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Effects of Ethinylestradiol/Cyproterone Acetate and Ethinylestradiol/Desogestrel Alone and in Combination with Low-Dose Metformin on Glucose and Lipid Homeostasis and Androgenic Hormone Profile in Hirsute Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Triple-Dummy Study

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journal of Biosciences and Medicines 2019年第8期7卷 13-26页

作者： Sanjeewani Fonseka Dilan D.j.Bandara Chandrika n.Wijeyaratne Indika B.Gawarammana nishan S.Kalupahana Shanthini Rosairo Ranjith Kumarasiri Faculty of Medicine University of PeradeniyaPeradeniyaSri Lanka Department of Obstetrics and Gynaecology Faculty of MedicineUniversity of ColomboColomboSri Lanka

Background: The effects of combined oral contraceptive pills and metformin on glucose and lipid metabolism and androgenic hormone profile of hirsute women with polycystic ovary syndrome (PCOS) are not clearly known. Aims: To determine the effect of ethinylestradiol (35 microg)/cyproterone acetate (2 mg) (EE/CPA) and ethinylestradiol (20 microg)/desogestrel 0.15 mg (EE/DES) alone and in combination with metformin on glucose and lipid metabolism and androgenic hormone profile in hirsute women with PCOS. Settings and Design: This randomised, double-blind, triple dummy study was conducted at the Department of Pharmacology, Faulty of Science, University of Peradeniya, Sri Lanka. Methods and Material: A total of 107 patients with PCOS (Rotterdam Consensus Conference Criteria 2003) having hirsutism of 8 or more in the modified Ferriman-Gallwey Score (mFGS), were randomised to receive four drug therapies (arm A: EE/CPA, arm B: EE/DES, arm C: EE/CPA plus metformin, arm D: EE/DES plus metformin). Body mass index, fasting plasma glucose, area under the curve of the oral glucose tolerance test, fasting serum insulin, serum leptin, fasting lipids, serum total testosterone, serum sex hormone-binding globulin were determined at initiation and 12 months. Homeostasis model assessment of beta cell function (HOMA-β), homeostasis model assessment-estimated insulin resistance (HOMA-IR) and free androgen index were calculated. Statistical analysis was done with two ways AnOVA. Results: There was no significant difference in outcome measures at 12 months between the treatment arms. Within the treatment arms, there was reduction of HOMA-β in arm B, serum leptin in arm C, cho/HDL ratio in arm D and an increase in total cholesterol and LDL-cholesterol in arms B and C. Conclusions: EE/DES and EE/CPA with and without low-dose metformin did not have a significant overall effect on glucose and lipid metabolism and androgenic hormonal profile in hirsute women with PCOS. However, desogestrel has r

关键词： Polycystic Ovary Syndrome Ethinylestradiol Cyproterone Acetate Desogestrel Metformin

应用基于深度学习的计算机辅助检测系统在穿刺活检后的胸片上诊断气胸

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国际医学放射学杂志 2019年第6期 751-751页

作者： S.Park S.M.Lee n.Kim j.choe Y.W.cho K.H.Do 朱逸峰 Department of Radiology and Research Institute of Radiology Asan Medical Center College of Medicine University of Ulsan

摘要目的回顾性评价卷积神经网络(Cnn)模型在经皮肺穿刺活检(PTnB)后的胸片中检测气胸的诊断效能。材料与方法本研究使用完整的26层You Only Look Once模型

关键词：深度学习检测系统穿刺活检

超快速乳腺DCE-MRI的达增强时间:肿瘤侵袭性的潜在影像标志物

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国际医学放射学杂志 2020年第5期 624-624页

作者： S.U.Shin n.cho S.Y.Kim S.H.Lee j.M.Chang W.K.Moon 赵海清 Department of Radiology Seoul National University Hospital

摘要目的本研究旨在探讨超快速MRI达增强时间(TTE)与乳腺癌组织病理学特征之间是否存在相关性。方法自2017年1月—8月共纳入连续的274例乳腺癌病人(年

关键词：

Reproduction,Development,and Growth Response to Captive Diets in the Shangcheng Stout Salamander,Pachyhynobius shangchengensis(Amphibia,Urodela,Hynobiidae)

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Asian Herpetological Research 2012年第3期3卷 192-197页

作者： Frank PASMAnS Geert P.j.j.nSSEnS Max SPARREBOOM3 jianping jIAnG Kanto nISHIKAWA Department of Pathology Bacteriology and Avian DiseasesFaculty of Veterinary MedicineGhent University Salisburylaan 1339820 MerelbekeBelgium Animal nutrition Laboratory Faculty of Veterinary MedicineGhent University Salisburylaan 1339820 MerelbekeBelgium netherlands Centre for Biodiversity naturalis P.O.Box 9517 NL-2300 RA LeidenThe Netherlands Chengdu Institute of Biology Chinese Academy of Sciences Graduate School of Human and Environmental Studies Kyoto UniversityYoshida-nihonmatsu-cho Sakyo606-8501 KyotoJapan

The Shangcheng stout salamander(Pachyhynobius shangchengensis) is a poorly known stream dwelling hynobiid salamander from China. We studied the reproduction, development and growth response of the salamander to different diets in captivity. Two females each produced two unique, striated egg sacs, with each containing 18 and 20, and 22 and 32 white eggs with an average diameter of 3.3 mm. Hatchlings(n = 27) had front- and hind-limb buds with interdigit membranes and a large yolk sac, and developed cornified finger and toe tips during further development. Metamorphosis occurred between d 441 and d 454 after hatching at an average total length of 94.8 mm(n = 21). These reproductive and developmental traits fit in well with the ancestral state reconstruction in hynobiids. If corrected for dry mass, feed conversion ratios obtained by feeding bloodworms(Chironomidae) to P. shangchengensis larvae and mealworms(Tenebrio molitor) to postmetamorphs, were very low(0.33 and 0.34 respectively), equaling a very high mass conversion efficiency.

关键词： Pachyhynobius shangchengensis husbandry reproduction nutrition development

Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara n.Akopov A.Aloisio F.Ameli L.Andricek n.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.Barrett j.Baudot A.Beaulieu j.Becker P.K.Behera j.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini n.Braun T.E.Browder A.Budano S.Bussino M.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.cho K.cho S.cho S.-K.choi S.choudhury D.Cinabro L.Corona L.M.Cremaldi S.Cunliffe T.Czank F.Dattola E.De La Cruz-Burelo G.De nardo M.De nuccio G.De Pietro R.de Sangro M.Destefanis S.Dey A.De Yta-Hernandez F.Di Capua S.Di Carlo j.Dingfelder Z.Doležal I.Domínguez jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman M.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich j.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty M.T.Hedges I.Heredia de la Cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata M.Hoek S.Hollitt T.Hotta C.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia j.Irakkathil jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.jackson W.W.jacobs D.E.jaffe E.-j.j.ng H.B.jeon S.jia Y.j.n C.joo j.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim D.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar D.Kotchetkov n.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger j.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-j.Kwon S.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri j.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven national Laboratory UptonNew York 11973 Budker Institute of nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo nacional de Ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–Synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKEnDAI) Hayama 240-0193 Gyeongsang national University Jinju 52828 Department of Physics and Institute of natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 j-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 InFn Laboratori nazionali di Frascati I-00044 Frascati InFn Sezione di napoli I-80126 Napoli InFn Sezione di Padova I-35131 Padova InFn Sezione di Perugia I-06123 Perugia

From April to july 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

乳腺肿块的评价:影响超声弹性成像质量的因素

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国际医学放射学杂志 2011年第3期 283-283页

作者： W.K.Moon n.cho S.j.Kim 赵芳 Department of Radiology and Clinical Research Institute Seoul National University Hospital the Institute of Radiation Medicine Seoul National University Medical Research Center

目的在可疑乳腺肿块的评价中,调查影响超声弹性成像质量的因素。材料与方法本前瞻性研究得到伦理审查委员会的批准,并获得知情同意书。2009年1月—2009年2月间,在超声引导穿刺活检前对268例病人[平均年龄

关键词：乳腺肿块超声弹性成像质量

实时超声弹性成像鉴别乳腺X线片的可疑微小钙化

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国际医学放射学杂志 2009年第5期32卷 505-505页

作者： n.cho W.K.Moon j.S.Park 秦乃姗 Department of Radiology Seoul National University Hospital28Yongon-dongChongno-guSeoul100-744Republic of Korea

本研究的目的是以组织学作为参考标准,回顾性评价超声弹性成像鉴别乳腺X线探查到可疑微小钙化的良恶性。2006年5月-2007年4月，于针吸活检前对77例（年龄24～67岁，平均46岁）乳腺X线探查到的微小钙化区（42例良性和35例恶性）行实时超... 详细信息

本研究的目的是以组织学作为参考标准,回顾性评价超声弹性成像鉴别乳腺X线探查到可疑微小钙化的良恶性。2006年5月-2007年4月，于针吸活检前对77例（年龄24～67岁，平均46岁）乳腺X线探查到的微小钙化区（42例良性和35例恶性）行实时超声弹性成像检查。在不知X线和组织学检查结果的情况下。

关键词：乳腺新生物钙化超声弹性成像组织特征

患子宫内膜癌日本妇女的主诉、患者特征与疾病预后的关系

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世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 58-59页

作者： Kodama j. Seki n. Ojima Y. 郭培奋 Department of Obstetrics and Gynecology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences 2-5-1 Shikata-cho Okayama 700-8558 Japan

Objective: To determine whether patient characteristics and presenting symptoms could be prognostic indicators for endometrial cancer in japanese women. Methods: Review of the medical charts, which included presenting symptoms and other patient characteristics, of 242 women who underwent surgical treatment for FIGO stage I-IV endometrial cancer. Results: FIGO stage, histologic grade, and lower abdominal pain were found to be significant independent factors for progression-free and overall survival. In contrast, abnormal uterine bleeding, comorbidities, and prior malignancy were not found to be prognostic factors. Conclusion: Lower abdominal pain was found to be an independent prognostic factor in endometrial cancer among japanese women.

关键词：疾病预后子宫出血预示作用

naming and outline of Dothideomycetes-2014 including proposals for the protection or suppression of generic names

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Fungal Diversity 2014年第6期69卷 1-55页

作者： nalin n.Wijayawardene Pedro W.Crous Paul M.Kirk David L.Hawksworth Saranyaphat Boonmee Uwe Braun Dong-Qin Dai Melvina j.D’souza Paul Diederich Asha Dissanayake Mingkhuan Doilom Singang Hongsanan E.B.Gareth j.nes johannes Z.Groenewald Ruvishika jayawardena james D.Lawrey jian-Kui Liu Robert Lücking Hugo Madrid Dimuthu S.Manamgoda Lucia Muggia Matthew P.nelsen Rungtiwa Phookamsak Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Dhanushka n.Wanasinghe Saowanee Wikee Ying Zhang Andre Aptroot H.A.Ariyawansa Ali H.Bahkali D.jayarama Bhat Cécile Gueidan Putarak chomnunti G.Sybren De Hoog Kerry Knudsen Wen-j.ng Li Eric H.C.McKenzie Andrew n.Miller Alan j.L.Phillips Marcin Piatek Huzefa A.Raja Roger S.Shivas Bernad Slippers joanne E.Taylor Qing Tian Yong Wang joyce H.C.Woudenberg Lei Cai Walter M.jaklitsch Kevin D.Hyde Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand Forestry and Agricultural Biotechnology Institute(FABI) University of PretoriaPretoria 0002South Africa CBS-KnAW Fungal Biodiversity Centre Uppsalalaan 83584 CT UtrechtThe Netherlands State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing100101People_s Republicof China Mycology Section Royal Botanic GardensKewRichmondSurrey TW93DSUK Department of Life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Departamento de Biología VegetalⅡ Facultad de FarmaciaUniversidad Complutense de MadridPlaza Ramón y CajalMadrid 28040Spain School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institut Für Biologie Martin-Luther-UniversitatBereich Geobotanik Und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Musée national d'histoire naturelle 25 Rue MunsterL-2160 LuxembourgLuxembourg Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Kingdom of Saudi Arabia Department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA Science and Education Integrative Research(Botany)The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA Institute of Plant Sciences University of GrazHolteigasse 68010GrazAustria Department of Life Science University of TriesteVia L.Giorgieri 10TriesteItaly Committee on Evolutionary Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA Fungal Biodiversity Laboratory(BFBD) National Center for Gen

Article 59.1,of the International Code of nomenclature for Algae,Fungi,and Plants(ICn;Melbourne Code),which addresses the nomenclature of pleomorphic fungi,became effective from 30 july *** that date,each fungal species can have one nomenclaturally correct name in a particular *** other previously used names for this species will be considered as *** older generic epithet takes priority over the younger *** widely used younger names proposed for use,must comply with Art.57.2 and their usage should be approved by the nomenclature Committee for Fungi(nCF).In this paper,we list all genera currently accepted by us in Dothideomycetes(belonging to 23 orders and 110 families),including pleomorphic and nonpleomorphic *** the case of pleomorphic genera,we follow the rulings of the current ICn and propose single generic names for future *** taxonomic placements of 1261 genera are listed as an *** names and suppressed names for 34 pleomorphic genera are listed *** and justifications are provided for possible proposed names after the list of *** are also provided on recent advances in our understanding of asexual and sexual morph linkages in Dothideomycetes.A phylogenetic tree based on four gene analyses supported 23 orders and 75 families,while 35 families still lack molecular data.

关键词： Article 59.1 Ascomycota One name Phylogeny Pleomorphism