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Study of biological markers in skin quality treatment by subcutaneous injection of a stabilized composition of 26 mg/mL of high molecular weight HA

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Plastic and Aesthetic Research 2022年第1期9卷 539-552页

作者： jérémie Bon Bétemps Samuel Gavard Molliard Basste Hadjab Mhd Badi Anas Ghazal Marco Cerrano Research and Development Department Kylane Laboratoires SAPlan-les-Ouates 1228Switzerland Art Clinic Riyadh 12432Saudi Arabia Derma Clinic Jeddah 23432Saudi Arabia Entourage Clinique Lausanne 1003Switzerland

Aim:Hyaluronic acid(HA)injectables have gained rapid acceptance for the treatment of skin rejuvenation.A novel HA/sorbitol composition intended for skin quality improvement containing 2.6%of high molecular weight HA stabilized by sorbitol was recently designed to be injected *** aim of this study was to assess the expression of biological markers of skin quality after administration of the ***:The HA/sorbitol composition was evaluated after injection into the superficial adipose tissue with ex vivo cultured human skin explants versus a product comparator to study the general morphology of the skin tissues and the expression of HA,elastin,collagen type Ⅰ,collagen type Ⅲ,and fibrillin-1 in the dermal ***:The results demonstrate that the HA/sorbitol composition is able to boost the production of HA,elastin,collagen type Ⅰ,collagen type Ⅲ,and fibrillin-1 in the dermis while providing a proper quality of skin ***:The HA/sorbitol composition improved biological markers of skin quality in the dermis after product injection into the superficial adipose *** novel composition can be considered as an attractive solution to treat skin aging by injecting a specific HA/sorbitol formulation to strategically target the subcutaneous tissue to improve the quality of the different layers of the skin.

关键词： Facial aging hyaluronic acid sorbitol skin quality biological markers

Analyze the Impact of ITS in Improving the Efficiency of Road Tax and Fee Collection Use of Digital Technologies in the City of Bujumbura

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Open journal of Applied Sciences 2024年第6期14卷 1464-1473页

作者： Fiston Niyonkuru Ilundu Wail Walumbuka jérémie Ndikumagenge Center of Research in Infrastructure Environment and Technology (CRIET) University of Burundi Bujumbura Burundi Computer Management Bukavu Higher Pedagogical Institute Bukavu Democratic Republic of the Congo University of Burundi Bujumbura Burundi

Road transport is currently one of the most important sectors affecting sustainable development and the improvement of the population’s standard of living. In some sub-Saharan African countries, including Burundi, the transport structure is vulnerable, under attack, or even damaged or destroyed. This is prompting decision-makers to look for every possible way to enable dynamic management of the road system, as well as the collection of tax revenues attributable to this sector. To reach this stage, we postulate that the introduction of the Intelligent Transport System (ITS) into the road tax and fee collection process would make a significant contribution (road safety, zero cash on silk Safety Officers, payment of a fine, eradication of road corruption etc.) to the digitization of the various transport sectors. As far as the city of Bujumbura is concerned (our field of intervention), the applicability of the present System could thus meet the expectations of the decision-maker, certain drivers and, by the same token, contribute to the promotion of Digital Technology in Burundi.

关键词： Intelligent Transport System Infra-Red Sensor Network OCR Algorithm Vision Systems Multi-Agent System

面向产品服务系统开发的客户需求和满意度分析

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面向产品服务系统开发的客户需求和满意度分析

作者： jérémie CHAUVIN 上海交通大学

学位级别：硕士

产品服务系统（PSS）通过整合产品与服务形成个性化的解决方案，为客户提供新的附加值。这种新的模式为生产者和客户带来新的优势，但也意味着新的设计开发过程需要更多的客户参与。只有这样，供应商才会懂得如何为客户创造真正的附加... 详细信息

产品服务系统（PSS）通过整合产品与服务形成个性化的解决方案，为客户提供新的附加值。这种新的模式为生产者和客户带来新的优势，但也意味着新的设计开发过程需要更多的客户参与。只有这样，供应商才会懂得如何为客户创造真正的附加值，预测未来的机遇，优势和改进方向。因此，本论文研究面向PSS开发，进行客户需求和满意度分析。本研究基于米其林中国公司的合作项目，作为“米其林车队解决方案”其林车的开发一个单元，用于轮胎的市场分析。与传统的产品制造系统相比，PSS更需要客户参与，这导致了PSS需要新的设计方法，以适应市场。新的设计方法使得PSS供应商能够更好地了解客户需求，掌握客户需求的动态演化过程。本研究的第一步是识别轮胎特性及相关服务的特殊需求，识别了27种特性，并将其分为5类。第二步设计调查问卷，进行市场调研，并收集了来自10个公司72名客户关于这27种特性的评价结果。每名客户回答了他们的满意度、各性能的相对重要性，以及他们的重要性分类（卡诺类）。第三步，基于主成分分析法(PCA)对收集的格式化后的结果进行了分析，从而通过消除包含在相关因素的冗余信息。通过PCA，从最初的27项满意度因素中提炼出了20中主要因素，从而得到了改善后的模型。第四步是进行回归分析，得到各组（性能，安全，质量，品牌，服务）对于整体客户满意度的相对影响。研究结果发现品牌、质量和服务的提高是最能够影响客户的满意度的主要因素。这也已被卡诺分析所证实。此外，本研究发现“性能”和“安全性”是基本因素，而“品牌”、“质量”和“服务”是有吸引力的因素。同时还发现客户的卡诺分类具有和服务经验相关联的演变效果，即从冷漠/有吸引力的要求发展为一维/必须的要求。本研究的结果可以使米其林了解哪些因素需要重点关注，以继续保持领先地位。米其林需要关注有吸引力的性能（服务、品牌和质量），并保持基本特征的性能（轮胎的性能和安全性）具有强劲水平。然而，本研究存在一定的局限性。首先，该研究只进行了有限的时间（一年），包括确定企业伙伴进行合作研究。因此，由于时间限制，只针对有限数量的客户进行了单一的调研。其次，本研究启动了米其林PSS的数据收集过程，但也是这种形式与客户的第一次互动。在本研究中，客户需求和它们沿着时间演化的基本结构已经建立，但是该模型需要更多的客户调研进行验证和提高。本论文最后提出了与米其林PSS开展进一步合作的工作设想。同时对推广面向每个客户的整合服务所提出了若干建议。根据本研究的结果，该过程将进一步激化更加高效的PSS。本研究的方法和结论需要通过米其林的PSS演化来继续执行和验证。这项工作可以由米其林和上海交通大学工业工程与管理系继续深化合作来实现。

关键词：产品服务系统(PSS) 客户满意度调查问卷主成分分析卡诺模型

Algorithms and Tools for Securing and Protecting Academic Data in the Democratic Republic of the Congo

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journal of Information Security 2022年第4期13卷 312-322页

作者： Gulain Mugaruka Buduge jérémie Ndikumagenge justin Buhendwa Nyenyezi Department of Management Computing for Companies Section of Commercial and Computing Sciences Teachers’ Training Collage of Bukavu Bukavu Democratic Republic of the Congo Department of ICT Faculty of Engineering Sciences University of Burundi Bujumbura Burundi Department of Maths-Physics Section of Exact Sciences Teachers’ Training College of Bukavu Bukavu Democratic Republic of the Congo

This paper deals with the implementation of algorithms and tools for the security of academic data protection in the Democratic Republic of the Congo. It consists principally in implementing two algorithms and two distinct tools to secure data and in this particular case, academic data of higher and university education in the Democratic Republic of the Congo. The design of algorithms meets the approach that any researcher in data encryption must use during the development of a computer system. Briefly, these algorithms are steps to follow to encrypt information in any programming language. These algorithms are based on symmetric and asymmetric encryption, the first one uses Christopher Hill’s algorithm, which uses texts in the form of matrices before they are encrypted and RSA as one of the asymmetric algorithms, it uses the prime numbers that we have encoded on more than 512 bits. As for tools, we have developed them in php which is only a programming language taken as an example because it is impossible to use all of them. The tools implemented are based on the algorithms of Caesar, Christopher Hill, and RSA showing how the encryption operations are carried out thanks to graphical interfaces. They are only tools for pedagogical reasons to help students and other researchers learn how to use developed algorithms. We have not developed them for pleasure but rather to be used in any information system, which would prevent and limit unauthorized access to computer systems. They will not be used only for the management of academic fees but for any other information system, which explains and shows the complexity of the tools developed. We have not been able to solve the problems of versions for the developed prototype, because if there is a new version later some functions may be obsolete, which would constitute the limitation of these tools. This work targets primarily the Ministry of Higher Education and Universities, which will make these results its own and implem

关键词： Computer Security Crypto Systems and Analysis Algorithms Encryption/Decryption

Obscure bleeding colonic duplication responds to proton pump inhibitor therapy

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World journal of Gastroenterology 2013年第35期19卷 5940-5942页

作者： jérémie jacques Fabrice Projetti Romain Legros Virginie Valgueblasse Matthieu Sarabi Paul Carrier Fabien Fredon Stéphane Bouvier Véronique Loustaud-Ratti Denis Sautereau Service d’Hépato-gastro-entérologie CHU Dupuytren

We report the case of a 17-year-old male admitted to our academic hospital with massive rectal *** childhood he had reported recurrent gastrointestinal bleeding and had two exploratory laparotomies 5and 2 years *** emergency abdominal computed tomography scan,gastroscopy and colonoscopy,performed after hemodynamic stabilization,were considered ***-dose intravenous proton pump inhibitor(PPI)therapy was initiated and bleeding stopped *** other massive rectal bleeds occurred 8 h after each cessation of PPI which led to a hemostatic laparotomy after negative gastroscopy and small bowel capsule *** showed long tubular duplication of the right colon,with fresh blood in the duplicated *** lower gastrointestinal bleeding is a difficult medical situation and potentially *** presence of ulcerated ectopic gastric mucosa in the colonic duplication explains the partial efficacy of PPI *** gastrointestinalbleeding responding to empiric anti-acid therapy should probably evoke the diagnosis of bleeding ectopic gastric mucosa such as Meckel’s diverticulum or gastrointestinal duplication,and gastroenterologists should be aware of this potential medical situation.

关键词： Colonic duplication Gastro-intestinal duplication Gastrointestinal bleeding Hemostatic colorectal surgery Proton pump inhibitor therapy

Ribavirin:Past,present and future

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World journal of Hepatology 2016年第2期8卷 123-130页

作者： Véronique Loustaud-Ratti Marilyne Debette-Gratien jérémie jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier Fédération Hépatologie CHU Dupuytren87042 LimogesFrance Service d’Hépatogastroentérologie CHU Limoges87042 LimogesFrance U850 INSERM Universitéde LimogesCHU Limoges87042 LimogesFrance Service de Bactériologie Virologie CHU Limoges87042 LimogesFrance U1092 INSERM Universitéde LimogesCHU Limoges87042 LimogesFrance Service de Pharmacologie CHU Limoges87042 LimogesFrance

Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs.

关键词： Ribavirin Hepatitis C Peginterferon Directacting antiviral agents

Characterization of a Multimodal and Multispectral Led Imager: Application to Organic Polymer’s Microspheres with Diameter Φ = 10.2 μm

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Optics and Photonics journal 2016年第7期6卷 171-183页

作者： Marcel A. Agnero jérémie T. Zoueu Kouakou Konan Laboratoire d’Instrumentation d’Image et Spectroscopie Institut National Polytechnique Félix Houphou&#235 t-Boigny Yamoussoukro C&#244 te d’Ivoire Laboratoire de Physique de la Matière Condensée et Technologie University Félix Houphou&#235 t-Boigny Abidjan C&#244 te d’Ivoire

Multispectral microscopy enables information enhancement in the study of specimens because of the large spectral band used in this technique. A low cost multimode multispectral microscope using a camera and a set of quasi-monochromatic Light Emitting Diodes (LEDs) ranging from ultraviolet to near-infrared wavelengths as illumination sources was constructed. But the use of a large spectral band provided by non-monochromatic sources induces variation of focal plan of the imager due to chromatic aberration which rises up the diffraction effects and blurs the images causing shadow around them. It results in discrepancies between standard spectra and extracted spectra with microscope. So we need to calibrate that instrument to be a standard one. We proceed with two types of images comparison to choose the reference wavelength for image acquisition where diffraction effect is more reduced. At each wavelength chosen as a reference, one image is well contrasted. First, we compare the thirteen well contrasted images to identify that presenting more reduced shadow. In second time, we determine the mean of the shadow size over the images from each set. The correction of the discrepancies required measurements on filters using a standard spectrometer and the microscope in transmission mode and reflection mode. To evaluate the capacity of our device to transmit information in frequency domain, its modulation transfer function is evaluated. Multivariate analysis is used to test its capacity to recognize properties of well-known sample. The wavelength 700 nm was chosen to be the reference for the image acquisition, because at this wavelength the images are well contrasted. The measurement made on the filters suggested correction coefficients in transmission mode and reflection mode. The experimental instrument recognized the microsphere’s properties and led to the extraction of the standard transmittance and reflectance spectra. Therefore, this microscope is used as a conventional

关键词： Multispectral Imaging Reference Wavelength Correction Coefficients Modulation Transfer Function

Anti-hepatitis C virus drugs and kidney

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World journal of Hepatology 2016年第32期8卷 1343-1353页

作者： Paul Carrier Marie Essig Marilyne Debette-Gratien Denis Sautereau Annick Rousseau Pierre Marquet jérémie jacques Véronique Loustaud-Ratti U850 INSERM Université de Limoges Service d’Hépato-gastroentérologie CHU Limoges

Hepatitis C virus(HCV) mainly targets the liver but can also induce extrahepatic manifestations. The kidney may be impacted via an immune mediated mechanism or a cytopathic effect. HCV patients are clearly at a greater risk of chronic kidney disease(CKD) than uninfected patients are, and the presence of CKD increases mortality. Interferon-based therapies and ribavirin are difficult to manage and are poorly effective in endstage renal disease and hemodialysis. These patients should be given priority treatment with new direct anti-viral agents(DAAs) while avoiding peginterferon and ribavirin. The first results were convincing. To aid in the correct use of these drugs in patients with renal insufficiency, their pharmacokinetic properties and potential renal toxicity must be known. The renal toxicity of these new drugs was not a safety signal in clinical trials, and the drugs are generally efficient in these frail populations. These drugs are usually well tolerated, but recent cohort studies have demonstrated that these new regimens may be associated with renal side effects, especially when using sofosbuvir combinations. HCV, renal diseases and comorbidities are intimately linked. The close monitoring of renal function is required, particularly for at-risk patients(transplanted, HIV-coinfected, CKD, hypertensive or diabetic patients). New DAA regimens, which will soon be approved, will probably change the landscape.

关键词： Nephrotoxicity Hepatitis C Direct anti-viral agents Kidney End-stage renal disease

Analysis of Mobile and Internet Network Coverage: Propagation of Electromagnetic Waves and Concept of Digital Divide in Burundi

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Open journal of Antennas and Propagation 2024年第1期12卷 1-18页

作者： Apollinaire Bigirimana jérémie Ndikumagenge Sami Tabbane Romeo Nibitanga Hassan Kibeya Center for Research in Infrastructure Environment and Technology (CRIET) Doctoral School of the University of Burundi Bujumbura Burundi Center for Research in Infrastructure Environment and Technology (CRIET) University of Burundi Bujumbura Burundi Higher School of Communications of Tunis Technological City of Communications Ariana Tunisia Faculty of Engineering Sciences Universit du Burundi Bujumbura Burundi

Mobile and Internet network coverage plays an important role in digital transformation and the exploitation of new services. The evolution of mobile networks from the first generation (1G) to the 5th generation is still a long process. 2G networks have developed the messaging service, which complements the already operational voice service. 2G technology has rapidly progressed to the third generation (3G), incorporating multimedia data transmission techniques. It then progressed to fourth generation (4G) and LTE (Long Term Evolution), increasing the transmission speed to improve 3G. Currently, developed countries have already moved to 5G. In developing countries, including Burundi, a member of the East African Community (ECA) where more than 80% are connected to 2G technologies, 40% are connected to the 3G network and 25% to the 4G network and are not yet connected to the 5G network and then still a process. The objective of this article is to analyze the coverage of 2G, 3G and 4G networks in Burundi. This analysis will make it possible to identify possible deficits in order to reduce the digital divide between connected urban areas and remote rural areas. Furthermore, this analysis will draw the attention of decision-makers to the need to deploy networks and coverage to allow the population to access mobile and Internet services and thus enable the digitalization of the population. Finally, this article shows the level of coverage, the digital divide and an overview of the deployment of base stations (BTS) throughout the country to promote the transformation and digital inclusion of services.

关键词： Coverage of Mobile Networks and Internet Digital Divide Rural and Isolated Areas Antenna Connectivity and Digital Inclusion