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neuronal injury and tumor necrosis factor-alpha immunoreactivity in the rat hippocampus in the early period of asphyxia-induced cardiac arrest under normothermia

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neural Regeneration Research 2017年第12期12卷 2007-2013页

作者： Hyun-j.n Tae Il j.n Kang Tae-Kyeong Lee jeong hwi cho jae-Chul Lee Myoung Cheol Shin Yoon Sung Kim j.n hwi cho j.ng-Dai Kim ji Hyeon Ahn joon Ha Park In-Shik Kim Hyang-Ah Lee Yang Hee Kim Moo-Ho Won Young joo Lee Bio-Safety Research Institute College of Veterinary Medicine Chonbuk National University Iksan South Korea Department of Food Science and nutrition Hallym University Chuncheon South Korea Department of neurobiology School of Medicine Kangwon National University Chuncheon South Korea Department of Emergency Medicine School of Medicine Kangwon National University Chuncheon South Korea Department of Emergency Medicine Samcheok Medical Center Samcheok South Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon South Korea Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Chuncheon South Korea Department of Obstetrics and Gynecology School of Medicine Kangwon National University Chuncheon South Korea Department of Surgery School of Medicine Kangwon National University Chuncheon South Korea Department of Emergency Medicine Seoul Hospital College of Medicine Sooncheonhyang University Seoul South Korea

Low survival rate occurs in patients who initially experience a spontaneous return of circulation after cardiac arrest（CA）. In this study, we induced asphyxial CA in adult male Sprague-Daley rats, maintained their body temperature at 37 ± 0.5°C, and then observed the survival rate during the post-resuscitation phase. We examined neuronal damage in the hippocampus using cresyl violet（CV） and Fluore-jade B（F-j B） staining, and pro-inflammatory response using ionized calcium-binding adapter molecule 1（Iba-1）, glial fibrillary acidic protein（GFAP）, and tumor necrosis factor-alpha（TnF-α） immunohistochemistry in the hippocampus after asphyxial CA in rats under normothermia. Our results show that the survival rate decreased gradually post-CA（about 63% at 6 hours, 37% at 1 day, and 8% at 2 days post-CA）. Rats were sacrificed at these points in time post-CA, and no neuronal damage was found in the hippocampus until 1 day post-CA. However, some neurons in the stratum pyramidale of the CA region in the hippocampus were dead 2 days post-CA. Iba-1 immunoreactive microglia in the CA1 region did not change until 1 day postCA, and they were activated（enlarged cell bodies with short and thicken processes） in all layers 2 days postCA. Meanwhile, GFAP-immunoreactive astrocytes did not change significantly until 2 days post-CA. TnF-α immunoreactivity decreased significantly in neurons of the stratum pyramidale in the CA1 region 6 hours post-CA, decreased gradually until 1 day post-CA, and increased significantly again 2 days post-CA. These findings suggest that low survival rate of normothermic rats in the early period of asphyxia-induced CA is related to increased TnF-α immunoreactivity, but not to neuronal damage in the hippocampal CA1 region.

关键词： nerve regeneration post-cardiac arrest syndrome normothermia neuronal damage gliosis tumor necrosis factor-alpha neural regeneration

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Clinical outcome of pediatric and young adult subclinical varicoceles:a single-institution experience

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Asian journal of Andrology 2021年第6期23卷 611-615页

作者： Patricia S cho Richard n Yu Harriet j Paltiel Matthew A Migliozzi Xiaoran Li Alyssia Venna David A Diamond Department of Urology University of Massachusetts Medical SchoolWorcesterMA 01655USA Department of Urology Boston Children's HospitalBostonMA 02115USA Department of Radiology Boston Children's HospitalBostonMA 02115USA

Subclinical varicocele represents an abnormality of veins of the pampiniform plexus on scrotal ultrasound(US)without a clinically palpable *** significance remains *** guidelines do not recommend surgical intervention,clinical management is *** there is limited information on long-term outcome of subclinical varicoceles due to challenges in diagnosis and management,we performed a single-institution,retrospective review of patients from October 1999 to October 2014 with subclinical varicocele and with available US studies reviewed by a single *** varicocele was defined as dilation of the pampiniform venous plexus on US involving≥2 vessels with diameter>2.5 mm,without clinical varicocele on physical examination or prior inguinal ***-six of 98 patients identified were confirmed as having a subclinical varicocele and *** mean age at initial visit was 15.5 years,with a mean follow-up of 26.5 *** majority were right-sided(69.4%,n=25),usually with a contralateral clinical *** asymmetry(>20%volume difference of the affected side by testicular atrophy index formula)was assessed in 9 patients with unilateral subclinical varicocele without contralateral clinical or subclinical varicocele and observed in 1 *** 17 patients with follow-up,3(17.6%)progressed to clinical varicocele without asymmetric testicular volume,as most remained subclinical or resolved without *** our experience,subclinical varicoceles appeared unlikely to progress to clinical varicoceles,to affect testicular volume,or to lead to *** our study is limited in numbers and follow-up,this information may aid clinical management strategies and guide future prospective studies.

关键词： adolescent pediatric subclinical varicocele

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MOLECULAR DESIGn OF LIGHT EMITTInG POLYMERS

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Chinese journal of Polymer Science 2000年第3期18卷 227-237页

作者： j.W.Yu j.K.Kim j.MHong Y.C.Kim H.n.cho D.Y.Kim C.Y.Kim Polymer Materials Laboratory Korea Institute of Science and TechnologyP.O.Box 131CheongryangSeoul 130-650.Korea

Fluorene-based alternating and statistical copolymers were synthesized by employing reaction methods of Wittig,Heck and *** copolymers were classified into three groups with the photoluminescence(PL)emission maxima at420,475 and 500 nm,*** copolymers with two chromophores having PL emission maxima at 420 and475 nm emitted light with the emission maximum at 475 nm on photoexcitation at 365 nm and improved the quantumefficiency by the energy ***,the intramolecular energy transfer was inefficient compared to the intermolecularenergy transfer when the two chromophores were apart from each other in the range of the Forster critical ***-pyridinedivinylene alternating copolymer was synthesized by the Wittig reaction and found to have physical,electronic andelectrochemical properties of the individual units *** double-layered light emitting diode(LED)with the statisticalcopolymer as an emitting layer and the pyridine-containing copolymer as an electron transporting-hole blocking layer,whichwere sandwiched between ITO and Al,displayed a quantum efficiency of 0.1%.

关键词： Light emitting polymers

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Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction

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neural Regeneration Research 2015年第8期10卷 1251-1257页

作者： ji Yun Ahn Hyun-j.n Tae jeong-hwi cho In Hye Kim ji Hyeon Ahn joon Ha Park Dong Won Kim j.n hwi cho Moo-Ho Won Seongkweon Hong jae-Chul Lee jeong Yeol Seo Department of Emergency Medicine Sacred Heart Hospital College of Medicine Hallym University Department of Emergency Medicine School of Medicine Kangwon National University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of neurobiology School of Medicine Kangwon National University Department of Emergency Medicine Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Surgery School of Medicine Kangwon National University

c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat cingulate and piriform cortices after myocardial infarction. neuronal degeneration in cingulate and piriform cortices after myocardial infarction was detected using cresyl violet staining, neu n immunohistochemistry and Fluoro-jade B histofluorescence staining. c-Fos-immunoreactive cells were observed in cingulate and piriform cortices at 3 days after myocardial infarction and peaked at 7 and 14 days after myocardial infarction. But they were hardly observed at 56 days after myocardial infarction. The chronological change of c-Fos expression determined by western blot analysis was basically the same as that of c-Fos immunoreactivity. These results indicate that myocardial infarction can cause the chronological change of immediate-early response gene c-Fos protein expression, which might be associated with the neural activity induced by myocardial infarction.

关键词： nerve regeneration paralimbic cortices myocardial infarction c-Fos cingulate cortex piriform cortex immunohistochemistry western analysis neural regeneration

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Biodegradation of alkylates under less agitated aquifer conditions

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journal of Environmental Sciences 2013年第8期25卷 1529-1538页

作者： jay j. cho Makram T. Suidan Albert D. Venosa URS Corporation 7720n 16th St. Ste 100 Phoenix AZ 85020 USA Faculty of Engineering and Architecture American University of Beirut Dean's officeP.O.Box 11-0236 Riad El Solh 1107 2020 Beirut Lebanon US Environmental Protection Agency National Risk Management Research LaboratoryCincinnati OH 45268 USA

The biodegradability of three alkylates （2,3-dimethylpentane, 2,4-dimethylpentane and 2,2,4-trimethylpentane） under less agitated aquifer conditions was investigated in this study. All three alkylates biodegraded completely under these conditions regardless of the presence or absence of ethanol or benzene, toluene, ethylbenzene, and xylenes （BTEX） in the feed. In the presence of ethanol, alkylates degradation was not inhibited by ethanol. However, alkylates degraded more slowly in the presence of BTEX suggesting competitive inhibition to microbial utilization of alkylates. In the sterile controls, alkylates concentrations remained unchanged throughout the experiments.

关键词： biodegradation alkylates inhibition BTEX ethanol

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Heavy Metals in Brown Rice(Oryza sativa L.) and Soil After Long-Term Irrigation of Wastewater Discharged from Domestic Sewage Treatment Plants

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Pedosphere 2011年第5期21卷 621-627页

作者： B.Y.CHUnG C.H.SOnG B.j.PARK j.Y.cho Advanced Radiation Technology Institute Korea Atomic Energy Research Institute(KAERI) Korea Testing & Research Institute(KTR) Department of Horticultural Science Chungbuk National University Department of Bio-environmental Chemistry Chonbuk National University

A pot experiment was conducted in a plastic film house to evaluate the translocation and uptake of heavy metals(Pb,Cd,Cu,and Zn) into brown rice(Oryza sativa L.) and the heavy metals residues in soils which had previously been irrigated with domestic wastewater for a long time(3 years).The range of Pb,Cd,Cu,and Zn was 5.10 ± 0.01,0.105 ± 0.017,5.76 ± 0.42,and 23.56 ± 1.40 mg kg-1,respectively in the domestic wastewater-irrigated soil,and 0.370 ± 0.006,0.011 ± 0.001,0.340 ± 0.04,and 2.05 ± 0.18 mg kg-1,respectively,in the domestic wastewater-irrigated brown *** results indicated that application of domestic wastewater to arable land slightly increased the levels of Pb,Cd,Cu,and Zn in soil and brown rice(P ncentrations of heavy metals in brown rice were lower than the recommended tolerable levels proposed by the joint FAO/WHO Expert Committee on Food ***,the continuous monitoring and pollution control of hazardous materials from domestic wastewater are needed in order to prevent excessive build-up of heavy metals in the food chain.

关键词： accumulation domestic wastewater ground water irrigation P2O5 total n

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放电对变压器油特性的影响(英文)

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高电压技术 2011年第11期37卷 2793-2799页

作者： j.S.n'cho I.Fofana T.Aka-ngnui A.Beroual Ecole Centrale de Lyon AMPERE CNRS UMR 500536Avenue Guy de Collongue69134EcullyFrance Canada Research Chair on Insulating Liquids and Mixed Dielectrics for Electrotechnology(ISOLIME) Universite du Quebec d ChicoutimiQcCanada

Petroleum based oils,the so-called mineral oils,are used for impregnating solid insulations or filling products of very large number of electric materials:transformers,reactors,cables,bushings,circuit breakers,tap changers, *** these equipments,oil is exposed to electrical stress and may experience electrical discharges under certain *** the electrical stress is unavoidable in power equipments,the ability of oil to resist decomposition under electrical stress is of great importance for the safety of these *** stress together with heat and moisture,in the presence of oxygen,oxidises the oil producing free radicals,acids and sludge that are deleterious to the *** this paper,the effect of electrical discharges on oil properties is *** results indicate that quality of oil is considerably affected with increasing voltage *** oil properties before and after voltage application allows assessing the outcome of random secondary chemical reactions between large oil born free radicals.

关键词： electrical discharge oil transformer dielectric dissipation factor(DDF) conductivity dissolved decay products turbidity interfacial tension total acid number water content

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Aqueous-processable,naphthalene diimide-based polymers for eco-friendly fabrication of high-performance,n-type organic electrolyte-gated transistors

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Science China Chemistry 2022年第5期65卷 973-978页

作者： Dahyun jeong Min je Kim Seungj.n Lee j.n-Woo Lee Youngwoong Kim Hyeong j.n Kim jeong Ho cho Bumjoon j.Kim Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Republic of Korea

Organic electrolyte-gated transistors(OEGTs) have the benefits of low power consumption and large current ***,the electrical performance of n-type OEGTs lags far behind that of p-type *** this study,we design a series of polymers,P(nDITEG-T) and P(nDIMTEG-T),comprising a naphthalene diimide backbone for n-type charge transport and oligo(ethylene glycol)(OEG) side chains for high ionic conductivity and eco-friendly solution *** incorporation of the OEG chain facilitates the electrochemical doping of the semiconductor by ions to realize high-performance,n-type ***,in OEGTs,P(nDITEG-T) achieves a high electron mobility of 1.0 × 10^(-1) cm^(2) V^(-1) s^(-1),which represents the highest value reported for solution-processed,n-type *** is noted that the fabrication of the OEGTs is achieved by solution processing with eco-friendly ethanol/water mixtures in virtue of the hydrophilic OEG *** work demonstrates the molecular design of the P(nDITEG-T) polymer and its significant ability to produce aqueous-processable,high-performance,and n-type OEGTs.

关键词： organic electrolyte-gated transistors n-type transistors oligo(ethylene glycol)polymers eco-friendly solution process high electron mobility

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Present Status of the KSTAR Superconducting Magnet System Development

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Plasma Science and Technology 2004年第5期6卷 2445-2450页

作者： Keeman Kim H.K.Park K.R.Park B.S.Lim S.I.Lee M.K.Kim Y.Chu W.H.Chung S.H.Baek j.Y.cho H.Yonekawa A.Chertovskikh Y.B.Chang j.S.Kim C.S.Kim D.j.Kim n.H.Song K.P.Kim Y.j.Song I.S.Woo W.S.Han D.K.Lee Y.K.Oh K.W.cho j.S.Park G.S.Lee H.j.Lee T.K.Ko S.j.Lee national NationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalKorea Atomic Energy Research InstituteDaejeonRepublic of KoreaYonsei UniversitySeoulRepublic of KoreaYonsei UniversitySeoulRepublic of Korea Fusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science

The mission of Korea Superconducting Tokamak Advanced Research (KSTAR)project is to develop an advanced steady-state superconducting tokamak for establishing a scientificand technological basis for an attractive fusion reactor. Because one of the KSTAR mission is toachieve a steady-state operation, the use of superconducting coils is an obvious choice for themagnet system. The KSTAR superconducting magnet system consists of 16 Toroidal Field (TF) coils and14 Poloidal Field (PF) coils. Internally-cooled Cable-In-Conduit Conductors (CICC) are put into usein both the TF and PF coil systems. The TF coil system provides a field of 3.5 T at the plasmacenter and the PF coil system is able to provide a flux swing of 17 V-sec. The major achievement inKSTAR magnet-system development includes the development of CICC, the development of a full-size TFmodel coil, the development of a coil system for background magnetic-field generation , theconstruction of a large-scale superconducting magnet and CICC test facility. TF and PF coils are inthe stage of fabrication to pave the way for the scheduled completion of KSTAR by the end of 2006.

关键词： superconducting magnet KSTAR CICC

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Glehnia fittoralis Extract Promotes neurogenesis in the Hippocampal Dentate Gyrus of the Adult Mouse through Increasing Expressions of Brain-Derived neurotrophic Factor and Tropomyosin-Related Kinase B

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Chinese Medical journal 2018年第6期131卷 689-695页

作者： joon Ha Park Bich na Shin ji Hyeon Ahn jeong hwi cho Tae-Kyeong Lee jae-Chul Lee Yong Hwan jeon II j.n Kang Ki-Yeon Yoo In Koo Hwang choong Hyun Lee Yoo Hun noh Sung-Su Kim Moo-Ho Won j.ng Dai Kim Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Chuncheon 24252 Korea Department of neurobiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Radiology School of Medicine Kangwon National University Chuncheon 24341 Korea Department of Food Science and nutrition Hallym University Chuncheon 24252 Korea epartment of Oral Anatomy College of Dentistry and Research Institute of Oral Biology Gangneung-Wonju National University Gangneung 25457 Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seou108826 Korea Department of Pharmacy College of Pharmacy Dankook University Cheonan 31116 Korea Famenity Biomedical Research Center Famenity Inc. Gyeonggi 13837 Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 24341 Korea

Background： Glehnia littoralis has been used for traditional Asian medicine, which has diverse therapeutic activities. However, studies regarding neurogenic effects of G. littoralis have not yet been considered. Therefore, in this study, we examined effects of G. littoralis extract on cell proliferation, neuroblast differentiation, and the maturation of newborn neurons in the hippocampus of adult mice. Methods： A total of 39 male ICR mice （12 weeks old） were randomly assigned to vehicle-treated and 100 and 200 mg/kg G. littoralis extract-treated groups （n = 13 in each group）. Vehicle and G. littoralis extract were orally administrated for 28 days. To examine neurogenic effects ofG. litmralis extract, we performed immunohistochemistry tbr 5-bromo-2-deoxyuridine （BrdU, an indicator for cell proliferation） and doublecortin （DCX, an immature neuronal marker） and double immunofluorescence staining for BrdU and neuronal nuclear antigen （neun, a mature neuronal marker）. In addition, we examined expressional changes of brain-derived neurotrophic factor （BDnF） and its major receptor tropomyosin-related kinase B （TrkB） using Western blotting analysis. Results： Treatment with 200 mg/kg, not 100 mg/kg, significantly increased number of BrdU-immunoreactive （＋） and DCX＋ cells （48.0 ±3.1and 72.0 ± 3.8 cells/section, respectively） in the subgranular zone （SGZ） of the dentate gyrus （DG） and BrdU＊/neun＋ cells （17.0 ±1.5 cells/section） in the granule cell layer as well as in the SGZ. In addition, protein levels of BDnF and YrkB （about 232% and 244% of the vehicle-treated group, respectively） were significantly increased in the DG of the mice treated with 200 mg/kg ofG. littoralis extract. Conclusion： G. littoralis extract promots cell proliferation, neuroblast differentiation, and neuronal maturation in the hippocampal DG, and neurogenic effects might be closely related to increases ofBDn F and TrkB proteins by G. littoralis extract treatment.

关键词： Brain-Derived neurotrophic Factor CellProliferation Glehnia littoralis neuroblast Differentiation Tropomyosin-Related Kinase B

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