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First-line endoscopic treatment with over-the-scope clips significantly improves the primary failure and rebleeding rates in high-risk gastrointestinal bleeding: A single-center experience with 100 cases

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World journal of Gastroenterology 2016年第41期22卷 9162-9171页

作者： Hans-jürgen Richter-Schrag Torben Glatz Christine Walker Andreas fischer Robert Thimme Center of Interdisciplinary Gastrointestinal Endoscopy Department of Medicine II Medical Center-University of Freiburg Faculty of Medicine University of Freiburg Department of General and Visceral Surgery Medical Center-University of Freiburg Faculty of Medicine University of Freiburg

AIM To evaluate rebleeding, primary failure(PF) and mortality of patients in whom over-the-scope clips(OTSCs) were used as first-line and second-line endoscopic treatment(FLET, SLET) of upper and lower gastrointestinal bleeding(UGIB, LGIB).METHODS A retrospective analysis of a prospectively collected database identified all patients with UGIB and LGIB in a tertiary endoscopic referral center of the University of Freiburg, Germany, from 04-2012 to 05-2016(n= 93) who underwent FLET and SLET with OTSCs. The complete Rockall risk scores were calculated from patients with UGIB. The scores were categorized as < or ≥ 7 and were compared with the original Rockall data. Differences between FLET and SLET were calculated. Univariate and multivariate analysis were performed to evaluate the factors that influenced rebleeding after OTSC *** Primary hemostasis and clinical success of bleeding lesions(without rebleeding) was achieved in 88/100(88%) and 78/100(78%), respectively. PF was significantly lower when OTSCs were applied as FLET compared to SLET(4.9% vs 23%, P = 0.008). In multivariate analysis, patients who had OTSC placement as SLET had a significantly higher rebleeding risk compared to those who had FLET(OR 5.3; P = 0.008). Patients with Rockall risk scores ≥ 7 had a significantly higher in-hospital mortality compared to those with scores < 7(35% vs 10%, P = 0.034). No significant differences were observed in patients with scores < or ≥ 7 in rebleeding and rebleeding-associated *** Our data show for the first time that FLET with OTSC might be the best predictor to successfully prevent rebleeding of gastrointestinal bleeding compared to SLET. The type of treatment determines the success of primary hemostasis or primary failure.

关键词： Gastrointestinal bleeding Rockall risk score Over-the-scope clip First-line endoscopic treatment Second-line endoscopic treatment

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Shifts in the Holstein dairy cow milk fat globule membrane proteome that occur during the first week of lactation are affected by parity

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journal of Animal Science and Biotechnology 2021年第2期12卷 534-548页

作者： Mallory C.Honan Megan j.Fahey Amanda j.fischer-Tlustos Michael A.Steele Sabrina L.Greenwood Department of Animal and Veterinary Sciences The University of VermontBurlingtonVT 05405USA Department of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada Department of Agriculture Food&Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2P5Canada

Background:The milk fat globule membrane(MFGM)proteomes of colostrum and transition milk are rich sources of proteins that are likely important for neonatal calf *** addition,characterization of these proteomes could also yield valuable information regarding mammary gland physiology of the early postpartum lactating *** objectives of this research were to characterize the MFGM proteomes of colostrum and transition milk through sample collections at four timepoints postpartum,including the first milking(M1,colostrum),second milking(M2,transition milk),fourth milking(M4,transition milk),and fourteenth milking(M14,mature milk),and compare these proteomes between multiparous(MP;n=10)and primiparous(PP;n=10)Holstein dairy *** MFGM proteins were labeled using Tandem Mass tagging and analyzed using liquid chromatography-tandem mass spectrometry(LC-MS/MS).Protein identification was completed using MASCOT and Sequest in Proteome Discoverer *** scaled abundance values were analyzed using PROC MIXED in SAS to determine the effects of milking(MIL),parity(PAR),and MIL×*** adaptive false-discovery rate(FDR)-adjusted P values were determined using PROC *** characterization and bioinformatic analysis were completed using a combination of PANTHER,Blast,and ***:A total of 104 common proteins were identified in each of the MFGM *** analysis revealed that 70.2%of identified proteins were affected by *** these,78.1%were lower in M14 compared with M1,including immune-related proteins lactotransferrin,lactadherin and *** affected 44.2%of *** the proteins affected by PAR,84.8%were higher in MP cows compared with PP cows,including apolipoprotein E and histones 2A,2B,3,and 4 *** subfamily 1 member 1A and annexin 5 were higher in samples from PP ***×parity affected 32.7%of identified proteins,including lactotransferrin,gelsolin,vitamin D binding protein,and S100 ***

关键词： Colostrum LC-MS/MS Parity

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Ammonium Improves Corn Phosphorus Acquisition Through Changes in the Rhizosphere Processes and Root Morphology

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Pedosphere 2019年第4期29卷 534-539页

作者： Elialdo Alves DE SOUZA Natália Rodrigues FERREIRA-ELOY camila da Silva GRASSMANN Ciro Antonio ROSOLEM Philip j.WHITE School of Agronomic Sciences Sao Paulo State University The james Hutton Institute

Dear Editor, Phosphorus (P) deficiency is the most limiting factor in tropical agriculture since most soils in this region are predominantly acids with high-energy P-binding compounds. Therefore, up to 90% of the P applied becomes fixed in soils, which raises environmental concerns and production costs (Syers et al., 2008). Thus, developing strategies to imptove P use efficiency (PUE) is essential to mitigate environmental problems and improve profits. These strategies should consider the soil-root-rhizosphere system because it is the most biochemical active site where nutrient uptake occurs (Hinsinger, 2011).

关键词： Root Morphology Rhizosphere Processes Dear Editor

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Do aphids actively search for ant partners？

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Insect Science 2015年第2期22卷 283-288页

作者： Christophe Y. fischer Maryse Vanderplanck Georges C. Lognay Claire Detrain Francois j. Verheggen Laboratory of Analytical Chemistry University of Liege Gembloux Agro-Bio Tech Gembloux Research Institute of Biosciences Laboratory of Zoology University of Mons Mons Unit of Social Ecology Universit6 Libre de Bruxelles Brussels Department of Functional and Evolutionary Entomology University of Liege Gembloux Agro-Bio Tech Gembloux Belgium

The aphid-ant mutnalistic relationships are not necessarily obligate for neither partners but evidence is that such interactions provide them strong advantages in terms of global fitness. While it is largely assumed that ants actively search for their mutualistic partners namely using volatile cues; whether winged aphids （i.e., aphids＇ most mobile form） are able to select ant-frequented areas had not been investigated so far. Ant-frequented sites would indeed offer several advantages for these aphids including a lower predation pressure through ant presence and enhanced chances of establishing mutuaslistic interactions with neighbor ant colonies. In the field, aphid colonies are often observed in higher densities around ant nests, which is probably linked to a better survival ensured by ants＇ services. Nevertheless, this could also result from a preferential establishment of winged aphids in ant-frequented areas. We tested this last hypothesis through different ethological assays and show that the facultative myrmecophilous black bean aphid, Aphisfabae L., does not orientate its search for a host plant preferentially toward ant-frequented plants. However, our results suggest that ants reduce the number of winged aphids leaving the newly colonized plant. Thus, ants involved in facultative myrmecophilous interactions with aphids appear to contribute to structure aphid populations in the field by ensuring a better establishment and survival of newly established colonies rather than by inducing a deliberate plant selection by aphid partners based on the proximity of ant colonies.

关键词： ant aphid Aphisfabae Lasius niger mutualism partner research

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Nicotinamide mononucleotide:a potential effective natural compound against insulin resistance

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2609-2610页

作者： julian Roos julia Zinngrebe Pamela fischer-Posovszky Department of Pediatrics and Adolescent Medicine Ulm University Medical CenterUlmGermany

Recently,a study published in Science by Yoshino et al.1 reported on a randomized,placebo-controlled,double-blind clinical trial to examine the effects of a 10-week nicotinamide mononucleotide(NMN)administration on human metabolism in 25 postmenopausal overweight or obese women with *** revealed positive effects of NMN on insulin sensitivity,insulin signalling,and tissue remodelling in skeletal muscle.

关键词： metabolism clinical

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The impact of COVID-19 on clinical outcomes of burn patients

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Burns & Trauma 2023年第1期11卷 792-799页

作者： Elliot T.Walters Alen Palackic camila Franco-Mesa Nikhil R.Shah Michael j.Erickson Steven E.Wolf Department of Surgery University of Texas Medical Branch301 UniversityGalvestonTXUSA Division of Plastic Aesthetic and Reconstructive SurgeryDepartment of SurgeryMedical University of GrazGrazAustria

Background:Multiple studies have shown the SARS-CoV-2 virus(COVID-19)to be associated with deleterious outcomes in a wide range of *** impact of COVID-19 has not been well investigated among burned *** suspect that patients will have worsened respiratory and thrombotic complications,ultimately leading to increased *** objective of this study is to determine the impact a concurrent infection of COVID-19 has on clinical outcomes after a burn ***:This is a retrospective,propensity matched,cohort *** examined a de-identified database of electronic medical records of over 75 million patients across 75 health care associations in the United States for patients treated for thermal burns from 1 january 2020,to 31 july 2021,and those who also were diagnosed with COVID-19 infection within one day before or after injury based on International Classification of Disease,tenth revision(ICD-10)*** participants included adults who were treated for a burn injury during the study ***:We included 736 patients with burn injury and concomitant COVID-19 infection matched to 736 patients with burn injury and no concurrent COVID-19 infection(total 1472 patients,mean age 36.3±24.3).We found no significant increase in mortality observed for patients with concurrent COVID-19(OR 1.203,95%CI 0.517-2.803;p=0.6675).We did observe significant increase in infections(OR 3.537,95%CI 2.798-4.471;p=0.0001),thrombotic complications(OR 2.342,95%CI 1.351-4.058;p=0.0018),as was the incidence of hypertrophic scarring(OR 3.368,95%CI 2.326-4.877;p=0.0001).Conclusions:We observed that concurrent COVID-19 infection was associated with an increase in infections,thrombosis and hypertrophic scarring but no increase in mortality in our cohort of burn patients.

关键词： COVID-19 infection mortality burn thrombosis scarring

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Problem Solving Solutions in Thermal Spray:HSE and Overspray

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有色金属（冶炼部分） 2008年第S1期 139-145页

作者： Hans Keller joachim Beczkowiak Stefan Zimmermann Benno Gries jürgen fischer H.C.Starck GmbH LaufenburgDeutschland H.C.Starck GmbH GoslarDeutschland

目前金属基材料的原材料成本对热喷涂涂层的经济性造成压力。特别是材料挥发和近期铼、钨、钴和镍基材料的价格增长,对各应用领域的许多涂层的经济性造成严重威胁。由于沉积效率的限制,喷涂中未沉积物问题变得越来越重要,不仅只是减少浪... 详细信息

目前金属基材料的原材料成本对热喷涂涂层的经济性造成压力。特别是材料挥发和近期铼、钨、钴和镍基材料的价格增长,对各应用领域的许多涂层的经济性造成严重威胁。由于沉积效率的限制,喷涂中未沉积物问题变得越来越重要,不仅只是减少浪费,还可以从材料自身价值角度去看。回收是解决这个问题的一个措施,特别是当废料中含有高价值金属时。欧洲执行的REACH(化学制品的注册、评估、授权)将会逐步强制淘汰标有有毒的材料和物质的使用。在热喷涂中使用这些有毒物质或使用热喷涂产品可能暂时是安全的,然而,从法律限制和从其他工业领域得到的指示表明,像WC-Co粉末这样的化学制品对人体有害。要想在将来的涂层工厂中保持竞争性,必须符合不断提高的更严格的环保和安全规程。

关键词：热喷涂粉末 WC-Co 健康和环保毒物学回收喷涂中未沉积物

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Bacteria may contribute to distant species recognition in ant-aphid mutualistic relationships

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Insect Science 2017年第2期24卷 278-284页

作者： Christophe Y. fischer Claire Detrain Philippe Thonart Eric Haubruge Frederic Francis Francois j. Verheggen Georges C. Lognay Laboratory of Analytical Chemistry University of Liege Gembloux Agro-Bio Tech Passage des Deportes 2 5030 Gembloux Unit of Social Ecology Universite Libre de Bruxelles CP231 50 avenue F. Roosevelt B-1050 Brussels Walloon Center of Industrial Biology University of Liege B40 Sart-Tilman 4000 Liege 4Functional and Evolutionary Entomology University of Liege Gembloux Agro-Bio Tech Passage des Deportes 2 5030 Gembloux Belgium

Mutualistic interactions between ant and aphid species have been the subject of considerable historical and contemporary investigations, the primary benefits being clean- ing and protection for the aphids and carbohydrate-rich honeydew for the ants. Questions remained, however, as to the volatile semiochemical factor influencing this relationship. A recent study highlighted the role of bacterial honeydew volatile compounds in ant at- traction. Here, ant＇s ability to distantly discriminate 2 aphid species was investigated based on bacterial honeydew semiochemicals emissions using a two-way olfactometer. Both the mutualistic aphid Aphis fabae L. and the nonmyrmecophilous aphid Acyrthosiphon pisum Harris were found to be attractive for the ant Lasius niger L. The level of attraction was similar in both assays （control vs. one of the aphid species）. However, when given a choice between these 2 aphid species, ants showed a significant preference for Aphis fabae. Honeydew volatiles, mostly from bacterial origins, are known to be a key element in ant attraction. Using the same olfactometry protocol, the relative attractiveness of volatiles emitted by honeydews collected from each aphid species and by bacteria isolated from each honeydew was investigated. Again, ants significantly preferred volatiles released by Aphis fabae honeydew and bacteria. This information suggests that microbial honeydew volatiles enable ants to distantly discriminate aphid species. These results strengthen the interest of studying the occurrence and potential impact of microorganisms in insect symbioses.

关键词： ant aphid bacteria honeydew mutualism recognition VOC

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Cross-sectional associations between cortical thiclmess and physical activity in older adults with spontaneous memory complaints:The MAPT Study

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journal of Sport and Health Science 2023年第3期12卷 324-332页

作者： jérémy Raffin Yves Rolland Clara fischer jean-Francois Mangin Audrey Gabelle Bruno Vellas Philipe de Souto Barreto the MAPT/DSA Group Gérontopôle de Toulouse Institut du VieillissementCentre Hospitalo-Universitaire de ToulouseToulouse 31000France UniversitéPaul-Sabatier/Institut National de la Santéet de la Recherche Médicale UnitéMixte de Recherche 1027 Facultéde médecineUniversity of Toulouse ⅢToulouse 31000France Centre pour l'Acquisition et le Traitement des Images Multicenter Neuroimaging Platform NeurospinUniversitéParis-SaclayGif sur Yvette 91191France Memory Resources and Research Center Montpellier University HospitalMontpellier 34295France Institut National de la Santéet de la Recherche Médicale Unité1061 i-site Montpellier Universitéd'Excellence University of MontpellierMontpellier 34090France 不详

Background:Age-related changes in brain structure may constitute the starting point for cerebral function *** activity(PA)demonstrated favorable associations with total brain volume,but its relationship with cortical thickness(CT)remains *** investigated the cross-sectional associations between PA level and CT in community-dwelling people aged 70 years and ***:A total of 403 older adults aged 74.8±4.0 years(mean±SD)who underwent a baseline magnetic resonance imaging examination and who had data on PA and confounders were *** was assessed with a *** were categorized according to PA *** linear regressions were used to compare the brain CT(mm)of the inactive group(no PA at all)with 6 active groups(growing PA levels)in 34 regions of ***:Compared with inactive persons,people who achieved PA at a level of 1500-1999 metabolic equivalent task-min/week(i.e.,about6-7 h of brisk walking for exercise) and those who achieved it at 2000-2999 metabolic equivalent task-min/week(i.e.,8-11 h of brisk walking for exercise)had higher CT in the fusiform gyrus and the temporal ***,dose-response associations between PA and CT were found in the fusiform gyrus(B=0.011,SE=0.004,adj.p=0.035),the temporal pole(B=0.026,SE=0.009,adj.p=0.048),and the caudal middle frontal gyrus,the entorhinal,medial orbitofrontal,lateral occipital,and insular ***:This study demonstrates a positive association between PA level and CT in temporal areas such as the fusiform gyrus,a brain region often associated to Alzheimer’s disease in people aged 70 years and *** investigations focusing on PA type may help to fulfil remaining knowledge gaps in this field.

关键词： Alzheimer's disease Brain aging Cortical thickness Physical activity

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Influence of experimental soil disturbances on the diversity of plants in agricultural grasslands

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journal of Plant Ecology 2014年第6期7卷 509-517页

作者： jörg Müller johannes Heinze jasmin joshi Steffen Boch Valentin H.Klaus Markus fischer Daniel Prati Institute of Biochemistry and BiologyUniversity of PotsdamMaulbeerallee 114469 PotsdamGermany Freie Universität Berlin Institut für BiologieBerlin-Brandenburg Institute of Advanced Biodiversity ResearchAltensteinstrasse 614195 BerlinGermany Institute of Plant Sciences University of BernAltenbergrain 213013 BernSwitzerland Institute of Landscape Ecology University of MünsterHeisenbergstr.248149 MünsterGermany Biodiversity and Climate Research Centre BIK-F Senckenberg Gesellschaft für Naturforschung603257 FrankfurtGermany

Aims and Methods Disturbance is supposed to play an important role for biodiversity and ecosystem stability as described by the intermediate disturbance hypoth-esis(IDH),which predicts highest species richness at intermediate levels of *** this study,we tested the effects of artificial soil distur-bances on diversity of annual and perennial vascular plants and bryo-phytes in a field experiment in 86 agricultural grasslands differing in land use in two regions of *** each grassland,we implemented four treatments:three treatments differing in application time of soil dis-turbances and one *** year after experimental disturbance,we recorded vegetation and measured biomass productivity and bare *** analysed the disturbance response taking effects of region and land-use-accompanied disturbance regimes into *** Findings Region and land-use type strongly determined plant species *** disturbances had small positive effects on the species richness of annuals,but none on perennials or *** ground was positively related to species richness of ***,exceeding the creation of 12%bare ground further distur-bance had a detrimental effect on bryophyte species richness,which corresponds to the *** biomass productivity was unaffected by disturbance our results indicate that the disturbance effect on spe-cies richness of annuals was not due to decreased overall produc-tivity,but rather due to short-term lowered inter-and intraspecific competition at the newly created ***,our results highlight the importance of soil disturbances for species richness of annual plants and bryophytes in agricultural ***,most grasslands were disturbed naturally or by land-use practices and our additional experimental soil dis-turbances only had a small short-term ***,total plant diversity in grasslands seemed to be more limited by the availabil-ity of propagules rather tha

关键词： annuals bryophytes colonization intermediate disturbance hypothesis microsites

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