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REDOX IMAGInG OF THE p53-DEPEnDEnT MITOCHOnDRIAL REDOX STATE In COLOn CAnCER EX VIVO

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journal of Innovative Optical Health Sciences 2013年第3期6卷 1-10页

作者： HE n.XU MIn feng LILY MOOn nATHAn DOLLOFF WAFIKEL-DEIRY LIn Z.LI Department of Radiology University of Pennsylvania PhiladelphiaPAUSA Britton Chance Laboratory of Redox Imaging johnson Research Foundation Department of Biochemistry and Biophysics Perelman School of Medicine University of Pennsylvania PhiladelphiaPAUSA Department of Medicine Penn State Hershey Medical Center and Penn State College of MedicineHersheyPAUSA Hematology/Oncology Penn State Hershey Medical Center HersheyPAUSA Abramson Cancer Center University of Pennsylvania PhiladelphiaPAUSA Institute of Translational Medicine and Therapeutics University of Pennsylvania PhiladelphiaPAUSA

The mitochondrial redox state and its heterogeneity of colon cancer at tissue level have not been previously *** has how p53 regulates mitochondial respi ration been measured at(deep)tissue level,presumably due to the unavailability of the technology that has sufficient spatial resolution and tissue penetration *** prior work demonstrated that the mito-chondrial redox state and its intnatumor heterogeneity is associated with cancer aggressiveness in human melanoma and breast cancer in mouse models,with the more metastatic tumons exhi-bit ing localized negions of more oxidized redox *** the Chance redox scanner with an in-plane spatial resolution of 200 pm,we imaged the mitochondrial redox state of the wild-type p53 colon tumors(HCT116 p53 ut)and the p5-deleted colon tumors(HCT116 p53-/-)by cllcting the fuorescence si gnals of nicotinamide adenine dimucleotide(nA DH)and oxidized flavoproteins [Fp,including favin adenine dinucleotide(FAD)]from the mouse xenogmafts snap frozen at low *** results show that:(1)both tumor lines have significant degree of intratumor heterogeneity of the redox state,typically exhibiting a distinct bi modal distribution that either correlates with the spatial core-rim pattern or the“hot/oold”oxida tion-roduction patches;.(2)the p531-group is significantly more beterogencous in the mitochondrial redox state and has a more oxidized turmor core compared to the p53 wt group when the tunor sizes of the two groups are matched;(3)the tumor size dependence of the redox indices(such as Fp and Fp redox ratio)is significant in the p531-group with the larger ones being more oxidized and more hetero-geneous in their redox state,particularly more oxidized in the tumor central regions;(4)the H&E staining images of tumor soctions grossly correlate with the redox *** present work is the first to reveal at the submillimeter scale the intratumor heterogeneity pattem of the mitochon-drial redox state in colon cancer and

关键词： nADH favoprotein intratumor heterogeneity HCT116 p53 null necrotic

丙泊酚对高血压合并超急性期非复杂型Stanford B型主动脉夹层患者血压和心率的作用

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中华急诊医学杂志 2024年第7期33卷 968-974页

作者：郑武洪肖鹏周海珺何宗存陈锋柯俊福建医科大学省立临床医学院福建省立医院福州大学附属省立医院急诊内科福州350001

目的探讨丙泊酚对高血压合并超急性期非复杂型Stanford B型主动脉夹层(hyperacute uncomplicated type B aortic dissection,HU-TBAD)患者血压和心率(heart rate,HR)的作用。方法本研究为单中心、双盲、随机对照试验,连续纳入2020年7月... 详细信息

目的探讨丙泊酚对高血压合并超急性期非复杂型Stanford B型主动脉夹层(hyperacute uncomplicated type B aortic dissection,HU-TBAD)患者血压和心率(heart rate,HR)的作用。方法本研究为单中心、双盲、随机对照试验,连续纳入2020年7月至2023年3月就诊于本院急诊科的HU-TBAD患者96例,以信封法随机均分为对照组和观察组,均予尼卡地平、瑞芬太尼、艾司洛尔和基础治疗。在此基础上,观察组予丙泊酚0.5 mg/kg静脉注射后续以1.0 mg/(kg·h)持续微量泵静脉输注,每15 min评估RASS评分以调整丙泊酚用量,维持RASS评分目标值于-2~0分,对照组则予等体积生理盐水。比较两组各时点收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)和HR的变化以及第0(T0 min)和60 min(T60 min)相关指标的变化;分析两组相关指标达标率和尿量、平均尼卡地平剂量、不良反应。干预结束后收住院继续予适当治疗并随访21 d。两组间数据比较采用独立样本t检验、Mann-Whitney U检验、χ2检验或Fisher's精确检验;两组不同时点的数据比较采用重复测量方差分析。结果两组一般资料相比较差异无统计学意义(均P>0.05)。两组各时点相比较,SBP、DBP和HR水平在不同时间、组间和组间与时间交互(组间×时间)差异有统计学意义(均Pn和T60 min时点相比较,不同时间氧合指数水平差异有统计学意义(P0.05);二氧化碳分压、呼吸频率和乳酸水平在不同时间和组间×时间存在统计学意义(均P0.05);在不同时间、组间和组间×时间心肌肌钙蛋白I水平差异无统计学意义(均P>0.05),而nRS评分差异有统计学意义(均Pn-1,2.50(2.00,2.50)vs.2.00(1.50,2.50),P0.05)。随访显示观察组出现夹层进展和入住ICU的比例较对照组均显著下降(19.57%vs.4.26%,23.91%vs.6.38%,均P<0.05)。结论丙泊酚增强瑞芬太尼的镇痛作用,协同降低高血压合并HU-TBAD患者的SBP、DBP和HR,改善预后。

关键词：丙泊酚主动脉夹层瑞芬太尼血压心率

Quasi-exactly Solvable Cases of the n-Dimensional Symmetric Quartic Anharmonic Oscillator

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Chinese Physics Letters 2012年第7期29卷 14-17页

作者： PAn feng XIE Ming-Xia SHI Chang-Liang j.P.DRAAYER Department of Physics Liaoning Normal UniversityDalian 116029 Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803-4001USA

The O( n) invariant quartic anharmonic oscillator is shown to be exactly solvable if the interaction parameter satisfies special *** problem is directly related to that of a quantum double well anharmonic oscillator in an external field.A finite dimensional matrix equation for the problem is constructed explicitly,along with analytical expressions for some excited states in the *** corresponding niven equations for determining the polynomial solutions for the problem are given.

关键词： field harmonic exactly

nitrogen transformations during pig manure composting

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journal of Environmental Sciences 2001年第4期13卷 401-405页

作者： HUAnG Guo-feng WU Qi-tang LI Fang-bai WOnG j.W.C College of natural Resources and Environment South China Agricultural UniversityWushanGuangzhou 510642 Department of Biology Hong Kong Baptist UniversityKowloonHKSAR

Composting is now suggested as one of the environmentally and friendly alternative method for disposal of solid organic wastes, as it leads to minimization, stabilization, and utilization of organic waste. Transformations of nitrogen were investigated in co-composting of pig manure with different amendments, such as sawdust and leaves. Samples were analyzed for pH, total-n, soluble nH4-n, soluble nO3-n and soluble organic-n. The total-n increased after 63 days of composting, as well as the soluble nO3-n and soluble organic-n. Soluble nH4,-n increased significantly and showed peak values at day 7, thereafter decreased sharply and gradually to lower levels. Seed germination index (GI) showed that co-composting of pig manure with sawdust reached maturity after 49 days of composting, while co-composting of pig manure with sawdust and leases required shorter time for 35 days. Soluble nH4-n was significantly negatively ( P nO3-n and soluble organic-n were significantly positively ( P nation index (GI). Addition of leaves in co-composting of pig manure with sawdust had no significant impacts on nitrogen transformations, but it was beneficial for maturity of pig manure compost.

关键词： pig manure composting nitrogen transformation maturity

Disease Risks of Childhood Obesity in China

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Biomedical and Environmental Sciences 2005年第6期18卷 401-410页

作者： YAn-PInG LI XIAO-GUAnG YAnG feng-YInG ZHAI jIAn-HUA piao WEn-HUA ZHAO jIAn ZHAnG GUAn-SHEnG MA national Institute for nutrition and Food Safety Chinese Center for Disease Control and Prevention 29 Nanwei Road Beijing 100050 China

Objective To estimate the relative risks of dyslipidemia, hypertension, diabetes mellitus, and metabolic syndromes among overweight and obese Chinese children compared with their normal weight counterparts. Methods Overweight and obesity were defined by age- and sex-specific BMI classification reference for Chinese children and adolescents. Pediatric metabolic syndrome （MetS） and each risk factor for MetS were defined using the criteria for US adolescents. Definition of hyper-TC, LDL, and dyslipidemia for adults was applied as well. General linear model factor analysis and chi-square test were used to compare the difference in metabolic indicators among normal weight, overweight, and obese groups. Multiple logistic regression analysis was performed to estimate the odds ratio of metabolic abnormalities between obesity, overweight, and normal weight children, after adjustment for living area, family economic level, age, sex, and daily exercise time and TV watching time, as well as different dietary indices in the model. Results Significant increases in blood lipids, glucose, and blood pressure were found among overweight and obese children as compared with their counterparts with normal weight. By applying WGOC-recommended BMI classification, the risks for hypertriglyceridemia, low HDL and dyslipidemia among overweight children were 1.9, 1.4, and 1.5 times, and was 3.3, 1.5, and 1.8 times among obese groups compared to their counterparts with normal weight after adjustment for age, sex, region, socioeconomic status, physical activity, and dietary intakes. The overweight and obese children （15-17.9 years） had a high-risk of developing hypertension, which was 2.3 and 2.9 times higher than their counterparts with normal weight. Above 90% obese adolescents had abdominal obesity, while less than 1% normal weight ones had abdominal obesity. no obese adolescents were free from any risk factors for MetS, while 36.9% of normal weight adolescents were from the risk factors. 83.

关键词： Chinese obese children Metabolic syndrome (MetS) Hypertension Lipids Relative risk

Enhanced separation of Pd(Ⅱ)and Pt(Ⅳ)from hydrochloric acid aqueous solution using 2-((2-methoxyethyl)thio)-1H-benzimidazole

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Rare Metals 2020年第12期39卷 1473-1482页

作者： Shao-Ping feng Kun Huang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Department of Chemistry College of ScienceHonghe UniversityMengzi 661199China

Separation of palladium(Pd)and platinum(Pt)by solvent extraction is difficult because of their extremely similar physicochemical *** of new extractants with a high extraction efficiency and excellent separation selectivity is the primary focus for enhancing the separation of Pd and Pt by solvent *** this study,a new extractant,2-((2-methoxyethyl)thio)-1 H-benzimidazole(MOBI),which contains n,S,and O atoms,was synthesized and used to separate Pd(Ⅱ)and Pt(Ⅳ)from a hydrochloric acid aqueous *** experimental results revealed that Pd(Ⅱ)and Pt(Ⅳ)were effectively separated under the optimal conditions:MOB I concentration of 0.005 mol·L^(-1),HCl concentration of0.2 mol·L^(-1),organic/aqueous(O/A)phase ratio of 1.0,and contact time of 15 *** separation coefficient between Pd(Ⅱ)and Pt(Ⅳ)was 1246.40,which indicates that MOBI has a higher selectivity for Pd(Ⅱ)than Pt(Ⅳ).In addition,the mechanism of coordination between Pd(Ⅱ)and MOBI was demonstrated through the slope method,Fourier transform infrared spectroscopy(FTIR),hydrogen-1 nuclear magnetic resonance spectroscopy(^(1)H nMR),and carbon-13 nuclear magnetic resonance spectroscopy(^(13)C nMR).The results revealed that MOBI could coordinate with Pd(Ⅱ)via the n atom in the benzimidazole ring of MOBI molecules to form[Pd(MOBI)_(2)Cl_(2)](O).

关键词： 2-((2-methoxyethyl)thio)-1H-benzimidazole Palladium Platinum Extraction Separation

Exceptional sets in Waring-Goldbach problem for fifth powers

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Frontiers of Mathematics in China 2021年第1期16卷 49-58页

作者： Zhenzhen feng Zhixin LIU School of Mathematics and Statistics Minnan Normal UniversityZhangzhou 363000China School of Mathematics Tianjin UniversityTianjin 300072China

We consider exceptional sets in the Waring-Goldbach problem for fifth *** example,we prove that all but O(n^(131/132))integers satisfying the necessary local conditions can be represented as the sum of 11 fifth powers of primes,which improves the previous results due to ***[***.,2005,57:298–327]and ***[*** Theory,2012,8:1247–1256].

关键词： Exceptional sets Waring-Goldbach problem circle method

Carbon-nitride-Based Materials for Advanced Lithium-Sulfur Batteries

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nano-Micro Letters 2022年第12期14卷 579-601页

作者： Wenhao Sun Zihao Song Zhenxing feng Yaqin Huang Zhichuan j.Xu Yi-Chun Lu Qingli Zou State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China Electrochemical Energy and Interfaces Laboratory Department of Mechanical and Automation EngineeringThe Chinese University of Hong KongHong Kong Special Administrative Region 999077People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Republic of Singapore School of Chemical Biologicaland Environmental EngineeringOregon State UniversityCorvallisOR 97331USA

Lithium-sulfur(Li-S)batteries are promising candidates for next-generation energy storage systems owing to their high energy density and low ***,critical challenges including severe shuttling of lithium polysulfides(LiPSs)and sluggish redox kinetics limit the practical application of Li-S *** nitrides(C_(x)n_(y)),represented by graphitic carbon nitride(g-C_(3)n_(4)),provide new opportunities for overcoming these *** a graphene-like structure and high pyridinic-n content,g-C_(3)n_(4) can effectively immobilize LiPSs and enhance the redox kinetics of S *** addition,its structure and properties including electronic conductivity and catalytic activity can be regulated by simple methods that facilitate its application in Li-S ***,the recent progress of applying C_(x)n_(y)-based materials including the optimized g-C_(3)n_(4),g-C_(3)n_(4)-based composites,and other novel C_(x)n_(y) materials is systematically reviewed in Li-S batteries,with a focus on the structure-activity *** limitations of existing C_(x)n_(y)-based materials are identified,and the perspectives on the rational design of advanced C_(x)n_(y)-based materials are provided for high-performance Li-S batteries.

关键词： Lithium-sulfur batteries Carbon nitride Polysulfide conversion Shuttle effect Anode protection

Marcinkiewicz integrals with rough kernels in H^(1)(s^(n-1))

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Frontiers of Mathematics in China 2021年第4期16卷 1163-1189页

作者： Daiqing ZHAnG feng LIU School of Computer Science and Mathematics Fujian University of TechnologyFuzhou 350118China Shandong University of Science and Technology Qingdao 266590China

This paper is devoted to studying the Marcinkiewicz integral operators associated to polynomial compound *** new bounds for the above operators on the Lebesgue,Triebel-Lizorkin,and Besov spaces are established by assuming that their rough kernels are given byΩ∈H^(1)(s^(n-1))and h∈Δ_(γ)(R_(+))for someγ>*** should be pointed out that the bounds are independent of h,Ω,γ,and the coefficients of the polynomials in the definition of the operators.

关键词： Marcinkiewicz integral polynomial curve H^(1)(s^(n-1)) Triebel-Lizorkin space