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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.flerlage Mark l.Dell’Acqua Brian M.Cox fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily firas Kobeissy juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel jonathan Grossberg Daniel l.Barrow Matthew f.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

laser induced photo-detachment of O2 in DC discharge

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Plasma Science and Technology 2018年第7期20卷 98-105页

作者： j r legorreta j l patiNo f b yousif Centro de Investigacion en Ciencias Universidad Autonoma del Estado de Morelos.Av.UniversidadNo.1001 Col.Chamilpa Cuemavaca MorelosMexico

Determination of the negative ion number density of O2 and O in a DC discharge of oxygen plasma was made employing langmuir probe in conjunction with eclipse laser photo- detachment technique. The temporal evolution of the extra electrons resulting from the photo- detachment of O2- and O- were used to evaluate the negative ion number density. The ratio of O2 number density to O varied from 0.03 to 0.22. Number density of both O~ and O increased with increasing power and decreased as the pressure was increased. Electron number density was evaluated from the electron energy distribution function （EEDf） using the I-V recorded characteristic curves. Electron temperature between 2 and 2.7 eV were obtained. Influence of the 02（al△g） metastable state is discussed.

关键词： electronegative plasma electron temperature langmuir probe negative ion number density

Non-existence of Shimura curves of Mumford type generically in the non-hyperelliptic locus

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Science China Mathematics 2025年

作者： Xin lü Shengli Tan Kang Zuo School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications(Ministry of Education) Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal University School of Mathematics and Statistics Wuhan University Institut für Mathematik Universit?t Mainz

We show that there does not exist any Shimura curve with a strictly maximal Higgs field generically in the Torelli locus of non-hyperelliptic curves of genus g≥4. In particular, Shimura curves of Mumford type are not...

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

frontotemporal dementia and amyotrophic lateral sclerosis:frontotemporal dementia(f T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with fTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Boundary discontinuous fourier analysis of thick beams with clamped and simply supported edges via CUf

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Chinese journal of Aeronautics 2017年第5期30卷 1708-1718页

作者： f.G.CANAlES j.l.MANTARI faculty of Mechanical Engineering Universidad de Ingenieriay Tecnologia ( UTEC) Lima 15063 Peru Department of Mechanical Engineering University of New Mexieo Albuquerque 87131 USA

This paper presents an analytical solution for static analysis of thick rectangular beams with different boundary conditions. Carrera＇s Unified formulation（CUf） is used in order to consider shear deformation theories of arbitrary order. The novelty of the present work is that a boundary discontinuous fourier approach is used to consider clamped boundary conditions in the analytical solution, unlike Navier-type solutions which are restricted to simply supported *** equations are obtained by employing the principle of virtual work. The numerical accuracy of results is ascertained by studying the convergence of the solution and comparing the results to those of a 3D finite element solution. Beams subjected to bending due to a uniform pressure load and subjected to torsion due to opposite linear forces are considered. Overall, accurate results close to those of 3D finite element solutions are obtained, which can be used to validate finite element results or other approximate methods.

关键词： Analytical solution Beam Clamped fourier Unified formulation

Speeding up transmissions of unknown quantum information along Ising-type quantum channels

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Chinese Physics B 2017年第1期26卷 125-130页

作者： W j Guo l f Wei Quantum Optoelectronics laboratory Southwest Jiaotong University Chengdu 610031 China State Key laboratory of Optoelectronic Materials and Technologies School of Physics Sun Yat-Sen University Guangzhou 510275 China

Quantum teleportation with entanglement channels and a series of two-qubit SWAP gates between the nearestneighbor qubits are usually utilized to achieve the transfers of unknown quantum state from the sender to the distant receiver. In this paper, by simplifying the usual SWAP gates we propose an approach to speed up the transmissions of unknown quantum information, specifically including the single-qubit unknown state and two-qubit unknown entangled ones,by a series of entangling and disentangling operations between the remote qubits with distant interactions. The generic proposal is demonstrated specifically with experimentally-existing Ising-type quantum channels without transverse interaction; liquid NMR-molecules driven by global radio frequency electromagnetic pulses and capacitively-coupled josephson circuits driven by local microwave pulses. The proposal should be particularly useful to set up the connections between the distant qubits in a chip of quantum computing.

关键词： unknown quantum information transfers Ising-type quantum chains NMR molecules superconducting circuits

Vibrational behavior of isotropic plate structures in contact with a bounded fluid via unified formulation

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Chinese journal of Aeronautics 2019年第4期32卷 921-937页

作者： f.G.CANAlES j.l.MANTARI faculty of Mechanical Engineering Instituto de Investigación en Ingeniería Naval(IDIIN)Universidad Nacional de Ingenieria(UNI) Department of Mechanical Engineering University of New Mexico

This paper presents an analytical solution for free vibration analysis of thick rectangular isotropic plates coupled with a bounded fluid for various boundary conditions. In order to consider displacement theories of an arbitrary order, the Carrera Unified formulation(CUf) is used. The eigenvalue problem is obtained by using the energy functional, considering plate and fluid kinetic energies as well as the potential energy of the plate. The Ritz method is used to evaluate the displacement variables, and the functions used in the Ritz series can be adjusted to consider any of the classical boundary conditions. The convergence of the solution is analyzed, and a validation of results considering open literature and 3D finite element software is performed. Parametric studies are carried out to obtain natural frequencies as a function of the side-to-thickness ratio, plate aspect ratio, fluid domain size, plate boundary conditions, and fluid-solid density ratio. Pressure and velocity in the fluid domain are evaluated in order to establish the consistency of the *** results for thick plates are obtained with a much lower computational cost compared to that of 3D finite element solutions.

关键词： Added mass fluid-structure interaction Plate Ritz method Unified formulation Vibration