检索结果-南通市图书馆

Brain-penetrating neurotrophic factor mimetics: HEr-096 as a disease-modifying therapy for Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SmN1 delivery to correct all neurological and systemic perturbations

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown rafael j.Yáñez-muñoz Heidi r.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SmA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SmA was understood in 1995 when loss or impairment of the survival motor neuron 1(SmN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SmN2,which can produce low levels(approximately 10%)of the full-length functional SmN protein,has led to the generation of SmA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SmN2 copy number is used as a proxy for the prediction of disease severity,with higher SmN2 copy number typically being associated with reduced severity of SmA,although this relationship is not absolute:some individuals with low SmN2 copy number have less severe SmA phenotypes and vice ***,the etiology of SmA is further complicated by other factors,such as non-typical nucleotide variants and SmN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen robert j.Thomas m.Brandon Westover can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA center for Translational Pain research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Status and prospects for symmetric organic redox flow batteries

在线全文

学校读者我要写书评

暂无评论

journal of Energy chemistry 2025年第1期100卷 125-143页

作者： md Al raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(OrFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric OrFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric OrFBs.

关键词： redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Genetic relationship between purebred and crossbred sow longevity

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

journal of Animal Science and Biotechnology 2017年第1期8卷 24-29页

作者： c.E.Abell r.L.fernando T.V.Serenius m.F.rothschild K.A.Gray K.j.Stalder Department of Animal Science Iowa State University Ames IA 50011-3150 USA Figen Ltd. PO Box 31960101 Seinajoki Finland Smithfield Premium Genetics 316 W. Charity Rd Rose Hill NC 28458 USA

Background： The overall breeding objective for a nucleus swine selection program is to improve crossbred commercial performance. most genetic improvement programs are based on an assumed high degree of positive relationship between purebred performance in a nucleus herd and their relatives＇ crossbred performance in a commercial herd. The objective of this study was to examine the relationship between purebred and crossbred sow longevity performance. Sow longevity was defined as a binary trait with a success occurring if a sow remained in the herd for a certain number of parities and including the cumulative number born alive as a measure of reproductive success. Heritabilities, genetic correlations, and phenotypic correlations were estimated using ***： results indicated little to no genetic correlations between crossbred and purebred reproductive *** indicates that selection for longevity or lifetime performance at the nucleus level may not result in improved longevity and lifetime performance at the crossbred level. Early parity performance was highly correlated with lifetime performance indicating that an indicator trait at an early parity could be used to predict lifetime performance. This would allow a sow to have her own record for the selection trait before she has been removed from the ***： results from this study aid in quantifying the relationship between purebred and crossbred performance and provide information for genetic companies to consider when developing a selection program where the objective is to improve crossbred sow performance. Utilizing crossbred records in a selection program would be the best way to improve crossbred sow productivity.

关键词： Binary traits Sow longevity Threshold model

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg marina manoraj jenny cheung jennifer Zhang Kaveh mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of medicine IndianapolisINUSA Division of Plastic and reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Fibre Optic Protection System for concrete Structures

在线全文

学校读者我要写书评

暂无评论

journal of materials Science & Technology 2006年第3期22卷 404-410页

作者： j.S.Leng A.Hameed D.Winter r.A.Barnes G.c.mays G.F.fernando centre for composite materials Harbin Institute of Technology Harbin 150001 China Engineering System Department Defence Academy of the United Kingdom Cranfield University Shrivenham Wiltshire SN6 8LA UK

The design concepts, modelling and implementation of various fibre optic sensor protection systems for development in concrete structures were investigated. Design concepts and on-site requirements for surface-mounted and embedded optical fibre sensor in concrete were addressed. Finite element （FE） modelling of selected sensor protection systems in strain-transfer efficiency from the structure to the sensing region was also studied. And experimental validation of specified sensor protection system was reported. results obtained indicate that the protection system for the sensors performs adequately in concrete environment and there is very good correlation between results obtained by the protected fibre optic sensors and conventional electrical resistance strain gauges.

关键词： Fibre optic sensor (FOS) Sensor protection system (SPS) concrete structures Extrinsic Fabry-Perot interferometer (EFPI) sensor Smart Structures Strain transfer

Heart failure in the elderly

在线全文

学校读者我要写书评

暂无评论

journal of Geriatric cardiology 2021年第3期18卷 219-232页

作者： Pablo Díez-Villanueva césar jiménez-méndez fernando Alfonso cardiology Department Hospital Universitario La PrincesaUniversidad Autónoma de MadridCIBER-CVMadridSpain

Heart failure(HF)is a clinical syndrome caused by structural and/or functional cardiac abnormalities,resulting in a reduced cardiac output and/or elevated intracardiac filling pressures at rest or during *** is a major public health problem with high prevalence and incidence,involving both high morbidity and mortality,but also high economic *** incidence of HF progressively increases with age,reaching around 20%among people over 75 years ***,HF represents the leading cause of hospitalization in patients older than 65 years in Western ***,some authors even consider HF a geriatric syndrome,entailing worse prognosis and high residual disability,and often associating some complex comorbidities,common in older population,that may further complicate the course of the *** the other hand,however,clinical course and prognosis may be often difficult to *** this article,main pathophysiological issues related to the aging heart are addressed,together with key aspects related to both diagnosis and prognosis in elderly patients with ***,main geriatric conditions,common in the elderly population,are reviewed,highlighting the importance of a comprehensive and multidisciplinary approach.

关键词： diagnosis elevated mortality