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Hyperspectral Imaging Based on Compressive Sensing: Determining Cancer Margins in Human Pancreatic Tissue <i>ex Vivo</i>, a Pilot Study

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Open journal of Medical Imaging 2021年第4期11卷 115-131页

作者： joseph Peller Cobey l. McGinnis Kyle j. Thompson Imran Siddiqui john Martinie David A. Iannitti Susan R. Trammell Department of Physics and Optical Science University of North Carolina at Charlotte Charlotte USA Carolinas Medical Center Charlotte USA

Cancer is the second-leading cause of death in the United State and surgery remains the primary treatment for most solid mass tumors. However, accurately identifying tumor margins in real-time remains a challenge. In this study, the design and testing of hyperspectral imaging (HSI) system based on a single-pixel camera engine is discussed. The primary advantage of a single pixel architecture over traditional scanning HSI techniques is its high sensitivity and potential to function at low light levels. The objective for the imaging system described here is to detect changes in the reflectance spectra of tissue and to use these differences to delineate tumor margins. This paper presents the results of a 19-patient pilot study that assesses the ability of the HSI system to use reflectance imaging to delineate adenocarcinoma tumor margins in human pancreatic tissue imaged ex vivo. Pancreatic tissue excised during pancreatectomy was imaged immediately after being sent to the pathology lab. A pathologist sectioned the tissue and placed samples into standard tissue embedding cassettes. These tissue samples were then imaged using the HSI system. After imaging, the samples were returned to the pathologist for processing and analysis. The HSI was later compared to the histological analysis. The spectral angle mapping (SAM) and support vector machine (SVM) algorithms were used to classify pixels in the HSI images as healthy or unhealthy in order to delineate margins. Good agreement between margins determined via HSI (using both SAM and SVM) and histology/white light imaging was found.

关键词： Hyperspectral Imaging Cancer Detection Reflectance Spectroscopy Single Pixel Camera

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Differences in Physiological Age Affect Diagnosis of Nitrogen Deficiencies in Cornfields

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Pedosphere 2008年第5期18卷 545-553页

作者： j. ZHANG A. M. BlACKMER T. M. BlACKMER Statistical Consulting Center Wright State University 3640 Colonel Glenn Highway Dayton Ohio 45435 （USA）. Department of Agronomy Iowa State University Ames Iowa 50011 （USA） Iowa Soybean Association 4554 114th Street Urbandale Iowa 50322 （USA）

Many studies have shown that chlorophyll meter readings （CMRs） can be used to diagnose deficiencies of nitrogen （N） during the growth of corn （Zea mays l.） in small-plot trials, but there is need to address additional problems encountered when diagnoses are made in fields of the size managed in production agriculture. A noteworthy difference between smallplot trials and production agriculture is the extent to which the effects of N are confounded with the effects of other factors such as tillage, landscape, soil organic matter and moisture content. We illustrate how some of these factors can cause differences in the physiological age of plants and introduce errors in the diagnoses of N deficiencies. We suggest methods （measuring the height to the youngest leaf collar and assigning leaf numbers by using the first leaf with pubescence and the ear leaf as references to identify growth stages） for minimizing these errors. The simplified method of growth stage identification can be used to select appropriate plants and leaves for making diagnoses in fields and to distinguish the effects of N from the effects of other factors that influence plant growth.

关键词： chlorophyll corn (Zea mays l.) nitrogen deficiency physiological age

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MORPHOlOGY EVOlUTION IN PTFE AS A FUNCTION OF MElT TIME AND TEMPERATURE——Ⅱ.lOW MOlECUlAR WEIGHT FOlDED CHAIN SINGlE CRYSTAlS AND BAND STRUCTURES

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Chinese journal of Polymer Science 2005年第2期23卷 137-145页

作者： j.YangandP.H.Geil T.C.longandP.Xu DepartmentofMaterialsScienceandEngineering UniversityoflUinois1304W.GreenSt.UrbanaIL61801 W.l.Gore＆Assocs. Inc.W.L.Gore＆Assocs.Inc.P.O.Box1220ElktonMD21921USA

The effect of sintering dispersed and bulk,low molecular weight(M_n=50,000 Da),nano-emulsionpolytetrafluoroethylene(PTFE)particles near their melting point is *** the nascent particles consisting of ca.75 nm diameter,hexagonal,single crystals,sintering at,e.g.,350℃,results,initially,in merger of neighboring particles,followed by individual molecular motion on the substrate and the formation of folded chain,lamellar single crystals andspherulites,and on-edge *** is suggested these structures develop,with time,in the mesomorphic“melt”.Sintering ofthe bulk resin yields extended chain,band structures,as well as folded chain lamellae;end-surface to end-surface merger,possibly by end-to-end polymerization,occurs with increasing time.

关键词： Polytetrafluoroethylene Nano-emulsion Single crystals Spherulites Banded structures Extended chain crystals Sintering.

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煤用钾盐催化剂催化气化制取甲烷

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煤炭转化 1983年第1期 34-36+14页

作者： l.j.Kaplan 周邦荣

埃克森研究和工程公司(Exxon Research and Engineering Co.)声称:本工艺方法将两个反应阶段——气化和甲烷化反应,结合在一起,并在一个流化床反应器里,产生出合成天然气,其总效率比惯用工艺方法更高。

关键词：催化剂碳酸钾钾碱碳酸盐烷烃甲烷沼气甲烷化反应催化气化钾盐钾石盐

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Evaluatingα-galactosylceramide as an adjuvant for live attenuated infuenza vaccines in pigs

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Animal Diseases 2022年第4期2卷 231-245页

作者： Bianca l.Artiaga Igor Morozov Russell Ransburgh Taeyong Kwon Velmurugan Balaraman Sabarish V.Indran Darling Melany De Carvalho Madrid Weihong Gu jamie Henningson Wenjun Ma jürgen A.Richt john P.Driver Department of Diagnostic Medicine&Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS 66506USA Division of Animal Sciences University of MissouriColumbiaMO 65211USA Department of Animal Sciences University of FloridaGainesvilleFL 32611USA

Natural killer T(NKT)cells activated with the glycolipid ligandα-galactosylceramide(α-GalCer)stimulate a wide variety of immune cells that enhance vaccine-mediated immune *** studies have used this approach to adjuvant inactivated and subunit infuenza A virus(IAV)vaccines,including to enhance cross-protective infuenza ***,less is known about whetherα-GalCer can enhance live attenuated infuenza virus(lAIV)vaccines,which usually induce superior heterologous and heterosubtypic immunity compared to non-replicating infuenza *** current study used the swine infuenza challenge model to assess whetherα-GalCer can enhance cross-protective immune responses elicited by a recombinant H3N2 lAIV vaccine(TX98ΔNS1)encoding a truncated NS1 *** one study,weaning pigs were administered the H3N2 TX98ΔNS1 lAIV vaccine with 0,10,50,and 100μg/kg doses ofα-GalCer,and subsequently challenged with a heterologous H3N2 *** treatment groups were protected from ***,the addition ofα-GalCer appeared to suppress nasal shedding of the lAIV *** another experiment,pigs vaccinated with the H3N2 lAIV,with or without 50μg/kg ofα-GalCer,were challenged with the heterosubtypic pandemic H1N1 *** vaccinated with the lAIV alone generated cross-reactive humoral and cellular responses which blocked virus replication in the airways,and signifcantly decreased virus *** the other hand,combining the vaccine withα-GalCer reduced cross-protective cellular and antibody responses,and resulted in higher virus titers in respiratory *** fndings suggest that:(i)high doses ofα-GalCer impair the replication and nasal shedding of the lAIV vaccine;and(ii)α-GalCer might interfere with heterosubtypic cross-protective immune *** research raise concerns that should be considered before trying to use NKT cell agonists as a possible adjuvant approach for lAIV vaccines.

关键词： Natural killer T cell Infuenza A virus Vaccine live attenuated infuenza virus Adjuvant α-Galactosylceramide Swine

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Evaluating the Ryman-laikre effect for marine stock enhancement and aquaculture

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Current Zoology 2016年第6期62卷 617-627页

作者： Robin S. WAPlES Kjetil HINDAR Sten KARlSSON jeffrey j. HARD National Marine Fisheries Service Northwest Fisheries Science Center 2725 Montlake Boulevard East Seattle WA 98112 USA Norwegian Institute for Nature Research (NINA) Trondheim 7485 Norway

The Ryman-laikre （R-l） effect is an increase in inbreeding and a reduction in total effective population size （NET） in a combined captive-wild system, which arises when a few captive parents produce large numbers of offspring. To facilitate evaluation of the R-l effect for scenarios that are relevant to marine stock enhancement and aquaculture, we extended the original R-l formula to explicitly account for several key factors that determine NeT, including the numbers of captive and wild adults, the ratio of captive to wild Ne/N （β）, productivity of captive and wild breeders, and removal of individuals from the wild for captive breeding. We show how to provide quantitative answers to questions such as： What scenarios lead to no loss of effective size？ What is the maximum effective size that can be achieved？ and What scenarios insure that NeTWill be no smaller than a specified value？ Important results include the following：（1） For large marine populations, the value of β becomes increasingly important as the captive contribution increases. Captive propagation will sharply reduce NeT unless the captive contribution is very small or β is very large （～10^3 or higher）. （2） Very large values of β are only possible if wild Ne/N is tiny. Therefore, large wild populations undergoing captive enhancement at even modest levels will suffer major reductions in effective size unless wild Ne is a tiny fraction of the census size （about 10 4 or lower）.

关键词： captive breeding effective population size inbreeding genetic drift.

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Pressure Effects on Structure and Dynamics of Metallic Glass-forming liquid with Miscibility Gap

Pressure Effects on Structure and Dynamics of Metallic Glass...

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第十一届中国钢铁年会

作者： Cheng Y. Wang P.F. Peng C.X. jia l.j. Wang Y.Y. Wang l. School of Mechanical Electrical & Information Engineering Shandong University (Weihai)

The metallic liquid with miscibility gap has been widely explored recently because of theincreasing plastic deformation abilityof phase-separated metallic *** the poor glass formation ability limits its application of the structural materials due to the positive mixing enthalpy of the two elements of all of *** the high pressure is in favor of the formation of the glass, in the paper, the effect of pressure on the structural and dynamical heterogeneity of phase-separated CuAg liquid is investigated by molecular dynamics simulation in the pressure range of 06 *** results clearly show that the pressure promotes the formation of metallic glass by increasing the number of five-fold symmetry cluster and dynamical relaxation time, meanwhile the liquid-liquid phase separation is also enhanced, the homogenous atom pairs show more stronger interaction than that of heterogeneous atom pairs with increasing *** dynamical heterogeneity is related to the formation of five-fold symmetry *** lower growing rate of W at higher pressure with decreasing temperature corresponds to the slow increasing of dynamical *** pressured glass with miscibility gap may act as a candidate glass with improving plastic formation *** results explore the structural and dynamics heterogeneity of phase separated liquid at atomic level.

关键词： glass-forming liquid with miscibility gap high pressure structural and dynamical heterogeneity

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Brillouin optical time-domain analysis for geotechnical monitoring

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journal of Rock Mechanics and Geotechnical Engineering 2015年第4期7卷 458-462页

作者： l.Zeni l.Picarelli B.Avolio A.Coscetta R.Papa G.Zeni C.Di Maio R.Vassallo A.Minardo DIII Second University of Naples Institute for Electromagnetic Sensing of the Environment (IREA) National Research Council DICDEA Second University of Naples School of Engineering University of Basilicata

In this paper, we show some recent experimental applications of Brillouin optical time-domain analysis （BOTDA） based sensors for geotechnical monitoring. In particular, how these sensors can be applied to detecting early movements of soil slopes by the direct embedding of suitable fiber cables in the ground is presented. Furthermore, the same technology can be used to realize innovative inclinometers, as well as smart foundation anchors.

关键词： Brillouin optical time-domain analysis(BOTDA)Tunnel engineeringDeformationDistributed monitoringHealth diagnosis

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马早期妊娠诊断方法之比较

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草食家畜 1986年第2期 16-17页

作者： j.l.Voss 郭成华

迄今,通过直肠触摸生殖道仍是母马妊娠诊断最常用的方法。最近已建立了超声波探查法和检测马绒毛膜促性腺激素(eCG)的免疫学方法。由马子宫内膜杯分泌的eCG,在妊娠35—40天出现在外周血液中,65—70天达峰值,120天后消失。检测eCG的方法... 详细信息

迄今,通过直肠触摸生殖道仍是母马妊娠诊断最常用的方法。最近已建立了超声波探查法和检测马绒毛膜促性腺激素(eCG)的免疫学方法。由马子宫内膜杯分泌的eCG,在妊娠35—40天出现在外周血液中,65—70天达峰值,120天后消失。检测eCG的方法有生物学测定法、血凝抑制试验(HIA)、放射免疫测定法、直接乳胶凝集法(DlA)、受体分析法和酶联免疫吸附法(ElISA)

关键词：早期妊娠母马超声波探查妊娠诊断诊断方法

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Advent of clean and green technology for preparation of low-cholesterol dairy cream powder:supercritical fluid extraction process

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Food Quality and Safety 2018年第4期2卷 205-211页

作者： Mousumi Ghosh Chitra j. Shubhangi Srivastava Hari Niwas Mishra Agricultural and Food Engineering Department Indian Institute of Technology KharagpurNalanda roadKharagpurWest Mednipore721302India

Objectives:Due to health issues related to cholesterol and the emphasis on manufacture of low cholesterol food products,the research was undertaken for the extraction of cholesterol from cream powder using supercritical fluid extraction(SCFE)*** and Methods:Face centered composite design(FCCD)was used to design the experiments with three independent variables viz.,extraction temperature(40˚C-75˚C),extraction pressure(100-250 bar)and dynamic time(2.5-3.5 h)taking two responses(cholesterol and fat content).The standardized flow rate and static time were 5 l/min(expanded CO_(2) gas)and 30 min,*** surface methodology was used for optimizing the process ***:It was found that higher operating pressure,low extraction temperature and moderate amount of dynamic time facilitated the removal of *** optimized process conditions of 75˚C,204 bar and 3.5 h dynamic time yielded 39%reduction in cholesterol content and 10.6%reduction in total fat content of the cream ***:Thus,a low cholesterol cream powder was developed with health benefits for people suffering from cardiovascular diseases.

关键词： cholesterol supercritical fluid extraction HPlC face-centred composite design response surface methodology

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