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An accurately fast algorithm of calculating reflection/transmission coefficients

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Science China(p.ysics,Mechanics & Astronomy) 2008年第7期51卷 823-846页

作者： CASTAGNA j p Dep.rtment of Earth and Atmosp.eric Sciences University of Houston

For the boundary between transversely isotrop.c media with a vertical axis of symmetry (VTI media), the interface between a liquid and a VTI medium, and the free-surface of an elastic half-sp.ce of a VTI medium, an accurately fast algorithm was p.esented for calculating reflection/transmission (R/T) coefficients. Sp.cially, the case of p.st-critical angle incidence was considered. Although we only p.rformed the numerical calculation for the models of the VTI media, the calculated results can be extended to the models of transversely isotrop.c media with a horizontal axis of rotation symmetry (HTI media). Comp.red to p.evious work, this algorithm can be used not only for the calculation of R/T coefficients of the boundary between ellip.oidally anisotrop.c media, but also for that between generally anisotrop.c media, and the sp.ed and accuracy of this algorithm are faster and higher. According to the anisotrop.c p.rameters of some rocks given by the p.blished literature, we p.rformed the calculation of R/T coefficients by using this algorithm and analyzed the effect of the rock anisotrop. on R/T coefficients. We used Snell's law and the energy balance p.incip.e to p.rform verification for the calculated results.

关键词： reflection/transmission coefficient AVO analysis anisotrop. VTI medium HTI medium

Ion-p.iring Hp.C methods to determine EDTA and DTp. in small molecule and biological p.armaceutical formulations

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journal of p.armaceutical Analysis 2016年第3期6卷 150-156页

作者： George Wang Frank p. Tomasella Analytical and Bioanalytical Develop.ent Pharmaceutical Development Bristol-Myers Squibb Company New Brunswick NJ 08903 USA

Ion-p.iring high-p.rformance liquid chromatograp.y-ultraviolet （Hp.C-UV） methods were develop.d to determine two commonly used chelating agents, ethylenediaminetetraacetic acid （EDTA） in Abilify （a small molecule drug with arip.p.azole as the active p.armaceutical ingredient） oral solution and die- thylenetriaminep.ntaacetic acid （DTp.） in Yervoy （a monoclonal antibody drug with ip.limumab as the active p.armaceutical ingredient） intravenous formulation. Since the analytes, EDTA and DTp., do not contain chromop.ores, transition metal ions （Cu2＋, Fe3＋） which generate highly stable metallocom- p.exes with the chelating agents were added into the samp.e p.ep.ration to enhance UV detection. The use of metallocomp.exes with ion-p.iring chromatograp.y p.ovides the ability to achieve the desired sensitivity and selectivity in the develop.ent of the method. Sp.cifically, the samp.e p.ep.ration in- volving metallocomp.ex formation allowed sensitive UV detection. Cop.er was utilized for the de- termination of EDTA and iron was utilized for the determination of DTp.. In the case of EDTA, a gradient mobile p.ase sep.rated the comp.nents of the formulation from the analyte. In the method for DTp., the active drug substance, ip.limumab, was eluted in the void. In addition, the op.imization of the concentration of the ion-p.iring reagent was discussed as a means of enhancing the retention of the aminop.lycarboxylic acids （Ap.As） including EDTA and DTp. and the sp.cificity of the method. The analytical method develop.ent was designed based on the chromatograp.ic p.op.rties of the analytes, the nature of the samp.e matrix and the intended p.rp.se of the method. Validation data were p.esented for the two methods. Finally, both methods were successfully utilized in determining the fate of the chelates.

关键词： EDTA DTp. Ion-p.iring Hp.C Arip.p.azole Ip.limumab

Early Evolution of Ap.crita (Insecta,Hymenop.era) as Indicated by New Findings in the Middle jurassic of Daohugou,Northeast China

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 834-873页

作者： Alexandr p. RASNITSYN ZHANG Haichun p.laeontological Institute Russian Academy of Sciences 117997 Moscow Russia Natural History Museum London SW7 5BD UK State Key Laboratory of p.laeobiology and Stratigrap.y （Nanjing Institute of Geology and p.laeontology the Chinese Academy of Sciences） Nanjing 210008 China

The classification and p.ylogeny of the basal Vesp.na （= Orussoidea ＋ Ap.crita） are reconsidered based p.imarily on rich and well p.eserved material from the Middle jurassic of Daohugou in Inner Mongolia, China. Comp.ratively smooth morp.ological transitions are traced from a Xip.ydriidae-like ancestor toward Orussoidea via the jurassic family Karatavitidae, and through Karatavitidae and the jurassic and Early Cretaceous family Ep.ialtitidae indep.ndently to Step.anidae, to Evanioidea, and, via the extinct jurassic Kuafuidae fam. nov. to the remaining Ap.crita. New hyp.thesis is p.op.sed concerning develop.ent of the characteristic wasp.waist of Ap.crita, which is sup.osed to ap.ear indep.ndently and in different ways in Evanioidea and in the rest of Ap.crita. As a result, six infraorders are p.op.sed for the suborder Vesp.na with the following taxonomic structure： infraorder Orussomorp.a including the only sup.rfamily Orussoidea （Karatavitidae ＋ p.roryssidae ＋ Orussidae）, infraorder Step.anomorp.a with the only sup.rfamily Step.anoidea （Ep.ialtitidae ＋ Step.anidae）, infraorder Evaniomorp.a with the only sup.rfamily Evanioidea of traditional comp.sition, infraorder Cerap.ronomorp.a with the sup.rfamih＇es Cerap.ronoidea s. str. and monotyp.cal Megalyroidea and Trigonaloidea, and the infraorders p.octotrup.morp.a, Ichneumonomorp.a, and Vesp.morp.a of traditional comp.sition. The family Kuafuidae is unp.aced to infraorder because it is p.tatively p.rap.yletic with resp.ct to Cerap.ronomorp.a, p.octotrup.morp.a, Ichneumonomorp.a and Vesp.morp.a. Described as new are Karatavites junfengi sp. nov, p.aeratavites wuhuaensis sp. nov., p. p.rsp.cuus sp. nov, p.stxip.ydria daohugouensis gen. et sp. nov., p. ningchengensis gen. et sp. nov., p.stxip.ydroides strenuus gen. et sp. nov., p.aeratavitoides amabilis gen. et sp. nov., p.oap.critus densip.diculus sp. nov., p. sculp.us sp. nov., p. longantennatus sp. nov., p. formosus sp. nov., p. atrop.s sp. nov., p. elegans sp. nov., S

关键词： Ap.crita origin wasp.waist origin Evanioidea fossil Hymenop.era Middle jurassic Daohugou

La_2O_3/TFE: An efficient system for room temp.rature synthesis of Hantzsch p.lyhydroquinolines

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Chinese Chemical Letters 2014年第8期25卷 1149-1152页

作者： Sunil U. Tekale Vijay p. p.gore Sushama S. Kauthale Rajendra p. p.war Dep.rtment of Chemistry Shri Muktanand College Dep.rtment of Chemistry Deogiri College

Lanthanum oxide（La2O3） in combination with 2,2,2-trifluoroethanol（TFE） was found to be an efficient system for the one-p.t, four-comp.nent synthesis of Hantzsch p.lyhydroquinoline derivatives from aromatic aldehydes, dimedone, ethyl acetoacetate and ammonium acetate at ambient temp.rature. The catalyst is heterogeneous and reusable, hence can be sep.rated easily and reused. The p.esent method is featured by mild reaction conditions, use of heterogeneous catalyst, non-chromatograp.ic p.rification,short reaction time and high yields, which make it an attractive route for the synthesis of p.lyhydroquinolines.

关键词： Hantzsch p.lyhydroquinolines La2O3 TFE

Environmental engineering of transition metal dichalcogenide op.oelectronics

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Frontiers of p.ysics 2018年第4期13卷 21-52页

作者： Trevor LaMountain Erik j. Lenferink Yen-jung Chen Teodor K. Stanev Nathaniel p. Stern Dep.rtment of p.ysics and Astronomy Northwestern University Evanston Illinois 60208 USA

The exp.osion of interest in two-dimensional van der Waals materials has been in many ways driven by their layered geometry. This feature makes p.ssible numerous avenues for assembling and ma- nip.lating the op.ical and electronic p.op.rties of these materials. In the sp.cific case of monolayer transition metal dichalcogenide semiconductors, the direct band gap.combined with the flexibility for manip.lation of layers has made this class of materials p.omising for op.oelectronics. Here, we review the p.op.rties of these layered materials and the various means of engineering these p.op.rties for op.oeleetronics. We summarize ap.roaches for control that modify their structural and chemical en- vironment, and we give p.rticular detail on the integration of these materials into engineered op.ical fields to control their op.ical characteristics. This combination of controllability from their layered surface structure and p.otonic environment p.ovide an exp.nsive landscap. for novel op.oelectronic p.enomena.

关键词： transition metal dichalcogenides op.oelectronics van der Waals materials heterostructures excitons

Bone regeneration using coculture of mesenchymal stem cells and angiogenic cells

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Frontiers of Materials Science 2014年第1期8卷 32-38页

作者： jin-Ling MA jeroen j. j. p. van den BEUCKEN ju-Li p.N Fu-Zhai CUI Su CHEN Dep.rtment of VIp.Service Beijing Stomatological Hospital Capital Medical University Beijing 100050 China Dep.rtment of Biomaterials Radboudumc Nijmegen the Netherlands Dep.rtment of Oral and Maxillofacial Surgery Beijing Stomatological Hospital Capital Medical University Beijing 100050 China State Key Laboratory of New Ceramics and Fine p.ocessing School of Materials Science and Engineering Tsinghua University Beijing 100084 China

Cellular strategies remain a crucial comp.nent in bone tissue engineering （BTE）. So far, the outcome of cell-based strategies from initial clinical trials is far behind comp.red to animal studies, which is suggested to be related to insufficient nutrient and oxygen sup.ly inside the Ussue-engineered constructs. Cocultures, by introducing angiogenic cells into osteogenic cell cultures, might p.ovide a solution for imp.oving vascularization and hence increasing bone formation for cell-based constructs. So far, p.e-clinical studies demonstrated that cocultures enhance vascularization and bone formation comp.red to monocultures. However, there has been no rep.rt on the ap.lication of cocultures in clinics. Therefore, this mini-review aims to p.ovide an overview regarding （i） critical p.rameters in cocultures and the outcomes of cocultures comp.red to monocultures in the currently available p.e-clinical studies using human mesenchymal stem cells imp.anted in orthotop.c animal models; and （ii） the usage of monocultures in clinical ap.lication in BTE.

关键词： mesenchymal stem cell (MSC) endothelial cell (EC) coculture vasculari-zation tissue regeneration

MULTIp.E-SCATTERING DETERMINATION TO THE LOCAL ADSORp.ION GEOMETRY OF SO_2/p.(111)

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Acta Metallurgica Sinica(English Letters) 2002年第1期15卷 81-86页

作者： S. Cao j.C. Tang p. Zhu L. Wang S.L Shen Dep.rtment of p.ysics and State Key laboratory for Silicon Material Zhejiang University Hangzhou 310027 China

We have calculated the sulp.ur 1s near edge X-ray absorp.ion fine structure (NEXAFS) sp.ctra of SO2 adsorbed on p. (111) in terms of the Multip.e-Scattering Cluster (MSC) method. The origin of the resonances in the NEXAFS sp.ctra has been revealed. By the MSC calculation and a (DV)-Xα study we have for the first time identified two weak features existing in S K-edge NEXAFS of SO2/p.(111) system, which are attributed to the interaction between the adsorbate and the substrate. Moreover, MSC calculation together with the reliability factor (R-factor) analysis are emp.oyed to determine the local adsorp.ion structures. These results are broadly in agreement with those of Fourier-transform analysis of the surface extended X-ray absorp.ion fine structure (SEXAFS).

关键词： Absorp.ion Geometry p.lladium Scattering Sulfur dioxide X ray sp.ctroscop.

Comp.tational analysis of deleterious missense mutations in asp.rtoacylase that cause Canavan's disease

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Science China(Life Sciences) 2012年第12期55卷 1109-1119页

作者： SREEVISHNUp.IYA K. CHANDRASEKARAN p. SENTHILKUMAR A. SETHUMADHAVAN R. SHANTHI V. DAISY p. NISHA j. RAMANATHAN K. RAjASEKARAN R. Bioinformatics Division School of Biosciences and Technology Vellore Institute of TechnologyVellore 632014 Tamil Nadu India Dep.rtment of Biotechnology Holy Cross CollegeTrichy 620002 Tamil Nadu India

In this work, the most detrimental missense mutations of asp.rtoacylase that cause Canavan's disease were identified comp.tationally and the substrate binding efficiencies of those missense mutations were analyzed. Out of 30 missense mutations, I-Mutant 2.0, SIFT and p.lyp.en p.ograms identified 22 variants that were less stable, deleterious and damaging resp.ctively. Subsequently, modeling of these 22 variants was p.rformed to understand the change in their conformations with resp.ct to the native asp.rtoacylase by comp.ting their root mean squared deviation (RMSD). Furthermore, the native p.otein and the 22 mutants were docked with the substrate NAA (N-Acetyl-Asp.rtic acid) to exp.ain the substrate binding efficiencies of those detrimental missense mutations. Among the 22 mutants, the docking studies identified that 15 mutants caused lower binding affinity for NAA than the native p.otein. Finally, normal mode analysis determined that the loss of binding affinity of these 15 mutants was caused by altered flexibility in the amino acids that bind to NAA comp.red with the native p.otein. Thus, the p.e- sent study showed that the majority of the substrate-binding amino acids in those 15 mutants disp.ayed loss of flexibility, which could be the theoretical exp.anation of decreased binding affinity between the mutant asp.rtoacylases and NAA.

关键词： missense mutation Canavan's disease asp.rtoacylase NAA flexibility

Methop.ene ap.lication and diet p.otein sup.lementation to male melon fly, Bactrocera cucurbitae, modifies female remating behavior

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Insect Science 2014年第5期21卷 637-646页

作者： Ihsan ul Haq Marc j. B. Vreysen p. E. A. Teal jorge Hendrichs Insect p.st Control Laboratory Joint FAO/IAEA Agriculture and Biotechnology Laboratories A-2444 Seibersdorf Austria NationalAgricultural Research Centre Park Road Islamabad 45500 Pakistan Center for Medical Agricultural and Veterinary EntomologyUSDA ARS Gainesville Florida 32604 USA Insect p.st Control Section Joint FAO/IAEA Division IAEA A-1400 Vienna Austria

Methop.ene （an analogue of juvenile hormone） ap.lication and feeding on a p.otein diet is known to enhance male melon fly, Bactrocera cucurbitae Coquillett （Dip.era： Tep.ritidae）, mating success. In this study, we investigated the effect of these treatments on male B. cucurbitae＇s ability to inhibit female remating. While 14-d-old females were fed on p.otein diet, 6-d-old males were exp.sed to one of the following treatments：（i） top.cal ap.lication of methop.ene and fed on a p.otein diet; （ii） no methop.ene but fed on a p.otein diet; （iii） methop.ene and sugar-fed only; and （iv） sugar-fed, 14-d-old males acted as controls. Treatments had no effect on a male＇s ability to dep.ess the female remating recep.ivity in comp.rison to the control. Females mated with p.otein-dep.ived males showed higher remating recep.ivity than females first mated with p.otein-fed males. Methop.ene and p.otein diet interaction had a p.sitive effect on male mating success during the first and second mating of females. Significantly more females first mated with sugar-fed males remated with p.otein-fed males and females first mated with methop.ene treated and p.otein-fed males were more likely to remate with similarly treated males. Females mating latency （time to start mating） was significantly shorter with p.otein-fed males, and mating duration was significantly longer with p.otein-fed males comp.red with p.otein-dep.ived males. These results are discussed in the context of methop.ene and/or dietary p.otein as p.erelease treatment of sterile males in area-wide control of melon fly integrating the sterile insect technique （SIT）.

关键词： Bactrocera cucurbitae methop.ene p.otein rich diet remating behavior SIT Tep.ritidae