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世界核地质科学 1987年第1期 22-28页

作者： j.leroy P.Holliger 夏毓亮

本文研究了法国利木赞马尔涅克(Margnac)和法内(Fanay)矿山的沥青铀矿、黄铁矿和铀石的矿物学和化学成分。结果表明,沥青铀矿的化学组成反映出含铀溶液和脉旁围岩之间有过化学交换。用U-Pb法测出原生沥青铀矿-黄铁矿组合形成年龄为276 M... 详细信息

本文研究了法国利木赞马尔涅克(Margnac)和法内(Fanay)矿山的沥青铀矿、黄铁矿和铀石的矿物学和化学成分。结果表明,沥青铀矿的化学组成反映出含铀溶液和脉旁围岩之间有过化学交换。用U-Pb法测出原生沥青铀矿-黄铁矿组合形成年龄为276 Ma。沥青铀矿的铀石化期间结晶出的方铅矿的铅同位素分析给出从沥青铀矿沉淀到铀石化的时间间隔为6 Ma。电子探针分析表明,热液转换或多或少地影响到所有沥青铀矿球粒,尽管形成的铀石量不多。这导致了富Si沥青铀矿的形成,并用Pb-Pb和一致线图解法获得体系年龄为270Ma。在某些样品中还发现矿物学上没被觉察出的再活化阶段,其年龄为170—175 Ma。最后,本工作确定了地热体系的寿命(20—30 Ma),据认为这个地热体系导致了二云母花岗岩的变正长岩化、沥青铀矿的沉淀及其再活化为铀石。

关键词：沥青铀矿黄铁矿方铅矿结晶作用铀成矿作用非晶铀矿铁矿物硫化矿物 U-Pb 铀石岛状硅酸盐矿物海西期同位素矿物学利木赞

Tackling heterogeneity in treatment-resistant breast cancer using a broad-spectrum therapeutic approach

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Cancer Drug Resistance 2022年第4期5卷 917-925页

作者： leroy Lowe j.William LaValley Dean W.Felsher Getting to Know Cancer(NGO) TruroNova Scotia B2N 1X5Canada Wellness Plan MD Ltd AustinTX 78759USA Division of Oncology Departments of Medicine and PathologyStanford UniversityCA CCSR 1105USA.

Tumor heterogeneity can contribute to the development of therapeutic resistance in cancer, including advancedbreast cancers. The object of the Halifax project was to identify new treatments that would address mechanisms oftherapeutic resistance through tumor heterogeneity by uncovering combinations of therapeutics that could targetthe hallmarks of cancer rather than focusing on individual gene products. A taskforce of 180 cancer researchers,used molecular profiling to highlight key targets responsible for each of the hallmarks of cancer and then findexisting therapeutic agents that could be used to reach those targets with limited toxicity. In many cases, naturalhealth products and re-purposed pharmaceuticals were identified as potential agents. Hence, by combining themolecular profiling of tumors with therapeutics that target the hallmark features of cancer, the heterogeneity ofadvanced-stage breast cancers can be addressed.

关键词： Breast cancer chemoresistance drug resistance targeted therapy

Band structure of reconstructed Cu2O(-110)

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Band structure of reconstructed Cu2O(-110)

Testing semiochemicals from aphid, plant and conspecific： attraction of Harmonia axyridis

ICAM Workshop Physics of Novel Energy Materials

作者： N.Barrett M.Izquierdo j.leroy F.Sirotti F.Bruneval L.Reining N.Vast DSM/IRAMIS/SPCSI Batiment 462 CEA Saclay 91191 Gif sur Yvette cedex Synchrotron Soleil L’Orme des MerisiersSt Aubin BP 48 91192 Gif sur Yvette DEN/DANS/DMN/SRMP Batiment 520 CEA Saclay 91191 Gif sur Yvette cedex Theory Group LSI/Polytechnique Ecole Polytechnique 91128 Palaiseau Laboratoire des Solides Irradiés CEA/DSM-CNRS UMR7642-Ecole Polytechnique 91120 Palaiseau

Cu2O is a model oxide, with a direct band gap of 2.17 eV. This system has been of theoretical interest since over more that 50 years due to its particular optical absorption spectrum (OAS). Recently, the interest has ...

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Insect Science 2012年第3期19卷 372-382页

作者： Pascal D. leroy Thomas Schillings julien Farmakidis Stephanie Heuskin Georges Lognay Francois j. Verheggen Yves Brostaux Eric Haubruge Frederic Francis Departments of Functional and Evolutionary Entomology Departments of Analytical Chemistry Departments of Applied Statistics Computer Science and Mathematics University of Liege Gembloux Agro-Bio Tech Gembloux Belgium

Harmonia axyridis Pallas （Coleoptera： Coccinellidae） is an invasive specie affecting the dynamics and composition of several guilds. Nowadays, no biological control method is available to reduce the populations of this harmful coccinellid. Attractants and semiochemicals seem to be the best alternative but only few studies have tested the impact of semiochemicals on this Asian lady beetle. In this work, through wind- tunnel experiments, semiochemicals from aphids （Z,E-nepetalactone, [E]-β-farnesene, a-pinene and β-pinene）, from coccinellids （[-]-β-earyophyllene） and from the nettle Urtica dioica L. were evaluated as potential attractants. The nettle volatile compounds （[Z]-3- hexenol and [E]-2-hexenal） were extracted using a Clevenger Apparatus and identified by headspace gas chromatography-mass spectroscopy. In the wind-tunnel experiments, the main components of the aphid alarm pheromone as well as a component of the aphid sexual pheromone strongly attracted both sexes of the Asian lady beetle while （-）-β- caryophyllene only attracted few individuals and had no impact on the males. The nettle extract as well as the （Z）-3-hexenol oriented both males and females to the odor source. The （E）-2-hexenal was shown to have no effect on females even if this green leaf volatile attracted males. Because Z,E-nepetalactone was identified as the most efficient attractant in the wind-tunnel experiments, this volatile was also tested in a potato field where H. axyridis has been showed to respond to this semiochemical. This study highlighted that Z,E-nepetalactone orientated the Asian lady beetle H. axyridis under natural condi- tions, indicating that this volatile compound could certainly help for an efficient biological control approach against this invasive specie.

关键词： aphids attractant Harmonia axyridis plant semiochemicals wind-tunnel

Honeydew volatile emission acts as a kairomonal message for the Asian lady beetle Harmonia axyridis （Coleoptera： Coccinellidae）

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Insect Science 2012年第4期19卷 498-506页

作者： Pascal D. leroy Stephanie Heuskin Ahmed Sabri Fran( ois j. Verheggen julien Farmakidis Georges Lognay Philippe Thonart jean-Paul Wathelet Yves Brostaux Eric Haubruge Departments of Functional and Evolutionary Entomology Departments of Analytical Chemistry University of Liege Gembloux Agro-BioTech Walloon Center of Industrial Biology University of Liege B40 4000 Sart-Tilman Departments of General and Organic Chemistry Departments of Appfied Statistics Computer Science and Mathematics University of Liege Gembloux Agro-Bio Tech Gembloux Belgium

The Asian lady beetle Harmonia axyridis Pallas is considered as an invasive species in most territories where it has been introduced. Because aphid honeydew acts as an attraetant for many aphid predators and parasitoids, the objectives of this work were to collect and identify the volatile compounds released from the aphid excretory product to evaluate how these semiochemicals could affect the H. axyridis foraging behavior. Twelve volatile chemicals were identified from the Megoura viciae Buckton honeydew including four alcohols, three ketones, three aldehydes, a pyrazine and a monoterpene. The volatiles 3-methyl-l-butanol and 3-methyl-butanal were highlighted as the two most abundant semiochemicals released from the M. viciae honeydew. Vieia faba L. plants treated with crude honeydew attracted more than 80% of the tested individuals with 40% of attracted beetles located on the plant. Four volatile compounds （3-hydroxy-2-butanone, 3-methyl-butanal, 3-methyl-1-butanol and limonene） were also highlighted to attract more than 75% of the coccinellids toward the odor source and to locate about 35% of them on the plants. Limonene was the most efficient attractant since 89% of the H. axyridis responded to this odor. The use of the identified semiochemicals as well as the composition of an artificial honeydew could certainly be helpful to control the dispersal of the Asian lady beetle H. axyridis.

关键词： aphid honeydew attractant Harmonia axyridis kairomone semiochemicals

印尼西爪哇Pongkor矿床:上新世浅成低温热液型Au-Ag-(Mn)矿床

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贵金属地质 2000年第1期9卷 60-63页

作者： j.P.Milesi E.Marcoux T.Sitorus M.Simandjuntak j.leroy L.Bailly 王海俊沈阳地质矿产研究所

Pongkor矿床属于浅成低温热液 Au-Ag矿床,金储量至少为98t,平均品位为16.4×10-6;银储量1026t,平均品位171.2×10-6.它是印尼新近发现的规模较大的Au-Ag矿床.冰长石40Ar/39Ar成矿年龄值为2.05±0.5Ma.矿床属于低硫化物浅成低温热液型,含... 详细信息

Pongkor矿床属于浅成低温热液 Au-Ag矿床,金储量至少为98t,平均品位为16.4×10-6;银储量1026t,平均品位171.2×10-6.它是印尼新近发现的规模较大的Au-Ag矿床.冰长石40Ar/39Ar成矿年龄值为2.05±0.5Ma.矿床属于低硫化物浅成低温热液型,含有4条主要的石英脉矿体.石英脉主要位于火山构造凹陷(破火山口)的内缘,形成于爆破溶结凝灰岩的喷发.该喷发产生了火山碎屑熔岩、火山砾及少量碎屑岩夹层,构成区内火山岩组合,不整合覆盖于中新世安山岩之上.

关键词：金矿床银矿床 Pongkor矿床矿床地质低温热液

Natural Rubber-Based Ionogels

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journal of Renewable Materials 2018年第3期6卷 251-258页

作者： TK.N.Tran A.Guyomard-Lack C.Cerclier B.Humbert G.Colomines j-F.Pilard R.Deterre j.Le Bideau E.leroy UBL IUT of NantesCNRSGEPEAUMR 61442 Avenue du professeur Jean ROUXELBP 53944475 CarquefouFrance UBL University of MaineUMR CNRS 6283Institute of Molecules and Materials of Le MansAvenue Olivier Messiaen72085 Le Mans Cedex 9France Institut des Matériaux jean Rouxel(IMN) Universitéde NantesCNRS2 rue de la HoussinièreBP 3222944322 Nantes cedex 3France UBL CNRSGEPEAUMR 6144CRTT37Boulevard de l’Université44606 St Nazaire CedexFrance

Natural rubber(NR),besides being an abundant renewable resource for the elastomer industry,can be a potential resource for the design of innovative biobased polymer *** present work is based on“telechelic”liquid natural rubber oligomers obtained by controlled chemical degradation of *** chain ends of such oligomers can then be functionalized(with acrylate functions in the present case)and reacted with multifunctional crosslinkers in order to form ***’s more,the initial solubility of such thermosetting system in an ionic liquid(IL)can be used for the formulation of *** solid networks typically containing 80%of IL were produced,resulting in high ionic conductivity *** oligomer chain length was shown to affect IL fragility due to confinement and specific interactions of ions with the host polymer network.

关键词： Natural rubber oligomers ionogels confinement ionic conductivity

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Surrealism

作者： Cathrin Klingsohr-leroy Uta Grosenick (Ed.) English translation Isabel Varea.

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页岩压裂所诱发微地震事件的相对定位技术

石油地质科技动态 2010年第1期 84-89页

作者： B．j．hulsey 宋建平（译）白振瑞（校）

通过所记录波形的互相关（cross—correlation）和偏移，匹配滤波技术（matched filtertechnique）已经成功地运用于微地震事件的相对定位。除此之外，它还可以校正辐射效应和近地表构造的影响。采用这种方法确定的相对位置与采用直接... 详细信息

通过所记录波形的互相关（cross—correlation）和偏移，匹配滤波技术（matched filtertechnique）已经成功地运用于微地震事件的相对定位。除此之外，它还可以校正辐射效应和近地表构造的影响。采用这种方法确定的相对位置与采用直接定位法（PSET（r）技术）确定的位置进行了对比。采用新方法得出了一个解集（solution set），这个解集揭示了两个平行的微地震事件分布带（trend），它们被解释为长1500英尺、宽100英尺的裂缝带。观察到了不对称的裂缝生长和以前已经历过压裂的层段再次被压开的现象。所观测的微地震事件的发展与泵压曲线存在时间一致性，这表明裂缝呈线性生长，生长速度为每分钟数英尺，而且诱发裂缝中可能有支撑剂进入。

关键词：地震事件定位技术诱发压裂页岩生长速度相对位置裂缝带