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Activatable chemiluminescence probe based on four-arm PEGconjugated-pyropheophorbide-a for in vivo autofluorescence-free imaging of peroxynitrite

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Science China Chemistry 2025年

作者： jianmei Ke Lei Ding Ronggui lian Cheng Zheng Wenjun Li Aixian Zheng Yupeng Sun Ming Wu Yongyi Zeng Xiaolong Liu Maochun Hong Xiaolong Zhang The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University Ganjiang Innovation Academy Chinese Academy of Sciences School of Rare Earths University of Science and Technology of China College of Chemistry Fuzhou University State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Peroxynitrite（ONOO-） is a highly reactive nitrogen species that plays pivotal roles in cell signal transduction and physiological or pathological progresses. However, commonly used ONOO-optical imaging probes are still hampered by high background/autofluorescence（fluorescence probe）, short emission wavelength, or poor selectivity in the case of chemiluminescence. Herein,we report a facile method to prepare an activatable chemiluminescence probe（PPA-PEG） with good biocompatibility and functionality for in vivo autofluorescence-free imaging of ONOO-. The PPA-PEG consists of pyropheophorbide-a（PPA）, a typical deep red photosensitizer that acts as both the recognition and signaling element, and 4-arm poly（ethylene glycol）(4-arm PEG), which improves the biosafety and water solubility of probe. These components can self-assemble into nanoparticles（namely PPA-PEG nanoprobe） in aqueous solution. The PPA-PEG nanoprobe showed an ultra-low chemiluminescence signal before interacting with ONOO-, but exhibited good selectivity, high sensitivity and a fast response toward ONOO-. The PPAPEG was successfully applied to image cellular ONOO-changes, as well as the endogenous ONOO-changes in inflammation models and subcutaneous or orthotopic hepatocellular carcinoma（HCC） tumors models in living mice. In vitro and in vivo studies verified the good detection and imaging capabilities of PPA-PEG for peroxynitrite, demonstrating suitable tissue penetration and a high signal-to-background ratio（SBR）. Thus, our nanoprobe can serve as a valuable activatable chemiluminescence imaging tool for studying important peroxynitrite-related chemical and biological applications.

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一种联合泰勒展开与最小二乘的运动目标被动雷达质心定位算法

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大地测量与地球动力学 2025年第1期45卷 41-47页

作者：廉一鸣江利明中国科学院精密测量科学与技术创新研究院武汉市430077 中国科学院大学地球与行星科学学院北京市100049

针对两步加权最小二乘(two stage weighted least squares,TSWLS)算法在复杂场景下对运动辐射源定位不精确、观测站位置和目标位置的几何关系与精度相关的问题,提出一种基于泰勒展开与两步加权最小二乘联合的运动目标被动雷达质心无源... 详细信息

针对两步加权最小二乘(two stage weighted least squares,TSWLS)算法在复杂场景下对运动辐射源定位不精确、观测站位置和目标位置的几何关系与精度相关的问题,提出一种基于泰勒展开与两步加权最小二乘联合的运动目标被动雷达质心无源定位算法。该方法首先利用两步加权最小二乘算法求解目标的位置与速度;再将所获得的目标参数作为泰勒展开的初始值构造定位误差方程,并通过迭代对目标寻优求解;最后利用联合算法和两步加权最小二乘算法分别获得估计值,对两次估计值进行质心定位得到最终结果。仿真实验表明,无论目标处于高速还是低速状态下,相较于传统的两步加权最小二乘算法和加权最小二乘(weighted least squares,WLS)算法,本文所提算法在鲁棒性和定位精度方面均有较大提高,且降低了观测站位置和目标位置几何关系对定位精度的影响。

关键词：被动雷达无源定位两步加权最小二乘泰勒展开质心定位

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Further mechanism of α/β interphase boundary evolution and dynamic globularization of Ti–5Al–2Sn–2Zr–4Mo–4Cr at elevated temperature deformation

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Progress in Natural Science:Materials International 2022年第4期32卷 490-497页

作者： lian Li Miaoquan Li School of Materials Science and Engineering Northwestern Polytechnical University

The evolution characterization of the α/β interphase boundaries of the isothermally compressed Ti–5Al–2Sn–2Zr–4Mo–4Cr with lamellar microstructure was carried out via electron backscatter diffraction(EBSD) and transmission electron microscope(TEM). The effect of the α/β interphase boundary evolution on the dynamic globularization was discussed, and the nucleation model for the β recrystallized grain at the cusp of αlath in the late stage of deformation in terms of the classic nucleation theory was established. The mean α/βinterface deviation angle from Burgers orientation relationship(BOR) increased continuously up to 18.9°with the increasing strain from 0.1 to 0.5, which was dominated by the continuous dynamic recrystallization. Restoration of BOR between α and β phases at the strains of 0.7 and 0.9 occurred due to the occurrence of recrystallized α andβ grains following BOR, which was rationalized by a nucleation model considering the stored energy of deformation provided the driving force for nucleation at the cusp of α lath. Loss of coherency of α/β interphase boundaries at a strain about 0.3 was responsible for accelerating the dynamic globularization of α lamellae since the energy of α/β interphase boundaries increased up to the maximum value when the non-coherent α/β interphase boundaries were formed. Restoration of coherency of α/β interphase boundaries due to the recrystallization nucleation in the late stage of deformation did not substantially affect the dynamic globularization since the α/αintraphase high-angle boundaries(HAGBs) were formed and the most α/β interphase boundaries were noncoherent.

关键词： Titanium Interphase boundary Burgers orientation relationship Dynamic recrystallization Dynamic globularization Model

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Validation of an improved two-fluid model with particle rotation for gas-solid fluidized bed

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Particuology 2023年第10期81卷 149-161页

作者： lian Wang Xihua Chu School of Civil Engineering Wuhan UniversityWuhan430072HubeiChina

Gas-solid fluidized beds are widely applied in chemical and process *** is of significance to establish a reasonable and effective mathematical model to explore the hydrodynamics of gas-particle system for industrial *** a less computationally demanding alternative to the discrete descriptions,two-fluid model considering kinetic theory of granular flow is often adopted to describe the fluidized behaviors of particles,but it cannot characterize the rotation of particles and its influence on the fluidized *** this study,to address the rotation effect of the fluidized particles,a two-fluid model combining the classical fluid and micropolar fluid is established,namely *** the CMTFM,classical fluid is used to describe the motion of gas phase,while micropolar fluid is adopted to describe the motion of particle phase,and the rotation of particles and its influence on the hydrodynamics of the gas-particle system are characterized by the degree of freedom of microrotation and the improved drag force based on micropolar *** the calculation of the gas-solid bubbling fluidized bed,we investigated the influence of the microstructure parameters,particle-particle collision restitution coefficient and inlet velocity,and the results are compared to those from TFM model and *** the analysis,it manifests that pressure drop and expansion height of the fluidized bed under the consideration of the microrotation effect are closer to the experiments,which demonstrates the feasibility and advantage of the classical-micropolar two-fluid model.

关键词： Gas-solid fluidized bed Two-fluid model Micropolar fluid Microstructure parameter Fluidized behaviors

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A copula-based approach to accommodate intra-household interaction in workers' daily maintenance activity stop generation modeling

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journal of Traffic and Transportation Engineering(English Edition) 2022年第1期9卷 59-68页

作者： You-lian Chu Parsons Transportation Group New YorkNY 10005USA

A new stop frequency model was developed to predict the daily number of maintenance activity stops made by individual household heads during a typical weekday. This new model was based on the modification of a conventional multivariate ordered probit(MOP) model by maintaining the probit assumption for the marginal distributions while introducing nonnormal dependence among the error terms using copula functions. Therefore, the copulabased MOP model would relieve the restriction of imposing joint normality on the error terms in the conventional MOP model. The new MOP model would not only account for the intrahousehold interactions in stop-making decisions, but also allow the best functional form to be determined for representing dependencies among household heads. Using the New York Metropolitan Transportation Council’s 2010/2011 regional household travel survey data, the copula-based MOP model was employed to examine stop-making behavior for individual household heads residing in New York City and its adjacent counties in Mid-Hudson Valley and New jersey. Empirical results provided useful insights into the observed effects of sociodemographics, land use density, transportation service, and work schedule together with potential unobserved common effects on the inter-relatedness of spousal stop-making decisions at the household level. The results show that the MOP model with a Clayton copula structure provides the best data fits and there is a very strong positive dependence among error terms of stop-making equations. Furthermore, the dependence among the maintenance activity propensities of household heads is asymmetric, with a stronger tendency of household heads to simultaneously have low maintenance activity levels than to simultaneously have high maintenance activity levels.

关键词： Stop-making propensity Maintenance activity episodes Multivariate ordered probit model Copula-based approach Intra-household interaction

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富水软弱大变形公路隧道复合式初支方法研究

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价值工程 2025年第1期44卷 102-104页

作者：闫连芝云南交投集团云岭建设有限公司昆明650000

高速公路建设过程中,隧道工程因其特殊性已经成为项目建设中的关键环节。在前期的勘测过程中,无法对隧道所在位置的地质条件进行详细的探测,使得其在施工过程中普遍存在地下水丰富、应力强度高以及大变形等诸多情况。本文以云南某高速... 详细信息

高速公路建设过程中,隧道工程因其特殊性已经成为项目建设中的关键环节。在前期的勘测过程中,无法对隧道所在位置的地质条件进行详细的探测,使得其在施工过程中普遍存在地下水丰富、应力强度高以及大变形等诸多情况。本文以云南某高速公路隧道开挖为例,该隧道在施工过程中存在地下水丰富、围岩软弱和大变形等现象。经相关技术研究后,决定采用复合式双层支护的方法,将下沉的变形值以及地下水涌出量控制在施工可接受范围内。拟为相类似工程提供经验参考。

关键词：公路隧道富水软弱大变形复合支护

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A SIMPLE SMOOTH EXACT PENALTY FUNCTION FOR SMOOTH OPTIMIZATION PROBLEM

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journal of Systems Science & Complexity 2012年第3期25卷 521-528页

作者： Shujun lian liansheng ZHANG College of Operations and Management Qufu Normal University Department of Mathematics Shanghai University

For smooth optimization problem with equMity constraints, new continuously differentiable penalty function is derived. It is proved exact in the sense that local optimizers of a nonlinear program are precisely the optimizers of the associated penalty function under some nondegeneracy assumption. It is simple in the sense that the penalty function only includes the objective function and constrained functions, and it doesn＇t include their gradients. This is achieved by augmenting the dimension of the program by a variable that controls the weight of the penalty terms.

关键词： Constrained optimization exact penalty function smooth penalty function.

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Low-light image enhancement algorithm using a residual network with semantic information

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The journal of China Universities of Posts and Telecommunications 2022年第2期29卷 52-62,84页

作者： Duan lian Tang Guijin jiangsu Key Laboratory of Image Processing and Image Communication Nanjing University of Posts and TelecommunicationsNanjing 210003China

Aiming to solve the poor performance of low illumination enhancement algorithms on uneven illumination images,a low-light image enhancement(LIME)algorithm based on a residual network was *** algorithm constructs a deep network that uses residual modules to extract image feature information and semantic modules to extract image semantic information from different ***,a composite loss function was also designed for the process of low illumination image enhancement,which dynamically evaluated the loss of an enhanced image from three factors of color,structure,and *** ensures that the model can correctly enhance the image features according to the image semantics,so that the enhancement results are more in line with the human visual *** results show that compared with the state-of-the-art algorithms,the semantic-driven residual low-light network(SRLLN)can effectively improve the quality of low illumination images,and achieve better subjective and objective evaluation indexes on different types of images.

关键词： image enhancement convolutional neural network(CNN) residual learning image semantics

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Application of Angular Momentum Theory to Constructing Basis Functions of Irreducible Representations of Icosahedral Group

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Chemical Research in Chinese Universities 2004年第2期20卷 166-175页

作者： lian-yong SchoolofChemistryandChemicalEngineering SouthwesternNormalUniversityChongqing400715P.R.China

A new method based on angular momentum theory was proposed to construct the basis functions of the irreducible representations(IRs) of point groups. The transformation coefficients, i. e., coefficients S, are the components of the eigenvectors of some Hermitian matrices, and can be made as real numbers for all pure rotation point groups. The general formula for coefficient S was deduced, and applied to constructing the basis functions of single-valued irreducible representations of icosahedral group from the spherical harmonics with angular momentum j≤7.

关键词： Irreducible representation Basis function I group Angular momentum

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Triple bottom-line consideration of sustainable plant disease management:From economic,sociological and ecological perspectives

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journal of Integrative Agriculture 2021年第10期20卷 2581-2591页

作者： HE Dun-chun jeremy j.BURDON XIE lian-hui jiasui ZHAN Institute of Eco-technological Economics School of Economics and TradeFujian Jiangxia UniversityFuzhou 350108P.R.China Fujian Key Lab of Plant Virology Institute of Plant VirologyFujian Agriculture and Forestry UniversityFuzhou 350002P.R.China CSIRO Agriculture CanberraA.C.T.2601Australia Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesUppsala 75007Sweden

Plant disease management plays an important role in achieving the sustainable development goals of the United Nations(UN)such as food security,human health,socio-economic improvement,resource conservation and ecological ***,technologies available are often limited due to different interests between producers and society and lacks of proper understanding of economic thresholds and the complex interactions among ecology,productivity and profitability.A comprehensive synergy and conflict evaluation of economic,sociological and ecological effects with technologies,productions and evolutionary principles as main components should be used to guide sustainable disease management that aims to mitigate crop and economic losses in the short term while maintaining functional farm ecosystem in the long ***,there should be an increased emphasis on technology development,public education and information exchange among governments,researchers,producers and consumers to broaden the options for disease management in the future.

关键词： plant disease management agricultural sustainability disease economics food security resource conservation

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