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Characterizing functional consequences of DnA copy number alterations in breast and ovarian tumors by spaceMap

journal of Genetics and Genomics 2018年第7期45卷 361-371页

作者： Christopher j.Conley Umut Ozbek Pei wang jie peng Department of Statistics University of California Davis Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai

We propose a novel conditional graphical model -- spaceMap -- to construct gene regulatory networks from multiple types of high dimensional omic profiles. A motivating application is to characterize the perturbation of DnA copy number alterations （CnAs） on downstream protein levels in tumors. Through a penalized multivariate regression framework, spaceMap jointly models high dimensional protein levels as responses and high dimensional CnAs as predictors. In this setup, spaceMap infers an undirected network among proteins together with a directed network encoding how CnAs perturb the protein network, spaceMap can be applied to learn other types of regulatory relationships from high dimensional molecular profiles, especially those exhibiting hub structures. Simulation studies show spaceMap has greater power in detecting regulatory relationships over competing methods. Additionally, spaceMap includes a network analysis toolkit for biological interpretation of inferred networks. We applies spaceMap to the CnAs, gene expression and proteomics data sets from CPTAC-TCGA breast （n = 77） and ovarian （n = 174） cancer studies. Each cancer exhibits disruption of＇ion transmembrane transport＇ and ＇regulation from RnA polymerase lI promoter＇ by CnA events unique to each cancer. Moreover, using protein levels as a response yields a more functionally-enriched network than using RnA expressions in both cancer types. The network results also help to pinpoint crucial cancer genes and provide insights on the functional consequences of important CnA in breast and ovarian cancers.

关键词： Integrative genomics Proteogenomics Conditional graphical models network analysis

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A Multi-View Gait Recognition Method Using Deep Convolutional neural network and Channel Attention Mechanism

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Computer Modeling in Engineering & Sciences 2020年第10期125卷 345-363页

作者： jiabin wang Kai peng College of Engineering Huaqiao UniversityQuanzhou362021China

In many existing multi-view gait recognition methods based on images or video sequences,gait sequences are usually used to superimpose and synthesize images and construct energy-like ***,information may be lost during the process of compositing image and capture EMG *** and the recognition accuracy may be introduced and affected respectively by some factors such as period *** better solve the problems,a multi-view gait recognition method using deep convolutional neural network and channel attention mechanism is ***,the sliding time window method is used to capture EMG ***,the back-propagation learning algorithm is used to train each layer of convolution,which improves the learning ability of the convolutional neural ***,the channel attention mechanism is integrated into the neural network,which will improve the ability of expressing gait *** a classifier is used to classify *** can be shown from experimental results on two public datasets,OULP and CASIA-B,the recognition rate of the proposed method can be achieved at 88.44%and 97.25%*** can be shown from the comparative experimental results,the proposed method has better recognition effect than several other newer convolutional neural network ***,the combination of convolutional neural network and channel attention mechanism is of great value for gait recognition.

关键词： EMG signal capture channel attention mechanism convolutional neural network multi-view gait recognition gait characteristics back-propagation

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Bacterial diversity in sediments of core MD05-2902 from the Xisha Trough,the South China Sea

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Acta Oceanologica Sinica 2014年第10期33卷 85-93页

作者： LI Tao wang peng State Key Laboratory of Marine Geology Tongji University Guangzhou Marine Geological Survey

A sediment core MD05-2902 was collected from the deep-sea basin of the Xisha Trough. The vertical distribution and diversity of bacteria in the core was investigated through ten sub-sampling with an interval of 1 m using bacterial 16 S rRnA gene as a phylogenetic bio-marker. Eighteen phylogenetic groups were identified from 16 S rRnA gene clone libraries. The dominant bacterial groups were jS1, Planctomycetes and Chloroflexi, which accounted for 30.6%, 16.6%, and 15.6% of bacterial clones in the libraries, respectively. In order to reveal the relationship between biotic and abiotic data, a nonmetric multidimensional scaling analysis was performed. The result revealed that the δ15n, δ13C, total organic carbon and total organic nitrogen possibly influenced the bacterial community structure. This study expanded our knowledge of the biogeochemical cycling in the Xisha Trough sediment.

关键词： Xisha Trough bacterial diversity 16S rRnA gene

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One-step synthesis of n,P co-doped porous carbon electrocatalyst for highly efficient nitrogen fixation

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nano Research 2022年第3期15卷 1779-1785页

作者： Sijia Zhao j.n wang peng wang Shuang wang j.nping Li College of Environmental Science and Engineering Taiyuan University of TechnologyJinzhong 030600China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization Taiyuan University of TechnologyTaiyuan 030024China

Heteroatom-doped porous carbon has attracted many researchers’interests owing to their hierarchical porous and more active sites for nitrogen reduction reaction(nRR).However,the development of simple synthesis strategies to fabricate efficient catalyst is still remaining a *** this work,a series of n,P co-doped porous carbon were prepared by one-step pyrolysis of zeolitic imidazolate framework(ZIF-8)and triphenylphosphine(TPP)under nitrogen *** obtained catalyst by calcinating ZIF-8 and TPP with the mass ratio of 1:5 for three hours was named as Pn-C-ZIF-8,which exhibited a high yield rate of ammonia(43.39μg·h^(–1)·mg^(–1)cat.)and Faraday efficiency(16.67%)in 0.05 M H2SO4 at–0.3 *** importantly,the Pn-C-ZIF-8 catalyst had superior selectivity that no hydrazine by-products were detected and long-term durability for 72 *** study provides an idea for the convenient design and preparation of heteroatom doped carbon materials.

关键词： n P co-doped carbon-based catalyst electrochemical ammonia synthesis metal organic framework pyrolysis

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Synthesis,Structure,and Property of a Three-dimensional Channel Quaternary Compound:Cs_(0.75(6))Er_(4.43(5))In_(3.32(6))S_(12)

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Chinese journal of Structural Chemistry 2013年第12期32卷 1873-1879页

作者： wang peng LIn Hua Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences University of Chinese Academy of Sciences

A new quaternary rare-earth sulfide, Cs0.75（6）Er443（5）In3.32（6）S12 （1）, is discovered by high temperature solid state reactions with a slight excess of CsCI flux. The structure is characterized by single-crystal X-ray diffraction data, while crystallizes in hexagonal space group P63/m （no. 176） with a = 12.0329（6）, c = 3.8693（5）A, V= 485.18（7） A3, Z = 1, Mr = 1606.57, Dc = 5.499 g/cm3,μ = 25.457 mm-1, F（000） = 752, the final R = 0.0337 and wR = 0.0904 for 328 observed reflections with I 〉 2σ（I）. Its structure features a three-dimensional framework with hexagonal channels that are centered by Cs cations. Such channels are formed by double chains of edge-sharing M（1）S6 （M（1） = Er（1）/In（1）） octahedra and single chains of Er（2）S6 triprism interconnected by corner-sharing. The syntheses, single-crystal analyses, optical band gap and magnetic property are reported.

关键词： high temperature solid state crystal structure,magnetic property optical band gap

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Optimal guidance against active defense ballistic missiles via differential game strategies

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Chinese journal of Aeronautics 2020年第3期33卷 978-989页

作者： Haizhao LIAnG jianying wang Yonghai wang Linlin wang peng LIU School of Aeronautics and Astronautics Sun Yat-sen UniversityGuangzhou 510275China Beij.ng Institute of Space Long March Vehicle Beijing 100076China

The optimal guidance problem for an interceptor against a ballistic missile with active defense is investigated in this paper.A class of optimal guidance schemes are proposed based on linear quadratic differential game method and numerical solution of Riccati differential *** choosing proper parameters, the proposed guidance schemes are able to drive the interceptor to the target and away from the defender ***, fuel cost, control saturation,chattering phenomenon and parameters selection were taken into *** of the proposed guidance schemes of the saddle point condition is proven ***, nonlinear numerical examples are included to demonstrate the effectiveness and performance of the developed guidance *** of control performance between different guidance schemes are presented and analysis.

关键词： Active defense Ballistic missile Differential game Guidance law Optimal guidance

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Effects of pressure on structure and dynamics of metallic glass-forming liquid with miscibility gap

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journal of Iron and Steel Research International 2018年第6期25卷 666-673页

作者： Yun Cheng peng-fei wang Chuan-xiao peng Li j.ng jia Yu-yang wang Li wang School of Mechanical Electrical and InformationEngineering Shandong University (Weihai)Weihai 264209 Shandong China

The metallic liquid with miscibility gap has been widely explored recently because of the increasing plastic deformation ability of phase-separated metallic glass. However, the poor glass-forming ability limits its application as the structural materials due to the positive mixing enthalpy of the two elements. Since high pressure is in favor of the formation of the glass, the effect of pressure on the structural and dynamical heterogeneity of phase-separated CusoAgso liquid is inves- tigated by molecular dynamics simulation in the pressure range of 0-16 GPa. The results clearly show that the pressure promotes the formation of metallic glass by increasing the number of fivefold symmetry cluster W and dynamical relaxation time; meanwhile, the liquid-liquid phase separation is also enhanced, and the homogenous atom pAlrs show stronger interaction than heterogeneous atom pAlrs with increasing pressure. The dynamical heterogeneity is related to the formation of fivefold symmetry clusters. The lower growing rate of W at higher pressure with decreasing temperature corresponds to the slow increase in dynamical heterogeneity. The pressured glass with miscibility gap may act as a candidate glass with improved plastic formation ability. The results explore the structural and dynamical heterogeneity of phase-separated liquid at atomic level.

关键词： Glass-forming liquid Miscibility gap High pressure Structural heterogeneity Dynamical heterogeneity Molecular dynamics simulation

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In situ strength profiles along two adjacent vertical drillholes from digitalization of hydraulic rotary drilling

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journal of Rock Mechanics and Geotechnical Engineering 2023年第1期15卷 146-168页

作者： Xuefan wang peng peng Zhigang Shan Zhongqi Yue Department of Civil Engineering The University of Hong KongHong KongChina PowerChina Huadong Engineering Corporation Limited HangzhouChina

Drilling speed and associated analyses from factual field data of hydraulic rotary drilling have not been fully *** paper provides the reference and comparison for the utilization of drilling information from two adjacent vertical drillholes that were formed with the same hydraulic rotary drilling machine and *** analysis of original factual data is presented to obtain the constant drilling speed during net drilling *** to the factual data along two adjacent drillholes,the digitalization results respectively include 461 linear zones and 210 linear zones with their constant drilling speeds and associated drilling *** digitalization results can accurately present the spatial distributions and interface boundaries of drilled geomaterials and the results are consistent with the paralleled site *** weighted average drilling speeds from 2.335 m/min to 0.044 m/min represent 13 types of drilled geomaterials from soils to hard *** quantitative relation between drilling speed and strength property is *** digitalization results can statistically profile the basic strength quality grades of III to VI from soils to hard *** thickness distributions of four strength quality grades are presented for each individual type of geomaterials along two *** total,50.2%of geomaterials from drillhole A are grade IV and 57.4%of geomaterials from drillhole B are grade *** digitalization results can offer an accurate and cost-effective tool to quantitatively describe the spatial distribution and in situ strength profile of drilled geomaterials in the current drilling projects.

关键词： Drilling process monitoring(DPM) Hydraulic rotary coring process Constant drilling speed Coring-resistant strength

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Recent progress in luminescent materials based on lanthanide complexes intercalated synthetic clays

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journal of Rare Earths 2019年第5期37卷 451-467页

作者： Yige wang peng Li Shufang wang Huanrong Li Hebei Provincial Key Lab of Green Chemical Technology and High Efficient Energy Saving School of Chemical Engineering and Technology Hebei University of Technology

Interest in lanthanide complexes in the synthetic clays remains growing considerably during the last decades because of the attractive features of the individuals. Synthetic clays like Laponite~? and Aminoclay show great potentials in building up the luminescent hybrid materials due to their obvious advantages such as high purity, high dispersibility(or solubility) in water to yield translucent gels and clear aqueous solution. Additionally, their strong adsorption capacity for non-polar molecules or complexes is favorable to the formation of water-soluble and aqueous processable luminescent materials. This feature article summarizes the latest developments in the design and preparation of highly luminescent organicinorganic hybrid materials with excellent aqueous process ability based on lanthanide complexes intercalated synthetic clays.

关键词： Hybrid materials Luminescence Lanthanide complex Clay Sensing Self-healing

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Conjugate Surfaces of a Family of Minimal Surfaces of Genus 1 with 4 Planar Ends in R3

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Chinese Annals of Mathematics,Series B 2024年第6期45卷 927-942页

作者： Yulin SHI peng wang Xiaozhen wang School of Mathematics and Statistics Fujian Key Laboratory of Mathematical Analysis and its Application Fujian Normal University Ganzhou Middle School School of Mathematics and Statistics Fujian Key Laboratory of Mathematical Analysis and its Applications Fujian Normal University Corresponding author.School of Mathematics and Statistics Fujian Key Laboratory of Mathematical Analysis and its Applications Fujian Normal University

Costa first constructed a family of complete minimal surfaces which have genus1 and 4 planar ends by use of Weierstrass-■*** are Willmore tori of Willmore energy 16π.In this paper,the authors consider the geometry of conjugate surfaces of these *** turns out that these conjugate surfaces are doubly periodic minimal surfaces with flat ends in ***,the authors can also perform a Lorentzian deformation on these Costa’s minimal tori,which produce a family of complete space-like stationary surfaces （i.e.,of zero mean curvature） with genus 1 and 4 planar ends in 4-dimensional Lorentz-Minkowski space R1～4.

关键词： 33E05 53A10 53C42 53C50 Conjugate surfaces Doubly periodic minimal surfaces Elliptic functions Weierstrass representation

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