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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Application of nanotechnology to dentistry:Impact of graphene nanocomposites on clinical air quality

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World journal of Clinical Cases 2025年第8期13卷 1-7页

作者： Ruth Rodríguez montaño mario A Alarcón-Sánchez melissa martínez nieto juan j Varela Hernández Sarah m Lomelímartínez Department of Health and Illness as an Individual and Collective Process University Center of TlajomulcoUniversity of GuadalajaraTlajomulco de Zuñiga 45641JaliscoMexico Institute of Research in Dentistry Department of Integral Dental ClinicsUniversity Center of Health SciencesUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Department of Biomedical Science Faculty of Chemical-Biological SciencesAutonomous University of GuerreroGuerrero 39090Mexico Instituto Odontológico del Pacífico Sur Chilpancingo de los Bravo 39022Mexico Independent Researcher Tijuana 22116Baja CaliforniaMexico Department of medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlan 47810JaliscoMexico master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraOcotlan 46200JaliscoMexico

Concerns about air quality in dental clinics where aerosol generation during procedures poses significant health risks,have prompted investigations on advanced disinfection *** editorial describes the strengths and limitations of ventilation and aerosol control measures in dental offices,especially with respect to the use of graphene *** potential of graphene nanocomposites as an innovative solution to aerosol-associated health risks is examined in this review due to the unique properties of graphene(e.g.,high con-ductivity,mechanical strength,and antimicrobial activity).These properties have produced promising results in various fields,but the application of graphene in dentistry remains *** recent study by ju et al which was published in World journal of Clinical Cases evaluated the effectiveness of graphene-based air disinfection systems in dental *** study demonstrated that graphene-based disinfection techniques produced significant reductions in suspended particulate matter and bacterial colony counts,when co-mpared with traditional *** these positive results,challenges such as material saturation,frequency of filter replacement,and associated costs must be addressed before widespread adoption of graphene-based disinfection techniques in clinical ***,there is need for further research on material structure optimization,long-term safety evaluations,and broader clinical applications,in order to maximize their positive impact on public health.

关键词： Graphene nanocomposites Antibacterial activity Biomedical applications Air disinfection

Zebrafish as a possible bioindicator of organic pollutants with effects on reproduction in drinking waters

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journal of Environmental Sciences 2015年第7期27卷 254-260页

作者： m.martínez-Sales F.García-Ximénez F.j.Espinós Aquaculture and Environmental Research Group (ACUmA) Polytechnic University of Valencia

Organic contaminants can be detected at low concentrations in drinking water, raising concerns for human health, particularly in reproduction. In this respect, we attempted to use the zebrafish as a bioindicator to detect the possible presence of these substances in drinking water, aiming to define the most relevant parameters to detect these substances, which particularly affect the development and reproduction of zebrafish. To this end, batches of30 embryos with the chorion intact were cultured in drinking waters from different sources,throughout their full life-cycle up to 5 months, in 20 L tanks. Six replicates were performed in all water groups, with a total of 24 aquariums. Two generations（F0 and F1） were studied and the following parameters were tested： in the F0 generation, survival and abnormality rates evaluated at 5 dpf（days post-fertilization） and at 5 mpf（months post-fertilization）,the onset of spawning and the fertility rate from 3 mpf to 5 mpf, and the sex ratio and underdeveloped specimens at 5 mpf. Furthermore, in the F0 offspring（F1）, survival and abnormality rates were evaluated at 5 dpf and the hatching rate at 72 hpf. These results revealed that the hatching rate is the most sensitive parameter to distinguish different levels of effects between waters during the early life stages, whereas the rate of underdeveloped specimens is more suitable at later life stages. Regarding adult reproduction, fertility rate was the most sensitive parameter. The possible reversibility or accumulative nature of such effects will be studied in future work.

关键词： Organic pollutants Bioindicator Development and reproduction parameters Drinking water Zebrafish

Interpolation of Ideal measures by Abstract K and j Spaces

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Acta mathematica Sinica,English Series 2007年第8期23卷 1357-1374页

作者： Luz m.FERnnDEZ-CABRERA Antón mARTínez Sección Departamental de matemática Aplicada Escuela de EstadísticaUniversidad Complutense de Madrid28040 MadridSpain Departamento de matemática Aplicada I E.T.S.Ingenieros IndustrialesUniversidad de Vigo36200

We work with the abstract K and j interpolation method generated by a sequence lattice Г. We investigate the deviation of an interpolated operator from a given operator ideal by establishing formulae for the ideal measure of the interpolated operator in terms of the ideal measures of restrictions of the operator. Formulae are given in terms of the norms of the shift operators on Г.

关键词： real interpolation ideal measures operator ideals shift operators

Synthesis and characterization of carbon-TiO2-CeO2 composites and their applications in phenol degradation

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journal of Rare Earths 2017年第6期35卷 551-558页

作者： y.Lara-López G.García-Rosales j.jiménez-Becerril Technological Institute of Toluca Posgrade and Research Division Ex-Rancho La Virgen S/N C.P. 50120 Metepec Mexico national Institute for nuclearResearch Chemistry Department. Carretera Mexico-Toluca S/N la Marquesa Ocoyoacac C.P. 52750 Mexico

The objective of this work was to synthesize particles of titanium oxide and cerium oxide supported on carbon, which was obtained through the pyrolysis of orange peel. The materials were characterized using scanning electron microscopy, X-ray diffraction, infrared spectroscopy, and the specific surface area from Brunauer-Emmett-Teller method. The photocatalytic properties of the synthesized materials were determined by the degradation of phenol in 30 mg/L aqueous solutions. TiO2-CeO2 particles were obtained with an average spherical size of 57 nm and were supported on the carbon surface; this material presented a specific surface area of 296 m2/g and degrades -40% of phenol after 240 min of UV irradiation.

关键词： phenol photocatalytic spherical pyrolysis irradiation Teller Brunauer ceria orange cerium

Aerodynamic load control on a dynamically pitching wind turbine airfoil using leading-edge protuberance method

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Acta mechanica Sinica 2020年第2期36卷 275-289页

作者： y.n.Zhang m.m.Zhang C.Cai j.Z.Xu Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China The Key Laboratory of Wind Energy Utilization of CAS Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Dalian national Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023China

The aerodynamic loads of wind turbine blades are substantially affected by dynamic stall induced by the variations of the angle of attack of local airfoil *** purpose of the present study is to explore the effect of leading-edge protuberances on the fluctuation of the aerodynamic performances for wind turbine airfoil during dynamic *** experimental investigation is carried out by a direct force measurement technique employing force balance at a Reynolds number Re=2×*** phase-averaged and instantaneous aerodynamic loads of the pitching airfoil,including the baseline and the wavy airfoil,are presented and *** phase-averaged results indicate that the effects of dynamic stall for the wavy airfoil can be delayed or minimized compared to the baseline airfoil,and the negative damping area of the wavy airfoil is significant decreased in full-stall *** effects of leading-edge protuberances are more notable at a higher reduced *** the instantaneous aerodynamic loads of the wavy airfoil,there is an observable reduction in fluctuations compared with baseline ***,spectral analysis is applied to quantitatively undercover the nonstationary features of the instantaneous aerodynamic *** is found that the leading edge protuberances can reduce the harmonics of the aerodynamic force signal,and enhance the stability of the aerodynamic loads under different reduced *** conclusion,leading-edge protuberances are found effective to reduce the fluctuation characteristics of the aerodynamic loads during the dynamic stall process,and help to improve the stability and prolong the service life of the wind turbine blades.

关键词： Wind turbine airfoil Dynamic stall Loads control Leading-edge protuberance Aerodynamic experiment

Finite Element Analysis of Push-Out Test of SiC Fiber Reinforced Titanium matrix Composites

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稀有金属材料与工程 2009年第A03期38卷 50-53页

作者： yuan m n yang y Q Huang B Zhang R j School of materials Northwestern Polytechnical University Xi＇an 710072 China

Based on the interphase layer model and the spring layer model, an improved interface model was developed to evaluate the interfacial shear strength of Titanium matrix composites(TmCs) and to analyze the effects of various parameters on the interfacial properties. The results showed that the improved interface model is more suitable for calculating the interfacial properties of SiC fiber reinforced titanium matrix composites. The interfacial shear strength of SiC/Timetal-834 predicted is 500 mPa. In addition, in order to better understand the interfacial properties of composites, some push out phenomenon were analyzed.

关键词：复合材料剪切强度碳化硅纤维物理性能