an increase in the electron mobility with the application of biaxial strain as also predicted from the basic theory of strain physics of metal oxide semiconductor （MOS） devices. The results have also been compared with numerically reported results and show good agreement.

关键词： mobility SiGe strained-Si phonon surface roughness columbic

Glycine-nitrate auto-combustion synthesis and magnetic properties of nanocrystalline ndAl_(x)Fe_(1-x)O_(3) perovskites

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journal of Rare Earths 2023年第1期41卷 108-115页

作者： E.A.nforna Hj.M.ngantchou j.n.Ghogomu Department of Fundamental Science Higher Technical Teacher Training CollegeUniversity of BamendaP.O.Box 39BambiliCameroon Department of Chemistry Faculty of SciencesUniversity of DoualaP.O.Box 24157DoualaCameroon Department of Chemistry The University of BamendaP.O.Box 39BambiliCameroon Department of Chemistry University of DschangP.O.Box 67DschangCameroon

The effect of substitution of Fe^(3+) by Al^(3+) on the structure and magnetic properties of ndAl_(x)Fe_(1-x)O_(3) perovskite nano-powders(x=0.0,0.1,0.2,0.3,0.4,and 0.5) prepared by the glycine-nitrate auto-combustion method was *** samples were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR),and energy dispersive X-ray spectroscopy(EDX).The magnetic properties of the samples were investigated using a vibrating sample magnetometer(VSM).The X-ray results for all samples reveal the formation of an orthorhombic perovskite phase(space group Pbnm) with no secondary *** crystallite sizes of the nanoparticles are found to decrease with increasing Al content,and are in the range of 53-38 *** images show spherical nanoparticles with *** FT-IR spectra confirm the presence of metal oxygen *** M-H loop of the pristine ndFeO_(3) sample is antiferromagnetic in the a b plane with weak ferromagnetism in the *** AI inclusions in the pristine polycrystal thereby creating magnetic vacancies is seen to influence the magnetic *** magnetic dilution results in enhanced magnetisation at low Al content;x=0.1,0.2(saturation magnetisation being 2.08 and 2.05 emu/g,respectively) compared to the pristine sample with a saturation magnetisation of 1.43 emu/g due to increased exchange *** dilution with nonmagnetic dopant induces the phase transition from weak ferromagnetic to paramagnetic depending on the impurity *** coercive field for ndFeO_(3) is found to be equal to 1950 Oe and decreases with *** findings lay a ground work for research in tuning magnetic properties and in spintronics with potential applications in data storage,switches and electronic devices.

关键词： Anti-ferromagnetism Weak ferromagnetism Orthorhombic ndAl_(x)Fe_(1-x)O_(3) Perovskite nanopowders Magnetic dilution

Different xylogenesis responses to atmospheric water demand contribute to species coexistence in a mixed pine–oak forest

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journal of Forestry Research 2023年第1期34卷 51-62页

作者： Marín Pompa-García j.julio Camarero Michele Colangelo Facultad de Ciencias Forestales y Ambientales de la Universidad juárez del Estado de Durango Río Papaloapan y Blvd.Durango S/N Col.Valle del SurDurangoMéxico Instituto Pirenaico de Ecología(IPE-CSIC) Avda.Montanna 1005ZaragozaSpain School of Agricultural ForestFood and Environmental SciencesUniv.BasilicataPotenzaItaly

Seasonal patterns of wood formation(xylogenesis)remain understudied in mixed pine-oak forests despite their contribution to tree coexistence through temporal niche *** was assessed in three pine species(Pinus cembroides,Pinus leiophylla,Pinus engelmannii)and one oak(Quercus grisea)coexisting in a semi-arid Mexican *** main xylogenesis phases(production of cambium cells,radial enlargement,cell-wall thickening and maturation)were related to climate data considering 5-15-day temporal *** pines,cambium activity maximized from mid-March to April as temperature and evaporation increased,whereas cell radial enlargement peaked from April to May and was constrained by high evaporation and low ***-wall thickening peaked from june to july and in August-September as maximum temperature and vapour pressure deficit(VPD)*** of earlywood and latewood tracheids occurred in May-june and june-july,enhanced by high minimum temperatures and VPD in *** and *** oak,cambial onset started in March,constrained by high minimum temperatures,and vessel radial enlargement and radial increment maximized in April as temperatures and evaporation increased,whereas early wood vessels matured from May to june as VPD ***,15-day wet conditions enhanced cell radial enlargement in *** and ***,whereas early-summer high 15-day temperature and VPD drove cell-wall thickening in *** night conditions and high evaporation rates during spring and summer enhanced *** earlier growth peak in oak and a higher responsiveness to spring-summer water demand in pines contributed to their coexistence.

关键词： Bimodal growth Drought Vapour pressure deficit Wood formation Xylem phenology