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Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

Bioactive Materials 2022年第10期7卷 173-186页

作者： Mauricio Gonçalves da costa Sousa Gabriela Conceiçao de Almeida Danilo Cesar Martins Mota Rosiane Andrade da costa Simoni Campos Dias Samuel Nunes Limberger Frank Ko Li Ting Lin Evan FHaney Hashem Etayash Beverlie Baquir Michael j.Trimble Ya Shen Zheng Su Markus Haapasalo Daniel Pletzer Letícia Chaves de Souza Glaucia Schuindt Teixeira Renato M.silva Robert E.W.Hancock Octavio Luiz Franco Taia Maria Berto Rezende Post-Graduation Program in Genomic Sciences and Biotechnology Catholic University of BrasíliaBrasíliaBrazil Dentistry Course Catholic University of BrasíliaBrasíliaBrazil Post-Graduation Program in Health Sciences University of BrasíliaBrazil LIMA Chemistry InstituteUniversity of Brasília-UNBBrasíliaBrazil Animal Biology Department Campus Darcy RibeiroUniversidade de BrasíliaBrazil Department of Materials Engineering Faculty of Applied ScienceUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of British ColumbiaVancouverBCCanada Department of Oral Biological and Medical Sciences Faculty of DentistryUniversity of British ColumbiaVancouverCanada Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Department of Endodontics School of DentistryUniversity of Texas Health Science Center at HoustonHoustonUSA Department of Prosthesis Faculty of DentistryRio de Janeiro State UniversityRio de JaneiroBrazil Post-Graduation Program in Biotechnology Catholic University Dom BoscoCampo GrandeMato Grosso do SulBrazil

Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for ***,different scaffolds were tested for use during the pulp revascularization process,including poly(vinyl alcohol)-PVA hydrogels or resins,collagen hydrogels and poly(vinyl alcohol)PVA/Chitosan(PVA/CS)*** on time to degradation(21 days),nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002(each at 50 mg/g).Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against Enterococcus faecalis,Staphylococcus aureus and a multispecies oral biofilm,besides anti-inflammatory *** in vivo subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation,when compared to empty teeth ***,we designed a strong antimicrobial,immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.

关键词： Regenerative endodontics Scaffolds Nanofibers Host defense peptides Ciprofloxacin IDR-1002

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Functional Morphology of the Spermatogenesis of Gir Bulls

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Agricultural Sciences 2020年第11期11卷 1081-1094页

作者： Daniel F. M. silva Fabio j. C. Faria Fernando H. G. Furtado Carlos A. C. Fernandes juliana C. B. silva Adriano Garcia Deiler S. costa Federal University of Mato Grosso do Sul Campo Grande Brazil University josé do Rosário Vellano Alfenas Brazil Embrapa Pantanal Corumbá Brazil Brazilian Zebu Breeders Association ABCZ Campo Grande Brazil Nucleus of Animal Production and Reproduction (NUPRA) Campo Grande Brazil

The purpose of this study was to evaluate the functional morphology of the spermatogenesis of Gir bulls, with emphasis on the testicular biometry and testicular parenchyma histomorphometry. Testicular fragments from eight Gir bulls were used. The fragments were fixed by tissue perfusion with Karnovsck’s solution, and inclusion was subsequently performed using glycol methacrylate. Histological sections of 4 μm were made and stained with a 1% toluidine blue-sodium borate solution. The mean age of the bulls was 8.0 ± 1.3 years and the mean body weight was 467.5 ± 26.7 kg. Testicular weight was 289.2 ± 30.5 g on average, and the average gonadosomatic index was 0.12% ± 0.02%. The seminiferous tubules, Leydig cells, stroma, and intertubular tissue composed 80.9% ± 1.7%, 5.4% ± 1.3%, 13.7% ± 1.1%, and 19.1% ± 1.7% of the total testicular weight, respectively. The mean length of the seminiferous tubule per gram of testicle was 17 ± 0.8 m. Losses during spermatogonia mitosis averaged 75.5% ± 3.22%, while losses were 30.6% ± 8.17% during the meiotic phase, which resulted in an average total loss of 81.49% ± 2.58% of cells during the entire process of spermatogenesis. The average daily sperm production per gram of parenchyma was 28.0 × 106 cells. It was concluded that the histometric measurements of testicular parameters in the Gir breed are within the averages reported for other zebu cattle breeds.

关键词： Spermatogonia Leydig Sertoli Testicle

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Osmoregulators in Hymenaea courbaril and Hymenaea stigonocarpa under water stress and rehydration

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journal of Forestry Research 2018年第6期29卷 1475-1479页

作者： Luma Castro de Souza Luana Moraes da Luz je′ssica Taynara da silva Martins Candido Ferreira de Oliveira Neto juscelino Goncalves Palheta Tamires Borges de Oliveira Ediane Conceicao Alves Risely Ferraz de Almeida Raimundo Leonardo Lima de Oliveira Roberto Cezar Lobo da costa Nariane Quaresma Vilhena Universidade estadual paulista ju′lio de mesquita filho JaboticabalSP 14884-900Brazil Universidade Federal Rural da Amazonia(UFRA) Campus CapanemaCapanema 68700-030Brazil Universidade Federal Rural da Amazonia Campus BelemBelem 66077-830Brazil Universidade Federal de Vicosa(UFV) Vicosa 36570-900Brazil Universidade Estadual Paulista ju′lio de Mesquita Fiho(UNESP) Jaboticabal 14884-900Brazil Universidade do Estado do Para′(UEPA) Bele′m 66113-200Brazil

The objective of this work was to evaluate the effect of different water deficiency and rehydration levels on the concentrations of osmoregulators in two plant species（Hymenaea courbaril and H. Stigonocarpa） in the Amazon. We adopted a 2×5×5 factorial system,referring to 2 species（H. courbaril and H. stigonocarpa）and 5 stages of hydration and rehydration. The five hydration and rehydration stages were established in:（1）Control treatment E0;（2） Plants with 13 days of stress after incubation—E13;（3） Plants with 26 days of stress E26;（4）The plants that were established after 26 days after incubation and rehydrated for two days（RD2）;（5） rehydrated for two days（RD4）. The plants that were established after 26 days after incubation and rehydrated for four days. The experiment totaled fifty young plants with five *** measurements were performed at the beginning of the experiment（E0） at 13（E13） and 26（E26） days after the water stress, in which the plants were rehydrated,repeating the analyses after two（RD2） and four（RD4）days. Both species increased the sucrose concentration by18%, with a decrease of 52% in starch content. The RD4 time presented the highest mean starch concentration(0.19 mmol g-1 of the residue for H. courbaril and0.27 mmol g;of residue for H. stigonocarpa). Increased proline concentrations were recorded for controls until RD2 for both species. For glycine betaine, the highest increases in treatments E26 and RD2 were observed for the H. courbaril species. Our rehydration period was not sufficient for total recovery of pre-stress concentrations of all studied solutes.

关键词： Amazonia Water stress Osmotic adjustment Proline Sucrose

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Crohn's disease and clinical management today:How it does?

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World journal of Methodology 2023年第5期13卷 399-413页

作者： Ronaldo Teixeira da silva júnior jonathan Santos Apolonio jessica Oliveira de Souza Nascimento Bruna Teixeira da costa Luciano Hasimoto Malheiro Marcel silva Luz Lorena Sousa de Carvalho Cleiton da silvaSantos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Crohn’s Disease(CD)is an Inflammatory Bowel Disease and is characterized by an immune-mediated *** etiology results from the interaction between genetic,enviromental and microbial *** pathophysiology,it involves high levels of interleukin(IL)-12,IL-17,and Th1 profile,along with loss of tolerance mechanisms,an increase in pro-inflammatory interleukins,beyond the possibility to affect any part of the gastrointestinal *** symptoms include abdominal pain,chronic diarrhea,weight loss,anorexia,and fatigue,as well as blood in the stool or ***,conditions comprising musculoskeletal,cutaneous,ocular,hepatic,and hematological alterations may be associated with this scenario and extra-intestinal presentation,such as erythema nodosum,anterior uveitis,osteoporosis,and arthritis can also ***,clinical history,exams as fecal calprotectin,ileocolonocopy,and capsule endoscopy can be performed in the diagnosis investigation,along with treatments to induce and maintain *** this sense,anti-inflammatory drugs,such as corticosteroids,immunomodulators,and biological agents,as well as surgery and non-pharmacological interventions plays a role in its *** aim of this review is to bring more current evidence to clinical management of CD,as well as to briefly discuss aspects of its pathophysiology,surveillance,and associated disorders.

关键词： Crohn's disease Inflammatory bowel diseases Diagnosis Treatment Immunomodulation Biological agents

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Dengue Climate Variability in Rio de janeiro City with Cross-Wavelet Transform

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journal of Environmental Protection 2022年第3期13卷 261-276页

作者： Suellen Araujo Franco dos Santos Hugo Abi Karam Augusto josé Pereira Filho jú lio Cesar Barreto da silva jose Luis Flores Rojas j.lio Migue Angeles Suazo Isela Leonor Vá squez Panduro Cesar Arturo Sanchez Peñ a Departamento de Meteorologia Instituto de Geoci&ecirc ncias Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brasil Departamento de Ciê ncias Atmosfé ricas Instituto de Astronomia Geofísica e Ci&ecirc ncias Atmosfé ricas Universidade de S&atilde o Paulo (IAG-USP) S&atilde o Paulo Brasil Programa de Pós-Graduaç ã o em Ciê ncias Ambientais Universidade Estadual do Rio de Janeiro (UERJ) Rio de Janeiro Brasil Instituto Geofísico do Peru (IGP) Lima Per&uacute Facultad de Ingeniería Forestal y Ambiental. Universidad Nacional Autó noma de Tayacaja Daniel Herná ndez Morillo (UNAT) Pampas Per&uacute Universidad Tecnoló gicadel Perú Faculdad de Engenier&iacute a Industrial Lima Per&uacute Centro de Previsã o do Tempo e Estudos Climá ticos Cachoeira Paulista Brasil Programa de Pó s-Graduaç ã o em Computaç ã o Aplicada Instituto Nacional de Pesquisas Espaciais (INPE) S&atilde o josé dos Campos S&atilde o Paulo SP Brasil

Dengue is one of the most prominent tropical epidemic diseases present in the Rio de janeiro city and Southeast part of Brazil, due to the widespread conditions of occurrence of the dengue vector, the mosquito Aedesaegypti, such as high-temperature days interlaced with afternoon or nocturnal rainstorms in summer. This work has the objective of investigating the relationships between variabilities of the El Ni?o-South Oscillation (ENSO) and greater epidemics of dengue in Rio de janeiro city. To accomplish this goal, the analysis and signal decomposition by cross-wavelet transform (WT) was applied to obtain the cross variability associated with variations of power and phase of both signals by characteristic periods and along with the time series. Data considered in the analysis are (the decimal logarithm of normalized value) of the monthly available notifications of dengue worsening, provided by the public health system of Brazil, and the Southern Oscillation Index (SOI) Ni?o 3.4 data, provided by the National Oceanic and Atmospheric Administration (NOAA), in the period 2000-2017. A maximum cross-wavelet power close to 0.45 was obtained for the representative period of 1 year and also to periods between 3 and 4 years, associated with the positive phase of the SOI index (i.e. , La Ni?a) or with a transition to the positive phase. The evolution of the combined variability of SOI and dengue can be expressed by progressive differences in phase along the time, eventually resulting in yielding phases (i.e., La Niña-Dengue epidemic).

关键词： Dengue Fever Cross-Wavelet Transform Analysis El Niño-Southern Oscillation Index

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Enterobacteria and Vibrio from Macrobrachium amazonicum prawn farming in Fortaleza,Ceará,Brazil

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Asian Pacific journal of Tropical Medicine 2016年第1期9卷 24-28页

作者： Débora de Souza Collares Maia Castelo-Branco jamille Alencar Sales Raimunda Samia Nogueira Brilhante Glaucia Morgana de Melo Guedes Yago Brito de Ponte Celia Maria de Souza Sampaio Tereza de jesus Pinheiro Gomes Bandeira josé Luciano Bezerra Moreira Lucas Pereira de Alencar Manoel de Araújo Neto Paiva Rossana de Aguiar Cordeiro André jalles Monteiro Waldemiro de Aquino Pereira-Neto josé j.lio costa Sidrim Marcos Fábio Gadelha Rocha Department of Pathology and Legal Medicine Postgraduate Program in Medical MicrobiologySpecialized Medical Mycology CenterFederal University of Ceará School of Veterinary Medicine Postgraduate Program in Veterinary SciencesState University of Ceará Department of Statistics and Applied Mathematics Federal University of Ceará

Objective:To investigate the isolation of enterobacteria associated with Macrobrachium amazonicum(***) farming and evaluate the in vitro antimicrobial susceptibility of Vibrio ***:Strains were isolated from female *** prawns and environmental and hatchery *** assays were used to identify bacterial genera and those belonging to the genus Vibrio were submitted to further analyses for species identification,through Vitek 2 automated system and *** test was performed according to Clinical Laboratory Standards ***:The following genera of enlerobacteria were recovered:Enterobacter(n=11),Citrobacter(n=10),Proteus(n=2),Serratia(n=2),Kluyvera(n=2),Providencia(n=2),Cedecea(n=1),Escherichia(n=1).Edwardsiella(n=1) and BulliauxeUa(n=1).As for Vibrio,three species were identified:Vibrio cholerae non-O1/non-O139(n=4).Vibrio vulnificus(***)(n=1) and Vibrio mimicus(n=1).Vibrio *** minimum inhibitory concentrations values within the susceptibility range established by Clinical Laboratory Standards Institute for almost all antibiotics,except for ***,which presented intermediate profile to ***:Enterobacteria do not seem to be the most important pathogens associated with *** farming,whereas the recovery of Vibrio *** larviculture,with emphasis on Vibrio cholerae and ***,deserves special attention due to their role as potentially zoonotic aquaculture-associated ***,the intermediate susceptibility of *** to ampicillin reflects the importance of monitoring drug use in prawn farming.

关键词： Prawn Water Enterobacteria Vibrio Antibiotics

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Petrography and geochemistry of exported Colombian coals:Implications from correlation and regression analyses

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Energy Geoscience 2021年第3期2卷 201-210页

作者： Segun A.Akinyemi Ferney Bohorquez Nazrul Islam Binoy K.Saikia Carlos H.Sampaio Tito j.Crissien Luis F.O.silva Environmental Remediation&Geopollution Group Department of GeologyFaculty of ScienceEkiti State University Ado EkitiP.M.B.5363Ado EkitiNigeria Department of Civil and Environmental Engineering Universidad de La CostaCalle 58#55-66.080002BarranquillaAtlanticoColombia Coal and Energy Group Materials Science&Technology DivisionCSIR-North East Institute of Science&TechnologyJorhat785006India Departament D’EnginyeriaMinera Industrial I TICSerra Húnter ProfUniversitatPolitecnica de Catalunya Barcelona TechAv.Bases de Manresa 61e63Manresa08242BarcelonaSpain

The petrology of coal,as determined by the microscopic analysis of organic and inorganic elemental constituents of coal,provides information on its nature and *** is used worldwide in the production of thermal energy and *** the case of high-quality Colombian coals,only limited studies have been carried *** present study presents the geochemical,mineralogical,and petrological characteristics of coal samples collected from Puerto Drummond in Cienaga,Colombia,to predict their potential ***,the ultimate,proximate,petrographic,gross calorific value(GCV),ash fusion temperature,Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),X-ray fluorescence(XRF),and Thermogravimetric(TG)analyses were employed in this *** petrological analysis reveals that Colombian coals are naturally more abundant in vitrinite(72%)than inertinite(14e23%)*** and aluminosilicate are the main minerals present as fine particles mixed with *** XRD and FTIR analyses show that the most common and dominant minerals are quartz,while gypsum,hematite,calcite and mica occur in lesser *** oxide composition of the coal ashes consists of 51e58%SiO2 and 18e25%Al2O3 as determined by XRF *** correlation and regression analysis,the moisture content shows a reverse correlation with GCV(Regression value of R2¼0.68).This study helps researchers to comprehend the importance of Colombian coals and presents various techniques for characterisation of coals.

关键词： Coal characterisation Geochemistry Mineralogy Coal petrology Colombia

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Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i>Incorporation of Phospholipids

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journal of Biophysical Chemistry 2017年第3期8卷 23-38页

作者： Franciane S. Marques Alysson Luiz M. Da silva Ricardo j. C. Mattoso Roque Aras Rogério jorge B. De Oliveira j.lio Cézar De Abreu Santos Fabio D. Couto Ricardo D. Couto PGBSMI/Goncalo Moniz Research Center (CPqGM) FIOCRUZ Foundation Center Salvador Brazil Department of Biofunction Health Institute of Science Federal University of Bahia/UFBA Salvador Brazil Clinical Biochemistry Laboratory Department of Clinical and Toxicological Analysis Faculty of Pharmacy Federal University of Bahia/UFBA Salvador Brazil Ana Neri Hospital SESAB and Federal University of Bahia/UFBA Salvador Brazil Naval Hospital of Salvador Brazilian Marine Forces Salvador Brazil Laboratory of Molecular Biology and Genetics at Center of Agricultural Environmental and Biological Sciences (CCAAB-UFRB) Cruz das Almas Brazil

End stage-renal-disease (ESRD) is associated with dyslipidemia and premature atherosclerosis. The study evaluates the effect of hemodialysis (HD) on HDL-remodeling between pre- and post-HD. Was conducted a cross-sectional study with 50 ESRD male patients, undergoing HD at Ana Neri Hospital, Salvador, Brazil. All individuals were on HD for at least 3 months, into a three sessions protocol for 3 - 4 hours per week, with a polysulfone low-flow basic-dialyzing-membrane and unfractionated-heparin. HDL Phospholipid-incorporation was measured by 14C-PL-scintillation-counting, expressed as %14C-PL/mL/hour. Paraoxonase (PON-1) activity was measured by spectrophotometry using paraoxon as substrate. Cardiovascular risk ratios and atherogenic index of plasma were calculated. Total cholesterol, HDL-C and non-HDL-C increased at post-HD on all age groups, but without triglycerides (TG) changes. TG/HDL-C decreased in 30 - 39 and 40 - 49 year (y) at post-HD (p 0.05). LDL-C/apoB increased in >60 y, after HD (p 60 (p 0.01). On the other hand, non-HDL-C/HDL-C reduced in 40 - 49 and >60 y, at post-HD (p 0.05). The linear-correlation between %14C-PL-incorporation and non-HDL-C/HDL-C was negative in 30 - 39 y, both at pre-HD (r = -0.90;p = 0.002) and post-HD (r = -0.78;p = 0.022). Linear-correlation between PON-1 and %14C-PL-incorporation was positive in >60 y, both at pre- (r = 0.63;p = 0.029) and post-HD (r = 0.65;p = 0.022). PON-1 activity increased at pre- (59 ± 30) and post-HD (73 ± 38) in 50 - 59 y (p 0.05). The %14C-PL-incorporation was reduced in >60 y (p 0.05), when compared to pre- and post-HD. ESRD patients undergoing HD shows important changes on lipid-profile, PON-1-activity, cardiac risk ratios and HDL-remodeling. These results demonstrate the influence of HD with a polysulfone low-flow basic-dialyzing-membrane and unfractionated-heparin on lipoprotein metabolism.

关键词： Hemodialysis Dyslipidemia Cardiovascular Risk Bioindices PLTP PON-1 HDL-Remodeling Low-Flow Polysulfone Dialyzing-Membrane

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Rainfall variability in the Brazilian northeast biomes and their interactions with meteorological systems and ENSO via CHELSA product

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Big Earth Data 2019年第4期3卷 315-337页

作者： Washington Luiz Félix Correia Filho joséFrancisco De Oliveira-júnior Dimas De Barros Santiago Paulo Miguel De Bodas Terassi Paulo Eduardo Teodoro Givanildo De Gois Claudio joséCavalcante Blanco Pedro Henrique De Almeida Souza Micejane da silva costa Heliofábio Barros Gomes Paulo joséDos Santos Institute of Atmospheric Sciences(ICAT) Federal University of Alagoas(UFAL)MaceióBrazil Postgraduate Program in Biosystems Engineering(PGEB) Federal Fluminense University(UFF)NiteróiBrazil Postgraduate Program in Meteorology Unidade Acadêmica de Ciências Atmosféricas(UACA)Federal Universityof Campina Grande(UFCG)Campina GrandeBrazil Postgraduate Program in Physical Geography University of São Paulo(USP)São PauloBrazil Federal University of Mato Grosso do Sul(UFMS) Chapadão do SulBrazil fSchool of Industrial Metallurgical Engineering of Volta Redonda Technological CenterUniversidade Federal Fluminense(UFF)Volta RedondaBrazil Faculty of Sanitary and Environmental Engineering(FAESA/ITEC) Federal University of Pará(UFPA)BelémBrazil

Brazilian biomes are home to a significant portion of the world’s biodiversity,with a total of 14%of existing species and still concentrate 20%of the world’s water ***,changes in biomes have a direct impact on rainfall patterns and water *** on this,the objective was to evaluate the variability of rainfall in the four existing biomes in the Northeast Brazil(NEB)and their interaction with the ENSO climate variability mode and regional scale meteorological systems via CHELSA *** this,monthly rainfall data were used from 1979 to 2013,with a spatial resolution of 1 km×1 km of the CHELSA product,and seasonal and annual rainfall patterns were extracted via *** was found that the rainy season in the Amazon,Caatinga and Cerrado biomes occurred between january and April,with varying intensities,except for the Atlantic *** seasonality patterns are associated with the NEB meteorological systems,with emphasis on ITCZ(all Biomes),UTCV(Amazon,Caatinga and Cerrado),Frontal Systems(extreme south of Caatinga,Cerrado and Atlantic Forest)and EWD/TWD in the(Atlantic Forest).In the inter-annual scale,the remarkable influence of ENSO was verified,mainly in the years 1983,1985,1989,1993,1998,2009 and *** is noteworthy that 1985 was the wettest year of the period,with a surplus in all biomes,while the driest year differs between the Amazon(1983),Atlantic Forest and Caatinga(1993)and Cerrado(2012)*** study via orbital product in NEB showed that anthropogenic processes and natural variability interfere with the forms of rain interception in the biomes and hence in rainfall patterns and water recycling in NEB.

关键词： Phytophysiognomy rainfall inter-annual variability water recycling climate change land use and occupation

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COVID-19 neuropsychiatric repercussions:Current evidence on the subject

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World journal of Methodology 2022年第5期12卷 365-380页

作者： Ronaldo Teixeira da silva júnior jonathan Santos Apolonio Beatriz Rocha Cuzzuol Bruna Teixeira da costa Camilo Santana silva Glauber Rocha Lima Araújo Marcel silva Luz Hanna Santos Marques Luana Kauany de SáSantos Samuel Luca Rocha Pinheiro Vinícius Lima de Souza Gonçalves Mariana Santos Calmon Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094Brazil Universidade Estadual do Sudoeste da Bahia Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083900Brazil

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has affected the entire world,causing the coronavirus disease 2019(COVID-19)pandemic since it was first discovered in Wuhan,China in December *** the clinical presentation of the disease,in addition to fever,fatigue,cough,dyspnea,diarrhea,nausea,vomiting,and abdominal pain,infected patients may also experience neurological and psychiatric repercussions during the course of the disease and as a post-COVID-19 ***,headache,dizziness,olfactory and gustatory dysfunction,cerebrovascular disorders,neuromuscular abnormalities,anxiety,depression,and post-traumatic stress disorder can occur both from the infection itself and from social distancing and *** to current evidence about this infection,the virus has the ability to infect the central nervous system(CNS)via angiotensin-converting enzyme 2(ACE2)receptors on host *** studies have shown the presence of ACE2 in nerve cells and nasal mucosa,as well as transmembrane serine protease 2,key points for interaction with the viral Spike glycoprotein and entry into the CNS,being olfactory tract and blood-brain barrier,through hematogenous dissemination,potential ***,the presence of SARS-CoV-2 in the CNS supports the development of neuropsychiatric *** management of these manifestations seems more complex,given that the dense parenchyma and impermeability of brain tissue,despite protecting the brain from the infectious process,may hinder virus ***,some alternatives used in non-COVID-19 situations may lead to worse prognosis of acute respiratory syndrome,requiring ***,the aim of this review is to bring more current points related to this infection in the CNS,as well as the repercussions of the isolation involved by the pandemic and to present perspectives on interventions in this scenario.

关键词： SARS-CoV-2 COVID-19 Central nervous system Quarantine Neurologic disorders Mental disorders

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